Spinal ganglioneuroblastoma--complete response to chemotherapy alone.

Abstract:

:Ganglioneuroblastoma in the spinal region is rare, the treatment of choice being surgical excision. We present a 21 year old male who was diagnosed to have this condition in the dorsolumbar spinal region. The tumour was extending intraspinally and was unresectable. Combination chemotherapy with Adriamycin (doxorubicin hydrochloride), vincristine, cyclophosphamide, etoposide, ifosfamide and cisplatin resulted in histologically proven complete remission. No radiotherapy or curative resection was done. The patient is alive without evidence of disease 24 months later. Never before has chemotherapy been successfully used as the sole modality of treatment in this condition. Our report raises important questions about the management of this rare condition, particularly in a situation of unresectability.

journal_name

Postgrad Med J

authors

Raina V,Kamble R,Tanwar R,Singh SP,Sharma S

doi

10.1136/pgmj.69.815.746

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

746-8

issue

815

eissn

0032-5473

issn

1469-0756

journal_volume

69

pub_type

杂志文章
  • An aggressive intrasinusoidal lymphoma presenting with marked systemic disturbance but normal imaging studies.

    abstract::A patient with an aggressive intrasinusoidal non-Hodgkins lymphoma, presenting with marked systemic disturbance but only a mildly raised alkaline phosphatase as a localising sign is described. All imaging studies of the liver were normal and the diagnosis was delayed until a percutaneous liver biopsy was performed. On...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.76.892.103

    authors: Camidge R,Ong E,Lucraft H

    更新日期:2000-02-01 00:00:00

  • Why do primary care doctors undertake postgraduate diploma studies in a mixed private/public Asian setting?

    abstract:OBJECTIVE:The aim of this study was to examine the reasons why primary care doctors undertake postgraduate diploma studies in a mixed private/public Asian setting. METHODS:Twenty four past or current postgraduate diploma students of the family medicine unit (FMU) of the University of Hong Kong participated in three fo...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2005.042077

    authors: Lam TP,Lam KF,Tse EY

    更新日期:2006-06-01 00:00:00

  • Persistent nephrogenic diabetes insipidus, tubular proteinuria, aminoaciduria, and parathyroid hormone resistance following longterm lithium administration.

    abstract::We report a patient who developed persistent nephrogenic diabetes insipidus associated with renal tubular acidosis, renal resistance to parathyroid hormone, aminoaciduria and proximal tubule pattern proteinuria in the presence of a reduced glomerular filtration rate (19-24 ml/min). A review of the previous reports of ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.776.479

    authors: Neithercut WD,Spooner RJ,Hendry A,Dagg JH

    更新日期:1990-06-01 00:00:00

  • The use of myocutaneous flaps by general surgeons.

    abstract::This is a study of the use of myocutaneous flaps by general surgeons in a district general hospital over a 5 year period, and shows that such work can be satisfactorily performed by general surgeons. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.768.738

    authors: Allan SM,Williams CR,Heddle RM,Jackson DB,Collins RE

    更新日期:1989-10-01 00:00:00

  • Junior doctors' views on reporting concerns about patient safety: a qualitative study.

    abstract:BACKGROUND:Enabling healthcare staff to report concerns is critical for improving patient safety. Junior doctors are one of the groups least likely to engage in incident reporting. This matters both for the present and for the future, as many will eventually be in leadership positions. Little is known about junior doct...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-133045

    authors: Hooper P,Kocman D,Carr S,Tarrant C

    更新日期:2015-05-01 00:00:00

  • A clinicopathological classification of granulomatous disorders.

    abstract::Granulomatous disorders comprise a large family sharing the histological denominator of granuloma formation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.76.898.457

    authors: James DG

    更新日期:2000-08-01 00:00:00

  • Cerebellar disturbance in psittacosis.

    abstract::A previously fit man developed psittacosis with marked cerebellar symptoms and signs. He was febrile but not confused, and he responded rapidly to treatment with erythromycin. Even if respiratory symptoms are minimal, psittacosis and other atypical pneumonias should be considered in any patient presenting with fever a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.751.382

    authors: Shee CD

    更新日期:1988-05-01 00:00:00

  • Oncogenic osteomalacia: strange tumours in strange places.

    abstract::Two patients presented with hypophosphataemic osteomalacia and were subsequently found to have small tumours unusual histopathology and location causing the osteomalacia. Each tumour was found after an intensive search for occult masses. Studies of vitamin D metabolism and renal tubular function before and after surge...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.714.349

    authors: Weiss D,Bar RS,Weidner N,Wener M,Lee F

    更新日期:1985-04-01 00:00:00

  • Associations of the NOS3 rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis.

    abstract:BACKGROUND:Circulating nitric oxide (NO) and lipid levels are closely associated with coronary artery disease (CAD). It is unclear whether the rs1799983 polymorphism in endothelial nitric oxide synthase (NOS3) gene is associated with plasma levels of NO and lipids. This systematic review and meta-analysis (Preferred Re...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,meta分析

    doi:10.1136/postgradmedj-2019-136396

    authors: Luo Z,Jia A,Lu Z,Muhammad I,Adenrele A,Song Y

    更新日期:2019-07-01 00:00:00

  • Chronic hepatitis B in hepatocarcinogenesis.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a wide geographical variation. Eighty per cent of HCC is attributed to hepatitis B virus (HBV). The predominant carcinogenic mechanism of HBV associated HCC is through the process of liver cirrhosis, but direct oncogenic effects of HB...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.047431

    authors: Park NH,Song IH,Chung YH

    更新日期:2006-08-01 00:00:00

  • What's in a smile? A review of the benefits of the clinician's smile.

    abstract::For millennia, the smile has been recognised as a powerful communication device, offering benefits to both giver and receiver with few drawbacks. A sign of compassion, empathy and friendliness, smiling can benefit healthcare professionals and their patients, helping to build a relationship of trust. But beware the fal...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2018-136286

    authors: Beamish AJ,Foster JJ,Edwards H,Olbers T

    更新日期:2019-02-01 00:00:00

  • FAST-TIA: a prospective evaluation of a nurse-led anterior circulation TIA clinic.

    abstract:BACKGROUND:Transient ischaemic attacks (TIAs) carry a significant early risk of stroke. New national guidelines state patients should be seen within 7 days of the incident, with higher-risk patients being seen within 24 h. Meeting these targets across the NHS poses a significant challenge. A novel approach to TIA asses...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2009.083162

    authors: Banerjee S,Natarajan I,Biram R,Sutton K,Ekeng G,Ames D,Chataway J

    更新日期:2009-12-01 00:00:00

  • Genetics of ischaemic heart disease.

    abstract::Coronary heart disease, especially when it affects younger individuals, tends to cluster in families. Known risk factors occur in 50-75% of patients with myocardial infarction. Yet commonly occurring risk factors are not strongly inherited, and the familial aggregation of coronary heart diseas may not be attributable ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.52.610.477

    authors: Epstein FH

    更新日期:1976-08-01 00:00:00

  • Effect of tricyclic antidepressants on analgesic activity in laboratory animals.

    abstract::A study has been made in rodents of the interactions between a range of psychotropic drugs, narcotic agonist and partial agonist analgesics, and pain. In rodents, tricyclic antidepressants do not alone reduce pain responses but, in combination with morphine or pentazocine, clomipramine enhances analgesic activity afte...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Lee RL,Spencer PS

    更新日期:1980-01-01 00:00:00

  • Approach to the patient with epilepsy in the outpatient department.

    abstract::Epilepsy is common and serious (prevalence 750 per 100 000) and has an impact upon employment, education, and driving. The diagnosis requires a detailed history including witness account. Clinicians must distinguish seizures particularly from syncope and psychogenic attacks. Electroencephalography and magnetic resonan...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2004.029298

    authors: Hadjikoutis S,Smith PE

    更新日期:2005-07-01 00:00:00

  • Influenza vaccination in the elderly.

    abstract::There is overwhelming evidence for the clinical efficacy of the influenza vaccine, especially in the elderly with chronic disease, reducing mortality and hospital admissions. There is also evidence to suggest that the influenza vaccine may be beneficial in the healthy elderly. There is some evidence to suggest that th...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.72.848.339

    authors: Morgan R,King D

    更新日期:1996-06-01 00:00:00

  • Primary Sjögren's syndrome, ulcerative colitis and selective IgA deficiency.

    abstract::A 24-year-old man with primary Sjögren's syndrome presented with xerophthalmia, xerostomia, and marked parotid swelling. He had a previous history of selective IgA deficiency and ulcerative colitis treated with sulphasalazine. Immunosuppression and withdrawal of sulphasalazine resulted in rapid resolution of the parot...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.72.850.499

    authors: Steuer A,McCrea DJ,Colaco CB

    更新日期:1996-08-01 00:00:00

  • Continuous electrocardiographic recording (Holter method) during indapamide treatment: a study of 40 cases.

    abstract::In 40 hypertensive patients continuous ECG recording was done before and after 30 days treatment with indapamide 2.5 mg. There was no change in heart rate. In addition, the incidence of extrasystoles was not changed in patients in whom the ECG was normal before treatment (30 cases) or in 8 of the 10 patients who had a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Haiat R,Lellouch A,Lanfranchi J,Witchitz S

    更新日期:1981-01-01 00:00:00

  • Azathioprine in chronic relapsing idiopathic polyneuropathy.

    abstract::A 33-year-old housewife with a 14-year history of relapsing polyneuropathy of unknown cause who has apparently responded to azathioprine therapy is described. The place of this form of treatment in idiopathic polyneuropathy is discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.660.734

    authors: Pentland B

    更新日期:1980-10-01 00:00:00

  • Surgical gender gap: a curriculum concordance and career vector perspective.

    abstract:INTRODUCTION:Women's participation in medicine has increased dramatically during the last 50 years, yet Office for National Statistics data (2016) regarding annual pay continue to show an unequivocal 34% deficit in female doctors' remuneration compared with their male counterparts. This study aimed to identify whether ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2017-135437

    authors: Brown C,Harries RL,Abdelrahman T,Thomas C,Pollitt MJ,Lewis WG

    更新日期:2018-09-01 00:00:00

  • Bilateral carpal tunnel syndrome associated with interleukin 2 therapy.

    abstract::We report the development of synchronous bilateral carpal tunnel syndrome in a woman with metastatic colorectal cancer, undergoing treatment with recombinant interleukin 2. A carpal tunnel decompression was carried out on the hand which was more severely affected, with a gradual recovery in median nerve function. To t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.801.587

    authors: Heys SD,Mills KL,Eremin O

    更新日期:1992-07-01 00:00:00

  • The empty sella syndrome.

    abstract::The empty sella syndrome (ESS) presents a varied clinical and radiographic picture. It may remain asymptomatic or may stimulate an intrasellar growth thereby causing diagnostic and therapeutic problems. An air encephalogram (AEG) is required for diagnosis. The purpose of this paper is to review the clinical and radiol...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.52.613.703

    authors: Sachdev Y,Evered DC,Appleby A,Hall R

    更新日期:1976-11-01 00:00:00

  • Knowledge and attitudes of breast self examination in a group of women in Shiraz, southern Iran.

    abstract:BACKGROUND:Breast cancer is the most common cause of cancer related deaths among women worldwide. The disease in women occurs at a younger age in Iran than in western communities. OBJECTIVE:To determine the practice of breast self examination (BSE) among 25-54-year-old women in Shiraz, southern Iran. METHODS:Using a ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2008.072678

    authors: Simi A,Yadollahie M,Habibzadeh F

    更新日期:2009-06-01 00:00:00

  • Testis cancer.

    abstract::Testis cancer is an increasing problem, especially in northern European male populations. However, survival has improved dramatically over one generation. Environmental factors may have a role in the aetiology with high oestrogen concentrations implicated. Testis cancer is subdivided between seminoma and non-seminoma....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2007.057992

    authors: Khan O,Protheroe A

    更新日期:2007-10-01 00:00:00

  • Florid granulomatous reaction in a seminoma.

    abstract::A case of seminoma of the testis complicated by an extensive granulomatous reaction is reported. This reaction was so florid that a benign condition was initially considered until further material for histology was examined and the correct diagnosis made. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.691.334

    authors: Pickard WR,Clark AH,Abel BJ

    更新日期:1983-05-01 00:00:00

  • Congenital and acquired conditions of the aortic root: multidetector computed tomography features.

    abstract::The aortic root links the left ventricle and ascending aorta and functions as a support structure for the aortic valve. It can be affected by a variety of congenital and acquired conditions, some of which are potentially life threatening. Echocardiography and cardiac magnetic resonance imaging are established non-inva...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2008.075531

    authors: Vargas HA,Hoey ET,Gopalan D,Agrawal SK,Screaton NJ,Gulati GS

    更新日期:2009-07-01 00:00:00

  • Propofol ('Diprivan') by intravenous infusion with nitrous oxide: dose requirements and haemodynamic effects.

    abstract::The new formulation of propofol appears to be approximately equipotent to the previous formulation when used as an infusion to supplement nitrous oxide anaesthesia in patients premedicated with morphine. Preliminary haemodynamic studies indicate that the emulsion formulation causes more arterial hypotension than the o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Coates DP,Prys-Roberts C,Spelina KR,Monk CR,Norley I

    更新日期:1985-01-01 00:00:00

  • Herpes simplex virus type 2: epidemiology and management options in developing countries.

    abstract::Genital herpes simplex virus type 2 (HSV2) is highly prevalent worldwide and an increasingly important cause of genital ulcer disease (GUD). Continued HSV2 transmission is facilitated by the large number of undiagnosed cases, the frequency of atypical disease and the occurrence of asymptomatic shedding. The lack of ea...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/sti.2006.020966

    authors: Paz-Bailey G,Ramaswamy M,Hawkes SJ,Geretti AM

    更新日期:2008-06-01 00:00:00

  • The management of congestive heart failure.

    abstract::Despite the remarkable advances in cardiovascular therapeutics over the past four decades, little impact has been made on either the incidence or mortality rate of congestive heart failure and it remains a major clinical and public health problem. Recent practice audits have suggested that proven efficacious therapies...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.73.858.194

    authors: McAlister FA,Teo KK

    更新日期:1997-04-01 00:00:00

  • Spontaneous mid-oesophageal rupture.

    abstract::The clinical presentation and management of spontaneous rupture of the middle third of the oesophagus is described in two patients. Early presentation and treatment in one case led to uncomplicated recovery. In the other patient late presentation and diagnosis resulted in delayed surgical intervention with an unsucces...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.634.559

    authors: Holt S,Millar JW,Heading RC,Charles RG

    更新日期:1978-08-01 00:00:00