Abstract：
:Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances. At present, the underlying mechanisms responsible for night-time itching are not well understood. Nocturnal pruritus may be related to the circadian rhythm of itch mediators and possibly the disruption of such patterns. Diurnal changes in skin physiology, such as temperature and barrier function, may also play a role. Currently, the paucity of specific treatment options for nocturnal pruritus is alarming and needs to be addressed by future research. This review describes the scale of the problem associated with nocturnal pruritus, the impact it has on patients, possible underlying mechanisms and, lastly, treatment options.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Patel T,Ishiuji Y,Yosipovitch Gdoi
10.2340/00015555-0280subject
Has Abstractpub_date
2007-01-01 00:00:00pages
295-8issue
4eissn
0001-5555issn
1651-2057journal_volume
87pub_type
杂志文章,评审abstract：:Terfenadine is a safe non-sedative H1-receptor antagonist. This study aimed to quantify the relative reduction in weal and flare area, thickness and erythema at 4, 8, 12 and 24 h following a single but variable oral dose of terfenadine compared with pre-treatment measurements, in order to compare the dose-effect relat...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, C...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,随机对照试验
doi：10.2340/00015555-2579
更新日期：2017-04-06 00:00:00
abstract：:The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomise...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,随机对照试验
doi：10.2340/00015555-2048
更新日期：2015-07-01 00:00:00
abstract：:Free fatty acids in sebum arise from lipolytic action of bacterial lipases. We have demonstrated an inhibitory effect of zinc on the lipase of the three Propionibacterium species found in human pilosebaceous follicles. We were also able to show a small corresponding fall in the free fatty acid content of skin surface ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:A fifty-year-old man with a history of recurrent bronchial and renal infections, and rheumatoid arthritis was admitted with a sunexposure-induced discoid lupus erythematosus. Complement levels and HLA typing of the patient and his family revealed a homozygous C2 deficiency in the patient and his HLA-identical healthy ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Diagnosing gonorrhoea from extra-genital as well as genital sites is important in managing this sexually transmitted disease. In this study we evaluated a screening procedure for Neisseria gonorrhoeae (GC) from all sample sites in a low-prevalence setting. A total of 69,252 specimens submitted for Chlamydia trachomati...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1192
更新日期：2012-01-01 00:00:00
abstract：:There are conflicting opinions concerning the epidermal immunofluorescence pattern in primary Sjögren's syndrome. In a prospective study of 12 patients we found a characteristic pattern of epidermal nuclear/cytoplasmic IgG deposits in 8 (67%). This pattern was associated with the presence of antibodies against SSA/Ro ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555575287289
更新日期：1995-07-01 00:00:00
abstract：:In this prospective study, 51 patients suffering from psoriasis and ichthyosis were treated with acitretin for 2 years. The average dose was 0.5 mg/kg/day. We have evaluated the efficacy and side effects, focusing on skeletal side effects. X-ray examinations were done before treatment and after 1 and 2 years. Forty-fi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555572445448
更新日期：1992-11-01 00:00:00
abstract：:A 73-year-old woman with rheumatoid arthritis was treated with Levamisole, 150 mg per day, on 2 days a week. Her arthritis improved, but she developed a severely itching rash, and the treatment was stopped after 6 months. Penicillamine was subsequently given and tolerated without skin complications. 15 months after re...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Although mosquito allergy induces the release of histamine, the itch-related response, scratching, is not effectively suppressed by blockade of H1 histamine receptors. To address this question, we examined the effects of neonatal capsaicin treatment on allergic reactions and H1 histamine receptor-expressing sensory ne...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0479
更新日期：2008-01-01 00:00:00
abstract：:Remission of psoriatic lesions was induced when the lesions were firmly pressed with a plastic cap held in place by an elastic bandage for 24 h or stretched with a negative pressure of 200 mmHg for 2 h. Seven out of 10 patients showed a clinical improvement of the treated psoriatic lesions. These lesions cleared withi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570176179
更新日期：1990-01-01 00:00:00
abstract：:A 39-year-old man presented with multiple basaloid follicular hamartomas involving the right side of his body in a systematized pattern following Blaschko's lines. His right leg was 22.5 cm shorter than the left, and rudimentary pre-axial polydactyly was noted on the left hand and the right foot. The teeth of the righ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0495
更新日期：2008-01-01 00:00:00
abstract：:Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The increasing incidence of melanoma prompts a need for efficient management of this patient group. In this study, we use the number needed to excise (NNE), as a measurement of the efficiency of diagnosing melanoma. From January 2009 to December 2012, postoperative records from all patients were prospectively register...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1831
更新日期：2014-11-01 00:00:00
abstract：:Human leukocytes and fibroblasts were cultured in medium containing 3H-8-methoxypsoralen (10(-6) M and 3.3 X 10(-6) M). At different stages during the culturing period the cells were exposed to ultraviolet light (1, 2, and 10 J/cm2). After the culture period the slides for chromosome analysis and smears of the cells w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155599750011336
更新日期：1999-03-01 00:00:00
abstract：:The effect of occlusion on epidermal morphology was studied at electron microscopic resolution. the morphological changes recorded were relatively mild, though conspicuous, and consisted in dilatation of the intercellular space, appearance of cytoplasmic vacuoles and an oedematous change in the dermis. Stereological a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The identification of mononuclear cells extracted from 12 basal cell carcinomas has been carried out by means of various assays such as the E rosette test, FITC anti-Ig conjugates and peroxidase conjugates viewed at an ultrastructural level. The relative quantities of B and T cells have been determined as well as the ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Altogether 525 PUVA-treated psoriatics were re-examined. The mean follow-up period since the beginning of PUVA therapy was 2.1 years (range 1-3.6 years). In 107 cases (20%) the total UVA dose was below 100 J/cm2 and in 20 (4%) over 1000 J/cm2. During PUVA treatment or at re-examination of 14 of the 525 patients (3%) w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:We investigated the usefulness of the restriction enzyme (RE) fingerprinting for epidemiological tracing in gonococcal disease. The RE patterns of three paired gonococcal isolates showed corresponding identical fingerprints. Within each of the three pairs of epidemiologically linked isolates the respective restriction...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:In an attempt to clarify the pathophysiology of haemodynamics in legs with venous ulcer we investigated the effect of a single intermittent pneumatic compression treatment on the peripheral resistance of leg arteries and the cutaneous laser Doppler flux in the leg. Eight patients with venous leg ulcers and 10 subjects...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155599750011435
更新日期：1999-03-01 00:00:00
abstract：:Two unusual structures were found in the epidermal Langerhans' cells of normal human adult skin: (1) an intramitochondrial crystalline lattice structure composed of numerous electron-dense, fine particles approximately 90 A in diameter, with a lucent spacing of nearly 90 A; (2) bundles of unusual cytoplasmic tubular s...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Horizontal sectioning of scalp biopsies is especially useful in hair diseases characterized by a reduction of follicles in size or number. Horizontal sectioning using standard cryo-microtomes is hampered by the differences in cutting properties between hair follicles and fatty tissue, resulting in loss of topography. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570335338
更新日期：1990-01-01 00:00:00
abstract：:ESR spectra of synthetic melanins formed from dopa and from 5-S-cysteinyldopa and of melanins isolated from human melanomas were studied. Alkali-soluble melanin synthesized from cysteinyldopa showed a signal similar to that of insoluble melanin synthesized from dopa, but also a simple fine structure. Trichochromes C a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Many patients with moderate-to-severe plaque psoriasis do not respond adequately to methotrexate monotherapy. This pilot study, with a small patient population, was performed to evaluate the effectiveness and safety of etanercept and methotrexate combination in patients with plaque psoriasis and inadequate response to...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2340/00015555-0511
更新日期：2008-01-01 00:00:00
abstract：:Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2924
更新日期：2018-06-08 00:00:00
abstract：:Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors. We compared 5-S-CD and eumelanin-related metabolites regarding the correlation of their production in melanoma and excretion in urine, versus the weight of B16 mouse melanoma. It ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Three patients with onychomycosis due to Trichophyton soudanense with an "endonyx" type of nail invasion are presented. Endonyx onychomycosis is clinically characterized by a diffuse milky-white discolouration of the affected nail, in the absence of nail bed hyperkeratosis or onycholysis. Nail plate surface and nail t...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155599750011714
更新日期：1999-01-01 00:00:00
abstract：:Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3363
更新日期：2020-10-06 00:00:00
