Abstract:
:There are conflicting opinions concerning the epidermal immunofluorescence pattern in primary Sjögren's syndrome. In a prospective study of 12 patients we found a characteristic pattern of epidermal nuclear/cytoplasmic IgG deposits in 8 (67%). This pattern was associated with the presence of antibodies against SSA/Ro and SSB/La in the serum and was also found in 2 out of 5 LE patients with monospecific antibodies against SSA/Ro. There is a resemblance to the pattern of dust-like particles described in the diseased skin of patients with subacute cutaneous LE. In one patient with primary Sjögren's syndrome, IgG deposits were confined to epidermal cell nuclei (in vivo ANA). Instead of antibodies against SSA/Ro or SSB/La, this particular patient had nRNP-antibodies. From this study, we conclude that the epidermal IgG deposits in primary Sjögren's syndrome may represent antibody binding to the sites within epidermal cells where the respective antigens are located.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Velthuis PJ,Nieboer C,Kater L,Hené RJsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
487-91issue
6eissn
0001-5555issn
1651-2057journal_volume
69pub_type
杂志文章abstract::Previous studies have shown that magnetic resonance imaging is more sensitive in assessing soft tissue and bone involvement in inflammatory arthritis than conventional radiography. Therefore the main objects of this study were to evaluate the frequency of hand involvement in psoriatic patients free from arthritic symp...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155598442809
更新日期:1998-11-01 00:00:00
abstract::Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3102
更新日期:2019-03-01 00:00:00
abstract::We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2340/00015555756569
更新日期:1995-01-01 00:00:00
abstract::Vulvar vestibulitis is a major cause of entry dyspareunia in young women. The aim of this study was to evaluate a self-reported history of bacterial vaginosis, candidiasis, use of oral contraception and nulli-pregnancy as risk factors for vestibulitis. A retrospective examination of medical records was performed for 4...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0250
更新日期:2007-01-01 00:00:00
abstract::Multicentric reticulohistiocytosis is a rare systemic disease of unknown aetiology characterized by erosive arthritis and cutaneous lesions consisting of multiple reddish-brown papules and nodules, mainly involving the face and distal upper extremities. It has been suggested that skin eruptions in multicentric reticul...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0961
更新日期:2011-03-01 00:00:00
abstract::Penicillin concentration in serum and cerebrospinal fluid (CSF) were estimated in 19 syphilitic patients given three different regimens: Penicillin G, 10 MIU i.v. three times a day (3 patients); procaine penicillin, 600 000 IU i.m. (11 patients); and penicillin V, 1.2 MIU by mouth four times a day (5 patients). Intrav...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Psoriasis is a chronic skin disease with substantial impact on patients' social and relational ways of living and subsequently on their quality of life. The aim of this study was to evaluate the health-related quality of life (HRQoL) of patients with moderate to severe psoriasis treated with short contact dithranol tr...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/00015550510027801
更新日期:2005-01-01 00:00:00
abstract::A female presenting multiple osteoma cutis lesions without underlying endocrinological disturbance was studied. Histologically, lesions revealed true bone formation with multiple osteoblastic cells. This was confirmed by demonstrating high alkaline phosphatase activity and osteonectin expression in osteoma cutis lesio...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572172174
更新日期:1992-01-01 00:00:00
abstract::Confocal laser scanning microscopy (CLSM) was used for quantitative analysis of CD1a+ cells in epidermis at irritant reactions. Sodium lauryl sulphate (2% and 4%) or non-anoic acid (20% and 80%) were applied to the skin of healthy volunteers under occlusion for 24 h. Skin biopsy specimens were taken after additional 2...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:101080/000155572348351
更新日期:1992-09-01 00:00:00
abstract::The 8-methoxypsoralen (8-MOP) plasma level was determined in 31 patients during treatment with PUVA (psoralen + UVA light). The UVA light source was of a low intensity type, giving only 2 mW/sec/cm2 and required an irradiation time of 30 minutes. The lesions of 19 patients healed completely. Following an oral dose reg...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischaemic causes (arterial disease and/or microvascular impairment). A retrospective, multic...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,多中心研究
doi:10.2340/00015555-2939
更新日期:2018-07-11 00:00:00
abstract::Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances. At present, the underlying mechanisms responsible for night-time itching are not well understood. Nocturnal pruritus may be related to the circadian rh...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,评审
doi:10.2340/00015555-0280
更新日期:2007-01-01 00:00:00
abstract::The prevalence of melanocytic naevi in children correlates with sun exposure and may serve as an objective population risk indicator of future melanoma incidence. The aim was to investigate if mobile teledermatology could offer a valid methodology compared with standard manual, face-to-face counting of naevi on the ba...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1950
更新日期:2015-03-01 00:00:00
abstract::We used T-cell receptor excision circles (TREC) to evaluate thymic function in adult patients with atopic dermatitis and psoriasis. We observed that men, but not women, with atopic dermatitis had a significantly faster decline in TREC content with increasing age compared with healthy men. In contrast, both men and wom...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0550
更新日期:2008-01-01 00:00:00
abstract::The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomise...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,随机对照试验
doi:10.2340/00015555-2048
更新日期:2015-07-01 00:00:00
abstract::Two cases of subacute cutaneous lupus erythematosus are described. Features which delayed diagnosis are discussed. The potential clinical and histopathological overlap between this condition and erythema multiforme is emphasized, drawing attention to the histological features which allow distinction. The possibility t...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015559850135869
更新日期:1998-01-01 00:00:00
abstract::Tobacco smoke and UV radiation are extrinsic risk factors for accelerated skin ageing. In this study the effects of smoking on wrinkling and ageing were assessed in males living in Northern Finland, where cumulative sun exposure is low. Smoking habits, age and facial wrinkling were estimated from facial photographs of...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550410014969
更新日期:2004-01-01 00:00:00
abstract::A skin biopsy is one of the most frequently performed procedures in the dermatology outpatient clinic, but doctors often do not consider the cognitive impact of the biopsy procedure. Based on "terror management theory," we reasoned that a skin biopsy increases patient compliance by unconsciously stimulating mortality ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0849
更新日期:2010-05-01 00:00:00
abstract::We evaluated the reproducibility of atopy patch test reactions and the quality and quantity of itch in 16 patients with atopic eczema and a history of a positive atopy patch test reaction, comparing three different application sites. The allergen was re-applied simultaneously on both forearms and the back. Intensity a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550410024418
更新日期:2005-01-01 00:00:00
abstract::The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual s...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550252948103
更新日期:2002-01-01 00:00:00
abstract::Altogether 525 PUVA-treated psoriatics were re-examined. The mean follow-up period since the beginning of PUVA therapy was 2.1 years (range 1-3.6 years). In 107 cases (20%) the total UVA dose was below 100 J/cm2 and in 20 (4%) over 1000 J/cm2. During PUVA treatment or at re-examination of 14 of the 525 patients (3%) w...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Forty-three nickel-allergic patients (40 females and 3 males) participated in this study which was designed to elucidate the correlation between quantitative in vivo and in vitro responses. All were patch-tested with various concentrations of nickel-sulphate serial-diluted in water. The lowest concentration eliciting ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Most dermatologists are aware of the benefits of dermoscopy, and a few are familiar with laser-scanning confocal microscopy. Beyond confocal, there are fully 11 different categories of optical techniques that have been applied to clinical dermatology. This article first provides a comprehensive tabular overview of all...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2717
更新日期:2017-01-01 00:00:00
abstract::To characterize the exposome of the Spanish population and its association with skin ageing a cross-sectional epidemiological study was conducted in men and women (18-60 years old). A total of 1,474 participants were included. Mean age (± standard deviation) was 40.84 ± 10.26 years. Most participants had Fitzpatrick s...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3500
更新日期:2020-05-28 00:00:00
abstract::Fifteen patients with nodular prurigo were treated with a trioxsalen bath (50 mg/150 l of water) and UVA given in an ordinary PUVA cabin. Good results were observed in 8 and moderate in 7 patients in the initial phase. The result was good or excellent in 13 of the 15 patients during maintenance treatment. The good res...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Phototherapy with ultraviolet (UV) radiation of wavelengths between 280 and 320 nm (UVB) is a safe and effective treatment for a variety of diseases. In addition to standard broadband UVB (bUVB), narrowband phototherapy with fluorescent bulbs emitting near monochromatic UV around 311 nm (nUVB) has become an important ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,评审
doi:10.1080/00015550510025579
更新日期:2005-01-01 00:00:00
abstract::Oral terbinafine is licensed for use in onychomycosis after positive confirmation of infection. We describe five cases of subacute cutaneous lupus erythematosus associated with terbinafine therapy. All cases had positive antibodies to extractable nuclear antigens, predominantly anti-Ro, and several had a history of pr...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550410018361
更新日期:2004-01-01 00:00:00
abstract::Bullous dermolysis of the newborn (BDN) is a subtype of dystrophic epidermolysis bullosa characterized by rapid improvement in skin fragility within the first months of life, associated with typical immunofluorescence and ultrastructural features. Inheritance can be autosomal dominant or recessive. We report here 4 ca...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2364
更新日期:2016-08-23 00:00:00
abstract::A series of agents with alleged photosensitizing properties has been studied in mice by a quantitative in vivo method for acute drug phototoxicity. The method, originally developed for phenothiazine studies, was found suitable for several drug groups with varying mechanism of action, such as tetracyclines, protoporphy...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Dyschromatosis symmetrica hereditaria (OMIM127400) is a rare autosomal dominant pigmentary genodermatosis caused by mutations in the RNA-specific adenosine deaminase (ADAR) gene. This study investigated 5 families and 3 sporadic patients with dyschromatosis symmetrica hereditaria in the Chinese Han population from Anh...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0168
更新日期:2007-01-01 00:00:00