In vitro fertilization of hamster eggs as a test system for drug effect on spermatozoa--lack of clomipramine effect.

abstract：:Hypersensitivity reactions to chemotherapy drugs pose significant difficulties in management, especially when no suitable alternative is available or acceptable and delay in continuation of treatment may be life-threatening. Such reactions may be IgE- or non-IgE-mediated and have varied manifestations. Timely recognit...

journal_title：Postgraduate medical journal

authors： Tham EH,Cheng YK,Tay MH,Alcasabas AP,Shek LP

更新日期：2015-03-01 00:00:00

abstract：:Twenty-four hour intragastric acidity was measured in nine volunteer subjects in a single-blind placebo-controlled cross-over study comparing the effects of famotidine with ranitidine. The volunteer subjects received famotidine (40 mg at night), famotidine (20 mg at night), ranitidine (300 mg at night) or placebo in a...

journal_title：Postgraduate medical journal

authors： Santana IA,Lanzon-Miller S,Pounder RE

更新日期：1986-01-01 00:00:00

abstract：:A case of acute oliguric renal failure following gentamicin and linocomycin therapy is described. Renal biopsy showed an acute interstitial nephritis. This was associated with high serum gentamicin levels and the later development of ototoxicity. Withdrawal of antibiotics and conservative measures was followed by rapi...

journal_title：Postgraduate medical journal

authors： Bell GM,Thomson D

更新日期：1980-06-01 00:00:00

abstract：:Common bile duct perforation causing biliary peritonitis is an unusual entity and a pancreatic calculus causing this perforation is all the more rare, and to our knowledge has not been reported previously. Such an unusual presentation of chronic calcific pancreatitis is herein reported. ...

journal_title：Postgraduate medical journal

authors： Kumar A,Kataria R,Chattopadhyay TK,Karak PK,Tandon RK

更新日期：1992-10-01 00:00:00

abstract：:Testis cancer is an increasing problem, especially in northern European male populations. However, survival has improved dramatically over one generation. Environmental factors may have a role in the aetiology with high oestrogen concentrations implicated. Testis cancer is subdivided between seminoma and non-seminoma....

journal_title：Postgraduate medical journal

authors： Khan O,Protheroe A

更新日期：2007-10-01 00:00:00

abstract：:The frequency and characteristics of chest pain and non-respiratory symptoms were investigated in patients admitted with acute asthma. One hundred patients with a mean admission peak flow rate of 38% normal or predicted were interviewed using a questionnaire. Chest pain occurred in 76% and was characteristically a dul...

journal_title：Postgraduate medical journal

authors： Edmondstone WM

更新日期：2000-07-01 00:00:00

abstract：:Fasting plasma and urinary calcium and urinary hydroxyproline are known to rise at the menopause, reflecting increased bone resorption. Oestradiol valerate and cyclic oestradiol valerate/DL-norgestrel are shown to reduce this evidence of increased bone loss. It is concluded that these preparations will be effective in...

journal_title：Postgraduate medical journal

authors： Crilly RG,Marshall DH,Nordin BE

更新日期：1978-01-01 00:00:00

abstract：:Although many of the fundamental biological features of toxoplasmosis are today well appreciated, the practical problem of prevention of its most serious consequence--disabling congenital disease, remains unsolved. The reasons vary in different communities, but are concerned with detection of the chief mode of spread,...

journal_title：Postgraduate medical journal

authors： Williams H

更新日期：1977-10-01 00:00:00

abstract：:The toxic effects of paracetamol in overdose quantities are well recognised but the occurrence of anaphylactoid reactions to paracetamol is infrequently identified by consumers and health care professionals. Nevertheless adverse reactions to this drug, even in therapeutic doses, can have fatal or near fatal consequenc...

journal_title：Postgraduate medical journal

authors： Ayonrinde OT,Saker BM

更新日期：2000-08-01 00:00:00

abstract：:A 61-year-old patient with treated Conn's syndrome due to multiple bilateral adrenocortical adenomata developed primary hyperparathyroidism. At operation, a parathyroid adenoma and a thyroid colloid nodule were found. Although adrenocortical adenomata and hyperplasia are common findings in multiple endocrine adenopath...

journal_title：Postgraduate medical journal

authors： Fertig A,Webley M,Lynn JA

更新日期：1980-01-01 00:00:00

abstract：:Verrucous carcinoma is a rare skin malignancy of squamous cell origin. It is characterised by negligible cellular atypia and a low mitotic rate. These are reflected in slow locally invasive behaviour and very infrequent metastatic spread. The tumour is also recognised in oral and anogenital sites. Cutaneous lesions pr...

journal_title：Postgraduate medical journal

authors： Munro NA,Smith C,Purushotham AD

更新日期：1999-11-01 00:00:00

abstract：:We describe the occurrence of primary hyperaldosteronism in two sisters. Although this is only the second published report of familial Conn's syndrome, it does have implications for the relatives of patients with Conn's syndrome and these are discussed. ...

journal_title：Postgraduate medical journal

authors： London N,Swales J,Hollinrake K,Bell P,Heagerty A

更新日期：1992-12-01 00:00:00

abstract：:As a tertiary referral centre of spinal surgery, the Royal National Orthopaedic Hospital (RNOH) handles hundreds of spinal cases a year, often with complex pathology and complex care needs. Despite this, issues were raised at the RNOH following lack of sufficient documentation of preoperative and postoperative clinica...

journal_title：Postgraduate medical journal

authors： Pace V,Farooqi O,Kennedy J,Park C,Cowan J

更新日期：2018-05-01 00:00:00

abstract：:Herpes simplex encephalitis may be underdiagnosed in Britain. We report eight patients treated at one hospital over three years. Fever, impaired consciousness or focal neurological signs were seen in all patients at presentation but herpes simplex encephalitis was rarely considered as the initial diagnosis. The electr...

journal_title：Postgraduate medical journal

authors： Gulliford MC,Chandrasekera CP,Cooper RA,Murphy RP

更新日期：1987-12-01 00:00:00

abstract：:Warfarin, a vitamin K antagonist, is the most widely used oral anticoagulant in the world. It is cheap and effective, but its use is limited in many patients by unpredictable levels of anticoagulation, which increases the risk of thromboembolic or haemorrhagic complications. It also requires regular blood monitoring a...

journal_title：Postgraduate medical journal

authors： Saraf K,Morris PD,Garg P,Sheridan P,Storey R

更新日期：2014-09-01 00:00:00

abstract：:A clinical and laboratory survey of systemic lupus erythematosus was conducted in 33 Arab patients in the UAE. Arthropathy (91%) followed by renal involvement (54%) and haematological disorders (45.5%) were the major clinical manifestations. Discoid rash (3%) was the least common. Apart from headaches, other neuropsyc...

journal_title：Postgraduate medical journal

authors： al-Attia HM

更新日期：1996-11-01 00:00:00

abstract：:Tuberculous infection of the oesophagus is rare. This is confirmed by our present review of cases managed in our teaching hospitals over a period of 18 years which uncovered only 11 patients. The main presentation is that of dysphagia whose algorithm of investigation should seek to differentiate tuberculosis from carc...

journal_title：Postgraduate medical journal

authors： Mokoena T,Shama DM,Ngakane H,Bryer JV

更新日期：1992-02-01 00:00:00

abstract：:Tuberculosis of the appendix is rare. It is usually secondary to tuberculosis elsewhere in the abdomen. Tuberculosis of the appendix is not associated with any specific clinical features and diagnosis is revealed only after histopathological examination. Appendicectomy should be performed in all patients with abdomina...

journal_title：Postgraduate medical journal

authors： Singh MK,Arunabh,Kapoor VK

更新日期：1987-10-01 00:00:00

abstract：:The most sensitive index of hepatic encephalopathy in 29 patients following a porta-caval shunt appeared to be the assessment of a close relative who had known the patient pre-operatively. They noticed that 19 of the 20 patients were mentally slower; 11 were markedly aggressive and 8 had become placid and uncaring abo...

journal_title：Postgraduate medical journal

authors： Gazzard BG,Price H,Dawson AM

更新日期：1986-03-01 00:00:00

abstract：PURPOSE OF THE STUDY:Iron deficiency anaemia (IDA) is associated with increased morbidity and mortality in heart failure patients. The aim of our audit was to evaluate the current practice in diagnosis and assessment of IDA in patients admitted with heart failure. STUDY DESIGN:We conducted a retrospective audit of pat...

journal_title：Postgraduate medical journal

authors： Simon S,Ioannou A,Deoraj S,Metaxa S,Mandal AKJ,Missouris CG

更新日期：2020-04-01 00:00:00

abstract：:We report a case of persistent chorea as a manifestation of thyrotoxicosis. The chorea was severe and persisted after the patient was rendered euthyroid. Dopamine antagonists only partially suppressed the involuntary movements during the first few months. It was eventually controlled with haloperidol, but whenever she...

journal_title：Postgraduate medical journal

authors： Javaid A,Hilton DD

更新日期：1988-10-01 00:00:00

abstract：INTRODUCTION:Potentially inappropriate medication (PIM) prescribing is a global problem. Limited data are available on the prevalence of PIMs in elderly patients with chronic kidney disease (CKD). We examined the PIM prevalence in elderly patients with CKD, the most common drugs implicated and the levels of polypharmac...

journal_title：Postgraduate medical journal

authors： Jones SA,Bhandari S

更新日期：2013-05-01 00:00:00

abstract：:In a cross-over study, 10 healthy adult volunteers received 1 g cefaclor and 1 g cephalexin orally 1 hour after a standard breakfast. Serum levels of cefaclor rose somewhat faster and were higher than those of cephalexin in the first 60 minutes. At the end of the second hour the serum concentration of cephalexin was 5...

journal_title：Postgraduate medical journal

authors： Simon C,Gatzemeier U

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:Two questions were addressed: (1) How much physical activity do patients with diabetes perform? (2) What are the perceived factors that prevent patients from doing more physical activity? RESEARCH DESIGN AND METHODS:Interview based questionnaires were distributed to consecutive patients attending the Diabetes ...

journal_title：Postgraduate medical journal

authors： Thomas N,Alder E,Leese GP

更新日期：2004-05-01 00:00:00

abstract：:Fifteen patients who had undergone a 14 inches X 4 inches jejuno-ileal bypass operation for obesity, 3 to 4 years earlier, were investigated by iliac bone biopsy, radiology and routine biochemistry, including 25-hydroxy-vitamin D and parathyroid hormone estimations. Two patients had histological osteomalacia which was...

journal_title：Postgraduate medical journal

authors： Gilmore IT,Eastwood JB,Ellis WR,Luck VA,Fenton S,O'Grady AJ,Harris E,Murray-Lyon IM

更新日期：1983-05-01 00:00:00

abstract：:Elective root replacement in Marfan syndrome has improved life expectancy in affected patients. Three forms of surgery are now available: total root replacement (TRR) with a valved conduit, valve sparing root replacement (VSRR) and personalised external aortic root support (PEARS) with a macroporous mesh sleeve. TRR c...

journal_title：Postgraduate medical journal

authors： Treasure T,Takkenberg JJ,Pepper J

更新日期：2016-02-01 00:00:00

abstract：:Two different doses of cefaclor advanced formulation (AF), a new sustained-release formulation of cefaclor, were compared with the regular formulation of cefaclor for efficacy and safety in the treatment of uncomplicated cystitis and asymptomatic bacteriuria. A 7-day course of treatment was used, and the trials were d...

journal_title：Postgraduate medical journal

authors： Hamilton-Miller JM,Iravani A,Brumfitt W,Byers KS,Dere WH

更新日期：1992-01-01 00:00:00

abstract：:The clinical syndrome of heart failure has been investigated so extensively that it may now almost be regarded as a metabolic disorder. Although an initial insult reduces cardiac pump efficacy, the resultant physiological response culminates in complex neurohormonal dysfunction. This has created confusion and prevente...

journal_title：Postgraduate medical journal

authors： Wright DJ,Tan LB

更新日期：1999-08-01 00:00:00

abstract：:Twelve healthy volunteers took part in a randomised, double-blind, balanced, cross-over study to investigate the effect of misoprostol on the pharmacokinetics of propranolol. The subjects took propranolol 80 mg twice daily by mouth plus either misoprostol 400 micrograms twice daily or placebo by mouth for 14.5 days, f...

journal_title：Postgraduate medical journal

authors： Bennett PN,Fenn GC,Notarianni LJ,Lee CE

更新日期：1991-05-01 00:00:00

abstract：:104 consecutive patients with upper gastrointestinal bleeding admitted to a district general hospital over a period of 20 months were considered for laser photocoagulation. 58 patients were found to have peptic ulcers, of which 42 had stigmata of recent haemorrhage accessible to laser photocoagulation. 17 were treated...

journal_title：Postgraduate medical journal

authors： Homer AC,Powell S,Vicary FR

更新日期：1985-01-01 00:00:00