Abstract:
:Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients. Conclusive diagnosis of drug allergy, however, still remains a major problem in daily clinical practice. Here, we present 2 patients with drug allergy to CPFX. In both cases the clinical suspicion for CPFX as the causative agent was confirmed in vitro by means of the lymphocyte transformation test, whereas epicutaneous patch tests remained negative. In vivo, a small percentage of the drug is biotransformed to the three major metabolites desethylene-, sulfo- and oxociprofloxacin. Though structurally closely related to their mother compound, these metabolites failed to induce in vitro lymphocyte proliferation in both patients. On the other hand, in vitro crossreactivity to ofloxacin, another fluorinated quinolone, could be demonstrated, which to our knowledge has not previously been reported.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Rönnau AC,Sachs B,von Schmiedeberg S,Hunzelmann N,Ruzicka T,Gleichmann E,Schuppe HCdoi
10.2340/0001555577285288subject
Has Abstractpub_date
1997-07-01 00:00:00pages
285-8issue
4eissn
0001-5555issn
1651-2057journal_volume
77pub_type
杂志文章abstract::The forearm skin of 10 Caucasians and 10 American Negroes was inoculated with Candida albicans and the severity of the ensuing dermatitis as well as the population of Candida and other aerobes in the inoculum site have been assessed. Negroid skin proved to be less susceptible to irritation, even though it harboured a ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Monocytes form a significant component of the inflammatory reaction taking place in the skin of atopic dermatitis and psoriasis. Chemokines are pivotal in mediating the attraction of leucocytes to sites of inflammation. The CC-chemokine, monocyte chemotactic protein 1 (MCP-1/CCL2), is expressed by keratinocytes in bot...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550410034444
更新日期:2004-01-01 00:00:00
abstract::The antibody activities and complement fixing ability of the IgG subclass antibodies of herpes gestationis (HG) and bullous pemphigoid (BP) antibodies were investigated. IgG was prepared by DEAE Affi-Gel Blue column. IgG3 and IgG 1.2.4 fractions were isolated through Protein-A Sepharose CL-4B column. In HG, neither Ig...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::We report the clinical variations and the duration of prodromal symptoms in 20 patients with bullous pemphigoid. Nearly two-thirds of the patients had prodromal symptoms. THe duration of the prodromal eruptions was up to 6 weeks if papular and/or urticarial and up to 2 years if eczematous, before the blisters appeared...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::ESR spectra of synthetic melanins formed from dopa and from 5-S-cysteinyldopa and of melanins isolated from human melanomas were studied. Alkali-soluble melanin synthesized from cysteinyldopa showed a signal similar to that of insoluble melanin synthesized from dopa, but also a simple fine structure. Trichochromes C a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::A patient with a Buschke-Loewenstein tumour associated with human papillomavirus type 6/11 is reported. He was intralesionally treated with human recombinant alpha-2b interferon (9 x 10(6) IU/day) three times weekly. The tumour completely disappeared within 5 months of continuous treatment which was well tolerated. Si...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555574457459
更新日期:1994-11-01 00:00:00
abstract::In an attempt to clarify the pathophysiology of haemodynamics in legs with venous ulcer we investigated the effect of a single intermittent pneumatic compression treatment on the peripheral resistance of leg arteries and the cutaneous laser Doppler flux in the leg. Eight patients with venous leg ulcers and 10 subjects...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750011435
更新日期:1999-03-01 00:00:00
abstract::Tissue from buccal and labial mucosal lesions of discoid lupus erythematosus (DLE) was studied in the electron microscope. The material comprised 10 patients, 7 of whom presented skin lesions as well. The epithelium showed a change in differentiation pattern from nonkeratinizing to keratinizing epithelium. Civatte bod...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Psoriasis is probably a T-cell-mediated autoimmune disease. Infectious models of autoimmune diseases have been proposed and in psoriasis, it has been suggested that there may be molecular mimicry between streptococcal antigens and epidermal keratins. The immunological profile of stable psoriasis plaques suggests, howe...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
doi:10.1080/000155500300012738
更新日期:2000-11-01 00:00:00
abstract::The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. The aim of this study was to clarify the pathogenesi...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3519
更新日期:2020-06-15 00:00:00
abstract::We took biopsies from similar sites on the scalps of normal controls, normal looking and hair loss areas of patients with alopecia areata. The specimens were sectioned serially and horizontally. We measured morphological parameters, such as the diameter of the hair shaft, the thickness of the inner root sheath, the di...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155599750011002
更新日期:1999-05-01 00:00:00
abstract::Actinomycotic mycetomas usually respond slowly to treatment with antibiotics. In an attempt to hasten clinical resolution, we used a 2-step regimen consisting of an intensive phase of therapy with penicillin, gentamycin and co-trimoxazole for 5-7 weeks, followed by maintenance therapy with amoxicillin and co-trimoxazo...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155500459367
更新日期:2000-09-01 00:00:00
abstract::The ultrastructural localization of copper and zinc superoxide dismutase (Cu,Zn-SOD) and manganese superoxide dismutase (Mn-SOD) was investigated in normal human skin by the post-embedding immunogold staining method. Epidermal keratinocytes were positive for both Cu,Zn-SOD and Mn-SOD. The Cu,Zn-SOD was predominantly l...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555734145
更新日期:1993-02-01 00:00:00
abstract::Psoriasis is a chronic skin disease with substantial impact on patients' social and relational ways of living and subsequently on their quality of life. The aim of this study was to evaluate the health-related quality of life (HRQoL) of patients with moderate to severe psoriasis treated with short contact dithranol tr...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/00015550510027801
更新日期:2005-01-01 00:00:00
abstract::Some confusion exists in the literature about which criteria should be used to define familial melanoma. This could explain the different reported frequencies of mutations in predisposing genes, mostly CDKN2A, in these patients. This study evaluated the human leucocyte antigen (HLA) class II genotype and the presence ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155500300012936
更新日期:2000-11-01 00:00:00
abstract::The ultrastructure of dermal connective tissue in two patients suffering from fibrodysplasia ossificans progressiva (syn myositis o.p.) was studied. The disorder starts with soft tissue swelling which subsequently ossify. The connective tissue of various organs may be affected. No defects in calcium metabolism have be...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::The aim of this retrospective study was to determine the type and prevalence of vascular patterns in the ulcerated and non-ulcerated portions of histologically proven basal cell carcinomas (BCCs) and correlate them with other dermoscopic and clinical features, including the clinically supposed diagnosis. Three authors...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2609
更新日期:2017-05-08 00:00:00
abstract::EMLA cream, which is used to provide analgesia prior to venepuncture, induces a skin-blanching reaction. This reaction may be caused by both skin hydration and vasoconstriction. Twenty healthy children with veins suitable for venepuncture on the dorsa of the hands or at the antecubital fossae had applied either EMLA c...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/000155500459268
更新日期:2000-09-01 00:00:00
abstract::The expression of Fc-IgG receptors on mononuclear phagocytes (monocytes/macrophages), as well as the activity of soluble immune suppressor supernatant of T-cell proliferation (SISS-T) factor have been investigated in 23 patients with squamous cell carcinoma (SCC) of the lower lip, including 8 patients with metastases ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomise...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,随机对照试验
doi:10.2340/00015555-2048
更新日期:2015-07-01 00:00:00
abstract::Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-d...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310006842
更新日期:2004-01-01 00:00:00
abstract::Many patients with psoriasis demonstrate psychological disturbances, including decreased health-related quality of life (HRQoL). The aim of this study was to evaluate selected personal resources and HRQoL in 168 in-patients with psoriasis vulgaris. The following questionnaires were used: Skindex-29, General Health Que...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1530
更新日期:2013-09-04 00:00:00
abstract::A 36-year-old Japanese woman with an extraskeletal osteochondroma in the left thumb is reported. A roentgenogram showed a calcified tumor, located at the distal portion of the left distal phalanx, which mimicked the fourth phalangeal bone. The pathogenesis might in this case be hamartomatous. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572287288
更新日期:1992-08-01 00:00:00
abstract::A review of a variety of cutaneous paraneoplastic conditions is presented. Although the conditions discussed appear in only 7-15% of cancer patients, they are considered indicators of possible underlying malignancy. ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,评审
doi:10.2340/0001555573161170
更新日期:1993-06-01 00:00:00
abstract::Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances. At present, the underlying mechanisms responsible for night-time itching are not well understood. Nocturnal pruritus may be related to the circadian rh...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,评审
doi:10.2340/00015555-0280
更新日期:2007-01-01 00:00:00
abstract::Although atopic dermatitis is a skin disorder, it includes immune deviations such as T-cell accumulation and activation in the skin, resulting in chronic, relapsing eczema. The T-lymphocyte activation in the skin is not accompanied by specific allergies in up to two thirds of the patients. It has been shown that T-cel...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555577020021
更新日期:1997-01-01 00:00:00
abstract::Human epidermal keratinocytes sense the presence of human skin microbiota through pathogen recognition receptors, such as toll-like receptors, and induce innate immune and inflammatory events. In healthy epidermis there is an absence of inflammation despite the continuous presence of cutaneous microbes, which is evide...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3707
更新日期:2021-01-13 00:00:00
abstract::The aim of this study was to assess quality of life in patients with scalp dermatitis using the Italian version of the Scalpdex, and to validate the instrument in Italian. The survey was conducted in outpatients with psoriasis, seborrhoeic dermatitis, alopecia, or follicular lichen. Data were completed on 194 patients...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,多中心研究
doi:10.2340/00015555-1731
更新日期:2014-07-01 00:00:00
abstract::Retinoid transfer into breast milk was studied in a psoriatric woman receiving oral acitretin at a dosage of 40 mg once daily. Concentrations of the parent compound and its main metabolite, 13-cis acitretin, were measured in serum and mature milk during the initial nine days of therapy, using reverse-phase high perfor...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555570487490
更新日期:1990-01-01 00:00:00
abstract::The prevalence of melanocytic naevi in children correlates with sun exposure and may serve as an objective population risk indicator of future melanoma incidence. The aim was to investigate if mobile teledermatology could offer a valid methodology compared with standard manual, face-to-face counting of naevi on the ba...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1950
更新日期:2015-03-01 00:00:00