Measurement of the effects of a single dose of prazosin on the cerebral blood flow in hypertensive patients.

Abstract:

:It was considered that the first dose reaction occurring with prazosin may have been due either to hypotension or to a specific reduction in cerebral blood flow. The development of a quantitative non-invasion nuclear medicine technique for cerebral flow has now made it possible to investigate the effects of prazosin on cerebral blood flow in hypertensive patients. This double-blind study showed a significant decrease in BP and a small just significant increase in cerebral blood flow following a single 1-mg dose of prazosin, when compared with a placebo. From these results, it is unlikely that the first dose reactions which occurred with prazosin were due to a specific reduction in cerebral blood flow.

journal_name

Postgrad Med J

authors

Rutland MD,Lee TY,Nimmon CC,Granowska M,Britton KE

doi

10.1136/pgmj.56.662.818

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

818-22

issue

662

eissn

0032-5473

issn

1469-0756

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验
  • Four years of experience of telemedicine for paediatric care in three Punjab hospitals, North India: achievements and lessons.

    abstract::Children in India constitute a very high risk group from mortality and morbidity due to lack of specialised healthcare. Remote care of paediatric patients by offsite specialists using telemedicine technology is a highly potential solution for coping up with the shortage of specialists in Indian subcontinent. We at a t...

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    pub_type: 杂志文章

    doi:10.1136/pgmj.2009.082735

    authors: Singh M,Das RR

    更新日期:2010-12-01 00:00:00

  • Cyclical release of vasoactive intestinal polypeptide (VIP) from a pancreatic islet cell apudoma.

    abstract::A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP). Diagnosis was confirmed by plasma VIP as measured by a radio-immunoassay technique now available. It...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.634.566

    authors: Devine BL,Carmichael HA,Russell RI,Joffe SN

    更新日期:1978-08-01 00:00:00

  • Gastric outlet obstruction due to gall stones (Bouveret syndrome).

    abstract::Gastric outlet obstruction by gall stone is a rare complication of a common disorder. Two cases are reported here. The investigations are conducted along the same lines as for pyloric stenosis. The diagnosis can be made with a barium meal or gastroscopy. Treatment is by surgical intervention after adequate resuscitati...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.744.909

    authors: Ah-Chong K,Leong YP

    更新日期:1987-10-01 00:00:00

  • Verrucous carcinoma of the female breast.

    abstract::Verrucous carcinoma is a rare skin malignancy of squamous cell origin. It is characterised by negligible cellular atypia and a low mitotic rate. These are reflected in slow locally invasive behaviour and very infrequent metastatic spread. The tumour is also recognised in oral and anogenital sites. Cutaneous lesions pr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.889.674

    authors: Munro NA,Smith C,Purushotham AD

    更新日期:1999-11-01 00:00:00

  • Coeliac disease with mild mucosal abnormalities: a report of four patients.

    abstract::In a routine adult gastroenterological practice, seventeen (15%) of 123 patients had small-intestinal biopsies which were neither normal nor were completely flat as found in classical coeliac disease. Some of these had a possible cause for the mild mucosal abnormality, but in six there was no other apparent cause and ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.617.134

    authors: Scott BB,Losowsky MS

    更新日期:1977-03-01 00:00:00

  • Tamoxifen for retroperitoneal fibrosis.

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    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.73.864.653

    authors: Frankart L,Lorge F,Donckier J

    更新日期:1997-10-01 00:00:00

  • Syndrome of downward gaze paralysis, amnesia and hypersomnolence.

    abstract::A 60 year old woman with computed tomographic-verified bilateral thalamic infarction is described. She demonstrated downward gaze paralysis, amnesia and hypersomnolence. On the functional level such tasks as walking and eating were disconcerting. Although there have been only a few reports of the complete triad it may...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.769.840

    authors: Nagaratnam N,Ghougassian DF,Mugridge V

    更新日期:1989-11-01 00:00:00

  • How much can elderly patients tell us about their medications?

    abstract::Two hundred and sixty one patients attending a geriatric service were asked to give details of their usual medications without reference to drug bottles or written lists. Recall was tested in 4 categories: name of drugs, drug dosage, frequency of administration, and reason for the drug being prescribed. Drug recall wa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.772.116

    authors: al Mahdy H,Seymour DG

    更新日期:1990-02-01 00:00:00

  • Profiles of calcium antagonists in cardiovascular disease with special reference to second-generation agents and amlodipine.

    abstract::The majority of second-generation calcium antagonists are dihydropyridines, some of which show vascular selectivity. Several new dihydropyridines have been developed with comparable pharmacodynamic properties to existing calcium antagonists in this class and greatly improved kinetic half-lives. Of these agents, amlodi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Opie LH

    更新日期:1991-01-01 00:00:00

  • Views of UK doctors in training on the timing of choosing a clinical specialty: quantitative and qualitative analysis of surveys 3 years after graduation.

    abstract:BACKGROUND:Workforce studies show a declining proportion of UK junior doctors proceeding directly to specialist training, with many taking career breaks. Doctors may be choosing to delay this important career decision. AIM:To assess doctors' views on the timing of choosing a clinical specialty. METHODS:Surveys of two...

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    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2017-135460

    authors: Lachish S,Goldacre MJ,Lambert TW

    更新日期:2018-11-01 00:00:00

  • Longitudinal study of Chinese patients with pernicious anaemia.

    abstract:BACKGROUND:The survival of whites who have been treated for pernicious anaemia (PA) is unaffected, apart from incurring a greater risk of gastric cancers. The long term outcome of PA in Chinese is unknown. METHODS:A hospital based prospective longitudinal study of Chinese PA patients was conducted. Patients with known...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2007.067421

    authors: Chan JC,Liu HS,Kho BC,Lau TK,Li VL,Chan FH,Leong IS,Pang HK,Lee CK,Liang YS

    更新日期:2008-12-01 00:00:00

  • Glomerulonephropathy of Laurence-Moon-Biedl syndrome.

    abstract::A patient with Laurence-Moon-Biedl syndrome and nephrotic range proteinuria is presented. Radiological investigation of the urinary tract revealed clubbed calyces but no evidence of obstruction or vesicoureteric reflux. Renal biopsy revealed occasional sclerotic glomeruli, extensive foot-process fusion and segmental g...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.754.621

    authors: Cheng IK,Chan KW,Chan MK,Kung A,Ma J,Wang C

    更新日期:1988-08-01 00:00:00

  • Imaging and management of greater trochanteric pain syndrome.

    abstract::Greater trochanteric pain syndrome (GTPS) is a commonly diagnosed regional pain syndrome with a wide spectrum of aetiologies, reflecting the anatomy of the structures outside the hip joint capsule. There are five muscle tendons that insert on to the greater trochanter and three bursae in the region of the greater troc...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2013-131828

    authors: Chowdhury R,Naaseri S,Lee J,Rajeswaran G

    更新日期:2014-10-01 00:00:00

  • Heatstroke and rhabdomyolysis presenting as fulminant hepatic failure.

    abstract::Heatstroke following vigorous exercise is reported in a young male. Severe hepatic and renal failure resulted but the patient completely recovered following treatment by active measures to reduce his core temperature. ...

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    pub_type: 杂志文章

    doi:10.1136/pgmj.64.748.157

    authors: Fidler S,Fagan E,Williams R,Dewhurst I,Cory CE

    更新日期:1988-02-01 00:00:00

  • Advance directives and living wills.

    abstract::Under certain circumstances, living wills or advance directives may carry legal force in the UK. This paper traces the development of advance directives, clarifies their current legal position and discusses potential problems with their use. Case histories are used to illustrate some of the common dilemmas which docto...

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    pub_type: 杂志文章

    doi:10.1136/pgmj.74.869.151

    authors: Stewart K,Bowker L

    更新日期:1998-03-01 00:00:00

  • Pancreatic ketoacidosis: ketonemia associated with acute pancreatitis.

    abstract::Ketonaemia is well documented as a consequence of prolonged starvation, acute alcoholism, and uncontrolled diabetes mellitus. However, its occurrence in acute pancreatitis has not been described. In this report, three patients who manifested ketoacidosis at the time of presentation of acute pancreatitis are described....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.831.32

    authors: Kabadi UM

    更新日期:1995-01-01 00:00:00

  • Junior doctors' views on reporting concerns about patient safety: a qualitative study.

    abstract:BACKGROUND:Enabling healthcare staff to report concerns is critical for improving patient safety. Junior doctors are one of the groups least likely to engage in incident reporting. This matters both for the present and for the future, as many will eventually be in leadership positions. Little is known about junior doct...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-133045

    authors: Hooper P,Kocman D,Carr S,Tarrant C

    更新日期:2015-05-01 00:00:00

  • Cytomegalovirus infection in the neonate and its prevention.

    abstract::About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.53.624.588

    authors: Stern H

    更新日期:1977-10-01 00:00:00

  • Prevalence of frailty and reliability of established frailty instruments in adult elective colorectal surgical patients: a prospective cohort study.

    abstract:PURPOSE:Large population studies now demonstrate that frailty is prevalent in all adult age groups. Limited data exist on the association between frailty and surgical outcome in younger patients. The aim of the study was to explore the agreement between frailty identification tools and collect pilot data on their predi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2020-139417

    authors: Dale MacLaine T,Baker O,Burke D,Howell SJ

    更新日期:2021-01-12 00:00:00

  • Oral disopyramide after admission to hospital with suspected acute myocardial infarction. U. K. Rythmodan Multicentre Study Group.

    abstract::A multi-centre double-blind randomized study is reported in which the effect on mortality of oral disopyramide (300 mg loading dose, then 100 mg qds) was compared with placebo in 1985 patients entering hospital with suspected acute myocardial infarction. Treatment was commenced with 24 hr of onset of symptoms (mean ti...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/pgmj.60.700.98

    authors:

    更新日期:1984-02-01 00:00:00

  • Caring for "incurables": the 150th anniversary of the Royal Hospital for Neuro-Disability, Putney.

    abstract::The Royal Hospital for Incurables (RHI), now known as the Royal Hospital for Neuro-Disability and situated on West Hill, Putney, was founded by Andrew Reed DD exactly 150 years ago. The RHI was thus the pioneer in modern times of long stay institutions for the sick and dying. It became one of the great Victorian chari...

    journal_title:Postgraduate medical journal

    pub_type: 历史文章,杂志文章

    doi:10.1136/pgmj.2003.017673

    authors: Cook GC

    更新日期:2004-07-01 00:00:00

  • The CREST syndrome--successful reduction of pulmonary hypertension by captopril.

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    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.60.708.672

    authors: Prouse PJ,Lahiri A,Gumpel JM

    更新日期:1984-10-01 00:00:00

  • Circadian rhythms in cardiovascular function.

    abstract::This short overview discusses circadian rhythms observed in cardiovascular events such as myocardial ischaemia and myocardial infarction, which occur most frequently in the morning. Changes in the frequency of occurrence seem to be related to, and may result from, circadian rhythms in factors such as heart rate, blood...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Fox KM,Mulcahy DA

    更新日期:1991-01-01 00:00:00

  • The use of erythropoietin in renal failure.

    abstract::The treatment of renal anaemia by recombinant human erythropoietin (EPO) is now well established. Several studies have examined the pharmacokinetics and efficacy of the drug given intravenously, intraperitoneally and subcutaneously and there is increasing evidence that the subcutaneous route has several advantages inc...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.67.783.9

    authors: Macdougall IC,Hutton RD,Coles GA,Williams JD

    更新日期:1991-01-01 00:00:00

  • Ovarian carcinoma presenting as pyrexia of unknown origin.

    abstract::A patient with a poorly differentiated clear cell adenocarcinoma of the ovary presenting as pyrexia of unknown origin is reported. Following resection of the tumour, her pyrexia resolved completely. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.712.177

    authors: Schofield PM,Kirsop BA,Reginald P,Harington M

    更新日期:1985-02-01 00:00:00

  • Republished: Improving hand hygiene in a paediatric hospital: a multimodal quality improvement approach.

    abstract:BACKGROUND:Effective hand hygiene has long been recognised as an important way to reduce the transmission of bacterial and viral pathogens in healthcare settings. However, many studies have shown that adherence to hand hygiene remains low, and improvement efforts have often not delivered sustainable results. The Childr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj-2011-000056rep

    authors: Jamal A,O'Grady G,Harnett E,Dalton D,Andresen D

    更新日期:2012-06-01 00:00:00

  • Holistic obstetrics: the origins of "natural childbirth" in Britain.

    abstract::The term "natural childbirth" denotes an approach to childbirth characterised by a bias towards physical and mental hygiene in the management of pregnancy and labour. It emerged in Britain in the interwar period, partly as a response to the growing interventionism of mainstream obstetrics. Its appeal since then has re...

    journal_title:Postgraduate medical journal

    pub_type: 历史文章,杂志文章

    doi:10.1136/pmj.79.929.168

    authors: Moscucci O

    更新日期:2003-03-01 00:00:00

  • Evaluation of vaginal antifungal formulations in vivo.

    abstract::Relatively simple and rapid procedures have been developed for evaluating the local efficacy of vaginal antifungal agents in vivo in a vaginal candidiasis model in ovariectomized rats. The results of this investigation indicate that the model and methods described are quite suitable for screening potential antifungal ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.55.647.648

    authors: McRipley RJ,Erhard PJ,Schwind RA,Whitney RR

    更新日期:1979-09-01 00:00:00

  • Colonoscopy in patients aged 80 years or older and its contribution to the evaluation of rectal bleeding.

    abstract::Colonoscopies performed in patients aged 80 years or older at the Sheba Medical Center were analysed according to the primary indication for the procedure: 101 colonoscopies were performed because of rectal bleeding of at least 2 months duration, and 335 for all other indications. Carcinoma of the large bowel was foun...

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    pub_type: 杂志文章

    doi:10.1136/pgmj.68.799.355

    authors: Bat L,Pines A,Shemesh E,Levo Y,Zeeli D,Scapa E,Rosenblum Y

    更新日期:1992-05-01 00:00:00

  • How, and when, can I restrain a patient?

    abstract::The need to restrain service users will vary according to the area of practice within which practitioners are employed. Many of the principles that relate to the issue of restraining service users are, however, applicable to all, or most, health and social care settings. While the emphasis should be on pre-emptive act...

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    pub_type: 杂志文章,评审

    doi:10.1136/pmj.2003.007302

    authors: Horsburgh D

    更新日期:2004-01-01 00:00:00