A review of the drug events reported by 12,917 patients treated with cephalexin.

abstract：:The present report is the first description to our knowledge of a clinical case of bacterial calcification in human infective endocarditic vegetations. Partial calcification of bacteria within vegetations may be a further mechanism of bacterial protection from host defences and antibiotics. Similar calcification has r...

journal_title：Postgraduate medical journal

authors： Poller DN,Curry A,Ganguli LA,Routledge RC

更新日期：1989-09-01 00:00:00

abstract：:The effective management of constipation in childhood requires an understanding of the ways that the physical and psychological factors interact. The early difficulty with defecation that leads to pain, fear, and refusal to use the pot or lavatory often progresses to the formation of vicious cycles of increasing faeca...

journal_title：Postgraduate medical journal

authors： Clayden G,Keshtgar AS

更新日期：2003-11-01 00:00:00

abstract：:A 17 year old woman presented with severe anaemia due to menorrhagia. On investigation, she was shown to have abnormalities of her haemostatic mechanism consistent with von Willebrand's disease Type I, although there was no family history of this disorder. In addition, she was shown to have severe primary hypothyroidi...

journal_title：Postgraduate medical journal

authors： Blesing NE,Hambley H,McDonald GA

更新日期：1990-06-01 00:00:00

abstract：:Malignant hyperthermia is a rare autosomal dominant trait that predisposes affected individuals to great danger when exposed to certain anaesthetic triggering agents (such as potent volatile anaesthetics and succinylcholine). A sudden hypermetabolic reaction in skeletal muscle leading to hyperthermia and massive rhabd...

journal_title：Postgraduate medical journal

authors： Ben Abraham R,Adnet P,Glauber V,Perel A

更新日期：1998-01-01 00:00:00

abstract：:The development of clinical governance in New Zealand has been pivotal to the country's health policy since 2009. Some of the key findings from one component of a national assessment project, which involved interviews with health professionals and managers at 19 of the country's 20 district health boards, are reviewed...

journal_title：Postgraduate medical journal

authors： Gauld R

更新日期：2014-01-01 00:00:00

abstract：:The acute haemodynamic effects of endralazine, a new hydralazine-like vasodilating agent, were studied in 6 patients with stable angina pectoris and proven coronary artery disease. Twenty minutes after intravenous administration of 5 mg endralazine heart rate and cardiac index increase, while mean arterial blood press...

journal_title：Postgraduate medical journal

authors： van der Wall EE,de Feyter PJ,Res JC,Roos JP,van Engelen CL

更新日期：1983-01-01 00:00:00

abstract：:Five cases of strangulated femoral hernia, all with a delay in establishing the diagnosis, are reported here. These cases illustrate the continuing difficulties experienced, both in primary care and hospital practice, in making this diagnosis despite the clinical awareness of this condition. ...

journal_title：Postgraduate medical journal

authors： Heys SD,Brittenden J

更新日期：1991-01-01 00:00:00

abstract：:Current maintenance immunosuppressive regimens for transplantation are based on three classes of drugs: corticosteroids, immunophilin-binding agents (eg, cyclosporin and tacrolimus), and antimetabolites (eg, azathioprine and mycophenolate). Drugs from the various classes inhibit the immune system at different points a...

journal_title：Postgraduate medical journal

authors： Vella JP,Sayegh MH

更新日期：1997-07-01 00:00:00

abstract：:Osteoporosis is a very common disorder, which results in an increase in fracture risk. The annual cost attributable to hip, vertebral, and wrist fractures in England and Wales is pound 1.7 billion. Significant mortality and morbidity are associated with osteoporotic fractures. The method that is most widely used for t...

journal_title：Postgraduate medical journal

authors： Christodoulou C,Cooper C

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Previous research has shown that sicker patients are less satisfied with their healthcare, but specific effects of adverse health outcomes have not been investigated. The present study aimed to assess whether patients who experience adverse outcomes, in hospital or after discharge, differ in their evaluation...

journal_title：Postgraduate medical journal

authors： Marang-van de Mheen PJ,van Duijn-Bakker N,Kievit J

更新日期：2008-02-01 00:00:00

abstract：:We report on 8 patients with giant lymph node hyperplasia (GLNH), diagnosed over a 10-year period. The age of the patients at diagnosis, the clinical presentation and the histological subtype varied, indicating that GNLH is a heterogeneous condition. One case was associated with liver cirrhosis, and in another patient...

journal_title：Postgraduate medical journal

authors： Baruch Y,Ben-Arie Y,Kerner H,Lorber M,Best LA,Gershoni-Baruch R

更新日期：1991-04-01 00:00:00

abstract：:A case of ovarian carcinoma and systemic amyloidosis in a 64 year old woman with nephrotic syndrome is reported. Immunohistochemical study of renal and rectal biopsy specimens revealed the presence of amyloidosis AA antigens, consistent with secondary amyloidosis. The absence of chronic inflammatory or infectious dise...

journal_title：Postgraduate medical journal

authors： Fernandez-Miranda C,Mateo S,Gonzalez-Gomez C,Ballestin C

更新日期：1994-07-01 00:00:00

abstract：:Weekly low dose methotrexate is an established treatment for rheumatoid arthritis, but its use in elderly people has not been adequately examined. The aim of this study was to evaluate its safety in elderly patients with rheumatoid arthritis. A retrospective review of the clinical records of rheumatoid arthritis patie...

journal_title：Postgraduate medical journal

authors： Hirshberg B,Muszkat M,Schlesinger O,Rubinow A

更新日期：2000-12-01 00:00:00

abstract：:There is evidence that acetylcholine antagonists at the neuromuscular junction and elsewhere can act by blocking the ionic channels opened by acetylcholine as well as by competing with acetylcholine for receptor sites. This type of uncompetitive antagonism can be distinguished from competitive antagonism in various wa...

journal_title：Postgraduate medical journal

authors： Rang HP

更新日期：1981-01-01 00:00:00

abstract：:Intraperitoneal free gas seen radiologically as air under the diaphragm nearly always indicates a perforated abdominal viscus that requires surgical intervention. Rarely, however, the presence of a pneumoperitoneum may not indicate an intra-abdominal perforation and thus may not require laparotomy. Such a situation is...

journal_title：Postgraduate medical journal

authors： Williams NM,Watkin DF

更新日期：1997-09-01 00:00:00

abstract：:Forty-five healthy men aged 21-34 years took part in a double-blind, parallel-group, placebo-controlled study of the effects of 28 days' treatment with lornoxicam 4 mg twice daily or indomethacin 50 mg twice daily on faecal blood loss and the endoscopic appearances of gastric and duodenal mucosa. After an initial endo...

journal_title：Postgraduate medical journal

authors： Warrington SJ,Debbas NM,Farthing M,Horton M,Johnston A,Thillainayagam A,Turner P,Ferber H

更新日期：1990-08-01 00:00:00

abstract：:It has long been recognised that intensive efforts are needed to reform medical education in order to meet the future needs of populations worldwide. Pressure for changes to the organisation, content and delivery of both undergraduate and postgraduate medical education has greatly increased in the last two decades. Th...

journal_title：Postgraduate medical journal

authors： Parsell GJ,Bligh J

更新日期：1995-07-01 00:00:00

abstract：:Spironolactone therapy is a well-known cause of hyperkalaemia, but in susceptible patient, it may also be associated with metabolic acidosis. We report a case of severe renal tubular acidosis (Type IV) with life-threatening hyperkalaemia caused by spironolactone, and discuss the mechanisms by which this may occur. ...

journal_title：Postgraduate medical journal

authors： O'Connell JE,Colledge NR

更新日期：1993-11-01 00:00:00

abstract：:The empty sella syndrome (ESS) presents a varied clinical and radiographic picture. It may remain asymptomatic or may stimulate an intrasellar growth thereby causing diagnostic and therapeutic problems. An air encephalogram (AEG) is required for diagnosis. The purpose of this paper is to review the clinical and radiol...

journal_title：Postgraduate medical journal

authors： Sachdev Y,Evered DC,Appleby A,Hall R

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Audience response systems (ARSs) are electronic devices that allow educators to pose questions during lectures and receive immediate feedback on student knowledge. The current literature on the effectiveness of ARSs is contradictory, and their impact on student learning remains unclear. OBJECTIVES:This rand...

journal_title：Postgraduate medical journal

authors： Mains TE,Cofrancesco J Jr,Milner SM,Shah NG,Goldberg H

更新日期：2015-07-01 00:00:00

abstract：:Primary gastric lymphoma is a rare tumour. It is thought that low grade gastric mucosa associated lymphoid tissue lymphoma has not been previously reported to occur in a patient with gastrojejunostomy. This report describes such a case. The patient presented with bleeding from non-healing stomal ulcers. The ulcers hea...

journal_title：Postgraduate medical journal

authors： Misra SP,Misra V,Dwivedi M

更新日期：2005-02-01 00:00:00

abstract：:Serum potassium concentration was normal (greater than or equal to 3.6 mmol/l) in 29 of 32 patients with the syndrome of inappropriate antidiuretic hormone excess (SIADH) associated with a bronchogenic carcinoma. In 11 of the patients there was no significant change in serum potassium concentration after correction of...

journal_title：Postgraduate medical journal

authors： Padfield PL,Morton JJ

更新日期：1979-10-01 00:00:00

abstract：:Vasoconstriction increases impedance to ventricular ejection and impairs the performance of the dilated myopathic heart. Vasodilator drug therapy by reducing vascular resistance, increasing vascular compliance and increasing vascular capacitance improves cardiac function and relieves the signs and symptoms of congesti...

journal_title：Postgraduate medical journal

authors： Cohn JN

更新日期：1986-06-01 00:00:00

abstract：:The majority of second-generation calcium antagonists are dihydropyridines, some of which show vascular selectivity. Several new dihydropyridines have been developed with comparable pharmacodynamic properties to existing calcium antagonists in this class and greatly improved kinetic half-lives. Of these agents, amlodi...

journal_title：Postgraduate medical journal

authors： Opie LH

更新日期：1991-01-01 00:00:00

abstract：:Although the relationship between group A streptococcal upper respiratory tract infection and the development of acute rheumatic fever has been known for many years, the pathogenetic mechanism(s) have never been defined. Thus, the mechanism of damage to the valves and to the myocardium in patients with rheumatic fever...

journal_title：Postgraduate medical journal

authors： Kaplan EL

更新日期：1992-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, im...

journal_title：Postgraduate medical journal

authors： Adams LA,Angulo P

更新日期：2006-05-01 00:00:00

abstract：:Percutaneous endoscopic gastrostomy (PEG) was performed on 28 elderly patients (mean age 82 years) who were dysphagic and intolerant of naso-gastric feeding. Twenty-six patients were recovering from a stroke; the interval between the onset of stroke and PEG averaged 63 days. The procedure was successful and well toler...

journal_title：Postgraduate medical journal

authors： Finucane P,Aslan SM,Duncan D

更新日期：1991-04-01 00:00:00

abstract：:The mechanisms, clinical features and management of the various forms of urticaria are discussed. The importance of histamine receptors, complement and the kinin cascade are reviewed. ...

journal_title：Postgraduate medical journal

authors： Taaffe A

更新日期：1977-12-01 00:00:00

abstract：:Eight patients with steroid-sensitive nephrotic syndrome which frequently relapsed despite cyclophosphamide treatment were given cyclosporin A (7.5 mg/kg/day to 10 mg/kg/day) for 8 to 12 weeks. Six had minimal change glomerulonephritis and two had focal segmental glomerulonephritis. Cyclosporin A was given to 5 patien...

journal_title：Postgraduate medical journal

authors： Chan MK,Cheng IK

更新日期：1987-09-01 00:00:00

abstract：:Long lists of causes of peripheral neuropathy make peripheral nerve disease a dry and uninspiring subject. A simple scheme based on the answers to just six questions should enable the clinician to recognise characteristic patterns, investigate relevant subgroups appropriately, and identify treatable disorders quickly:...

journal_title：Postgraduate medical journal

authors： Overell JR

更新日期：2012-02-01 00:00:00