Putative site(s) and mechanism(s) of action of flupirtine, a novel analgesic compound.

abstract：:Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour. We describe, and illustrate, a patient presenting with features related to cardiac tamponade and intracardiac obstruction. Transthoracic echocardiography initially showed a large mass wit...

journal_title：Postgraduate medical journal

authors： Dubrey S,Grocott-Mason R,Mittal T,Burke M

更新日期：2008-03-01 00:00:00

abstract：:High flow arteriogenic priapism is uncommon and usually occurs after trauma to the genitoperineal area. The onset of prolonged erection can be delayed and is often relatively pain free. Arteriography in this case illustrated the causative bilateral arteriocavernosal fistulae and pseudoaneurysms. Treatment consisted of...

journal_title：Postgraduate medical journal

authors： Gujral S,MacDonagh RP,Cavanagh PM

更新日期：2001-03-01 00:00:00

abstract：INTRODUCTION:Approximately 366 million people worldwide live with diabetes and this figure is expected to rise. Among the correct diagnosis, there will be errors in the diagnosis, classification and coding, resulting in adverse health and financial implications. AIM:To determine the prevalence and characteristics of d...

journal_title：Postgraduate medical journal

authors： Seidu S,Davies MJ,Mostafa S,de Lusignan S,Khunti K

更新日期：2014-01-01 00:00:00

abstract：:We describe the case of an acromegalic woman with primary infertility who was treated with clomiphene, and subsequently developed pituitary apoplexy. ...

journal_title：Postgraduate medical journal

authors： Walker AB,Eldridge PR,MacFarlane IA

更新日期：1996-03-01 00:00:00

abstract：:Three cases of severe and irreversible alopecia occurring in patients with common variable immunodeficiency are described. In all three cases, hair loss developed after the diagnosis of immune deficiency; one of the patients also had extensive vitiligo. A fourth patient had vitiligo in the absence of alopecia. No chan...

journal_title：Postgraduate medical journal

authors： Spickett G,Prentice AG,Wallington T,Webster AD,Chapel H

更新日期：1991-03-01 00:00:00

abstract：:Serum concentrations of LH, FSH, testosterone and prolactin were measured in patients with hypertension treated with propranolol (34 cases), methyldopa (13 cases), and methyldopa + propranolol (11 cases). The results were compared with those obtained in 18 controls (hospital out-patients). There were no differences in...

journal_title：Postgraduate medical journal

authors： Taylor RG,Crisp AJ,Hoffbrand BI,Maguire A,Jacobs HS

更新日期：1981-07-01 00:00:00

abstract：:It was considered that the first dose reaction occurring with prazosin may have been due either to hypotension or to a specific reduction in cerebral blood flow. The development of a quantitative non-invasion nuclear medicine technique for cerebral flow has now made it possible to investigate the effects of prazosin o...

journal_title：Postgraduate medical journal

authors： Rutland MD,Lee TY,Nimmon CC,Granowska M,Britton KE

更新日期：1980-12-01 00:00:00

abstract：:Four studies have been carried out on propofol in this department, one being part of a multicentre trial. The minimum induction dose in unpremedicated patients was found to be 2.5 mg/kg. Propofol has been shown to be an acceptable induction agent, although with an incidence of pain on injection which is much higher wh...

journal_title：Postgraduate medical journal

authors： Grounds RM,Morgan M,Lumley J

更新日期：1985-01-01 00:00:00

abstract：:We report the case of a young man with Fusobacterium necrophorum meningitis who developed bilateral carotid artery stenosis associated with thrombosis of the cavernous sinuses. Intraluminal clot was present in the region of the stenoses for which he was anticoagulated. The clinical presentation, problems with diagnosi...

journal_title：Postgraduate medical journal

authors： Jones TH,Bergvall V,Bradshaw JP

更新日期：1990-09-01 00:00:00

abstract：:A patient with severe pulmonary hypertension due to pulmonary arteriolar obliteration complicating a long standing CREST variant of systemic sclerosis showed improvement in cardiac output and exercise tolerance during treatment with captopril, which was discontinued because of persistent systemic hypotension. It is su...

journal_title：Postgraduate medical journal

authors： Prouse PJ,Lahiri A,Gumpel JM

更新日期：1984-10-01 00:00:00

abstract：:A young woman with a previous history of anorexia nervosa presented with severe finger clubbing. Urine samples intermittently contained significant amounts of aspartylglucosamine. Liver biopsy showed abnormal cytoplasmic inclusions in phagocytic cells. The patient was found to be abusing senna laxative. ...

journal_title：Postgraduate medical journal

authors： Malmquist J,Ericsson B,Hultén-Nosslin MB,Jeppsson JO,Ljungberg O

更新日期：1980-12-01 00:00:00

abstract：:A patient suffering from typhoid fever with severe pancytopenia is presented. Bone marrow examination revealed extensive haemophagocytosis which possibly contributed to the pancytopenia. ...

journal_title：Postgraduate medical journal

authors： Sood R,Roy S,Kaushik P

更新日期：1997-01-01 00:00:00

abstract：:In a cross-over study, 10 healthy adult volunteers received 1 g cefaclor and 1 g cephalexin orally 1 hour after a standard breakfast. Serum levels of cefaclor rose somewhat faster and were higher than those of cephalexin in the first 60 minutes. At the end of the second hour the serum concentration of cephalexin was 5...

journal_title：Postgraduate medical journal

authors： Simon C,Gatzemeier U

更新日期：1979-01-01 00:00:00

abstract：:There has been a dramatic change in the way that resuscitation decisions are made for older hospital inpatients in the UK. In less than 20 years many geriatric medicine wards have moved from an "opt-in" policy (where the default position is not to provide resuscitation) to a position where resuscitation is widely avai...

journal_title：Postgraduate medical journal

authors： Bowker L

更新日期：2009-11-01 00:00:00

abstract：AIM:To establish an updated clinical profile of adenocarcinoma of the lung. DESIGN:Retrospective review of clinical charts, chest radiography, and computed tomography of consecutive patients who attended Queen Mary Hospital in Hong Kong between June 1995 and December 1997. RESULTS:In the 115 patients studied, 13% wer...

journal_title：Postgraduate medical journal

authors： Lam B,Lam WK,Lam CL,Ooi GC,Ho JC,Wong MP,Tsang KW

更新日期：2001-11-01 00:00:00

abstract：:Metabolic acidosis and hyperlactataemia are important, independent findings in acute illness, and the combination of these abnormalities carries a grave prognosis. Despite this there is still controversy about the most appropriate therapy of lactic acidosis, and the relationship of commonly used acid base measurements...

journal_title：Postgraduate medical journal

authors： Nimmo GR,Grant IS,Mackenzie SJ

更新日期：1991-01-01 00:00:00

abstract：:Thirteen patients with mild primary hyperparathyroidism who were taking thiazide diuretics intermittently for periods of up to 18 months were followed up for a mean of 5.3 years. No significant difference was found in either plasma total calcium corrected for albumin or whole blood ionized calcium in these patients be...

journal_title：Postgraduate medical journal

authors： Farquhar CW,Spathis GS,Barron JL,Levin GE

更新日期：1990-09-01 00:00:00

abstract：:Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist. In both cases, spontaneous resolution occurred over several weeks following withdrawal of the drug. ...

journal_title：Postgraduate medical journal

authors： Sheehan-Dare RA,Goodfield MJ

更新日期：1988-06-01 00:00:00

abstract：:The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit...

journal_title：Postgraduate medical journal

authors： Kennedy PG

更新日期：1988-03-01 00:00:00

abstract：:A patient presented with tracking of pus from a chronic appendiceal abscess along the lateral cutaneous nerve of the thigh. In the absence of such a tunnel, which is only present in a small proportion of individuals, the infection would have resulted in a subinguinal psoas abscess. Although pus may conceivably extend ...

journal_title：Postgraduate medical journal

authors： Gatt D

更新日期：1985-11-01 00:00:00

abstract：:The differing aspects of fibrocystic disease are presented. The various histological components making up the breast account for the variegated presentation of symptoms and findings. Pain, tenderness and nodularity represent the greatest problem with the former two prompting the patient to seek relief. The latter symp...

journal_title：Postgraduate medical journal

authors： Humphrey LJ,Estes NC

更新日期：1979-01-01 00:00:00

abstract：:The role of prostaglandins in inflammation is still disputed. Some workers have attempted to fit prostaglandins into a simple model, i.e. inflammatory leads to chemical mediator leads to vascular response. Recent work has shown that this approach may be misleading. An alternative model is proposed, involving the inter...

journal_title：Postgraduate medical journal

authors： Williams TJ

更新日期：1977-11-01 00:00:00

abstract：:Acute bacterial meningitis is a common neurological emergency and a leading cause of death and neurological disability worldwide. Diagnosis is based on clinical and microbiological findings with neuroimaging in the form of CT reserved for those with specific adverse clinical features or when an underlying cause such a...

journal_title：Postgraduate medical journal

authors： Hughes DC,Raghavan A,Mordekar SR,Griffiths PD,Connolly DJ

更新日期：2010-08-01 00:00:00

abstract：:A 12-year-old boy presented with typical features of short incubation tetanus. Spastic paraparesis with a mid-thoracic sensory level was present from the time of the initial examination. X-rays of the spine and lumbar myelogram were normal. The paraparesis improved rapidly and within a month the patient was free of ne...

journal_title：Postgraduate medical journal

authors： Bahemuka M

更新日期：1981-07-01 00:00:00

abstract：:Tuberculous infection of the oesophagus is rare. This is confirmed by our present review of cases managed in our teaching hospitals over a period of 18 years which uncovered only 11 patients. The main presentation is that of dysphagia whose algorithm of investigation should seek to differentiate tuberculosis from carc...

journal_title：Postgraduate medical journal

authors： Mokoena T,Shama DM,Ngakane H,Bryer JV

更新日期：1992-02-01 00:00:00

abstract：:A patient with Laurence-Moon-Biedl syndrome and nephrotic range proteinuria is presented. Radiological investigation of the urinary tract revealed clubbed calyces but no evidence of obstruction or vesicoureteric reflux. Renal biopsy revealed occasional sclerotic glomeruli, extensive foot-process fusion and segmental g...

journal_title：Postgraduate medical journal

authors： Cheng IK,Chan KW,Chan MK,Kung A,Ma J,Wang C

更新日期：1988-08-01 00:00:00

abstract：:The use of self-expanding metal stents can markedly improve the care of patients with inoperable oesophageal malignancy. The stents can be easily introduced without the need for general anaesthesia. They have fewer complications during insertion than rigid stents and fewer complications than laser therapy. With these ...

journal_title：Postgraduate medical journal

authors： Murphy GJ

更新日期：1995-08-01 00:00:00

abstract：:Diuretics are used extensively in hospitals and in community medical practice for the management of cardiovascular diseases. They are used frequently as the first line treatment for mild to moderate hypertension and are an integral part of the management of symptomatic heart failure. Although diuretics have been used ...

journal_title：Postgraduate medical journal

authors： Shah SU,Anjum S,Littler WA

更新日期：2004-04-01 00:00:00

abstract：:Isolated left ventricular non-compaction is a rare, morphologically distinct primary genetic cardiomyopathy, which was first described in children, but is becoming increasingly recognised in adults. The most common clinical manifestations include heart failure, arrhythmias and embolic events, and in children it may be...

journal_title：Postgraduate medical journal

authors： Nair SB,Khattar RS

更新日期：2009-04-01 00:00:00

abstract：:Altogether 42 million people worldwide have been infected with HIV, and 12 million have died over the last 20 years. Effective antiretroviral therapy has lead to sustained HIV viral suppression and immunological recovery in patients who have been infected with the virus. The incidence of AIDS has declined in the Weste...

journal_title：Postgraduate medical journal

authors： Thaker HK,Snow MH

更新日期：2003-01-01 00:00:00