Skin barrier properties in patients with recessive X-linked ichthyosis.

Abstract:

:Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin response to SLS were studied by measurement of transepidermal water loss (TEWL), electrical capacitance and erythema index. No statistically significant difference in basal TEWL was found between the two groups. The skin response to SLS was found to be statistically significantly increased in controls compared to ichthyosis patients, when evaluated by TEWL. When evaluated by erythema index a statistically significant increase in redness was found in controls, but not in ichthyosis patients. Electrical capacitance, reflecting skin hydration, was significantly reduced in RXLI patients as compared to controls. The water permeability barrier in RXLI patients was not found to be impaired, and skin reactivity was found to be decreased in RXLI patients as compared to controls.

journal_name

Acta Derm Venereol

authors

Johansen JD,Ramsing D,Vejlsgaard G,Agner T

doi

10.2340/0001555575198201

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

202-4

issue

3

eissn

0001-5555

issn

1651-2057

journal_volume

75

pub_type

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