Cyclical release of vasoactive intestinal polypeptide (VIP) from a pancreatic islet cell apudoma.

Abstract:

:A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP). Diagnosis was confirmed by plasma VIP as measured by a radio-immunoassay technique now available. It is suggested that the cyclical nature of the symptoms in this case was due to cyclical release of VIP from the tumour in response to an unknown stimulus. Perfusion studies confirmed the excess secretory state of water, sodium and chloride in the small intestine. Symptoms were completely abolished by surgery and the progress is being monitored by means of serial plasma VIP estimations to detect any early recurrence of metastatic disease.

journal_name

Postgrad Med J

authors

Devine BL,Carmichael HA,Russell RI,Joffe SN

doi

10.1136/pgmj.54.634.566

subject

Has Abstract

pub_date

1978-08-01 00:00:00

pages

566-70

issue

634

eissn

0032-5473

issn

1469-0756

journal_volume

54

pub_type

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