Genetics of ischaemic heart disease.

Abstract:

:Coronary heart disease, especially when it affects younger individuals, tends to cluster in families. Known risk factors occur in 50-75% of patients with myocardial infarction. Yet commonly occurring risk factors are not strongly inherited, and the familial aggregation of coronary heart diseas may not be attributable to familial resemblance in serum cholesterol and blood pressure levels. Alternatively, such aggregation may be due to unknown familial risk factors. Nevertheless, screening of relatives of individuals with evident risk factors is of importance, and environmental manipulation is likely to be of value in prevention of coronary heart disease.

journal_name

Postgrad Med J

authors

Epstein FH

doi

10.1136/pgmj.52.610.477

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

477-80

issue

610

eissn

0032-5473

issn

1469-0756

journal_volume

52

pub_type

杂志文章
  • Lornoxicam, indomethacin and placebo: comparison of effects on faecal blood loss and upper gastrointestinal endoscopic appearances in healthy men.

    abstract::Forty-five healthy men aged 21-34 years took part in a double-blind, parallel-group, placebo-controlled study of the effects of 28 days' treatment with lornoxicam 4 mg twice daily or indomethacin 50 mg twice daily on faecal blood loss and the endoscopic appearances of gastric and duodenal mucosa. After an initial endo...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/pgmj.66.778.622

    authors: Warrington SJ,Debbas NM,Farthing M,Horton M,Johnston A,Thillainayagam A,Turner P,Ferber H

    更新日期:1990-08-01 00:00:00

  • The role of the media.

    abstract::There is an increasing awareness on the part both of the media and the profession of the need to co-operate in providing information and education on medical matters. This co-operation should be strongly encouraged. Where children are concerned the opportunities for education are great. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.629.225

    authors: Jolly H

    更新日期:1978-03-01 00:00:00

  • Investigation of cereal toxicity in coeliac disease.

    abstract::Coeliac disease is exacerbated by wheat gluten. A review of methods for the purification, identification and quantitation of wheat proteins to investigate coeliac disease is presented. Recent developments including amino acid sequencing and expression of wheat protein peptides in E. coli should permit characterization...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.63.743.767

    authors: Ciclitira PJ,Ellis HJ

    更新日期:1987-09-01 00:00:00

  • Paradoxical vocal cord motion disorder: past, present and future.

    abstract::Paradoxical vocal cord motion disorder (PVCM), also called vocal cord dysfunction, is an important differential diagnosis for asthma. The disorder is often misdiagnosed as asthma leading to unnecessary drug use, very high medical utilisation and occasionally tracheal intubation or tracheostomy. Laryngoscopy is the gol...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.052522

    authors: Ibrahim WH,Gheriani HA,Almohamed AA,Raza T

    更新日期:2007-03-01 00:00:00

  • Parent preferences for telephone coaching to prevent and manage childhood obesity.

    abstract:OBJECTIVE:To assess parent preferences for utilisation of a parent-focused, telephone-based coaching service, or 'FITLINE,' to prevent or manage childhood obesity. METHODS:A cross-sectional survey of parents of children aged 2-12 years was conducted at a paediatric practice in Greater Boston, Massachusetts, USA, betwe...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-132928

    authors: Blaine RE,Pbert L,Geller AC,Powers EM,Mitchell K

    更新日期:2015-04-01 00:00:00

  • Lung carcinoid related Cushing's syndrome: report of three cases and review of the literature.

    abstract::Three patients with lung carcinoid related Cushing's syndrome (LCRCS) treated at Frenchay Hospital, Bristol between 1984 and 1994 are described. The first patient presented with hyperpigmentation 13 years after bilateral adrenalectomy. The second patient had no recurrence or metastases 14 years after removal of a typi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.77.909.464

    authors: Amer KM,Ibrahim NB,Forrester-Wood CP,Saad RA,Scanlon M

    更新日期:2001-07-01 00:00:00

  • Peliosis of the spleen: possible association with chronic renal failure and erythropoietin therapy.

    abstract::Splenic peliosis was identified at necropsy in a 62-year-old woman receiving continuous ambulatory peritoneal dialysis for end-stage renal failure, and erythropoietin therapy for uraemia and anaemia. The immediate cause of death was arrhythmia related to ischaemic heart disease, following an episode of intramuscular h...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.71.838.493

    authors: Lam KY,Chan AC,Chan TM

    更新日期:1995-08-01 00:00:00

  • Is non-steroidal anti-inflammaory drug (NSAID) enteropathy clinically more important than NSAID gastropathy?

    abstract::The side effects of conventional non-steroidal anti-inflammatory drugs (NSAIDs) on the stomach is undoubtedly a serious public health problem contributing significantly to the morbidity and mortality of patients receiving these drugs. However, the damage of NSAIDs is not confined to the stomach. Indeed the short term ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2005.039586

    authors: Adebayo D,Bjarnason I

    更新日期:2006-03-01 00:00:00

  • Magnetic resonance imaging in fetal medicine: a pictorial review of current and developing indications.

    abstract::Improvements in magnetic resonance (MR) imaging now permit diagnostic images of the fetus to be obtained. Ultrasound remains vital in all aspects of fetal imaging but MR provides a useful second line imaging test. Its value is best researched in fetal central nervous system disorders but it can be applied in other are...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2009.083543

    authors: Weston MJ

    更新日期:2010-01-01 00:00:00

  • Caring for "incurables": the 150th anniversary of the Royal Hospital for Neuro-Disability, Putney.

    abstract::The Royal Hospital for Incurables (RHI), now known as the Royal Hospital for Neuro-Disability and situated on West Hill, Putney, was founded by Andrew Reed DD exactly 150 years ago. The RHI was thus the pioneer in modern times of long stay institutions for the sick and dying. It became one of the great Victorian chari...

    journal_title:Postgraduate medical journal

    pub_type: 历史文章,杂志文章

    doi:10.1136/pgmj.2003.017673

    authors: Cook GC

    更新日期:2004-07-01 00:00:00

  • Camel bites: report of severe osteolysis as late bone complications.

    abstract::Four cases of severe osteolysis of bones subsequent to camel bite are described. The first had osteolysis of the ribs with traumatic diaphragmatic hernia. Two cases had similar appearances of gross osteolysis of the shafts of the radius and ulna, whilst one had osteolysis of the humeral shaft. The similarities in the ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.770.900

    authors: al-Boukai AA,Hawass NE,Patel PJ,Kolawole TM

    更新日期:1989-12-01 00:00:00

  • Out-of-hours work in cardiothoracic surgery: implications of the New Deal and Calman for training.

    abstract::With the introduction of the New Deal and the Calman Report, the duration of higher specialist training will be halved. We have examined the effect of reduced on-call rotas on exposure to relatively uncommon out-of-hours emergencies in cardiothoracic surgery. Operations for post-infarction ventricular septal defect, a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.884.351

    authors: Kelty C,Duffy J,Cooper G

    更新日期:1999-06-01 00:00:00

  • What is osteoporosis?

    abstract::Osteoporosis is a very common disorder, which results in an increase in fracture risk. The annual cost attributable to hip, vertebral, and wrist fractures in England and Wales is pound 1.7 billion. Significant mortality and morbidity are associated with osteoporotic fractures. The method that is most widely used for t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.79.929.133

    authors: Christodoulou C,Cooper C

    更新日期:2003-03-01 00:00:00

  • Detection of hepatic encephalopathy.

    abstract::The most sensitive index of hepatic encephalopathy in 29 patients following a porta-caval shunt appeared to be the assessment of a close relative who had known the patient pre-operatively. They noticed that 19 of the 20 patients were mentally slower; 11 were markedly aggressive and 8 had become placid and uncaring abo...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.725.163

    authors: Gazzard BG,Price H,Dawson AM

    更新日期:1986-03-01 00:00:00

  • Typhoid fever with severe pancytopenia.

    abstract::A patient suffering from typhoid fever with severe pancytopenia is presented. Bone marrow examination revealed extensive haemophagocytosis which possibly contributed to the pancytopenia. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.73.855.41

    authors: Sood R,Roy S,Kaushik P

    更新日期:1997-01-01 00:00:00

  • Pediatric Emergency Care Applied Research Network head injury clinical prediction rules are reliable in practice.

    abstract:OBJECTIVE:The Pediatric Emergency Care Applied Research Network (PECARN) traumatic brain injury (TBI) age-based clinical prediction rules identify children at very low risk of a significant head injury who can safely avoid CT. Our goal was to independently validate these prediction rules. DESIGN:Cross-sectional study....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2013-305004rep

    authors: Schonfeld D,Bressan S,Da Dalt L,Henien MN,Winnett JA,Nigrovic LE

    更新日期:2015-11-01 00:00:00

  • Non-Hodgkin's lymphoma presenting as 'chronic active toxoplasmosis'.

    abstract::We report the case of a 58 year old man in whom an unusually prolonged infection with Toxoplasma gondii was the presenting feature of an underlying non-Hodgkin's lymphoma. This case demonstrates the particular usefulness of the IgM ELISA test in monitoring disease activity. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.757.883

    authors: Dudley NJ,Balfour AH

    更新日期:1988-11-01 00:00:00

  • Postgraduate medical education quality metrics panels can be enhanced by including learner outcomes.

    abstract::Postgraduate medical education (PME) quality assurance at Health Education England (HEE) currently relies upon survey data. As no one metric can reflect all aspects of training, and each has its limitations, additional metrics should be explored. At HEE (West Midlands), we explored the use of learner outcomes, special...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2020-138669

    authors: Pinnell J,Tranter A,Cooper S,Whallett A

    更新日期:2020-11-12 00:00:00

  • Republished: Daily consultant gastroenterologist ward rounds: reduced length of stay and improved inpatient mortality.

    abstract:BACKGROUND:For gastroenterology, The Royal College of Physicians reiterates the common practice of two to three consultant ward rounds per week. The Royal Bolton Hospital NHS Foundation Trust operated a 26-bed gastroenterology ward, covered by two consultants at any one time. A traditional system of two ward rounds per...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2012-100033rep

    authors: Singh S,Lipscomb G,Padmakumar K,Ramamoorthy R,Ryan S,Bates V,Crompton S,Dermody E,Moriarty K

    更新日期:2012-10-01 00:00:00

  • Percutaneous endoscopic gastrostomy in elderly patients.

    abstract::Percutaneous endoscopic gastrostomy (PEG) was performed on 28 elderly patients (mean age 82 years) who were dysphagic and intolerant of naso-gastric feeding. Twenty-six patients were recovering from a stroke; the interval between the onset of stroke and PEG averaged 63 days. The procedure was successful and well toler...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.786.371

    authors: Finucane P,Aslan SM,Duncan D

    更新日期:1991-04-01 00:00:00

  • Rehabilitation medicine.

    abstract::The nature of rehabilitation medicine is outlined in terms of its objectives, its methods, the patient groups which it seeks to help and its relationships to other specialties. Some major advances of recent years are discussed, such as the development of the impairment/disability/handicap framework. With particular em...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.841.665

    authors: Cozens JA,Chamberlain MA

    更新日期:1995-11-01 00:00:00

  • Cerebellar disturbance in psittacosis.

    abstract::A previously fit man developed psittacosis with marked cerebellar symptoms and signs. He was febrile but not confused, and he responded rapidly to treatment with erythromycin. Even if respiratory symptoms are minimal, psittacosis and other atypical pneumonias should be considered in any patient presenting with fever a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.751.382

    authors: Shee CD

    更新日期:1988-05-01 00:00:00

  • Barriers to physical activity in patients with diabetes.

    abstract:PURPOSE:Two questions were addressed: (1) How much physical activity do patients with diabetes perform? (2) What are the perceived factors that prevent patients from doing more physical activity? RESEARCH DESIGN AND METHODS:Interview based questionnaires were distributed to consecutive patients attending the Diabetes ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2003.010553

    authors: Thomas N,Alder E,Leese GP

    更新日期:2004-05-01 00:00:00

  • Republished paper: Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events.

    abstract:OBJECTIVE:To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation. METHODS:Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2010.199026rep

    authors: Mackay DF,Irfan MO,Haw S,Pell JP

    更新日期:2011-04-01 00:00:00

  • Coeliac disease with mild mucosal abnormalities: a report of four patients.

    abstract::In a routine adult gastroenterological practice, seventeen (15%) of 123 patients had small-intestinal biopsies which were neither normal nor were completely flat as found in classical coeliac disease. Some of these had a possible cause for the mild mucosal abnormality, but in six there was no other apparent cause and ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.617.134

    authors: Scott BB,Losowsky MS

    更新日期:1977-03-01 00:00:00

  • Acute pancreatitis: assessment and management.

    abstract::In the 1920s Moynihan described acute pancreatitis as "..the most terrible of all intra-abdominal calamities". He established a practice of immediate surgical intervention to remove the toxic products accumulating in the peritoneal cavity, and this treatment was endorsed by most centres, remaining the standard therapy...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.72.847.277

    authors: Skaife P,Kingsnorth AN

    更新日期:1996-05-01 00:00:00

  • A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis.

    abstract::Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic rev...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/thx.2006.075754

    authors: Steingart KR,Henry M,Laal S,Hopewell PC,Ramsay A,Menzies D,Cunningham J,Weldingh K,Pai M

    更新日期:2007-11-01 00:00:00

  • Acute transverse myelopathy complicating tetanus.

    abstract::A 12-year-old boy presented with typical features of short incubation tetanus. Spastic paraparesis with a mid-thoracic sensory level was present from the time of the initial examination. X-rays of the spine and lumbar myelogram were normal. The paraparesis improved rapidly and within a month the patient was free of ne...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.57.669.443

    authors: Bahemuka M

    更新日期:1981-07-01 00:00:00

  • Early structured core training of junior trainees in ophthalmology.

    abstract::The implementation of modernizing medical careers (MMC) has resulted in some specialties being allocated very inexperienced trainees such as ophthalmology. We aim to describe the process of implementation of MMC and how it may affect the service provision in smaller specialities such as ophthalmology. A methodical app...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2007.064188

    authors: Patel N,Zia R,Dewitd D,Morris S,Ionides A

    更新日期:2007-12-01 00:00:00

  • Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy.

    abstract:OBJECTIVE:To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE). METHODS:Twenty four 3 day old piglets were permanently ligated common carotid arteries b...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2004.030114

    authors: Cheng Y,Liu GR,Guan JT,Guo YL,Li YK,Wu RH

    更新日期:2005-09-01 00:00:00