Oedema and vasodilatation in inflammation: the relevance of prostaglandins.

Abstract:

:The role of prostaglandins in inflammation is still disputed. Some workers have attempted to fit prostaglandins into a simple model, i.e. inflammatory leads to chemical mediator leads to vascular response. Recent work has shown that this approach may be misleading. An alternative model is proposed, involving the interaction of two chemical agents, i.e. a vascular permeability-increasing mediator (such as histamine or bradykinin) and a vasodilator (prostaglandin) which potentiates the plasma exudation produced by the permeability-increasing mediator. The results obtained in testing this model support the further proposal that non-steroidal anti-inflammatory compounds suppress inflammatory swelling by inhibiting vasodilatation.

journal_name

Postgrad Med J

authors

Williams TJ

doi

10.1136/pgmj.53.625.660

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

660-2

issue

625

eissn

0032-5473

issn

1469-0756

journal_volume

53

pub_type

杂志文章
  • Mastication and acid secretion.

    abstract::The gastric acid response and the buffer capacity of the stomach were measured in 30 control subjects and 22 duodenal ulcer patients in response to a masticatory (solid) and a non-masticatory (homogenized) meal having the same chemical composition. The peak acid output values were equal after a masticatory and after a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.60.702.272

    authors: Dubey P,Nundy S

    更新日期:1984-04-01 00:00:00

  • Subarachnoid haemorrhage: difficulties in diagnosis and treatment.

    abstract::Aneurysmal subarachnoid haemorrhage is associated with a uniquely severe headache of acute onset. Classical cases are readily identified as such, although this is not always the case. Four cases who were admitted to a district general hospital within a 3-month period are presented, because they demonstrate a variety o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.74.878.743

    authors: Johnston SD,Robinson TJ

    更新日期:1998-12-01 00:00:00

  • Liver transplantation for hepatitis C virus related liver disease.

    abstract::Liver transplantation is a useful treatment for end stage liver disease of all aetiologies but recurrent disease presents an ongoing challenge, particularly for hepatitis C virus (HCV) where recurrence is almost universal. Immunosuppression is needed for all patients after transplantation and should be tailored to the...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2005.034082

    authors: Gee I,Alexander G

    更新日期:2005-12-01 00:00:00

  • Clinical and biochemical experiences with danazol in the treatment of endometriosis in cases with female infertility.

    abstract::Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. The rationale is well explained by Dmowski and Scommegna (1976). As endocrine treatment alone cannot control severe cases...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Mettler L,Semm K

    更新日期:1979-01-01 00:00:00

  • 'Epidemic neuromyasthenia' in Southwest Ireland.

    abstract::During the course of an obscure illness in a teenage girl it was eventually realized that the diagnosis was 'epidemic neuromyasthenia'. The illness which occurred between February and September 1976 was characterized by fatigue, pallor, headache, nuchal pain, alterations in mentation, dizziness, nausea and vomiting, p...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.637.731

    authors: Corridan JP

    更新日期:1978-11-01 00:00:00

  • Interstitial nephritis.

    abstract::Interstitial nephritis is an inflammatory process within the renal interstitium, and was one of the first observations made in the description of renal histopathology. Many different conditions are associated with an interstitial nephritis, and as a clinical diagnosis the term has little use unless causation is define...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.73.857.151

    authors: Dhillon S,Higgins RM

    更新日期:1997-03-01 00:00:00

  • Leuco-erythroblastosis following withdrawal from glucocorticoid therapy.

    abstract::Leuco-erythroblastosis has many known associations (Burkett, Cox and Fields, 1965; Weick, Hagedorn and Linman, 1974; Retief, 1964), but the only ones related to drug therapy are the well established response to haematinics (Burkett et al., 1965) and one possible case following anti-epileptic therapy (Retief, 1964). Th...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.621.391

    authors: Trenchard PM,Wells CE,Jarriwalla AG

    更新日期:1977-07-01 00:00:00

  • Clinicolaboratory profile of 33 Arabs with systemic lupus erythematosus.

    abstract::A clinical and laboratory survey of systemic lupus erythematosus was conducted in 33 Arab patients in the UAE. Arthropathy (91%) followed by renal involvement (54%) and haematological disorders (45.5%) were the major clinical manifestations. Discoid rash (3%) was the least common. Apart from headaches, other neuropsyc...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.72.853.677

    authors: al-Attia HM

    更新日期:1996-11-01 00:00:00

  • Treatment of airways obstruction.

    abstract::This review of the treatment of airways obstruction attempts to demonstrate that treatment needs to be guided by an understanding of pathophysiology and pathogenesis as well as a knowledge of the natural history of the diseases underlying airways obstruction and their causes. This enables effective health education an...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Clark TJ

    更新日期:1983-01-01 00:00:00

  • Effect of oral famotidine on 24-hour intragastric acidity.

    abstract::Twenty-four hour intragastric acidity was measured in nine volunteer subjects in a single-blind placebo-controlled cross-over study comparing the effects of famotidine with ranitidine. The volunteer subjects received famotidine (40 mg at night), famotidine (20 mg at night), ranitidine (300 mg at night) or placebo in a...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Santana IA,Lanzon-Miller S,Pounder RE

    更新日期:1986-01-01 00:00:00

  • Injury rate and patterns of Sydney grade cricketers: a prospective study of injuries in 408 cricketers.

    abstract:BACKGROUND:The grade cricket competition, also known as premier cricket, supplies players to the state and national teams in Australia. The players involved are generally high-performing amateur (subelite) club cricketers. However, to date, there is no study on the injury epidemiology of Australian grade cricket. AIM:...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135861

    authors: Soomro N,Redrup D,Evens C,Strasiotto LP,Singh S,Lyle D,Singh H,Ferdinands RED,Sanders R

    更新日期:2018-08-01 00:00:00

  • Maintenance pharmacological immunosuppressive strategies in renal transplantation.

    abstract::Current maintenance immunosuppressive regimens for transplantation are based on three classes of drugs: corticosteroids, immunophilin-binding agents (eg, cyclosporin and tacrolimus), and antimetabolites (eg, azathioprine and mycophenolate). Drugs from the various classes inhibit the immune system at different points a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.73.861.386

    authors: Vella JP,Sayegh MH

    更新日期:1997-07-01 00:00:00

  • Ileo-caecal tuberculosis in immigrants.

    abstract::Four cases of ileo-caecal tuberculosis in Asian immigrants were seen in a 6-month period at The London Hospital. Although rare in Caucasians, this condition is an important cause of gastrointestinal symptoms in this ethnic group. Definitive diagnosis can frequently be made only by histological examination and culture ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.632.410

    authors: Croker J,Record CO,Wright JT

    更新日期:1978-06-01 00:00:00

  • Mediastinal carcinoid tumour with unusual manifestations.

    abstract::A rare case of mediastinal carcinoid tumour with superior vena cava obstruction, and osteolytic as well as osteoblastic secondaries in the bones is described. The relevant literature is reviewed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.65.763.327

    authors: Aggarwal P,Sharma SK,Chattopadhyay TK,Mukhopadhyay AK

    更新日期:1989-05-01 00:00:00

  • Management of acute ventilatory failure.

    abstract::Acute ventilatory failure is a challenging yet increasingly common medical emergency reflecting the growing burden of respiratory disease. It is not a diagnosis in itself but the end result of a diversity of disease processes culminating in arterial hypoxaemia and hypercapnia. This review focuses on key management iss...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2005.043208

    authors: Chakrabarti B,Calverley PM

    更新日期:2006-07-01 00:00:00

  • Upper gastro-intestinal endoscopy and radiology in the elderly.

    abstract::The results of oesophago-gastro-duodenoscopy (OGD) and radiology in one hundred consecutive elderly patients were reviewed to assess the efficacy, safety and acceptability of endoscopy in this age group. False positive radiological features occurred in two of nine patients with normal endoscopic examinations. The rema...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.630.257

    authors: Stanley TV,Cocking JB

    更新日期:1978-04-01 00:00:00

  • Drug interaction with anti-mycobacterial treatment as a cause of clopidogrel resistance.

    abstract::The case is reported of a patient presenting with recurrent acute myocardial infarction due to stent thrombosis resulting from possible clopidogrel resistance caused by interaction between clopidogrel and anti-tuberculosis drugs. A brief overview of drug interaction as a risk factor for clopidogrel resistance is given...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2007.065193

    authors: Srinivasan M,Smith D

    更新日期:2008-04-01 00:00:00

  • Congenital central alveolar hypoventilation syndrome (Ondine's Curse): effectiveness of early home ventilation for normal development.

    abstract::An 8 month old Caucasian girl, with congenital central alveolar hypoventilation syndrome (Ondine's Curse), was discharged with her home ventilation managed by her parents. Her subsequent neurophysical development assessed at 22 months of age was satisfactory. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.787.471

    authors: Chang YL,Meerstadt PW

    更新日期:1991-05-01 00:00:00

  • Putative site(s) and mechanism(s) of action of flupirtine, a novel analgesic compound.

    abstract::The mechanisms of the antinociceptive action of flupirtine, a novel non-opioid analgesic, were investigated in animals. It was found that this effect could be abolished by pre-treatment with reserpine. Furthermore, it could be dose-dependently antagonized by yohimbine and changes in the EEG of the rat observed after a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Szelenyi I,Nickel B

    更新日期:1987-01-01 00:00:00

  • A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis.

    abstract::Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic rev...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/thx.2006.075754

    authors: Steingart KR,Henry M,Laal S,Hopewell PC,Ramsay A,Menzies D,Cunningham J,Weldingh K,Pai M

    更新日期:2007-11-01 00:00:00

  • Acute myeloblastic leukaemia associated with solitary plasmacytoma of the ilium.

    abstract::A 72 year old man developed acute myeloblastic leukaemia two years after he had been treated with local curative therapy and chemotherapy for a solitary plasma cytoma of the ilium. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.734.1131

    authors: Maharaj D,Dolan G

    更新日期:1986-12-01 00:00:00

  • Primary nongestational choriocarcinoma of the ovary.

    abstract::Primary choriocarcinoma of the ovary arising, presumably, from a germ cell is extremely rare. The patient, a 16 year old girl who presented with dysuria and frequency of micturition developed fatal haemoperitoneum due to rupture of a pure primary nongestational ovarian choriocarcinoma. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.718.757

    authors: Raju GC,Woo J,Marchack D,Naraynsingh V

    更新日期:1985-08-01 00:00:00

  • An unusually severe case of the cast syndrome.

    abstract::A severe case of the cast syndrome is described following Harrington rod distraction and application of a body cast. The case was unusual as it presented late with no warning symptoms and progressed rapidly to death. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.694.539

    authors: Kennedy RH,Cooper MJ

    更新日期:1983-08-01 00:00:00

  • Acute transverse myelopathy complicating tetanus.

    abstract::A 12-year-old boy presented with typical features of short incubation tetanus. Spastic paraparesis with a mid-thoracic sensory level was present from the time of the initial examination. X-rays of the spine and lumbar myelogram were normal. The paraparesis improved rapidly and within a month the patient was free of ne...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.57.669.443

    authors: Bahemuka M

    更新日期:1981-07-01 00:00:00

  • Four years of experience of telemedicine for paediatric care in three Punjab hospitals, North India: achievements and lessons.

    abstract::Children in India constitute a very high risk group from mortality and morbidity due to lack of specialised healthcare. Remote care of paediatric patients by offsite specialists using telemedicine technology is a highly potential solution for coping up with the shortage of specialists in Indian subcontinent. We at a t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2009.082735

    authors: Singh M,Das RR

    更新日期:2010-12-01 00:00:00

  • Continuous electrocardiographic recording (Holter method) during indapamide treatment: a study of 40 cases.

    abstract::In 40 hypertensive patients continuous ECG recording was done before and after 30 days treatment with indapamide 2.5 mg. There was no change in heart rate. In addition, the incidence of extrasystoles was not changed in patients in whom the ECG was normal before treatment (30 cases) or in 8 of the 10 patients who had a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Haiat R,Lellouch A,Lanfranchi J,Witchitz S

    更新日期:1981-01-01 00:00:00

  • Prognostic factors in Wegener's granulomatosis.

    abstract::We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1-11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multip...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.817.856

    authors: Briedigkeit L,Kettritz R,Göbel U,Natusch R

    更新日期:1993-11-01 00:00:00

  • Investigation of cereal toxicity in coeliac disease.

    abstract::Coeliac disease is exacerbated by wheat gluten. A review of methods for the purification, identification and quantitation of wheat proteins to investigate coeliac disease is presented. Recent developments including amino acid sequencing and expression of wheat protein peptides in E. coli should permit characterization...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.63.743.767

    authors: Ciclitira PJ,Ellis HJ

    更新日期:1987-09-01 00:00:00

  • Prevention of venous thromboembolism in Wales: results of a survey among general surgeons.

    abstract:OBJECTIVE:To examine the current attitudes towards the prevention of venous thromboembolism among a cohort of surgeons. DESIGN:A postal survey, comprising a questionnaire covering various aspects of venous thromboembolism prophylaxis was sent to all (n=84) consultant general surgeons in Wales. RESULTS:Replies were re...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.78.916.88

    authors: Williams EV,Williams RS,Hughes JL,Williams KL,Foster ME,Lewis MH

    更新日期:2002-02-01 00:00:00

  • Posterior leukoencephalopathy syndrome.

    abstract::Posterior leukoencephalopathy syndrome is a newly recognised brain disorder that predominantly affects the cerebral white matter. Oedematous lesions particularly involve the posterior parietal and occipital lobes, and may spread to basal ganglia, brain stem, and cerebellum. This rapidly evolving neurological condition...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.77.903.24

    authors: Garg RK

    更新日期:2001-01-01 00:00:00