Polymyositis complicating D-penicillamine treatment.

abstract：:A host/vector system suitable for large-scale production of HBsAg has been constructed and optimized in terms of the expression plasmid and yeast host strain in order to permit fermentation to very high cell densities. The final expression plasmid contains the coding sequence of the major HBsAg protein (P24) flanked b...

journal_title：Postgraduate medical journal

authors： Harford N,Cabezon T,Colau B,Delisse AM,Rutgers T,De Wilde M

更新日期：1987-01-01 00:00:00

abstract：:Two cases of patients with ischaemic colitis requiring operative treatment are presented. Both had received a commonly used psychotropic drug in large dosage before the acute episode. Evidence is produced which may link the drugs used with the condition of ischaemic colitis. ...

journal_title：Postgraduate medical journal

authors： Gollock JM,Thomson JP

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:The International Diabetes Attitudes, Wishes, and Needs (DAWN) programmes have shown the existence of a critical gap in self management support and access to the support system. This study aims to evaluate the effectiveness of the diabetes mellitus (DM) self management programme, with partnership between gen...

journal_title：Postgraduate medical journal

authors： Lee A,Siu CF,Leung KT,Lau LC,Chan CC,Wong KK

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF THE STUDY:There are approximately 35 000 in-hospital cardiac arrests in the UK each year. Successful resuscitation requires integration of the medical science, training and education of clinicians and implementation of best practice in the clinical setting. In 2015, the International Liaison Committee on Res...

journal_title：Postgraduate medical journal

authors： Carberry J,Couper K,Yeung J

更新日期：2017-11-01 00:00:00

abstract：:The clinical features, treatment and survival of 36 patients with microscopic polyarteritis diagnosed between 1957-1988 have been reviewed. All had a focal segmental necrotizing glomerulonephritis on renal biopsy with evidence of a small vessel vasculitis. Most had a prodromal illness of less than 1 month. Severity of...

journal_title：Postgraduate medical journal

authors： Rodgers H,Guthrie JA,Brownjohn AM,Turney JH

更新日期：1989-08-01 00:00:00

abstract：:In the 1920s Moynihan described acute pancreatitis as "..the most terrible of all intra-abdominal calamities". He established a practice of immediate surgical intervention to remove the toxic products accumulating in the peritoneal cavity, and this treatment was endorsed by most centres, remaining the standard therapy...

journal_title：Postgraduate medical journal

authors： Skaife P,Kingsnorth AN

更新日期：1996-05-01 00:00:00

abstract：:The anti-hypertensive effect of 250 mg tienilic acid was comparable to that of 50 mg hydrochlorothiazide. Unlike hydrochlorothiazide, tienilic acid caused a statistically significant decrease in the serum uric acid values. Clinically non-significant rises in blood urea nitrogen and serum creatinine occurred with both ...

journal_title：Postgraduate medical journal

authors： McMahon FG,Ryan JR,Jain AK

更新日期：1979-01-01 00:00:00

abstract：:The literature of the outbreaks of 'epidemic neuromyasthenia' (ENM) from 1934 to 1955 has been selected to show that the disease affects other people besides young adult females in hospitals and nursing homes. There have been district epidemics, in which the male: female ratio was almost even and several male outbreak...

journal_title：Postgraduate medical journal

authors： Parish JG

更新日期：1978-11-01 00:00:00

abstract：:Unstable and unpredictable disease control in diabetes or asthma, with frequent hospitalisations, is frequently referred to as 'brittle'. We describe two cases of Addison's disease with recurrent hospitalisations in hypo-adrenal crises. Both patients had significant psychosocial disruption, and failure to take hydroco...

journal_title：Postgraduate medical journal

authors： Gill GV,Williams G

更新日期：2000-03-01 00:00:00

abstract：:Under certain circumstances, living wills or advance directives may carry legal force in the UK. This paper traces the development of advance directives, clarifies their current legal position and discusses potential problems with their use. Case histories are used to illustrate some of the common dilemmas which docto...

journal_title：Postgraduate medical journal

authors： Stewart K,Bowker L

更新日期：1998-03-01 00:00:00

abstract：:Clinical, endocrinological and computed tomographic features of three patients with unusual manifestations or complications of craniofacial involvement of fibrous dysplasia are presented. One patient with polyostotic fibrous dysplasia presented in late pregnancy with acute onset of bilateral optic nerve compression an...

journal_title：Postgraduate medical journal

authors： Daly BD,Chow CC,Cockram CS

更新日期：1994-01-01 00:00:00

abstract：:We describe two patients with associations of hereditary neuropathies and heritable skeletal disorders not previously reported. The first patient had Marfan's syndrome and hereditary motor and sensory neuropathy Type 1. The second patient had Ehlers-Danlos syndrome, Klippel-Feil syndrome and tomaculous neuropathy. ...

journal_title：Postgraduate medical journal

authors： Chattopadhyay AK,Kandler RH,Sharrack B

更新日期：1995-04-01 00:00:00

abstract：:An 84 year old woman who was a heavy smoker presented with clinical features suggestive of acute exacerbation of chronic obstructive lung disease complicated by left ventricular failure. She responded poorly to treatment and then the finding of stridor, only when she was in the supine position, led to the diagnosis of...

journal_title：Postgraduate medical journal

authors： Antonios TF,Singer DR,Millard FJ,Wilson AG,MacGregor GA

更新日期：1994-12-01 00:00:00

abstract：:Antiphospholipid syndrome is a disorder of recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies. It was first described in a group of patients with systemic lupus erythematosus but has since been associated with a wide range of c...

journal_title：Postgraduate medical journal

authors： Samadian S,Estcourt L

更新日期：1999-01-01 00:00:00

abstract：:Episodic muscular weakness, commonly associated with alterations of serum potassium, is the cardinal feature of periodic paralysis. The combination of transient hyperkalaemia and rigors occurring during febrile episodes of malaria is suggested as the underlying cause which precipitated the muscular paralysis. Three pa...

journal_title：Postgraduate medical journal

authors： Senanayake N,Wimalawansa SJ

更新日期：1981-05-01 00:00:00

abstract：:The pharmacokinetics of a single oral dose of clomipramine were examined in a group of depressed patients, 8 female and 2 male with a mean age of 51 years (range 21-78). Their mean clomipramine half-life was 36 hours and mean plasma clomipramine clearance 73 litres per hour, with a wide range in each case. These resul...

journal_title：Postgraduate medical journal

authors： Dawling S,Braithwaite RA,McAuley R,Montgomery SA

更新日期：1980-01-01 00:00:00

abstract：:The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit...

journal_title：Postgraduate medical journal

authors： Kennedy PG

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Enabling healthcare staff to report concerns is critical for improving patient safety. Junior doctors are one of the groups least likely to engage in incident reporting. This matters both for the present and for the future, as many will eventually be in leadership positions. Little is known about junior doct...

journal_title：Postgraduate medical journal

authors： Hooper P,Kocman D,Carr S,Tarrant C

更新日期：2015-05-01 00:00:00

abstract：:Although many of the fundamental biological features of toxoplasmosis are today well appreciated, the practical problem of prevention of its most serious consequence--disabling congenital disease, remains unsolved. The reasons vary in different communities, but are concerned with detection of the chief mode of spread,...

journal_title：Postgraduate medical journal

authors： Williams H

更新日期：1977-10-01 00:00:00

abstract：:Forty-five healthy men aged 21-34 years took part in a double-blind, parallel-group, placebo-controlled study of the effects of 28 days' treatment with lornoxicam 4 mg twice daily or indomethacin 50 mg twice daily on faecal blood loss and the endoscopic appearances of gastric and duodenal mucosa. After an initial endo...

journal_title：Postgraduate medical journal

authors： Warrington SJ,Debbas NM,Farthing M,Horton M,Johnston A,Thillainayagam A,Turner P,Ferber H

更新日期：1990-08-01 00:00:00

abstract：:Verrucous carcinoma is a rare skin malignancy of squamous cell origin. It is characterised by negligible cellular atypia and a low mitotic rate. These are reflected in slow locally invasive behaviour and very infrequent metastatic spread. The tumour is also recognised in oral and anogenital sites. Cutaneous lesions pr...

journal_title：Postgraduate medical journal

authors： Munro NA,Smith C,Purushotham AD

更新日期：1999-11-01 00:00:00

abstract：:We present a 78-year-old woman with clinical acute hypopituitarism in whom pathologic findings showed lymphocytic hypophysitis and retroperitoneal fibrosis. Lymphocytic hypophysitis should be included in the differential diagnosis of hypopituitarism at any age. The association with idiopathic retroperitoneal fibrosis ...

journal_title：Postgraduate medical journal

authors： Alvarez A,Cordido F,Sacristán F

更新日期：1997-11-01 00:00:00

abstract：:Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported...

journal_title：Postgraduate medical journal

authors： Oppenheimer SM,Hoffbrand BI,Dormandy TL,Parker N,Wickens DG

更新日期：1987-03-01 00:00:00

abstract：:Chemotherapy-induced nausea and vomiting (CINV) remains one of the most debilitating toxicities associated with cancer treatment. In recent decades, significant strides have been made in our understanding of the pathophysiology of CINV, making way to more effective targeted pharmacotherapies, especially 5-hydroxytrypt...

journal_title：Postgraduate medical journal

authors： Tageja N,Groninger H

更新日期：2016-01-01 00:00:00

abstract：:Hypercalcaemia occurs in up to 80% of patients with adult T-cell leukaemia-lymphoma (ATLL) associated with human T-cell leukaemia virus-1 infection. Elevated serum levels of 1,25-dihydroxycholecalciferol, implicated in the pathogenesis of hypercalcaemia in lymphoma, and of parathyroid hormone-related protein (PTHrP), ...

journal_title：Postgraduate medical journal

authors： Johnston SR,Hammond PJ

更新日期：1992-09-01 00:00:00

abstract：:Eight patients with endobronchial tuberculosis diagnosed on bronchoscopy were treated with antituberculosis drugs and a course of prednisone. The progress of the endobronchial lesions was assessed on repeated examinations. The course of the disease was variable and the endobronchial narrowing improved in two patients ...

journal_title：Postgraduate medical journal

authors： Chan HS,Sun A,Hoheisel GB

更新日期：1990-10-01 00:00:00

abstract：:Exercise is known to have a vast array of health benefits. It may however confer delirious effects on most body systems, with the cardiovascular system taking particular prominence. Athletes in particular are known to be at a higher risk for sudden cardiac death as a result of several cardiac adaptations which take pl...

journal_title：Postgraduate medical journal

authors： Abela M,Sammut L

更新日期：2017-12-01 00:00:00

abstract：:Upper gastrointestinal bleeding is one of the commonest emergencies encountered by general physicians. Once haemodynamic stability has been achieved, therapeutic endoscopy is vital in control and arrest of bleeding. Various methods are available and the evidence is reviewed as to the most optimal approach. Clinical pa...

journal_title：Postgraduate medical journal

authors： Arasaradnam RP,Donnelly MT

更新日期：2005-02-01 00:00:00

abstract：:Posterior leukoencephalopathy syndrome is a newly recognised brain disorder that predominantly affects the cerebral white matter. Oedematous lesions particularly involve the posterior parietal and occipital lobes, and may spread to basal ganglia, brain stem, and cerebellum. This rapidly evolving neurological condition...

journal_title：Postgraduate medical journal

authors： Garg RK

更新日期：2001-01-01 00:00:00

abstract：:Colonoscopies performed in patients aged 80 years or older at the Sheba Medical Center were analysed according to the primary indication for the procedure: 101 colonoscopies were performed because of rectal bleeding of at least 2 months duration, and 335 for all other indications. Carcinoma of the large bowel was foun...

journal_title：Postgraduate medical journal

authors： Bat L,Pines A,Shemesh E,Levo Y,Zeeli D,Scapa E,Rosenblum Y

更新日期：1992-05-01 00:00:00