Cytomegalovirus infection in the neonate and its prevention.

Abstract:

:About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produce neutralizing antibody in volunteers without significant side effects or detectable virus excretion. The problems of developing such a vaccine for use in man, namely, attenuation, antigenic differences among virus strains, reactivation of latent infection and oncogenicity, are briefly discussed.

journal_name

Postgrad Med J

authors

Stern H

doi

10.1136/pgmj.53.624.588

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

588-91

issue

624

eissn

0032-5473

issn

1469-0756

journal_volume

53

pub_type

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