The use of erythropoietin in renal failure.

Abstract:

:The treatment of renal anaemia by recombinant human erythropoietin (EPO) is now well established. Several studies have examined the pharmacokinetics and efficacy of the drug given intravenously, intraperitoneally and subcutaneously and there is increasing evidence that the subcutaneous route has several advantages including the requirement for a lower dose. It is also important to stress the need for careful determination of baseline iron status of all patients before commencing EPO therapy. In the long term the extremely high iron stores of transfusion dependent patients will disappear. In the short term, however, the majority of the patients whose serum ferritin is less than 100 micrograms/l will require iron supplementation to allow an appropriate haemoglobin response. Alternatively, a fall in transferrin saturation to less than 20% is certainly an indication for iron supplementation and if oral iron therapy is not adequate then intravenous preparations may have to be considered. Although the anaemia of renal failure can be fully corrected by EPO, partial correction may be sufficient to reverse the problems of reduced exercise capacity, myocardial ischaemia and cardiomegaly which are frequently associated with end-stage renal disease. Partial correction will also result in a lesser rise in whole blood viscosity and, in turn, possibly reduce hypertension, thrombosis and increased peripheral resistance and thus lessen the side effects of EPO therapy.

journal_name

Postgrad Med J

authors

Macdougall IC,Hutton RD,Coles GA,Williams JD

doi

10.1136/pgmj.67.783.9

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

9-15

issue

783

eissn

0032-5473

issn

1469-0756

journal_volume

67

pub_type

杂志文章,评审
  • Recurrent thrombosis and anticardiolipin antibodies associated with adenocarcinoma of the lung.

    abstract::A case of adenocarcinoma of the lung, in which high titre anticardiolipin antibodies were associated with recurrent venous thromboses resistant to all forms of therapy, is described. It is suggested that such an autoimmune response may be a contributory factor in the para-neoplastic development of vascular thromboses....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.774.316

    authors: Shaukat MN,Hughes P

    更新日期:1990-04-01 00:00:00

  • Antenatal appendicular perforation.

    abstract::Antenatal appendicular perforation leading to localized meconium peritonitis and intestinal obstruction is reported in a premature neonate. The baby was successfully treated by a limited ileocaecal resection. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.745.1001

    authors: Narasimharao KL,Mitra SK,Pathak IC

    更新日期:1987-11-01 00:00:00

  • Hospital-acquired serum phosphate derangements and their associated in-hospital mortality.

    abstract:BACKGROUND:We aimed to report the incidence of hospital-acquired hypophosphataemia and hyperphosphataemia along with their associated in-hospital mortality. METHODS:We included 15 869 adult patients hospitalised at a tertiary medical referral centre from January 2009 to December 2013, who had normal serum phosphate le...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2020-138872

    authors: Thongprayoon C,Cheungpasitporn W,Chewcharat A,Petnak T,Mao MA,Srivali N,Bathini T,Vallabhajosyula S,Qureshi F,Kashani K

    更新日期:2020-10-21 00:00:00

  • Chronic hepatitis B in hepatocarcinogenesis.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a wide geographical variation. Eighty per cent of HCC is attributed to hepatitis B virus (HBV). The predominant carcinogenic mechanism of HBV associated HCC is through the process of liver cirrhosis, but direct oncogenic effects of HB...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.047431

    authors: Park NH,Song IH,Chung YH

    更新日期:2006-08-01 00:00:00

  • Acute lymphoblastic leukaemia presenting with arthritis in an adult patient.

    abstract::The earliest manifestations of leukaemia often include rheumatic signs and symptoms. Arthritis is a well recognised complication of leukaemia in children, but acute and chronic leukaemia may also cause arthritis in adults. Leukaemic arthritis may occur at any time during the course of leukaemia and may be the presenti...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.885.425

    authors: Usalan C,Ozarslan E,Zengin N,Büyükaýk Y,Güllü YH

    更新日期:1999-07-01 00:00:00

  • Severe thiazide-induced hyponatraemia during treatment with enalapril.

    abstract::A patient is described who developed mild hyponatraemia on two occasions when treated with bendrofluazide alone, but severe hyponatraemia when treated with the combination of enalapril and bendrofluazide. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.746.1105

    authors: Collier JG,Webb DJ

    更新日期:1987-12-01 00:00:00

  • Review on therapeutic targets for COVID-19: insights from cytokine storm.

    abstract:INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been caused the greatest pandemic of our century. Many of the deaths related to it are due to a systemic inflammatory response, which has been called 'cytokine storm'. OBJECTIVES:We developed a comprehensive review of the pathophysiology mec...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2020-138791

    authors: Mélo Silva Júnior ML,Souza LMA,Dutra REMC,Valente RGM,Melo TS

    更新日期:2020-10-02 00:00:00

  • Lornoxicam in clinical practice.

    abstract::Three studies reported here have confirmed that lornoxicam is effective in osteoarthritis and the ideal dose appears to be 12 mg daily. Overall, lornoxicam appears to be a useful drug in the treatment of both osteo- and rheumatoid arthritis, from the data presently available. ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Berry H,Ollier S

    更新日期:1990-01-01 00:00:00

  • Global health training in US obstetrics and gynaecology residency programmes: perspectives of students, residents and programme directors.

    abstract:BACKGROUND:Benefits of exposure to global health training during medical education are well documented and residents' demand for this training is increasing. Despite this, it is offered by few US obstetrics and gynaecology (OBGYN) residency training programmes. OBJECTIVES:To evaluate interest, perceived importance, pr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-133144

    authors: Nathan LM,Banks EH,Conroy EM,McGinn AP,Ghartey JP,Wagner SA,Merkatz IR

    更新日期:2015-12-01 00:00:00

  • Coeliac disease and goitre.

    abstract::Two cases of coeliac disease associated with thyroid enlargement are presented. One had a large simple adenomatous goitre which was removed surgically and the other had histological confirmation of lymphadenoma (Hashimoto's disease). ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.616.95

    authors: Robinson TJ

    更新日期:1977-02-01 00:00:00

  • Cefaclor compared with amoxycillin acute otitis media with effusion: a preliminary report.

    abstract::A double-blind, randomized clinical trial comparing cefaclor with amoxycillin in the treatment of acute otitis media with effusion (OME) in infants and children is being conducted at Children's Hospital of Pittsburgh. Although the randomization code has not yet been broken, the results of treating the first 55 childre...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Bluestone CD,Beery QC,Michaels RH,Zanotti ML,Stool SE,Grundfast KM,Wright CM,Mandel EM

    更新日期:1979-01-01 00:00:00

  • Destructive bone lesions in primary amyloidosis.

    abstract::We describe a patient with primary amyloidosis in whom multiple osteolytic lesions caused by amyloid bone tumours developed, and review the clinical features of the 18 cases with primary amyloidosis in whom destructive bone lesions have been reported. In contrast to amyloidosis associated with multiple myeloma, destru...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.733.1037

    authors: Kramer MR,van Dijk JM,Hadas I,Hershko C

    更新日期:1986-11-01 00:00:00

  • Sudden cardiac death among competitive adult athletes: a review.

    abstract::Sudden cardiac death is the leading cause of mortality among young athletes with an incidence of 1-2 per 100,000 athletes per annum. It is described as 'an event that is non-traumatic, non-violent, unexpected, and resulting from sudden cardiac arrest within six hours of previously witnessed normal health'. Most predis...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2011-130215

    authors: Pugh A,Bourke JP,Kunadian V

    更新日期:2012-07-01 00:00:00

  • Pattern of renal amyloidosis in Indian patients.

    abstract::Two hundred and thirty-three patients with renal amyloidosis were studied in an attempt to identify the incidence and pattern of the disease in northern India. The incidence of amyloidosis was 1.01% of 6431 post-mortems and 8.4% of 1980 renal biopsies from patients who presented with clinical evidence of glomerular di...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.57.663.31

    authors: Chugh KS,Datta BN,Singhal PC,Jain SK,Sakhuja V,Dash SC

    更新日期:1981-01-01 00:00:00

  • Age at obesity and association with subsequent dementia: record linkage study.

    abstract:OBJECTIVE:Obesity in mid-life may increase the risk of subsequent dementia. Our objective was to study this risk, focusing on differences by age at the time of recording of obesity, in a large defined population. METHODS:A record linkage cohort study was undertaken using national administrative statistical data on hos...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-132571

    authors: Wotton CJ,Goldacre MJ

    更新日期:2014-10-01 00:00:00

  • Gentamicin-resistant enterococci and endocarditis.

    abstract::We report a case of endocarditis associated with a highly gentamicin-resistant enterococcus that failed to respond to conventional antibiotic combination therapy. Clinical resolution was achieved following cardiac surgery and antimicrobial treatment dictated by in vitro testing of the patient's organism. Laboratories ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.764.390

    authors: Holliman R,Smyth E

    更新日期:1989-06-01 00:00:00

  • Evolving role of cardiac CT in the diagnosis of coronary artery disease.

    abstract::Non-invasive assessment of coronary artery patency has been attempted with different imaging modalities over the last few decades. The continuous motion of the heart, the respiratory movement, together with the small and tortuous nature of the coronary arteries, made this a technically challenging task. Over the last ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2009.093815

    authors: Yerramasu A,Venuraju S,Lahiri A

    更新日期:2011-03-01 00:00:00

  • Post-exposure prophylaxis for blood borne viral infections in healthcare workers.

    abstract::Healthcare workers have a high risk of occupational exposure, more so in developing countries, with high incidence of blood borne diseases and prevalence of unsafe practices. Among the various blood borne diseases, the most common and important ones are HIV infection, hepatitis B, and hepatitis C. Most of the occupati...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.79.932.324

    authors: Varghese GM,Abraham OC,Mathai D

    更新日期:2003-06-01 00:00:00

  • Barriers to physical activity in patients with diabetes.

    abstract:PURPOSE:Two questions were addressed: (1) How much physical activity do patients with diabetes perform? (2) What are the perceived factors that prevent patients from doing more physical activity? RESEARCH DESIGN AND METHODS:Interview based questionnaires were distributed to consecutive patients attending the Diabetes ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2003.010553

    authors: Thomas N,Alder E,Leese GP

    更新日期:2004-05-01 00:00:00

  • Occult small bowel adenocarcinoma complicating Crohn's disease: a report of three cases.

    abstract::Three patients with Crohn's disease are described who were treated by ileal resection for intestinal obstruction. Histological examination of the resected specimen in each case established the diagnosis of adenocarcinoma of the small intestine complicating Crohn's disease. This diagnosis should be considered in patien...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.833.172

    authors: Gillen CD,Wilson CA,Walmsley RS,Sanders DS,O'Dwyer ST,Allan RN

    更新日期:1995-03-01 00:00:00

  • Pitfalls in the interpretation of common biochemical tests.

    abstract::This review considers some of the more common problems in the interpretation of the results of biochemical tests and, where possible, highlights ways in which errors can be identified or avoided. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.76.893.129

    authors: Ayling RM

    更新日期:2000-03-01 00:00:00

  • Prevalence and characteristics in coding, classification and diagnosis of diabetes in primary care.

    abstract:INTRODUCTION:Approximately 366 million people worldwide live with diabetes and this figure is expected to rise. Among the correct diagnosis, there will be errors in the diagnosis, classification and coding, resulting in adverse health and financial implications. AIM:To determine the prevalence and characteristics of d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.1136/postgradmedj-2013-132068

    authors: Seidu S,Davies MJ,Mostafa S,de Lusignan S,Khunti K

    更新日期:2014-01-01 00:00:00

  • Missed Addisonian crisis in surgical wards.

    abstract::Three women were admitted to the surgical wards with acute gastro-intestinal symptoms and despite good clinical (pigmentation, hypotension) and biochemical (hyponatraemia, acidosis) evidence of Addisonian crisis had unnecessary investigations with delay in the diagnosis and appropriate management of this medical emerg...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.739.367

    authors: Small M,MacCuish AC,Thomson JA

    更新日期:1987-05-01 00:00:00

  • Putative site(s) and mechanism(s) of action of flupirtine, a novel analgesic compound.

    abstract::The mechanisms of the antinociceptive action of flupirtine, a novel non-opioid analgesic, were investigated in animals. It was found that this effect could be abolished by pre-treatment with reserpine. Furthermore, it could be dose-dependently antagonized by yohimbine and changes in the EEG of the rat observed after a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Szelenyi I,Nickel B

    更新日期:1987-01-01 00:00:00

  • Nonvalvular myocardial involvement in metastatic carcinoid disease.

    abstract::A patient with the unusual post mortem finding of myocardial metastatic carcinoid tumour without classical valvular or endocardial carcinoid disease is described. This rare occurrence may represent an aggressive type of carcinoid tumour, with metastatic disease occurring before the development of classical fibrous val...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.72.854.751

    authors: Davis G,Birbeck K,Roberts D,Naqvi N

    更新日期:1996-12-01 00:00:00

  • The carditis/cardiomyopathy of rheumatic fever: relationship to pathogenesis.

    abstract::Although the relationship between group A streptococcal upper respiratory tract infection and the development of acute rheumatic fever has been known for many years, the pathogenetic mechanism(s) have never been defined. Thus, the mechanism of damage to the valves and to the myocardium in patients with rheumatic fever...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Kaplan EL

    更新日期:1992-01-01 00:00:00

  • Heatstroke and rhabdomyolysis presenting as fulminant hepatic failure.

    abstract::Heatstroke following vigorous exercise is reported in a young male. Severe hepatic and renal failure resulted but the patient completely recovered following treatment by active measures to reduce his core temperature. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.748.157

    authors: Fidler S,Fagan E,Williams R,Dewhurst I,Cory CE

    更新日期:1988-02-01 00:00:00

  • Non-vitamin K antagonist oral anticoagulants (NOACs): clinical evidence and therapeutic considerations.

    abstract::Warfarin, a vitamin K antagonist, is the most widely used oral anticoagulant in the world. It is cheap and effective, but its use is limited in many patients by unpredictable levels of anticoagulation, which increases the risk of thromboembolic or haemorrhagic complications. It also requires regular blood monitoring a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2014-132605

    authors: Saraf K,Morris PD,Garg P,Sheridan P,Storey R

    更新日期:2014-09-01 00:00:00

  • Immunogenicity of a recombinant DNA hepatitis B vaccine in neonates.

    abstract::Infants of HBsAg-positive mothers (Group I) as well as those born to women without HBV markers (Group II) were vaccinated with a 10 micrograms dose of a recombinant DNA hepatitis B vaccine within 24 hours after birth according to a 0, 1, and 2 month schedule, with a booster dose planned 12 months later. Vaccination re...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Meheus A,Alisjahbana A,Vranckx R,Sukadi A,Usman A,Ngantung W,Sugita E,Safary A,André F,Reniers J

    更新日期:1987-01-01 00:00:00

  • The implementation of cardiac arrest treatment recommendations in English acute NHS trusts: a national survey.

    abstract:PURPOSE OF THE STUDY:There are approximately 35 000 in-hospital cardiac arrests in the UK each year. Successful resuscitation requires integration of the medical science, training and education of clinicians and implementation of best practice in the clinical setting. In 2015, the International Liaison Committee on Res...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2016-134732

    authors: Carberry J,Couper K,Yeung J

    更新日期:2017-11-01 00:00:00