Abstract:
:The lysosomal enzyme beta-hexosaminidase and the melanocyte specific enzyme tyrosinase were examined in human melanoma cell cultures. The beta-hexosaminidase activity of the medium was approximately 40% of the total cellular activity after 24 h, while after 48 h the activity in the medium was twice that of the cells. The tyrosinase activity in the medium was 5% and 19% of the total cellular activity after the 24 h and 48 h incubation, respectively. The low level of lactate dehydrogenase activity in the medium after 24 as well as 48 h of incubation indicated that the release of beta-hexosaminidase and tyrosinase was not due to membrane injury. The data suggest, that 1) beta-hexosaminidase may be a candidate for tumor markers in malignant melanoma, and 2) the tyrosinase activity found in sera of melanoma patients may be due, at least partly, to enzyme release by living cancer cells.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Karg E,Hultberg B,Isaksson A,Rosengren E,Rorsman Hdoi
102340/0001555570286290subject
Has Abstractpub_date
1990-01-01 00:00:00pages
286-90issue
4eissn
0001-5555issn
1651-2057journal_volume
70pub_type
杂志文章abstract::Vulvar vestibulitis is a major cause of entry dyspareunia in young women. The aim of this study was to evaluate a self-reported history of bacterial vaginosis, candidiasis, use of oral contraception and nulli-pregnancy as risk factors for vestibulitis. A retrospective examination of medical records was performed for 4...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-0250
更新日期:2007-01-01 00:00:00
abstract::Assessment of the effectiveness of teledermatology has been hampered by the variety of outcome measures used, limiting the possibility for meta-analysis. This systematic mapping review classified the outcome measurement instruments used in randomized controlled trials of teledermatology conducted between 2008 and 2018...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3312
更新日期:2019-12-01 00:00:00
abstract::The introduction of biologics has changed treatment patterns as well as costs in patients with psoriasis. This study was performed to estimate direct and indirect costs of the psoriasis population in Sweden, and to analyse changes in costs between 2006 and 2009. The study population was identified in national register...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1895
更新日期:2015-02-01 00:00:00
abstract::Peripheral blood T-cell subpopulations were evaluated in 32 patients affected by viral warts and in 32 unaffected individuals belonging to a control group. A significant decrease was found in total lymphocytes as well as OKT3 and OKT4 subsets among affected patients. A significant negative correlation was also found b...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Bullous dermolysis of the newborn (BDN) is a subtype of dystrophic epidermolysis bullosa characterized by rapid improvement in skin fragility within the first months of life, associated with typical immunofluorescence and ultrastructural features. Inheritance can be autosomal dominant or recessive. We report here 4 ca...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2364
更新日期:2016-08-23 00:00:00
abstract::We report 3 cases of pruriginous papular eruption of HIV disease, in which demodectic mites were found in the pilosebaceous follicles which were surrounded by a granulomatous inflammatory infiltrate. Papular eruption of HIV disease is a distinctive clinicopathological entity, whose pathogenicity is not known. Our obse...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555574320322
更新日期:1994-07-01 00:00:00
abstract::A female presenting multiple osteoma cutis lesions without underlying endocrinological disturbance was studied. Histologically, lesions revealed true bone formation with multiple osteoblastic cells. This was confirmed by demonstrating high alkaline phosphatase activity and osteonectin expression in osteoma cutis lesio...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572172174
更新日期:1992-01-01 00:00:00
abstract::Low molecular weight oligomers of an epoxy resin of bisphenol A diglycidyl ether type were isolated by gel permeation chromatography. The sensitizing capacity of these oligomers was assessed with the "guinea pig maximization test". The oligomer with the molecular weight of 340 sensitized 80% to 100% of the animals, bu...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Interleukin-17A inhibitors are a promising alternative to tumor necrosis factor-α inhibitors for the treatment of psoriasis. In-class switch has been hardly investigated for interleukin-17A inhibitors. We report the experience (2017-2018) of a tertiary medical center with interleukin-17A-inhibitor switch in patients w...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3200
更新日期:2019-07-01 00:00:00
abstract::Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis a...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen planus, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Recor...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-3009
更新日期:2018-11-05 00:00:00
abstract::Urinary excretion of glycosaminoglycans was measured in 10 patients with pretibial myxoedema, 7 of whom also had thyroid-associated ophthalmopathy, and in 3 additional patients with ophthalmopathy but no skin changes. Total uronic acid excretion was raised above control levels in only 2 patients, who had both eye and ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555576368370
更新日期:1996-09-01 00:00:00
abstract::Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the pot...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310016544
更新日期:2003-01-01 00:00:00
abstract::Actinomycotic mycetomas usually respond slowly to treatment with antibiotics. In an attempt to hasten clinical resolution, we used a 2-step regimen consisting of an intensive phase of therapy with penicillin, gentamycin and co-trimoxazole for 5-7 weeks, followed by maintenance therapy with amoxicillin and co-trimoxazo...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/000155500459367
更新日期:2000-09-01 00:00:00
abstract::High-dose intravenous immunoglobulin (IVIG) therapy is used in patients with severe autoimmune blistering diseases that are refractory to standard immunosuppressive therapy. To determine the efficacy and frequency of adverse events of IVIG therapy, we retrospectively analysed data for 16 patients with pemphigus vulgar...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1471
更新日期:2013-05-01 00:00:00
abstract::is missing (Short communication). ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2734
更新日期:2017-10-02 00:00:00
abstract::The initiation of the antihistamine effect of a single dose of acrivastine (8 mg) or cetirizine (10 mg) on wheals and itch induced by histamine dihydrochloride (10 mg/ml) in the prick test was studied in a randomized cross-over design employing 20 healthy medical students. The prick test was performed before ingestion...
journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2340/0001555573350351
更新日期:1993-10-01 00:00:00
abstract::Tissue from buccal and labial mucosal lesions of discoid lupus erythematosus (DLE) was studied in the electron microscope. The material comprised 10 patients, 7 of whom presented skin lesions as well. The epithelium showed a change in differentiation pattern from nonkeratinizing to keratinizing epithelium. Civatte bod...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::A report is given of the successful treatment with transfer factor as an additional therapeutic agent of a patient in the tumour stage of mycosis fungoides who had not responded to conventional treatment with nitrogen mustard, methotrexate, or grenz rays alone. Besides twelve injections of transfer factor, the patient...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subty...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,评审
doi:10.2340/00015555-3388
更新日期:2020-01-30 00:00:00
abstract::Radiological examination of the hands was performed in 41 patients with systemic sclerosis. Pathological changes were found in 39 patients. Eighteen patients had subcutaneous calcifications and 11 had atrophy of the finger pulps. Bone resorption of ungual tufts was found in 11 patients. Juxta-articular osteoporosis wa...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Demonstrating T-cell clonality has become an important approach supporting a diagnosis of malignant T-cell neoplasms. A comparative study between Genescan analysis, polyacrylamide gel and agarose gel electrophoresis in visualizing T-cell receptor gamma gene rearrangement was performed on 25 biopsy specimens from 18 pa...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550310015798
更新日期:2004-01-01 00:00:00
abstract::BRAF and NRAS genetic analyses are time-consuming and can delay treatment choices in patients with metastatic melanomas presenting with acute deterioration. We compared the rapid, real-time, fully automated molecular diagnosis platform Idylla™ with next-generation sequencing (NGS) and immunohistochemistry for detectio...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-2738
更新日期:2018-01-12 00:00:00
abstract::Tobacco smoke and UV radiation are extrinsic risk factors for accelerated skin ageing. In this study the effects of smoking on wrinkling and ageing were assessed in males living in Northern Finland, where cumulative sun exposure is low. Smoking habits, age and facial wrinkling were estimated from facial photographs of...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.1080/00015550410014969
更新日期:2004-01-01 00:00:00
abstract::The burning mouth syndrome is characterized by an unpleasant sensation of burning in the oral cavity, without clinical signs. Causal factors may be psychogenic, systemic or local. The aim of the study was to determine the significance of contact allergy in the pathogenesis of burning mouth syndrome. Fifteen patients w...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555576488490
更新日期:1996-11-01 00:00:00
abstract::Thirteen patients with port wine stains (PWS) were treated with argon laser therapy. Before and at different points in time following treatment, skin blood perfusion and temperature were mapped with laser Doppler imaging and thermography. In nine patients no elevation in blood perfusion was observed in the PWS in comp...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:102340/0001555572610
更新日期:1992-01-01 00:00:00
abstract::Atopic dermatitis (AD) has a big impact on quality of life. The usefulness of health-related quality of life questionnaires for children with AD in general practice, and the relationship of quality of life to disease severity, as assessed by parents and by investigators, however, is not known. This study used the Infa...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555-1026
更新日期:2011-03-01 00:00:00
abstract::The aim of this study was to assess quality of life in patients with scalp dermatitis using the Italian version of the Scalpdex, and to validate the instrument in Italian. The survey was conducted in outpatients with psoriasis, seborrhoeic dermatitis, alopecia, or follicular lichen. Data were completed on 194 patients...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章,多中心研究
doi:10.2340/00015555-1731
更新日期:2014-07-01 00:00:00
abstract::Patients with clinical features of dorsal macular amyloidosis but without subepidermal amyloid deposits were followed for 2-11 years. The clinical appearance was fairly stable during this period of time, with little tendency of healing. Only 2 of the patients developed typical macular amyloidosis during the follow-up....
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555576302304
更新日期:1996-07-01 00:00:00
abstract::1,182 males and 155 females attending an STD clinic from June 1984 to October 1985 were investigated for the presence of antibodies to human immunodeficiency virus (HIV). 348 (29.5%) of the males and 5 (3.2%) of the females were antibody positive (ab+). 237 of the males were initially antibody negative (ab-) and were ...
journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00