Abstract：
:Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1β expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1β blockade in FD.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Eyraud A,Milpied B,Thiolat D,Darrigade AS,Boniface K,Taïeb A,Seneschal Jdoi
10.2340/00015555-2924subject
Has Abstractpub_date
2018-06-08 00:00:00pages
570-575issue
6eissn
0001-5555issn
1651-2057journal_volume
98pub_type
杂志文章abstract：UNLABELLED:Disperse dyes, which are used for colouring synthetic textile fibres, are well-known contact sensitisers. To investigate the outcome of patch-testing with a textile dye mix (TDM) at 7 dermatology clinics in Sweden, a TDM tested at 2 concentrations was included into the baseline series during one year. The mi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-1956
更新日期：2015-04-01 00:00:00
abstract：:Early alterations in the epidermis of human volunteers following 60 degrees and 95 degrees C burns were studied by means of electron microscopy. The blister was induced at 30 seconds following a 60 degrees C burn for 1 and 3 minutes by disintegration of the basal cells just above the basement membrane, and, in additio...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Some confusion exists in the literature about which criteria should be used to define familial melanoma. This could explain the different reported frequencies of mutations in predisposing genes, mostly CDKN2A, in these patients. This study evaluated the human leucocyte antigen (HLA) class II genotype and the presence ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155500300012936
更新日期：2000-11-01 00:00:00
abstract：:Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3363
更新日期：2020-10-06 00:00:00
abstract：:Immunoreactivity (IR) of substance P (SP) and Vasoactive Intestinal Peptide (VIP) were determined by radioimmunoassay in serum of 56 patients with inflammatory skin diseases, in blister fluid of 40 patients with spontaneous blisters and 31 subjects with induced skin blisters. Serum concentrations of SP-IR and VIP-IR w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Using the mouse, photoallergy to the antiarrhythmic agent quinidine could be induced following systemic administration. After pretreatment with cyclophosphamide 150 mg/kg, groups of 5-10 mice were injected i.p. with quinidine chloride 100 mg/kg on 2 consecutive days, followed by exposure of shaved abdominal skin to UV...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Radiological examination of the hands was performed in 41 patients with systemic sclerosis. Pathological changes were found in 39 patients. Eighteen patients had subcutaneous calcifications and 11 had atrophy of the finger pulps. Bone resorption of ungual tufts was found in 11 patients. Juxta-articular osteoporosis wa...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The urine of an albino woman contained small quantities of 5-S-cysteinyldopa; 6-hydroxy-5-methoxyindole-2-carboxylic acid, a melanin precursor metabolite, was lacking. The 5-S-cysteinyldopa excretion observed may reflect non-specific oxidation of dopa. Two other albino patients showed normal values for the excretion o...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Vulvar vestibulitis is a major cause of entry dyspareunia in young women. The aim of this study was to evaluate a self-reported history of bacterial vaginosis, candidiasis, use of oral contraception and nulli-pregnancy as risk factors for vestibulitis. A retrospective examination of medical records was performed for 4...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0250
更新日期：2007-01-01 00:00:00
abstract：:There are conflicting opinions concerning the epidermal immunofluorescence pattern in primary Sjögren's syndrome. In a prospective study of 12 patients we found a characteristic pattern of epidermal nuclear/cytoplasmic IgG deposits in 8 (67%). This pattern was associated with the presence of antibodies against SSA/Ro ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In order to establish whether or not here is an association between cancer and intense growth of seborrheic keratosis, the so-called Leser-Trelat sign, we conducted a case control study in which the number and features of seborrheic keratosis in 82 patients with recent solid tumours, were compared with 82 age- and sex...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Localized heat urticaria is a rare disorder, in which the nature of the mediator is not fully established. We report the case of a 41-year-old woman with the condition, dependent upon mast cell integrity, in which histamine was demonstrated as the dominant, if not sole mediator. Non-sedative antihistamines conferred s...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Two unusual structures were found in the epidermal Langerhans' cells of normal human adult skin: (1) an intramitochondrial crystalline lattice structure composed of numerous electron-dense, fine particles approximately 90 A in diameter, with a lucent spacing of nearly 90 A; (2) bundles of unusual cytoplasmic tubular s...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:An analysis of the month of birth in 210 patients with atopic dermatitis and a positive prick test towards the house dust mite (Dermatophagoides pteronyssinus) showed a significantly higher prevalence of birth in the interval May to November when compared with the expected distribution (p less than 0.01). A subdivisio...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:In a patient affected with acrodermatitis continua Hallopeau, acitretin (Ro 10-1670) monotherapy resulted in a complete clearance of pustulation at a dosage of 45 mg per day. At this dosage the leukotriene B4-induced intraepidermal accumulation of polymorphonuclear leukocytes was markedly inhibited. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:A cutaneous mycoses caused by Ulocladium chartarum in a heart transplant recipient is reported. The infection cleared after complete surgical excision and 6 months of oral itraconazole therapy. In vitro activity of amphotericin B, fluconazole, itraconazole, voriconazole, ravuconazole and terbinafine against the clinic...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.1080/00015550310007256
更新日期：2003-01-01 00:00:00
abstract：:Three different enzyme-linked immunosorbent assays (ELISA) and Western blot were compared in regard to the detection of antibodies to Borrelia burgdorferi in sera from 100 patients with erythema migrans and from 100 controls. For IgG detection, a commercial indirect ELISA kit with flagellum antigen (flagellum ELISA) w...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Irritation and staining, the side effects of dithranol and related compounds have previously been studied after a single chamber-exposure. To mimic the therapeutic situation, the chamber application was repeated for 3 weeks on the uninvolved back skin of 17 psoriasis patients. In equimolar concentrations corresponding...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Sympathetic dysfunction and skin microvascular arteriovenous shunting with insufficient nutritive perfusion and tissue hypoxia have been reported in patients with erythromelalgia. The objective of this study was to determine whether iloprost, a synthetic prostacyclin analogue--primarily a vasodilator and inhibitor of ...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/00015550310015031
更新日期：2003-01-01 00:00:00
abstract：:The hairless mouse has been used as a model to distinguish between local and systemic atrophogenic effects of topical steroids. Hydrocortisone-17-butyrate, betamethasone-17-valerate, budesonide and clobetasol-17-propionate were applied topically daily for 21 days. Skinfold thickness and dermal DNA synthesis of treated...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. The aim of this study was to clarify the pathogenesi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3519
更新日期：2020-06-15 00:00:00
abstract：:Psoriasis is probably a T-cell-mediated autoimmune disease. Infectious models of autoimmune diseases have been proposed and in psoriasis, it has been suggested that there may be molecular mimicry between streptococcal antigens and epidermal keratins. The immunological profile of stable psoriasis plaques suggests, howe...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：10.1080/000155500300012738
更新日期：2000-11-01 00:00:00
abstract：:The functions of polymorphonuclear leukocytes (PMNs) emigrating into the skin and of others separated simultaneously from the circulation were determined and compared in healthy individuals. The PMNs emigrating into the skin were separated with a skin chamber technique. The C3 rosette forming capacities of the skin mi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-trigg...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/000155557213
更新日期：1992-01-01 00:00:00
abstract：:The expected 4-week cure rate after conventional treatment of bacterial vaginosis are only 65-70%. In an attempt to improve the cure rate by adding probiotic lactobacilli we performed a double-blind placebo-controlled study of adjuvant lactobacilli treatment after an open treatment with vaginal clindamycin ovules. Wom...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1080/00015550410022249
更新日期：2005-01-01 00:00:00
abstract：:Epipodophyllotoxin (VP-16-213) was administered to 9 patients with mycosis fungoides in various stages, most of them in the advanced tumour stage. In 4 of the patients VP-16 was combined with cyclophosphamide. VP-16 alone or in combination with cyclophosphamide was capable of inducing remission initially in all cases,...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The lysosomal enzyme beta-hexosaminidase and the melanocyte specific enzyme tyrosinase were examined in human melanoma cell cultures. The beta-hexosaminidase activity of the medium was approximately 40% of the total cellular activity after 24 h, while after 48 h the activity in the medium was twice that of the cells. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570286290
更新日期：1990-01-01 00:00:00
abstract：:Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:A case of incontinentia pigmenti achromians syndrome with associated abnormalities occurring in a 21-year-old woman is reported. Since birth she has had whorling macular, hypopigmented areas on the skin of the lateral, anterior, and posterior aspects of the trunk. Histopathological picture: the melanocytes in the depi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Previous immunofluorescence studies on pyoderma gangrenosum (PG) proved negative. Biopsies from the ulcer edge of 8 patients with PG were examined by immunofluorescence microscopy. Deposits of complement C3 were seen in the vessel walls of all samples, IgM in three and IgA in one. Granular deposits of C3 were seen at ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555562340341
更新日期：1982-01-01 00:00:00
