Acute pancreatitis: assessment and management.

Abstract:

:In the 1920s Moynihan described acute pancreatitis as "..the most terrible of all intra-abdominal calamities". He established a practice of immediate surgical intervention to remove the toxic products accumulating in the peritoneal cavity, and this treatment was endorsed by most centres, remaining the standard therapy for the next 20 years. In the 1940s, the mortality of patients treated surgically was shown to be far higher than those treated conservatively, and a more conservative line of management was recommended, comprising nasogastric stomach decompression, intravenous fluid therapy, opiate analgesia, and the administration of atropine. Despite half a century passing, a clinician would not be criticised for adopting such a regime today, which in part reflects the lack of understanding of this condition and the failure of seemingly appropriate therapy. Reduction in mortality is a consequence of advances in intensive care preventing the high early mortality of organ failure, but the area of specific therapy remains elusive. While this is so, the mortality rates for these patients will remain static, while the doctor continues to feel clinically impotent.

journal_name

Postgrad Med J

authors

Skaife P,Kingsnorth AN

doi

10.1136/pgmj.72.847.277

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

277-83

issue

847

eissn

0032-5473

issn

1469-0756

journal_volume

72

pub_type

杂志文章,评审
  • Lymphoplasmacytoid lymphoma elaborating lambda chain paraprotein with amyloid deposition in Sjögren's syndrome.

    abstract::A woman presented with painful enlargement of her parotid and submandibular glands. She was shown to have the previously unreported combination of idiopathic thrombocytopenic purpura, Sjögren's syndrome, Hashimoto's disease, and myasthenia gravis. Parotid gland biopsy and bone marrow examination showed the presence of...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.763.323

    authors: Savage AW,Shareef DS,Maher EJ,Bennett MH,Thomas DJ

    更新日期:1989-05-01 00:00:00

  • Hyperosmolar non-ketotic diabetic coma and rhabdomyolysis.

    abstract::Rhabdomyolysis is a rare but potentially fatal complication of hyperosmolar states. We report a case of severe hyperosmolar non-ketotic diabetic coma causing rhabdomyolysis in a young man. Despite very high levels of creatine kinase there was no detectable myoglobinuria. Creatine kinase estimation should be a standard...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.70.819.44

    authors: Trump D,O'Hanlon S,Rinsler M,Sharp P

    更新日期:1994-01-01 00:00:00

  • Thrombotic thrombocytopenic purpura associated with pregnancy in two sisters.

    abstract::Two sisters suffered from thrombotic thrombocytopenic purpura late in their first pregnancies. HLA typing of the patients and their immediate family members demonstrated no obvious relationship. Hereditary aspects, association with pregnancy, prognosis and management of pregnant women with TTP are discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.809.229

    authors: Alqadah F,Zebeib MA,Awidi AS

    更新日期:1993-03-01 00:00:00

  • Heparin-associated skin necrosis.

    abstract::A case of skin necrosis at the sites of injection of subcutaneous heparin is described. The patient went on to develop heparin-induced thrombocytopenia and pulmonary embolism. Review of the previously described cases of heparin-associated skin necrosis reveals that this sequence of events is not uncommon. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.66.777.573

    authors: Fowlie J,Stanton PD,Anderson JR

    更新日期:1990-07-01 00:00:00

  • Haemorrhage through the ampulla of Vater.

    abstract::A patient with chronic pancreatitis presented with a series of massive upper gastrointestinal haemorrhages due to bleeding into the pancreatic duct. This report emphasizes the value of intensive investigation before surgery, since it may be impossible to identify the site of bleeding at laparotomy. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.716.533

    authors: Ribbans WJ,Pounder RE,Lindsay I

    更新日期:1985-06-01 00:00:00

  • 'Bolam' to 'Montgomery' is result of evolutionary change of medical practice towards 'patient-centred care'.

    abstract::The Supreme Court judgement in 'Montgomery v Lanarkshire Health Board' has caused a change in the law concerning the duty of doctors on disclosure of information to patients regarding risks. The law now requires a doctor to take reasonable care to ensure that the patient is aware of any material risks involved in any ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2016-134236

    authors: Lee A

    更新日期:2017-01-01 00:00:00

  • Massive cardiac invasion by amelanotic melanoma with obstructive clinical features.

    abstract::Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour. We describe, and illustrate, a patient presenting with features related to cardiac tamponade and intracardiac obstruction. Transthoracic echocardiography initially showed a large mass wit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2007.065540

    authors: Dubrey S,Grocott-Mason R,Mittal T,Burke M

    更新日期:2008-03-01 00:00:00

  • Primary pulmonary hypertension associated with human immunodeficiency virus infection.

    abstract::Several cardiorespiratory diseases can complicate human immunodeficiency virus infection. Primary pulmonary hypertension is a rare clinical disorder which carries a bad prognosis. More than 90 cases of HIV-associated primary pulmonary hypertension have been reported to date. Although its pathogenesis remains unknown, ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.74.873.400

    authors: Golpe R,Fernandez-Infante B,Fernandez-Rozas S

    更新日期:1998-07-01 00:00:00

  • Continuous electrocardiographic recording (Holter method) during indapamide treatment: a study of 40 cases.

    abstract::In 40 hypertensive patients continuous ECG recording was done before and after 30 days treatment with indapamide 2.5 mg. There was no change in heart rate. In addition, the incidence of extrasystoles was not changed in patients in whom the ECG was normal before treatment (30 cases) or in 8 of the 10 patients who had a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Haiat R,Lellouch A,Lanfranchi J,Witchitz S

    更新日期:1981-01-01 00:00:00

  • Life-threatening Mycoplasma pneumoniae infection.

    abstract::Pneumonia due to Mycoplasma pneumoniae is common, but it is rarely life-threatening. A case is reported in a previously healthy adult whose illness was severe enough to require treatment with intermittent positive pressure ventilation (IPPV) for 14 days and which resolved after treatment with corticosteroids. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.659.675

    authors: McGonigle R,Wagstaff JK

    更新日期:1980-09-01 00:00:00

  • Submandibular chronic sialadenitis presenting with alcohol-induced pain.

    abstract::A 32 year old man with alcohol-induced pain over a right submandibular swelling is described. Excision biopsy of this swelling revealed chronic sialadenitis and the symptoms promptly ceased following this excision. We speculate on the possible pathophysiological mechanism. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.781.949

    authors: Okany CC,Akinsete I,Akinyanju OO

    更新日期:1990-11-01 00:00:00

  • Fatal tension pneumoperitoneum due to aerophagy.

    abstract::A case of fetal tension pneumoperitoneum following gastric perforation due to aerophagy is described. Comment is made on the probably pathogenesis. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.657.516

    authors: Hutchinson GH,Alderson DM,Turnberg LA

    更新日期:1980-07-01 00:00:00

  • Shaken baby syndrome.

    abstract::Shaken baby syndrome is the most common cause of death or serious neurological injury resulting from child abuse. It is specific to infancy, when children have unique anatomic features. Subdural and retinal haemorrhages are markers of shaking injury. An American radiologist, John Caffey, coined the name whiplash shake...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.78.926.732

    authors: Blumenthal I

    更新日期:2002-12-01 00:00:00

  • Biliary peritonitis secondary to perforation of common bile duct: an unusual presentation of chronic calcific pancreatitis.

    abstract::Common bile duct perforation causing biliary peritonitis is an unusual entity and a pancreatic calculus causing this perforation is all the more rare, and to our knowledge has not been reported previously. Such an unusual presentation of chronic calcific pancreatitis is herein reported. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.804.837

    authors: Kumar A,Kataria R,Chattopadhyay TK,Karak PK,Tandon RK

    更新日期:1992-10-01 00:00:00

  • Community-acquired pneumonia: doctors do not follow national guidelines.

    abstract:OBJECTIVES:Appropriate assessment of community-acquired pneumonia (CAP) allows accurate severity scoring and hence optimal management, leading to reduced morbidity and mortality. British Thoracic Society (BTS) guidelines provide an appropriate score. Adherence to BTS guidelines was assessed in our medical assessment un...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.056556

    authors: Collini P,Beadsworth M,Anson J,Neal T,Burnham P,Deegan P,Beeching N,Miller A

    更新日期:2007-08-01 00:00:00

  • Mentoring perception and academic performance: an Academic Health Science Centre survey.

    abstract:PURPOSE:To determine the association between professors' self-perception of mentoring skills and their academic performance. DESIGN:Two hundred and fifteen professors from Imperial College London, the first Academic Health Science Centre (AHSC) in the UK, were surveyed. The instrument adopted was the Mentorship Skills...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2015-133542

    authors: Athanasiou T,Patel V,Garas G,Ashrafian H,Shetty K,Sevdalis N,Panzarasa P,Darzi A,Paroutis S

    更新日期:2016-10-01 00:00:00

  • Significance of idiopathic deep venous thrombosis.

    abstract::The risk of developing an overt malignancy after an isolated deep venous thrombosis (DVT) is poorly documented. We therefore reviewed a series of patients in whom a solitary idiopathic DVT had been proven by venography at least 12 months earlier. No patient had developed a malignancy at follow-up. However, decreased f...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.60.702.275

    authors: O'Connor NT,Cederholm-Williams SA,Fletcher EW,Allington M,Sharp AA

    更新日期:1984-04-01 00:00:00

  • Prognostic value of long non-coding RNA 01296 expression in human solid malignant tumours: a meta-analysis.

    abstract::Long intergenic non-coding RNA 01296 (LINC01296) has been reported to play an important role in many human malignancies, but a consistent perspective has not been established now. To explore the prognostic value of LINC01296 in different types of human solid malignant tumours, we performed this meta-analysis.An electr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/postgradmedj-2019-136684

    authors: Dai C,Dai C,Ni H,Xu Z

    更新日期:2020-01-01 00:00:00

  • UK survey of non-medical use of prescription drugs (NMURx) as a valuable source of general population illicit drug use data.

    abstract:PURPOSE OF STUDY:The aim of the study is to describe the prevalence of illicit drug use in England and Wales using data from the UK Survey of Non-Medical Use of Prescription Drugs (NMURx) programme and to compare against the well-established Crime Survey England and Wales (CSEW). The rationale is that recreational and ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135798

    authors: Ng FL,Rockhill K,Black J,May KP,Whittington MD,Wood DM,Dargan PI,Green JL

    更新日期:2018-11-01 00:00:00

  • Bacterial calcification in infective endocarditis.

    abstract::The present report is the first description to our knowledge of a clinical case of bacterial calcification in human infective endocarditic vegetations. Partial calcification of bacteria within vegetations may be a further mechanism of bacterial protection from host defences and antibiotics. Similar calcification has r...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.767.665

    authors: Poller DN,Curry A,Ganguli LA,Routledge RC

    更新日期:1989-09-01 00:00:00

  • Congestive cardiomyopathy and endobronchial granulomas as manifestations of Churg-Strauss syndrome.

    abstract::Churg-Strauss syndrome is a systemic vasculitis. Its most frequent complications are heart diseases and asthma. Usually, cardiological manifestations are pericarditis, cardiac failure and myocardial infarction. Endobronchial granulomas identified by bronchoscopy are unusual. We present the case of a man with congestiv...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.836.365

    authors: Alvarez-Sala R,Prados C,Armada E,Del Arco A,Villamor J

    更新日期:1995-06-01 00:00:00

  • Community-acquired bacteraemic Acinetobacter pneumonia with survival.

    abstract::A 65 year old man was admitted with segmental consolidation of the left upper lobe after having stayed in a hotel for 2 days. He deteriorated rapidly on conventional antibiotic therapy and required ventilatory support. Acinetobacter calcoaceticus var. anitratus was grown from the sputum and blood cultures, which was t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.818.934

    authors: Achar KN,Johny M,Achar MN,Menon NK

    更新日期:1993-12-01 00:00:00

  • A clinicopathological analysis of 26 patients with infection-associated haemophagocytic lymphohistiocytosis and the importance of bone marrow phagocytosis for the early initiation of immunomodulatory treatment.

    abstract:OBJECTIVE:To analyse the clinicopathological presentation, outcome and importance of bone marrow haemophagocytosis in patients with infection-associated haemophagocytic lymphohistiocytosis (IA-HLH) in a tertiary care hospital in Northern India. STUDY DESIGN:Between January 2007 and December 2009, 26 consecutive patien...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2012-130955

    authors: Nair V,Das S,Sharma A,Sharma S,Sharma P,Ray S,Bhattacharya S

    更新日期:2013-04-01 00:00:00

  • Outcomes of the short Synacthen test: what is the role of the 60 min sample in clinical practice?

    abstract::In recent years, the short Synacthen test (SS) has become the most widely used test to assess adrenal reserve. Despite its frequent use, there are still several areas related to the short Synacthen test (SST), which have no consensus including the optimum sampling times, that is, whether a 60 min post-Synacthen admini...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2019-136669

    authors: Dineen R,Mohamed A,Gunness A,Rakovac A,Cullen E,Barnwell N,Neary C,Behan LA,Boran G,Gibney J,Sherlock M

    更新日期:2020-02-01 00:00:00

  • Troponin T elevation in lobar lung disease.

    abstract::Two patients with a rise in cardiac troponin T (cTnT) concentrations during the course of lobar pneumonia, without any evidence of acute coronary syndrome or renal failure, are presented. The increase in cTnT concentration is considered a highly sensitive marker of cardiac injury, although it may also rise in other co...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.78.918.244

    authors: Weinberg I,Cukierman T,Chajek-Shaul T

    更新日期:2002-04-01 00:00:00

  • Diurnal rhythms and clinical events in coronary artery disease.

    abstract::Patients with coronary atherosclerosis present with angina, myocardial infarction and sudden death, most often caused by atherosclerotic stenosis complicated by spasm and/or occlusive thrombosis. All of these events have been shown to exhibit similar diurnal rhythms, with a peak incidence in the morning after waking a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Selwyn AP,Raby K,Vita JA,Ganz P,Yeung A

    更新日期:1991-01-01 00:00:00

  • Isolated left ventricular non-compaction: an emerging cause of heart failure in adults.

    abstract::Isolated left ventricular non-compaction is a rare, morphologically distinct primary genetic cardiomyopathy, which was first described in children, but is becoming increasingly recognised in adults. The most common clinical manifestations include heart failure, arrhythmias and embolic events, and in children it may be...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2008.070144

    authors: Nair SB,Khattar RS

    更新日期:2009-04-01 00:00:00

  • Hypertension in the West Indies.

    abstract::Hypertension is the most common chronic disease in the West Indies, and is a major health problem today being among the 10 most common causes of death in the English-speaking territories of the region. Most patients have essential hypertension. Renal failure, stroke, and cardiac failure are the most common complicatio...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.696.616

    authors: Grell GA

    更新日期:1983-10-01 00:00:00

  • Evaluation of renal function in elderly heart failure patients on ACE inhibitors.

    abstract::A total of 187 heart failure patients aged 65-92 years, with pretreatment serum creatinine levels below 200 mumol/l, were monitored for more than 12 months on angiotensin-converting enzyme (ACE) inhibitor therapy. Optimal ACE inhibitor dosage was found in 27% of patients, while a significant deterioration in renal fun...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.883.275

    authors: Jolobe OM

    更新日期:1999-05-01 00:00:00

  • First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.

    abstract::Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-C...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.817.885

    authors: Kendra JR,Rugman FP,Flaherty TA,Myers A,Horsfield N,Barton A,Russell L

    更新日期:1993-11-01 00:00:00