Abstract:
:A noninvasive Finn Chamber sampling method and HPLC analysis were used to determine epidermal urocanic acid (UCA) concentrations of psoriasis patients during 4 weeks of heliotherapy on the Spanish Canary Islands and a follow-up period of 8 weeks. During heliotherapy the epidermal cis-UCA concentration increased from a mean initial value of 0.2 nmol/cm2 to a mean final value of 2.9 nmol/cm2. The total UCA concentration decreased during the first week of heliotherapy from an initial value of 5.5 nmol/cm2 to a nadir of 2.0 nmol/cm2. Thereafter, a steady increase was recorded in the total UCA level, with a maximum of 10.2 nmol/cm2 in week 2 of the post-treatment follow-up period. Suberythemal sun exposures caused near-maximal UCA isomerization, and during heliotherapy the cis isomer constituted 63.7-74.3% of the total UCA concentration. Clinical response of psoriasis to heliotherapy, however, seemed to be independent of UCA isomer levels.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Snellman E,Koulu L,Pasanen P,Lammintausta K,Neuvonen K,Ayräs P,Jansén CTdoi
102340/000155555571231233subject
Has Abstractpub_date
1992-01-01 00:00:00pages
231-3issue
3eissn
0001-5555issn
1651-2057journal_volume
72pub_type
杂志文章abstract::Ureaplasma urealyticum is a causative agent of non-gonococcal urethritis and is implicated in the pathogenesis of several other diseases. However, U. urealyticum is also frequently found in the normal genitourinary tract. To characterize the distribution pattern of biovars and genotypes in normal physical check-up wom...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310007157
更新日期:2003-01-01 00:00:00
abstract::To characterize the exposome of the Spanish population and its association with skin ageing a cross-sectional epidemiological study was conducted in men and women (18-60 years old). A total of 1,474 participants were included. Mean age (± standard deviation) was 40.84 ± 10.26 years. Most participants had Fitzpatrick s...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3500
更新日期:2020-05-28 00:00:00
abstract::Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin disorder caused by mutations in the COL7A1 gene, which encodes collagen VII (COL7). Skin ulcers in RDEB patients are sometimes slow to heal. We describe here the therapeutic response of intractable skin ulcers in two patients with generalized RDEB ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0776
更新日期:2010-03-01 00:00:00
abstract::The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575190192
更新日期:1995-05-01 00:00:00
abstract::A skin biopsy is one of the most frequently performed procedures in the dermatology outpatient clinic, but doctors often do not consider the cognitive impact of the biopsy procedure. Based on "terror management theory," we reasoned that a skin biopsy increases patient compliance by unconsciously stimulating mortality ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0849
更新日期:2010-05-01 00:00:00
abstract::Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen i...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::Horizontal sectioning of scalp biopsies is especially useful in hair diseases characterized by a reduction of follicles in size or number. Horizontal sectioning using standard cryo-microtomes is hampered by the differences in cutting properties between hair follicles and fatty tissue, resulting in loss of topography. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570335338
更新日期:1990-01-01 00:00:00
abstract::In order to find image descriptors enabling the characterization of sclerotic skin of morphea plaques and their objective differentiation from normal skin, we studied 52 lesions in 35 patients affected by plaque type morphea. Echographic evaluations were carried out using a 20 MHz B-scanner, providing cross-sectional ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575442445
更新日期:1995-11-01 00:00:00
abstract::A series of 446 inpatients with drug eruption was studied to determine the causative agent and the clinical type. In over a half of the cases a provocation test confirmed the drug responsible for the reaction. Sulphonamides/trimethoprim and ampicillin/penicillin followed by phenazones were the most frequent agents cau...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Although atopic dermatitis is a skin disorder, it includes immune deviations such as T-cell accumulation and activation in the skin, resulting in chronic, relapsing eczema. The T-lymphocyte activation in the skin is not accompanied by specific allergies in up to two thirds of the patients. It has been shown that T-cel...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555577020021
更新日期:1997-01-01 00:00:00
abstract::Confounding from comorbidity and socioeconomic status may have biased earlier findings of all-cause mortality among patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We therefore examined all-cause mortality among 72,295 Danish patients with BCC, 11,601 with SCC, and 383,714 age- and gender-m...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0899
更新日期:2010-07-01 00:00:00
abstract::It has been shown recently that immunotherapy for advanced melanoma is effective. However, in order to improve the efficacy of immunotherapy, the identification of more specific melanoma-associated antigens is urgently needed. Kinesin family member 20A (KIF20A) has been reported to be a promising immunotherapeutic tar...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1416
更新日期:2012-11-01 00:00:00
abstract::A case of juvenile xanthogranuloma in a female newborn infant is reported. Red-brown, flat, well-demarcated lesions were present at birth on her scalp, face and trunk. During the following year of observation the eruptions regressed slowly and spontaneously. Light and electron microscopy revealed histiocytes and Touto...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Biopsies obtained from both the perilesional areas and clinically uninvolved skin of patients with pemphigus vulgaris (PV) were studied for antigen-presenting cell and lymphocyte phenotype and/or activation phenotype using monoclonal antibodies in avidin-biotin-peroxidase complex staining. Perilesional PV skin contain...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The releasability of arachidonic acid-derived inflammatory mediators (eicosanoids) from peripheral blood leukocytes has been tested in patients with atopic eczema and healthy, non-atopic controls. Spontaneous and stimulated release of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and leukotriene C4 (LTC4) has been me...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Infection can be a trigger and an aggravating factor in psoriasis. Antibacterial and/or antifungal agents are commonly used in the treatment of intertriginous psoriasis, because it is believed that flexures in psoriasis are often colonized by Candida species and Staphylococcus aureus. Bacterial and fungal cultures wer...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310007463
更新日期:2003-01-01 00:00:00
abstract::The effect of topical indomethacin on the weal and flare response was measured in 9 patients with chronic dermographic urticaria. An augmentation of dermographic wealing by topical indomethacin was shown with lowering of the weal threshold from 22.3 +/- 4.7 g/mm2 (mean +/- SEM, n = 9) to 16.4 +/- 3.8 (p < 0.005), but ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/000155557379
更新日期:1993-02-01 00:00:00
abstract::Biopsies for electron microscopy were obtained from syphilitic chancres of 7 patients, 6 males and one female. In 4 of the patients, Treponemata pallida were seen gathering around peripheral nerves and invading the spaces between Schwann cells and their basal lamina. No definite degenerative changes were seen in the a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Itching is the most frequent symptom in dermatology. Little is known about its occurrence and its characteristics in the general population. Instruments specifically designed to measure itch are scarce. The aim of this pilot study was to develop and validate an instrument measuring prevalence and characteristics of ch...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0641
更新日期:2009-01-01 00:00:00
abstract::The anti-inflammatory mechanisms of minocycline, an antibiotic used in the treatment of the inflammatory component of acne, are only partially understood. In addition to inflammation due to cytokines (IL-1, IL-6, TNF-alpha, etc.), recent studies have shown that neuropeptide-mediated neurogenic inflammation may play an...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750010625
更新日期:1999-07-01 00:00:00
abstract::Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Recor...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3009
更新日期:2018-11-05 00:00:00
abstract::In order to study the flare-up of contact allergy, 35 patients with a contact allergy to gold were given an intramuscular injection of 10 mg gold sodium thiomalate, i.e. the anti-rheumatic drug Myocrisin. Clinical reactions comprised an eczematous flare-up of previously positive patch tests to gold and of a previous d...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The incidence of refractory atopic dermatitis has increased in teenagers and young adults. The purpose of this study was to control the skin symptoms of such patients in daily life. Seventy patients repeatedly took a 10-min 42 degrees C acidic hot-spring bath twice daily. The skin symptoms were improved in 76% of case...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
doi:10.2340/0001555577452454
更新日期:1997-11-01 00:00:00
abstract::Neuromediators may influence the immune response. To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930....
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555576102106
更新日期:1996-03-01 00:00:00
abstract::Patients with psoriasis who are being treated with biologics require intensive monitoring. However, the monitoring tool teledermatology is not commonly used. We investigated the applicability of a mobile phone based teledermatological system for monitoring psoriasis patients on biologic therapy. Nineteen patients were...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1148
更新日期:2011-10-01 00:00:00
abstract::Retinoid transfer into breast milk was studied in a psoriatric woman receiving oral acitretin at a dosage of 40 mg once daily. Concentrations of the parent compound and its main metabolite, 13-cis acitretin, were measured in serum and mature milk during the initial nine days of therapy, using reverse-phase high perfor...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570487490
更新日期:1990-01-01 00:00:00
abstract::Epipodophyllotoxin (VP-16-213) was administered to 9 patients with mycosis fungoides in various stages, most of them in the advanced tumour stage. In 4 of the patients VP-16 was combined with cyclophosphamide. VP-16 alone or in combination with cyclophosphamide was capable of inducing remission initially in all cases,...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The increasing incidence of melanoma prompts a need for efficient management of this patient group. In this study, we use the number needed to excise (NNE), as a measurement of the efficiency of diagnosing melanoma. From January 2009 to December 2012, postoperative records from all patients were prospectively register...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1831
更新日期:2014-11-01 00:00:00
abstract::The possible relationship between skin capacitance and the mechanical properties of the skin was studied using non-invasive techniques. Skin hydration was changed by soaking skin with tap water. Hydration of the skin increased the capacitance significantly (p less than 0.01) and hysteresis (creeping phenomenon) (p les...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570245247
更新日期:1990-01-01 00:00:00
abstract::We used T-cell receptor excision circles (TREC) to evaluate thymic function in adult patients with atopic dermatitis and psoriasis. We observed that men, but not women, with atopic dermatitis had a significantly faster decline in TREC content with increasing age compared with healthy men. In contrast, both men and wom...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0550
更新日期:2008-01-01 00:00:00