Lymphoplasmacytoid lymphoma elaborating lambda chain paraprotein with amyloid deposition in Sjögren's syndrome.

Abstract:

:A woman presented with painful enlargement of her parotid and submandibular glands. She was shown to have the previously unreported combination of idiopathic thrombocytopenic purpura, Sjögren's syndrome, Hashimoto's disease, and myasthenia gravis. Parotid gland biopsy and bone marrow examination showed the presence of a rare lymphoplasmacytoid lymphoma. There was amyloid deposition in the parotid glands, gums and on muscle biopsy. Immunohistochemical staining of the parotid lymphoma and amyloid was monotypic for lambda light chains, and there was also a lambda chain paraprotein. It is felt that the lymphoplasmacytic lymphoma was responsible for the light chain amyloidosis.

journal_name

Postgrad Med J

authors

Savage AW,Shareef DS,Maher EJ,Bennett MH,Thomas DJ

doi

10.1136/pgmj.65.763.323

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

323-6

issue

763

eissn

0032-5473

issn

1469-0756

journal_volume

65

pub_type

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