A clinicopathological classification of granulomatous disorders.

Abstract:

:Granulomatous disorders comprise a large family sharing the histological denominator of granuloma formation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity. There is a complex interplay between invading organism or prolonged antigenaemia, macrophage activity, a Th1 cell response, B cell overactivity and a vast array of biological mediators. Differential diagnosis and management demand a skilful interpretation of clinical findings and pathological evidence. They are classified into infections, vasculitis, immunological aberration, leucocyte oxidase deficiency, hypersensitivity, chemicals, and neoplasia.

journal_name

Postgrad Med J

authors

James DG

doi

10.1136/pmj.76.898.457

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

457-65

issue

898

eissn

0032-5473

issn

1469-0756

journal_volume

76

pub_type

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