The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.

Abstract:

:The anti-hypertensive effect of 250 mg tienilic acid was comparable to that of 50 mg hydrochlorothiazide. Unlike hydrochlorothiazide, tienilic acid caused a statistically significant decrease in the serum uric acid values. Clinically non-significant rises in blood urea nitrogen and serum creatinine occurred with both diuretics. The hypouricaemic effect of tienilic acid given in a daily dose of 125 mg was significantly greater than that of 500 mg probenecid. Glucose tolerance in patients with mild maturity onset diabetes mellitus deteriorated with both tienilic acid and hydrochlorothiazide treatments with no statistically significant difference noted between the two treatments. Tienilic acid was well tolerated and no clinically significant haematological or biochemical abnormalities were noted.

journal_name

Postgrad Med J

authors

McMahon FG,Ryan JR,Jain AK

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

75-80

eissn

0032-5473

issn

1469-0756

journal_volume

55 Suppl 3

pub_type

临床试验,杂志文章,随机对照试验
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    doi:

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Berry H,Ollier S

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Dubb JW,Stote RM,Maass AR,Hwang BV,Familiar RG,Alexander F

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    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章

    doi:

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    pub_type: 临床试验,杂志文章

    doi:

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    pub_type: 杂志文章

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