Immunogenicity of a recombinant DNA hepatitis B vaccine in neonates.

Abstract:

:Infants of HBsAg-positive mothers (Group I) as well as those born to women without HBV markers (Group II) were vaccinated with a 10 micrograms dose of a recombinant DNA hepatitis B vaccine within 24 hours after birth according to a 0, 1, and 2 month schedule, with a booster dose planned 12 months later. Vaccination results in 14 (Group I) and 47 (Group II) neonates showed that at two months after the third dose of vaccine, 86% (6/7) and 100% (37/37), respectively, seroconverted, with anti-HBs geometric mean titres of 80 IU/l and 266 IU/l in the respective groups. No adverse reactions to the vaccine were observed. These preliminary results indicate that the recombinant DNA hepatitis B vaccine is safe and highly immunogenic in newborns.

journal_name

Postgrad Med J

authors

Meheus A,Alisjahbana A,Vranckx R,Sukadi A,Usman A,Ngantung W,Sugita E,Safary A,André F,Reniers J

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

139-41

eissn

0032-5473

issn

1469-0756

journal_volume

63 Suppl 2

pub_type

杂志文章
  • COVID-19 in patients with heart failure: the new and the old epidemic.

    abstract::Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread in nearly 200 countries in less than 4 months since its first identification; accordingly, the coronavirus disease 2019 (COVID 2019) has affirmed itself as a clinical challenge. The prevalence of pre-existing cardiovascular diseases in patients wi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2020-138080

    authors: Sisti N,Valente S,Mandoli GE,Santoro C,Sciaccaluga C,Franchi F,Cameli P,Mondillo S,Cameli M

    更新日期:2020-07-30 00:00:00

  • Fever, hepatosplenomegaly and pancytopenia in a patient living in the Mediterranean region.

    abstract::A 24 year old woman living in the Mediterranean region of Turkey present with a three-month history of weight loss and irregular fever that was peaking at 40 degrees C with shivering. No definite aetiology could be identified in a local hospital. A bacterial infection had been suspected, but antibiotic therapy, at fir...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.74.870.237

    authors: Büyükaşik Y,Ileri NS,Haznedaroğlu IC,Demiroğlu H,Dündar S

    更新日期:1998-04-01 00:00:00

  • The challenge of providing mentorship in primary care.

    abstract::In the changing National Health Service, there is an increasing awareness of stress related problems in the medical workforce. Mentorship has been shown to help with both stress reduction and adaptation to change. There are recognised difficulties with providing mentorship for doctors but there are ways in which these...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.054155

    authors: MacLeod S

    更新日期:2007-05-01 00:00:00

  • Acute pancreatitis and Cushing's syndrome.

    abstract::A case of acute necrotizing pancreatitis in a 53-year-old man with an ectopic adrenocorticotrophin (ACTH) producing bronchial carcinoma is described. The aetiology of acute pancreatitis in relation to steroid therapy and malignancy is discussed and it is suggested that excess endogenous steroid production may also cau...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.60.707.618

    authors: Clague HW,Warren B,Krasner N

    更新日期:1984-09-01 00:00:00

  • Cardiovascular complications of cirrhosis.

    abstract::Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction and electrophysiological abnormalities...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/gut.2006.112177

    authors: Møller S,Henriksen JH

    更新日期:2009-01-01 00:00:00

  • Chronic kidney disease presenting acutely: presentation, clinical features and outcome of patients with irreversible chronic kidney disease who require dialysis immediately.

    abstract:BACKGROUND:Patients with irreversible chronic kidney disease who require dialysis immediately are a subset of ultra late referrals for whom the term chronic kidney disease presenting acutely might usefully be applied. Although well known to nephrologists and recognised as a specific group with considerable problems, li...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2009.078956

    authors: Wolfe M,Almond A,Robertson S,Donaldson K,Isles C

    更新日期:2010-07-01 00:00:00

  • Cognitive impairment among patients with multiple sclerosis: associations with employment and quality of life.

    abstract:OBJECTIVES:To explore the relationship between cognitive impairment and conventional measures of disability in multiple sclerosis (MS), quality of life (QOL) and employment status using the brief international cognitive assessment for multiple sclerosis (BICAMS) in the routine outpatient clinic. METHODS:62 patients wi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2016-134071

    authors: Campbell J,Rashid W,Cercignani M,Langdon D

    更新日期:2017-03-01 00:00:00

  • The role of the media.

    abstract::There is an increasing awareness on the part both of the media and the profession of the need to co-operate in providing information and education on medical matters. This co-operation should be strongly encouraged. Where children are concerned the opportunities for education are great. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.629.225

    authors: Jolly H

    更新日期:1978-03-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection.

    abstract::The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.64.749.180

    authors: Kennedy PG

    更新日期:1988-03-01 00:00:00

  • A review of amlodipine in myocardial ischaemia.

    abstract::Amlodipine is a dihydropyridine calcium antagonist with a unique pharmacokinetic profile providing advantages over other therapies of its kind. It has been shown to possess high oral absorption, long elimination half-life, smooth onset of action and long duration of pharmacodynamic activity. These properties result in...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Taylor SH

    更新日期:1991-01-01 00:00:00

  • A comparative study of automated blood pressure recorders.

    abstract::Four automated blood pressure machines (Arteriosonde 1225, Bosomat 11D, Elag Koln BE 237R and Omron HEM 3) have been compared with each other and with the Hawksley Random Zero Sphygmomanometer in 18 subjects with a wide range of BP. Each form of measurement provided a high degree of internal consistency. The Arterioso...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/pgmj.56.662.815

    authors: Rubin P,McLean K,Reid J

    更新日期:1980-12-01 00:00:00

  • Transient ischaemic attacks related to carotid stenosis precipitated by straining, bending, and sneezing.

    abstract::Three patients are described in whom one or more carotid territory transient ischaemic attacks (TIAs) were preceded by sneezing, straining, or bending over. It is argued that the mechanism involved dislodgment of embolic material from the site of carotid atheroma. This mechanism should be considered as an alternative ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.881.145

    authors: Harrison MJ

    更新日期:1999-03-01 00:00:00

  • Jaundice following warfarin therapy.

    abstract::A case of intrahepatic cholestatic jaundice following warfarin therapy is described. The patient made a complete recovery on withdrawal on the drug. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.659.671

    authors: Jones DB,Makepeace MC,Smith PM

    更新日期:1980-09-01 00:00:00

  • The prevalence and nosocomial acquisition of Clostridium difficile in elderly hospitalized patients.

    abstract::Rectal swabs obtained from 10 of 49 chronic-care geriatric patients were positive for Clostridium difficile, for a prevalence rate of 20.4%. Simultaneous sampling of 29 patients in an acute geriatric ward revealed four colonized patients, for a prevalence rate of 13.7%. A prospective study of C. difficile colonization...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.807.45

    authors: Rudensky B,Rosner S,Sonnenblick M,van Dijk Y,Shapira E,Isaacsohn M

    更新日期:1993-01-01 00:00:00

  • Vertebral osteomyelitis due to Pseudomonas aeruginosa.

    abstract::A case of vertebral osteomyelitis due to Pseudomonas aeruginosa is described and the problems of diagnosis and treatment discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.620.347

    authors: Denham MJ,Goodwin CS

    更新日期:1977-06-01 00:00:00

  • Primary peritonitis in children and adults.

    abstract::Five cases of primary peritonitis are presented, with a sixth related case of pneumococcal peritonitis secondary to a ruptured ovarian cyst. The patients comprised 4 young girls who recovered, and 2 elderly females who died. Pneumococci were isolated in 3 patients; no organism was found in the other 3. One case of pri...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.687.21

    authors: Armitage TG,Williamson RC

    更新日期:1983-01-01 00:00:00

  • Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?

    abstract::Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and is recognised as a major public health burden. Large-scale epidemiological studies have demonstrated an independent relationship between OSAS and various cardiovascular disorders. The pathogenesis of cardiovascular complications in OSAS is not ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/thx.2008.105577

    authors: Ryan S,Taylor CT,McNicholas WT

    更新日期:2009-12-01 00:00:00

  • Bilateral carpal tunnel syndrome associated with interleukin 2 therapy.

    abstract::We report the development of synchronous bilateral carpal tunnel syndrome in a woman with metastatic colorectal cancer, undergoing treatment with recombinant interleukin 2. A carpal tunnel decompression was carried out on the hand which was more severely affected, with a gradual recovery in median nerve function. To t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.801.587

    authors: Heys SD,Mills KL,Eremin O

    更新日期:1992-07-01 00:00:00

  • Diagnosis and management of chronic persistent dry cough.

    abstract::Cough is one of the commonest symptoms of lung disease and is a frequent problem encountered in general practice as well as in hospital practice. A wide range of disease processes may present with cough and definitive treatment depends on making an accurate diagnosis of the cause. A diagnostic work-up for patients wit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.72.852.594

    authors: Chung KF,Lalloo UG

    更新日期:1996-10-01 00:00:00

  • Defining normal variables of right ventricular size and function in pulmonary hypertension: an echocardiographic study.

    abstract:BACKGROUND:Right ventricular (RV) fractional area change and tricuspid annular plane systolic excursion (TAPSE) are recognised methods for assessing RV function. However, the way in which these variables are affected by varying degrees of pulmonary hypertension (PH) has not been well characterised. METHODS:RV end-syst...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2007.059642

    authors: López-Candales A,Dohi K,Rajagopalan N,Edelman K,Gulyasy B,Bazaz R

    更新日期:2008-01-01 00:00:00

  • Early structured core training of junior trainees in ophthalmology.

    abstract::The implementation of modernizing medical careers (MMC) has resulted in some specialties being allocated very inexperienced trainees such as ophthalmology. We aim to describe the process of implementation of MMC and how it may affect the service provision in smaller specialities such as ophthalmology. A methodical app...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2007.064188

    authors: Patel N,Zia R,Dewitd D,Morris S,Ionides A

    更新日期:2007-12-01 00:00:00

  • Response to thyrotrophin-releasing hormone in atrial dysrhythmias.

    abstract::Seventy-eight clinically euthyroid patients with atrial dysrhythmias, either established or paroxysmal, and sixty-three patients in sinus rhythm with coronary disease were screened for hyperthyroidism using thyroid function tests including the thyroid-stimulating hormone (TSH) response to thyrotrophin-releasing hormon...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.636.658

    authors: Symons C,Myers A,Kingstone D,Boss M

    更新日期:1978-10-01 00:00:00

  • Presynaptic receptors and modulation of the release of noradrenaline, dopamine and GABA.

    abstract::A review of the role of presynaptic receptors in the modulation of neurotransmitter release indicates two types of presynaptic receptors. By means of presynaptic inhibitory autoreceptors a neurotransmitter can regulate its own release. In addition, presynaptic receptors are acted upon by other endogenous compounds, ei...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Langer SZ,Arbilla S

    更新日期:1981-01-01 00:00:00

  • Management of leg ulcers.

    abstract::Leg ulcer is a leading cause of morbidity among older subjects, especially women in the Western world. About 400 years BC, Hippocrates wrote, "In case of an ulcer, it is not expedient to stand, especially if the ulcer be situated on the leg". Hippocrates himself had a leg ulcer. The best treatment of any leg ulcer dep...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.76.901.674

    authors: Sarkar PK,Ballantyne S

    更新日期:2000-11-01 00:00:00

  • Periodic paralysis complicating malaria.

    abstract::Episodic muscular weakness, commonly associated with alterations of serum potassium, is the cardinal feature of periodic paralysis. The combination of transient hyperkalaemia and rigors occurring during febrile episodes of malaria is suggested as the underlying cause which precipitated the muscular paralysis. Three pa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.57.667.273

    authors: Senanayake N,Wimalawansa SJ

    更新日期:1981-05-01 00:00:00

  • In vitro fertilization of hamster eggs as a test system for drug effect on spermatozoa--lack of clomipramine effect.

    abstract::Clomipramine may affect reproduction in male rats and dogs, while other psychotropic drugs can affect sperm motility in vitro. This study investigates the motility of hamster sperm and the fertilization of hamster eggs in vitro with epididymal sperm from alpha-chlorohydrin-pretreated males, and after preincubation wit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Stein DM,Schnieden H

    更新日期:1980-01-01 00:00:00

  • Percutaneous endoscopic gastrostomy in elderly patients.

    abstract::Percutaneous endoscopic gastrostomy (PEG) was performed on 28 elderly patients (mean age 82 years) who were dysphagic and intolerant of naso-gastric feeding. Twenty-six patients were recovering from a stroke; the interval between the onset of stroke and PEG averaged 63 days. The procedure was successful and well toler...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.786.371

    authors: Finucane P,Aslan SM,Duncan D

    更新日期:1991-04-01 00:00:00

  • Cimetidine in the management of the Zollinger-Ellison syndrome.

    abstract::The first case of the Zollinger-Ellison syndrome treated from the outset continuously for more than a year with the histamine H2-receptor antagonist cimetidine is reported. Symptomatic response has been dramatic and sustained, marked endoscopic improvement has been observed with healing of oesophageal, gastric and sto...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.626.749

    authors: Larkworthy W,Davies HL

    更新日期:1977-12-01 00:00:00

  • Economic evaluation of gastric ulcer prophylaxis in patients with arthritis receiving non-steroidal anti-inflammatory drugs.

    abstract::This study assesses the economic benefits of misoprostol in the prophylaxis of gastric ulcers larger than 0.3 cm in patients with osteoarthritis receiving non-steroidal anti-inflammatory drugs. Independent epidemiological data were obtained for patients in Scotland and the West Midlands. Co-diagnosis of arthritis with...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章

    doi:10.1136/pgmj.66.778.639

    authors: Knill-Jones R,Drummond M,Kohli H,Davies L

    更新日期:1990-08-01 00:00:00

  • Learning curves in surgery: variables, analysis and applications.

    abstract::Learning curves graphically represent the relationship between learning effort and learning outcome. Learning curves are increasingly used in research, the design of randomised controlled trials, the assessment of competency, healthcare education and training programme design. In this review we have outlined the princ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2018-135880

    authors: Valsamis EM,Chouari T,O'Dowd-Booth C,Rogers B,Ricketts D

    更新日期:2018-09-01 00:00:00