Evaluation of vaginal antifungal formulations in vivo.

abstract：:A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP). Diagnosis was confirmed by plasma VIP as measured by a radio-immunoassay technique now available. It...

journal_title：Postgraduate medical journal

authors： Devine BL,Carmichael HA,Russell RI,Joffe SN

更新日期：1978-08-01 00:00:00

abstract：:Two hundred and thirty-three patients with renal amyloidosis were studied in an attempt to identify the incidence and pattern of the disease in northern India. The incidence of amyloidosis was 1.01% of 6431 post-mortems and 8.4% of 1980 renal biopsies from patients who presented with clinical evidence of glomerular di...

journal_title：Postgraduate medical journal

authors： Chugh KS,Datta BN,Singhal PC,Jain SK,Sakhuja V,Dash SC

更新日期：1981-01-01 00:00:00

abstract：:Cystinuria is an autosomal recessive disorder in renal tubular and intestinal transport of dibasic amino acids, which results in increased urinary excretion of cystine, ornithine, lysine and arginine. It affects 1 in 20 000 people and is caused by a defect in the rBAT gene on chromosome 2. Development of urinary tract...

journal_title：Postgraduate medical journal

authors： Ahmed K,Dasgupta P,Khan MS

更新日期：2006-12-01 00:00:00

abstract：:Testis cancer is an increasing problem, especially in northern European male populations. However, survival has improved dramatically over one generation. Environmental factors may have a role in the aetiology with high oestrogen concentrations implicated. Testis cancer is subdivided between seminoma and non-seminoma....

journal_title：Postgraduate medical journal

authors： Khan O,Protheroe A

更新日期：2007-10-01 00:00:00

abstract：:Interstitial nephritis is an inflammatory process within the renal interstitium, and was one of the first observations made in the description of renal histopathology. Many different conditions are associated with an interstitial nephritis, and as a clinical diagnosis the term has little use unless causation is define...

journal_title：Postgraduate medical journal

authors： Dhillon S,Higgins RM

更新日期：1997-03-01 00:00:00

abstract：:Episodic muscular weakness, commonly associated with alterations of serum potassium, is the cardinal feature of periodic paralysis. The combination of transient hyperkalaemia and rigors occurring during febrile episodes of malaria is suggested as the underlying cause which precipitated the muscular paralysis. Three pa...

journal_title：Postgraduate medical journal

authors： Senanayake N,Wimalawansa SJ

更新日期：1981-05-01 00:00:00

abstract：:We report two patients with primary adenocarcinoma of the duodenum who underwent successful pancreatico-duodenectomy (modified Whipple operation). One patient died from an unrelated cause three years following surgery whilst the other remains well and clinically free of disease 3 years after resection. An aggressive s...

journal_title：Postgraduate medical journal

authors： Carragher A,Russell C

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Obesity has been declared a 21st century pandemic by WHO. Yet surveys reveal physicians-in-training are uncomfortable managing obesity. One major barrier is the lack of residency education on obesity management. This study incorporates an obesity-specific didactic curriculum into an internal medic...

journal_title：Postgraduate medical journal

authors： Acosta A,Azzalin A,Emmons CJ,Shuster JJ,Jay M,Lo MC

更新日期：2014-11-01 00:00:00

abstract：:Clinical, endocrinological and computed tomographic features of three patients with unusual manifestations or complications of craniofacial involvement of fibrous dysplasia are presented. One patient with polyostotic fibrous dysplasia presented in late pregnancy with acute onset of bilateral optic nerve compression an...

journal_title：Postgraduate medical journal

authors： Daly BD,Chow CC,Cockram CS

更新日期：1994-01-01 00:00:00

abstract：:Abnormalities in the serum concentrations of calcium, phosphate, parathyroid hormone and vitamin D develop with declining renal function, leading in turn to renal osteodystrophy. Observational data now suggest that these disturbances in bone and mineral metabolism play an important role in the development of vascular ...

journal_title：Postgraduate medical journal

authors： Connor A

更新日期：2009-05-01 00:00:00

abstract：:Learning curves graphically represent the relationship between learning effort and learning outcome. Learning curves are increasingly used in research, the design of randomised controlled trials, the assessment of competency, healthcare education and training programme design. In this review we have outlined the princ...

journal_title：Postgraduate medical journal

authors： Valsamis EM,Chouari T,O'Dowd-Booth C,Rogers B,Ricketts D

更新日期：2018-09-01 00:00:00

abstract：:Evidence is now accumulating on both clinical and experimental grounds that the retina is an a priori source of inflammatory activity. Reactive inflammation in the retina may produce many of the clinical signs previously ascribed to uveal inflammation. Autoimmune mechanisms are probably responsible for the majority of...

journal_title：Postgraduate medical journal

authors： Sanders MD,Graham EM

更新日期：1988-07-01 00:00:00

abstract：:104 consecutive patients with upper gastrointestinal bleeding admitted to a district general hospital over a period of 20 months were considered for laser photocoagulation. 58 patients were found to have peptic ulcers, of which 42 had stigmata of recent haemorrhage accessible to laser photocoagulation. 17 were treated...

journal_title：Postgraduate medical journal

authors： Homer AC,Powell S,Vicary FR

更新日期：1985-01-01 00:00:00

abstract：:Tourette's syndrome is a neuropsychiatric disorder characterised by motor and phonic tics. Although tics are common in children, only about 1% of those affected meet the criteria for Tourette's syndrome, and many are not disabled by it. Associated problems such as attention deficit hyperactivity disorder and obsessive...

journal_title：Postgraduate medical journal

authors： Rickards H

更新日期：2011-02-01 00:00:00

abstract：:A patient with an aggressive intrasinusoidal non-Hodgkins lymphoma, presenting with marked systemic disturbance but only a mildly raised alkaline phosphatase as a localising sign is described. All imaging studies of the liver were normal and the diagnosis was delayed until a percutaneous liver biopsy was performed. On...

journal_title：Postgraduate medical journal

authors： Camidge R,Ong E,Lucraft H

更新日期：2000-02-01 00:00:00

abstract：:A host/vector system suitable for large-scale production of HBsAg has been constructed and optimized in terms of the expression plasmid and yeast host strain in order to permit fermentation to very high cell densities. The final expression plasmid contains the coding sequence of the major HBsAg protein (P24) flanked b...

journal_title：Postgraduate medical journal

authors： Harford N,Cabezon T,Colau B,Delisse AM,Rutgers T,De Wilde M

更新日期：1987-01-01 00:00:00

abstract：:A total of 187 heart failure patients aged 65-92 years, with pretreatment serum creatinine levels below 200 mumol/l, were monitored for more than 12 months on angiotensin-converting enzyme (ACE) inhibitor therapy. Optimal ACE inhibitor dosage was found in 27% of patients, while a significant deterioration in renal fun...

journal_title：Postgraduate medical journal

authors： Jolobe OM

更新日期：1999-05-01 00:00:00

abstract：:The treatment of renal anaemia by recombinant human erythropoietin (EPO) is now well established. Several studies have examined the pharmacokinetics and efficacy of the drug given intravenously, intraperitoneally and subcutaneously and there is increasing evidence that the subcutaneous route has several advantages inc...

journal_title：Postgraduate medical journal

authors： Macdougall IC,Hutton RD,Coles GA,Williams JD

更新日期：1991-01-01 00:00:00

abstract：:Prostatic involvement is an unusual complication of Wegener's granulomatosis. We report two cases with this complication and emphasize the importance of recognizing this manifestation in diagnosis and management of the disease condition. ...

journal_title：Postgraduate medical journal

authors： Tung KT,Woolf A,Falzon M

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The grade cricket competition, also known as premier cricket, supplies players to the state and national teams in Australia. The players involved are generally high-performing amateur (subelite) club cricketers. However, to date, there is no study on the injury epidemiology of Australian grade cricket. AIM:...

journal_title：Postgraduate medical journal

authors： Soomro N,Redrup D,Evens C,Strasiotto LP,Singh S,Lyle D,Singh H,Ferdinands RED,Sanders R

更新日期：2018-08-01 00:00:00

abstract：CONTEXT:In Sweden, patient malpractice claims are handled administratively and compensated if an independent physician review confirms patient injury resulting from medical error. Full access to all malpractice claims and hospital discharge data for the country provided a unique opportunity to assess the validity of pa...

journal_title：Postgraduate medical journal

authors： Pukk-Härenstam K,Ask J,Brommels M,Thor J,Penaloza RV,Gaffney FA

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:Potentially inappropriate medication (PIM) prescribing is a global problem. Limited data are available on the prevalence of PIMs in elderly patients with chronic kidney disease (CKD). We examined the PIM prevalence in elderly patients with CKD, the most common drugs implicated and the levels of polypharmac...

journal_title：Postgraduate medical journal

authors： Jones SA,Bhandari S

更新日期：2013-05-01 00:00:00

abstract：:Osteoporosis is a very common disorder, which results in an increase in fracture risk. The annual cost attributable to hip, vertebral, and wrist fractures in England and Wales is pound 1.7 billion. Significant mortality and morbidity are associated with osteoporotic fractures. The method that is most widely used for t...

journal_title：Postgraduate medical journal

authors： Christodoulou C,Cooper C

更新日期：2003-03-01 00:00:00

abstract：:Most vertebral haemangiomas are asymptomatic. A case of spinal reconstruction for symptomatic extraosseous thoracic haemangioma using a titanium cage is reported. Radiographs of the T11 vertebra demonstrated characteristic vertical striations. Magnetic resonance imaging and computed tomography showed spinal cord compr...

journal_title：Postgraduate medical journal

authors： Ogura T,Mori M,Hayashida T,Osawa T,Hase H

更新日期：2002-09-01 00:00:00

abstract：:Rectal swabs obtained from 10 of 49 chronic-care geriatric patients were positive for Clostridium difficile, for a prevalence rate of 20.4%. Simultaneous sampling of 29 patients in an acute geriatric ward revealed four colonized patients, for a prevalence rate of 13.7%. A prospective study of C. difficile colonization...

journal_title：Postgraduate medical journal

authors： Rudensky B,Rosner S,Sonnenblick M,van Dijk Y,Shapira E,Isaacsohn M

更新日期：1993-01-01 00:00:00

abstract：:I report a case of a large liver abscess causing a severe debilitating condition in which the diagnosis was delayed by several weeks following two normal ultrasound scans at days 5 and 19 of the illness. Up to one in four cases of liver abscess can be missed on ultrasound. A high degree of clinical suspicion must be m...

journal_title：Postgraduate medical journal

authors： Bunney RG

更新日期：1988-05-01 00:00:00

abstract：:Warfarin, a vitamin K antagonist, is the most widely used oral anticoagulant in the world. It is cheap and effective, but its use is limited in many patients by unpredictable levels of anticoagulation, which increases the risk of thromboembolic or haemorrhagic complications. It also requires regular blood monitoring a...

journal_title：Postgraduate medical journal

authors： Saraf K,Morris PD,Garg P,Sheridan P,Storey R

更新日期：2014-09-01 00:00:00

abstract：:Overdosage with cardiac glycosides is well documented, but not usually fatal. A case is described in which cardiac arrest in asystole was associated with a serum digoxin level of 50-4 microgram/1, the highest concentration yet reported after oral administration. ...

journal_title：Postgraduate medical journal

authors： Nicholls DP

更新日期：1977-05-01 00:00:00

abstract：:Various tumours, in particular lymphomas, have been reported in association with azathioprine treatment, both after renal transplantation and in other conditions. A case is reported here of acute myeloid leukaemia associated with azathioprine therapy for rheumatoid arthritis, and this is now the third case reported in...

journal_title：Postgraduate medical journal

authors： Gilmore IT,Holden G,Rodan KS

更新日期：1977-03-01 00:00:00

abstract：:Amlodipine is a dihydropyridine calcium antagonist with a unique pharmacokinetic profile providing advantages over other therapies of its kind. It has been shown to possess high oral absorption, long elimination half-life, smooth onset of action and long duration of pharmacodynamic activity. These properties result in...

journal_title：Postgraduate medical journal

authors： Taylor SH

更新日期：1991-01-01 00:00:00