Neurological complications of human immunodeficiency virus infection.


:The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seropositive for HIV alone as well as those with the established AIDS syndrome. Specific therapy is available for certain of these neurological conditions, but the clinical course in others is untreatable and progressive. Although it seems likely that the pathogenesis of some of these syndromes such as the AIDS-dementia complex are due to the direct effect of HIV on the nervous system, in others the neurological injury probably occurs as a consequence of the immunosuppression which HIV induces, or immune-mediated mechanisms.


Postgrad Med J


Kennedy PG




Has Abstract


1988-03-01 00:00:00












  • Pyogenic liver abscess with two normal ultrasound scans.

    abstract::I report a case of a large liver abscess causing a severe debilitating condition in which the diagnosis was delayed by several weeks following two normal ultrasound scans at days 5 and 19 of the illness. Up to one in four cases of liver abscess can be missed on ultrasound. A high degree of clinical suspicion must be m...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Bunney RG

    更新日期:1988-05-01 00:00:00

  • Association between ADAMTS7 TagSNPs and the risk of myocardialinfarction.

    abstract:PURPOSE OF THE STUDY:Genome-wide association studies have revealed an association of ADAMTS7 polymorphisms with the risk of cardiovascular diseases. Nonetheless, the role of ADAMTS7 polymorphisms on myocardial infarction (MI) risk remains poorly understood. Here, we aim to evaluate the effect of ADAMTS7 tag single nucl...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Liang LL,Zhou YL,Cheng J,Xiao YT,Tang ZB,Liu SM,Lian JC,Wang XX,Liu X,Xiong XD

    更新日期:2019-09-01 00:00:00

  • A clinicopathological analysis of 26 patients with infection-associated haemophagocytic lymphohistiocytosis and the importance of bone marrow phagocytosis for the early initiation of immunomodulatory treatment.

    abstract:OBJECTIVE:To analyse the clinicopathological presentation, outcome and importance of bone marrow haemophagocytosis in patients with infection-associated haemophagocytic lymphohistiocytosis (IA-HLH) in a tertiary care hospital in Northern India. STUDY DESIGN:Between January 2007 and December 2009, 26 consecutive patien...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Nair V,Das S,Sharma A,Sharma S,Sharma P,Ray S,Bhattacharya S

    更新日期:2013-04-01 00:00:00

  • Phaeochromocytoma and acute cardiovascular death (with special reference to myocardial infarction).

    abstract::The causes of death, as determined by autopsy, in 10 patients dying from the acute effects of phaeochromocytoma were myocardial infarction (five patients), left ventricular failure (two patients), cerebral haemorrhage (two patients) and circulatory collapse with malignant phaeochromocytoma (one patient). Most patients...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Cohen CD,Dent DM

    更新日期:1984-02-01 00:00:00

  • The changing context of undergraduate medical education.

    abstract::It has long been recognised that intensive efforts are needed to reform medical education in order to meet the future needs of populations worldwide. Pressure for changes to the organisation, content and delivery of both undergraduate and postgraduate medical education has greatly increased in the last two decades. Th...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Parsell GJ,Bligh J

    更新日期:1995-07-01 00:00:00

  • Failure of conventional chemotherapy in aggressive lymphomas.

    abstract::Between 1975 and 1982 in 2 centres in Glasgow, 53 previously untreated patients with aggressive non-Hodgkin's lymphomas received chemotherapy consisting of one of the following regimens-CVP, MOPP, CHOP or BACOP. Twenty nine patients (55%) entered complete remission (CR), 20 (38%) had partial remission (PR) and 4 (7%) ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Cunningham D,Hepplestone A,Gilchrist NL,Dagg JH,Evans IL,Soukop M

    更新日期:1987-01-01 00:00:00

  • Association between serum amyloid A levels and cancers: a systematic review and meta-analysis.

    abstract:OBJECTIVE:Increased serum amyloid A (SAA) levels have been investigated in various human malignancies, but a consistent perspective has not been established to date. This study systematically reviewed the association between SAA levels and cancers. METHODS:Cochrane Library, PubMed and Embase were carefully searched fo...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,meta分析,评审


    authors: Zhou J,Sheng J,Fan Y,Zhu X,Tao Q,He Y,Wang S

    更新日期:2018-09-01 00:00:00

  • UK survey of non-medical use of prescription drugs (NMURx) as a valuable source of general population illicit drug use data.

    abstract:PURPOSE OF STUDY:The aim of the study is to describe the prevalence of illicit drug use in England and Wales using data from the UK Survey of Non-Medical Use of Prescription Drugs (NMURx) programme and to compare against the well-established Crime Survey England and Wales (CSEW). The rationale is that recreational and ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Ng FL,Rockhill K,Black J,May KP,Whittington MD,Wood DM,Dargan PI,Green JL

    更新日期:2018-11-01 00:00:00

  • Therapy of fungal infections of the central nervous system.

    abstract::Fungal infections of the central nervous system present a considerable challenge to available chemotherapy and other forms of treatment. The particular difficulties are discussed here, after an account of the fungi involved and their sensitivity to antifungal agents. Cryptococcal, coccidioidal and candidal infections ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Speller DC

    更新日期:1979-09-01 00:00:00

  • Caverno-saphenous shunt in the treatment of priapism.

    abstract::The painful pathological condition of the penis, priapism, is usually associated with serious destructive changes which lead to impotence if treatment is with-held or delayed. Conservative therapy is slow, uncertain and usually ineffective. Early surgical decompression of the corpora cavernosa, repeated if necessary, ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Ihekwaba FN,Lawani J

    更新日期:1981-02-01 00:00:00

  • Treatment of non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, im...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Adams LA,Angulo P

    更新日期:2006-05-01 00:00:00

  • Endobronchial ultrasound guided transbronchial needle aspiration.

    abstract::Staging for non-small cell lung cancer (NSCLC) requires accurate assessment of the mediastinal lymph nodes which determines treatment and outcome. As radiological staging is limited by its specificity and sensitivity, it is necessary to sample the mediastinal nodes. Traditionally, mediastinoscopy has been used for eva...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Medford AR,Bennett JA,Free CM,Agrawal S

    更新日期:2010-02-01 00:00:00

  • What's in a smile? A review of the benefits of the clinician's smile.

    abstract::For millennia, the smile has been recognised as a powerful communication device, offering benefits to both giver and receiver with few drawbacks. A sign of compassion, empathy and friendliness, smiling can benefit healthcare professionals and their patients, helping to build a relationship of trust. But beware the fal...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Beamish AJ,Foster JJ,Edwards H,Olbers T

    更新日期:2019-02-01 00:00:00

  • Thrombotic thrombocytopenic purpura associated with pregnancy in two sisters.

    abstract::Two sisters suffered from thrombotic thrombocytopenic purpura late in their first pregnancies. HLA typing of the patients and their immediate family members demonstrated no obvious relationship. Hereditary aspects, association with pregnancy, prognosis and management of pregnant women with TTP are discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Alqadah F,Zebeib MA,Awidi AS

    更新日期:1993-03-01 00:00:00

  • The management of congestive heart failure.

    abstract::Despite the remarkable advances in cardiovascular therapeutics over the past four decades, little impact has been made on either the incidence or mortality rate of congestive heart failure and it remains a major clinical and public health problem. Recent practice audits have suggested that proven efficacious therapies...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: McAlister FA,Teo KK

    更新日期:1997-04-01 00:00:00

  • Primary pulmonary hypertension associated with human immunodeficiency virus infection.

    abstract::Several cardiorespiratory diseases can complicate human immunodeficiency virus infection. Primary pulmonary hypertension is a rare clinical disorder which carries a bad prognosis. More than 90 cases of HIV-associated primary pulmonary hypertension have been reported to date. Although its pathogenesis remains unknown, ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Golpe R,Fernandez-Infante B,Fernandez-Rozas S

    更新日期:1998-07-01 00:00:00

  • How much can elderly patients tell us about their medications?

    abstract::Two hundred and sixty one patients attending a geriatric service were asked to give details of their usual medications without reference to drug bottles or written lists. Recall was tested in 4 categories: name of drugs, drug dosage, frequency of administration, and reason for the drug being prescribed. Drug recall wa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: al Mahdy H,Seymour DG

    更新日期:1990-02-01 00:00:00

  • Slow viruses and chronic disease of the central nervous system.

    abstract::Although recognized since the 1930s, slow infections have only recently received considerable attention. There are three types, group A (related to the type C RNA viruses), group B (bizarre agents such as scrapie and kuru) and group C (viruses such as measles which normally produce acute infections but which are behav...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Sutton RN

    更新日期:1979-02-01 00:00:00

  • Pseudomembranous enterocolitis complicating ampicillin therapy.

    abstract::A case of fatal pseudomembranous enterocolitis associated with ampicillin therapy is described and possible mechanisms for its production discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Read L,Cove-Smith JR

    更新日期:1977-06-01 00:00:00

  • Improving residents' clinical approach to obesity: impact of a multidisciplinary didactic curriculum.

    abstract:BACKGROUND/OBJECTIVES:Obesity has been declared a 21st century pandemic by WHO. Yet surveys reveal physicians-in-training are uncomfortable managing obesity. One major barrier is the lack of residency education on obesity management. This study incorporates an obesity-specific didactic curriculum into an internal medic...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Acosta A,Azzalin A,Emmons CJ,Shuster JJ,Jay M,Lo MC

    更新日期:2014-11-01 00:00:00

  • Cyclical release of vasoactive intestinal polypeptide (VIP) from a pancreatic islet cell apudoma.

    abstract::A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP). Diagnosis was confirmed by plasma VIP as measured by a radio-immunoassay technique now available. It...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Devine BL,Carmichael HA,Russell RI,Joffe SN

    更新日期:1978-08-01 00:00:00

  • Plasma sex hormone concentrations in men with hypertension treated with methyldopa and/or propranolol.

    abstract::Serum concentrations of LH, FSH, testosterone and prolactin were measured in patients with hypertension treated with propranolol (34 cases), methyldopa (13 cases), and methyldopa + propranolol (11 cases). The results were compared with those obtained in 18 controls (hospital out-patients). There were no differences in...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Taylor RG,Crisp AJ,Hoffbrand BI,Maguire A,Jacobs HS

    更新日期:1981-07-01 00:00:00

  • Multiple strokes after initiation of steroid therapy in giant cell arteritis.

    abstract::We report the case of a 66 year old woman with clinical manifestations of giant-cell arteritis, positive temporal artery biopsy and excellent response to prednisone, who developed massive cerebral infarcts after 5 days of treatment. Computed tomographic and magnetic resonance imaging scans revealed multiple infarcts i...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Collazos J,García-Moncó C,Martín A,Rodriguez J,Gómez MA

    更新日期:1994-03-01 00:00:00

  • Patterns of acute oncology admissions: an exploratory analysis of over 7000 patient episodes.

    abstract:BACKGROUND:Following the National Chemotherapy Advisory Group report, calling for better management of patients with cancer admitted acutely to hospital, Clatterbridge Cancer Centre, with Merseyside and Cheshire Cancer Network, implemented an acute oncology service (AOS) for the region's seven acute trusts. STUDY DESI...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Neville-Webbe HL,Wong H,Marshall E

    更新日期:2016-11-01 00:00:00

  • Development of Hodgkin's disease in the course of liver cirrhosis and impaired monocyte function.

    abstract::The monocyte function, as measured by phagocytosis and killing of Candida albicans and Candida pseudotropicalis by peripheral blood monocytes, was found impaired in a patient with cirrhosis of the liver on two separate determinations before the occurrence of bleeding from oesophageal varices. Unexpectedly, Hodgkin's d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dan M,Hassner A,Jedwab M,Shibolet S

    更新日期:1984-07-01 00:00:00

  • In vitro fertilization of hamster eggs as a test system for drug effect on spermatozoa--lack of clomipramine effect.

    abstract::Clomipramine may affect reproduction in male rats and dogs, while other psychotropic drugs can affect sperm motility in vitro. This study investigates the motility of hamster sperm and the fertilization of hamster eggs in vitro with epididymal sperm from alpha-chlorohydrin-pretreated males, and after preincubation wit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Stein DM,Schnieden H

    更新日期:1980-01-01 00:00:00

  • Implementation of British Thoracic Society guidelines for acute exacerbation of chronic obstructive pulmonary disease: impact on quality of life.

    abstract:BACKGROUND:The British Thoracic Society (BTS) guidelines have not been examined collectively for their impact on chronic obstructive pulmonary disease (COPD). Whether intensive outpatient follow up of COPD patients after acute admission, using these guidelines, improved quality of life compared to the "usual practice" ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dheda K,Crawford A,Hagan G,Roberts CM

    更新日期:2004-03-01 00:00:00

  • Palmar-plantar erythema associated with combination chemotherapy.

    abstract::We report three cases of a distinctive palmar-plantar erythema associated with the treatment of non-Hodgkin's lymphoma and acute myeloid leukaemia. The rash is characterized by a painful, sharply demarcated, intense erythema of the palms and/or soles followed by bulla formation, desquamation and healing. The eruption ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Pagliuca A,Kaczmarski R,Mufti GJ

    更新日期:1990-03-01 00:00:00

  • Misoprostol does not alter the pharmacokinetics of propranolol.

    abstract::Twelve healthy volunteers took part in a randomised, double-blind, balanced, cross-over study to investigate the effect of misoprostol on the pharmacokinetics of propranolol. The subjects took propranolol 80 mg twice daily by mouth plus either misoprostol 400 micrograms twice daily or placebo by mouth for 14.5 days, f...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bennett PN,Fenn GC,Notarianni LJ,Lee CE

    更新日期:1991-05-01 00:00:00

  • COVID-19 in patients with heart failure: the new and the old epidemic.

    abstract::Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread in nearly 200 countries in less than 4 months since its first identification; accordingly, the coronavirus disease 2019 (COVID 2019) has affirmed itself as a clinical challenge. The prevalence of pre-existing cardiovascular diseases in patients wi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Sisti N,Valente S,Mandoli GE,Santoro C,Sciaccaluga C,Franchi F,Cameli P,Mondillo S,Cameli M

    更新日期:2020-07-30 00:00:00