Abstract:
:Loricrin, the major component of the cornified envelope, is normally expressed in the granular layer of epidermis during the last steps of keratinocyte differentiation. Using an antiloricrin antiserum (A8-73), an increased expression of this envelope precursor was found in some disorders of hyperorthokeratosis (ichthyosiform erythroderma; lichen ruber), but not in others (keratodermia ichthyosis vulgaris). In disorders accompanied by parakeratosis, a sign of incomplete differentiation (psoriasis, prurigo nodularis) loricrin was not detected, whereas the tissue expressed filaggrin. Treatment of normal skin with retinoic acid, increasing epidermal thickness in some subjects, led to an increased expression of loricrin. Loricrin might be a useful indicator of the extent of terminal epidermal differentiation in skin disorders.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Juhlin L,Magnoldo T,Darmon Mdoi
102340/0001555572407409subject
Has Abstractpub_date
1992-11-01 00:00:00pages
407-9issue
6eissn
0001-5555issn
1651-2057journal_volume
72pub_type
杂志文章abstract::Two cases of subacute cutaneous lupus erythematosus are described. Features which delayed diagnosis are discussed. The potential clinical and histopathological overlap between this condition and erythema multiforme is emphasized, drawing attention to the histological features which allow distinction. The possibility t...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015559850135869
更新日期:1998-01-01 00:00:00
abstract::Considerable interest has been recently generated concerning the use of natural compounds, anti-oxidants in particular, in photoprotection. Two of the best known anti-oxidants are vitamins C and E, both of which have been shown to be somewhat effective in different models of photodamage. Very little has been reported,...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555576264268
更新日期:1996-07-01 00:00:00
abstract::Twenty-one patients with Behçet's disease were typed for HLA antigens. The controls were 50 subjects randomly chosen from a local population and 24 apparently healthy subjects of the same ethnic groupings as those of the patients. The study revealed significant differences in the frequencies of various antigens in the...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Patients with mood depression have been found to have a higher prevalence of seborrheic dermatitis (SD), possibly related to their tendency to live indoors. The prevalence of outpatients with SD has now been found to be directly related to the number of gloomy days in the area. Since UV light might not be the only rea...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575190192
更新日期:1995-05-01 00:00:00
abstract::Thirteen patients with port wine stains (PWS) were treated with argon laser therapy. Before and at different points in time following treatment, skin blood perfusion and temperature were mapped with laser Doppler imaging and thermography. In nine patients no elevation in blood perfusion was observed in the PWS in comp...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572610
更新日期:1992-01-01 00:00:00
abstract::Skin perfusion pressure in fingers in 6 normal persons and 12 patients suffering from generalized scleroderma was estimated as the minimum external counterpressure required to stop 133Xenon wash-out. The isotope was introduced atraumatically into the skin, and local counter-pressure was exerted by a miniature blood pr...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::One of the prepolymers used in Ultraviolet (UV) curing ink formulations is acrylated polyester. The prepolymer investigated is a dimethacrylated polyester, thus a saturated polyester terminated with methacrylic groups. In conventional UV-curing coatings the prepolymer commonly used is an unsaturated polyester. Three o...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Human leukocytes and fibroblasts were cultured in medium containing 3H-8-methoxypsoralen (10(-6) M and 3.3 X 10(-6) M). At different stages during the culturing period the cells were exposed to ultraviolet light (1, 2, and 10 J/cm2). After the culture period the slides for chromosome analysis and smears of the cells w...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomise...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,随机对照试验
doi:10.2340/00015555-2048
更新日期:2015-07-01 00:00:00
abstract::Eosinophilic pustular folliculitis is an inflammatory skin disease characterized by pruritic follicular papulopustules. It is usually resistant to topical and/or systemic corticosteroids, but it responds well to systemic indomethacin. We report here two patients with classical-type disease who were treated with system...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0759
更新日期:2010-01-01 00:00:00
abstract::Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischaemic causes (arterial disease and/or microvascular impairment). A retrospective, multic...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,多中心研究
doi:10.2340/00015555-2939
更新日期:2018-07-11 00:00:00
abstract::Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2924
更新日期:2018-06-08 00:00:00
abstract::Mesotherapy is a treatment method devised for controlling pain syndromes or diseases by subcutaneous microinjections given at or around the involved areas at short intervals of time. Different adverse effects have been described due to this modality of treatment. This report describes 3 patients with cutaneous infecti...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550152572967
更新日期:2001-08-01 00:00:00
abstract::A 15-month-old boy with pachyonychia congenita is described. The patient also had follicular keratosis, leukokeratosis of the tongue, and blisters on the soles. Histopathological examination of the follicular keratosis showed hyperkeratosis and acanthosis. Horny plugs were located in sweat pores. By electron microscop...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Patients with atopic dermatitis were found to have an about 7-fold increased spontaneous proliferative response of peripheral blood lymphocytes and an about 4-fold elevation of CD3-dependent lymphocyte transformation as compared to normal controls. The CD3-dependent lymphocyte response in patients with severe atopic d...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575353356
更新日期:1995-09-01 00:00:00
abstract::Previously we observed that systemic CyA induces hair growth in an experimental model of human scalp skin graft transplanted onto nude mice. In the present study we investigated the role of topical CyA in the murine transplantation model, using human split-thickness skin grafts (HSTSG). Ten mice grafted with 1-mm-thic...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::With fluorescence-histochemical methods (FIF method) pigment-producing cells were investigated in benign and malignant skin lesions. Here, pigment cells appear predominantly dendritic, whilst they are separated from each other by keratinocytes, cells of hair follicles, or cells of sebaceous glands. In lentigo maligna ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575287289
更新日期:1995-07-01 00:00:00
abstract::Free fatty acids in sebum arise from lipolytic action of bacterial lipases. We have demonstrated an inhibitory effect of zinc on the lipase of the three Propionibacterium species found in human pilosebaceous follicles. We were also able to show a small corresponding fall in the free fatty acid content of skin surface ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The lysosomal enzyme beta-hexosaminidase and the melanocyte specific enzyme tyrosinase were examined in human melanoma cell cultures. The beta-hexosaminidase activity of the medium was approximately 40% of the total cellular activity after 24 h, while after 48 h the activity in the medium was twice that of the cells. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570286290
更新日期:1990-01-01 00:00:00
abstract::Three women with hyperkeratosis lenticularis perstans (HLP) are described. The lesions developed after the age of 45 and there was no family history of this disease. The possible role of UV-light in the pathogenesis of this disease is discussed. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::GM1-gangliosidosis (GM1) is one of the metabolic storage diseases, of which a differential diagnosis requires an array of biochemical assays to determine the enzyme deficiency. This approach is not only time-consuming and costly but also unavailable to most hospital laboratories. However, a presumptive diagnosis of GM...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555573412415
更新日期:1993-12-01 00:00:00
abstract::Scalp psoriasis is associated with hair loss and an increased telogen/anagen ratio. Topical treatment of scalp psoriasis (with corticosteroids, dithranol or tar) results in decreased scaling, induration and erythema of the plaques. Calcipotriol is effective in the treatment of psoriasis vulgaris. However, the potent g...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2340/0001555575388390
更新日期:1995-09-01 00:00:00
abstract::Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients. Conclusive diagnosis of drug allergy, however, still remains a major problem in daily clinical practice. Here, we present 2 patients with drug allergy to CPFX. In both c...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555577285288
更新日期:1997-07-01 00:00:00
abstract::The anti-inflammatory mechanisms of minocycline, an antibiotic used in the treatment of the inflammatory component of acne, are only partially understood. In addition to inflammation due to cytokines (IL-1, IL-6, TNF-alpha, etc.), recent studies have shown that neuropeptide-mediated neurogenic inflammation may play an...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750010625
更新日期:1999-07-01 00:00:00
abstract::The hair root status (trichogram) was studied in eleven patients with primary and eight with secondary syphilis. Variables studied in addition to the hair roots were absence or presence of hair root sheaths, deformities and hair roots with angulations exceeding 20 degrees. A decrease in the number of anagen hair roots...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Bullous dermolysis of the newborn (BDN) is a subtype of dystrophic epidermolysis bullosa characterized by rapid improvement in skin fragility within the first months of life, associated with typical immunofluorescence and ultrastructural features. Inheritance can be autosomal dominant or recessive. We report here 4 ca...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2364
更新日期:2016-08-23 00:00:00
abstract::Previous studies on skin topically photosensitized with trimethylpsoralen and subsequently irradiated with long-wave UV light have demonstrated an increase in melanosome size and changes in the distribution patterns of melanosomes, suggesting the possibility of gene derepression or the induction of a somatic mutation ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::5-S-Cysteinyldopa and dopa concentrations in serum were studied by high-performance liquid chromatography (HPLC) in patients with psoriasis treated by 8-methoxypsoralen and UVA light. A marked increase in 5-S-Cysteinyldopa was found after 3 days' treatment, although no increase in pigmentation could yet be observed. T...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00