Treatment of non-alcoholic fatty liver disease.

Abstract:

:Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defences in the liver. Weight loss and exercise improve insulin sensitivity. Bariatric surgery may improve liver histology in patients with morbid obesity. Insulin sensitising drugs showed promise in pilot trials as have a number of hepatoprotective agents. Further randomised, well controlled trials are required to determine the efficacy of these drugs.

journal_name

Postgrad Med J

authors

Adams LA,Angulo P

doi

10.1136/pgmj.2005.042200

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

315-22

issue

967

eissn

0032-5473

issn

1469-0756

pii

82/967/315

journal_volume

82

pub_type

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