Effect of tricyclic antidepressants on analgesic activity in laboratory animals.

Abstract:

:A study has been made in rodents of the interactions between a range of psychotropic drugs, narcotic agonist and partial agonist analgesics, and pain. In rodents, tricyclic antidepressants do not alone reduce pain responses but, in combination with morphine or pentazocine, clomipramine enhances analgesic activity after single doses yet increases the onset and degree of tolerance to morphine on repeated injection. The tricyclic antidepressant maprotiline, in contrast, reduced both the rate of development and extent of morphine tolerance. In morphine-dependent rats, repeated injections of clomipramine or maprotiline exerted a mixed effect upon the abstinence syndrome, some behavioural signs being potentiated whilst others were suppressed. These studies suggest that combining maprotiline with morphine will improve the control of chronic pain states.

journal_name

Postgrad Med J

authors

Lee RL,Spencer PS

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

19-24

eissn

0032-5473

issn

1469-0756

journal_volume

56 Suppl 1

pub_type

杂志文章
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    abstract:AIM:To obtain the views of specialist registrars on specialty care in the community. METHOD:Specialist registrars from five Deaneries in England completed an online questionnaire about their views on employment prospects, the role of specialty care in the community, and the need for additional training in this area. ...

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    doi:10.1136/pgmj.2006.054320

    authors: Azam N,Moshkovska T,Mayberry JF

    更新日期:2007-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/pgmj.55.646.533

    authors: Jackson MA,Talbot S,Thomas DW,Lee HA

    更新日期:1979-09-01 00:00:00

  • Lifestyle medicine course for family medicine residents: preliminary assessment of the impact on knowledge, attitudes, self-efficacy and personal health.

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    doi:10.1136/postgradmedj-2016-134726

    authors: Malatskey L,Bar Zeev Y,Tzuk-Onn A,Polak R

    更新日期:2017-09-01 00:00:00

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    abstract::A patient with acute lymphoblastic leukaemia who developed ovarian and uterine leukaemic relapse while in bone marrow remission is described. Pelvic relapse is rarely reported during the clinical course of leukaemia in females. Pelvic ultrasonography, a non-invasive procedure, was of value as an aid in detecting pelvi...

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    doi:10.1136/pgmj.58.685.724

    authors: Cantwell B,Cantwell D,Fennelly JJ

    更新日期:1982-11-01 00:00:00

  • Endobronchial tuberculosis--is corticosteroid treatment useful? A report of 8 cases and review of the literature.

    abstract::Eight patients with endobronchial tuberculosis diagnosed on bronchoscopy were treated with antituberculosis drugs and a course of prednisone. The progress of the endobronchial lesions was assessed on repeated examinations. The course of the disease was variable and the endobronchial narrowing improved in two patients ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.66.780.822

    authors: Chan HS,Sun A,Hoheisel GB

    更新日期:1990-10-01 00:00:00

  • Continuous electrocardiographic recording (Holter method) during indapamide treatment: a study of 40 cases.

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    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Haiat R,Lellouch A,Lanfranchi J,Witchitz S

    更新日期:1981-01-01 00:00:00

  • Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.

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    doi:10.1136/pgmj.65.770.950

    authors: Webberley MJ,Murray JA

    更新日期:1989-12-01 00:00:00

  • Post-typhoid anhidrosis: a clinical curiosity.

    abstract::A 19-year-old girl developed generalised anhidrosis following typhoid fever. Elaborate investigations disclosed nothing abnormal. A skin biopsy revealed the presence of atrophic as well as normal eccrine glands. This appears to be the third case of its kind in the English literature. It is postulated that typhoid feve...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.837.435

    authors: Raveenthiran V

    更新日期:1995-07-01 00:00:00

  • Cardiac tamponade after thrombolysis.

    abstract::Thrombolysis has been very effective in reducing the morbidity and mortality from acute myocardial infarction. Serious adverse events are not uncommon, however. We describe a case in which a haemopericardium and tamponade developed in a patient with a history of recurrent idiopathic pericarditis and to whom streptokin...

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    pub_type: 杂志文章

    doi:10.1136/pgmj.70.824.455

    authors: Heymann TD,Culling W

    更新日期:1994-06-01 00:00:00

  • Cellular profile of bronchoalveolar lavage fluid in Turkish miners.

    abstract::Pneumoconiosis is still a health problem in Turkey and has a relatively high incidence. Retired underground miners were investigated to document alveolitis, and to observe the difference in the cellular profiles of bronchoalveolar lavage (BAL) fluid with or without pneumoconiosis. Twenty nine retired male miners and 1...

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

    doi:10.1136/pmj.77.903.24

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  • Ethnic minorities, health provision and the 1976 Race Relations Act.

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    pub_type: 杂志文章

    doi:10.1136/pgmj.66.782.1043

    authors: Bedi R,MacEwen M

    更新日期:1990-12-01 00:00:00

  • Extreme metabolic alkalosis with fludrocortisone therapy.

    abstract::We present an unusual case of extreme metabolic alkalosis resulting from severe hypokalaemia caused by unmonitored fludrocortisone therapy. Biochemical aspects of the disorder are discussed, as is the successful treatment with diuretics and potassium replacement. Some dangers of this therapy and necessary precautions ...

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    pub_type: 杂志文章

    doi:10.1136/pgmj.59.694.506

    authors: Burns A,Brown TM,Semple P

    更新日期:1983-08-01 00:00:00

  • Psychiatric morbidity in primary hyperparathyroidism.

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    pub_type: 杂志文章

    doi:10.1136/pgmj.65.767.628

    authors: McAllion SJ,Paterson CR

    更新日期:1989-09-01 00:00:00

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    journal_title:Postgraduate medical journal

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    doi:10.1136/pgmj.63.745.995

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    更新日期:1987-11-01 00:00:00

  • Non-vitamin K antagonist oral anticoagulants (NOACs): clinical evidence and therapeutic considerations.

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    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2014-132605

    authors: Saraf K,Morris PD,Garg P,Sheridan P,Storey R

    更新日期:2014-09-01 00:00:00

  • Morphine: myths, morality and economics.

    abstract::It is a tragedy that morphine is scarcely available for between 1.3 and 2.5 billion people whilst 3.5 million cancer patients suffer needlessly. In only 10 countries is its consumption rising, in many more only codeine consumption shows an increase, and in many areas even in the Western world prescribing is grossly li...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Doyle D

    更新日期:1991-01-01 00:00:00

  • Subconjunctival haemorrhage: a feature of acute severe asthma.

    abstract::Bilateral subconjunctival haemorrhage was observed on 5 separate occasions in 4 patients presenting a fulminant form of acute severe asthma. Four of these episodes required ventilatory support. All patients recovered from their asthma attack after treatment with bronchodilators, corticosteroids, and oxygen. The incide...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.717.579

    authors: Rodriguez-Roisin R,Torres A,Agustí AG,Ussetti P,Agustí-Vidal A

    更新日期:1985-07-01 00:00:00

  • Pubic osteomyelitis presenting as irritable hip.

    abstract::Two cases of pubic osteomyelitis presenting as a painful hip are reported. In both cases the diagnosis was delayed by the unusual presentation and by the limited radiological investigation. Pubic osteomyelitis is rare in childhood but should be considered in the differential diagnosis of the 'irritable hip'. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.738.301

    authors: Weinberg JR,Berman L,Dootson G,Mitchell R

    更新日期:1987-04-01 00:00:00

  • Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy.

    abstract:OBJECTIVE:To establish a cerebral hypoxia ischaemic model in piglets and to explore the early diffusion weighted imaging (DWI) as well as the expression of heat shock protein 70 (HSP70) with hypoxic ischaemic encephalopathy (HIE). METHODS:Twenty four 3 day old piglets were permanently ligated common carotid arteries b...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2004.030114

    authors: Cheng Y,Liu GR,Guan JT,Guo YL,Li YK,Wu RH

    更新日期:2005-09-01 00:00:00

  • Pseudo-splenomegaly as a result of subphrenic abscess.

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    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.723.29

    authors: Snape J,Baker AR,Rees Y

    更新日期:1986-01-01 00:00:00

  • Teaching M&M rounds skills: enhancing and assessing patient safety competencies using the Ottawa M&M model.

    abstract:BACKGROUND:Postgraduate medical education bodies and national patient safety institutes recommend that trainees develop patient safety competencies such as those for Morbidity and Mortality (M&M) rounds, yet there exists no model for their educational delivery. OBJECTIVE:We studied the effect of a single educational i...

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    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2015-133265

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    更新日期:2016-11-01 00:00:00

  • Mycobacteria as a cause of infective exacerbation in bronchiectasis.

    abstract::In 91 patients with bronchiectasis seen over 6 years, a positive mycobacterial culture was obtained in 12 cases (13%). The organisms isolated were Mycobacterium tuberculosis in nine cases, Mycobacterium avium in two cases and Mycobacterium tuberculosis and chelonei were obtained on separate occasions in one case. Comp...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.805.896

    authors: Chan CH,Ho AK,Chan RC,Cheung H,Cheng AF

    更新日期:1992-11-01 00:00:00

  • Calcium antagonists and beta blockade--a useful combination.

    abstract::Treatment of angina with a single drug often proves unsatisfactory because of dose-related unwanted effects or occasionally an adverse effect on the angina. A combination of a beta-blocking agent and a calcium antagonist drug might achieve satisfactory control of angina at acceptable doses of each drug. Widespread app...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Geddes JS

    更新日期:1983-01-01 00:00:00

  • Pancreatic ketoacidosis: ketonemia associated with acute pancreatitis.

    abstract::Ketonaemia is well documented as a consequence of prolonged starvation, acute alcoholism, and uncontrolled diabetes mellitus. However, its occurrence in acute pancreatitis has not been described. In this report, three patients who manifested ketoacidosis at the time of presentation of acute pancreatitis are described....

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    pub_type: 杂志文章

    doi:10.1136/pgmj.71.831.32

    authors: Kabadi UM

    更新日期:1995-01-01 00:00:00

  • The challenge of providing mentorship in primary care.

    abstract::In the changing National Health Service, there is an increasing awareness of stress related problems in the medical workforce. Mentorship has been shown to help with both stress reduction and adaptation to change. There are recognised difficulties with providing mentorship for doctors but there are ways in which these...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.054155

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    更新日期:2007-05-01 00:00:00

  • A randomised controlled trial of subcutaneous sodium salicylate therapy for osteoarthritis of the thumb.

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    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/pgmj.2009.087643

    authors: Smith AS,Doré CJ,Dennis L,Julius A,Mackworth-Young CG

    更新日期:2010-06-01 00:00:00

  • Massive haematemesis and melaena from a Meckel's diverticulum.

    abstract::A case of Meckel's diverticulum in a middle-aged man presenting acutely with haematemesis and melaena is reported. Such a presentation has not to our knowledge been previously reported in this age group. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.698.786

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    更新日期:1983-12-01 00:00:00

  • Testis cancer.

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    更新日期:2007-10-01 00:00:00

  • The pathogenesis of dilated cardiomyopathy.

    abstract::Using the WHO/ISFC definition and recommendations of nomenclature for cardiomyopathies, the aetiology is unknown. Over many years research has concentrated on defining pathogenetic mechanisms and owing to the widespread use of the bioptome-permitting recovery of fresh endomyocardial tissue-myocarditis has emerged as b...

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    pub_type: 杂志文章

    doi:

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    更新日期:1992-01-01 00:00:00