Response to thyrotrophin-releasing hormone in atrial dysrhythmias.

Abstract:

:Seventy-eight clinically euthyroid patients with atrial dysrhythmias, either established or paroxysmal, and sixty-three patients in sinus rhythm with coronary disease were screened for hyperthyroidism using thyroid function tests including the thyroid-stimulating hormone (TSH) response to thyrotrophin-releasing hormone (TRH). All had normal levels of serum thyroxine (T4) apart from three with dysrhythmias who were found to have hyperthyroidism. Twenty per cent of patients with atrial dysrhythmias and 10% of those in sinus rhythm had exaggerated TSH response to TRH. Thirty-six per cent of patients with an exaggerated response of TSH to TRH had significant titres of thyroid auto-antibodies compared with 15% with positive antibodies in those with normal TSH response to TRH. Auto-immune thyroid disease may be more closely related to heart disease than has previously been recognized. Rapid atrial dysrhythmias may occur in the presence of a normal serum thyroxine, high levels of TSH and positive thyroid antibodies.

journal_name

Postgrad Med J

authors

Symons C,Myers A,Kingstone D,Boss M

doi

10.1136/pgmj.54.636.658

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

658-62

issue

636

eissn

0032-5473

issn

1469-0756

journal_volume

54

pub_type

杂志文章
  • Safety of low dose methotrexate in elderly patients with rheumatoid arthritis.

    abstract::Weekly low dose methotrexate is an established treatment for rheumatoid arthritis, but its use in elderly people has not been adequately examined. The aim of this study was to evaluate its safety in elderly patients with rheumatoid arthritis. A retrospective review of the clinical records of rheumatoid arthritis patie...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.76.902.787

    authors: Hirshberg B,Muszkat M,Schlesinger O,Rubinow A

    更新日期:2000-12-01 00:00:00

  • Birmingham Medical Research Expeditionary Society 1977 Expedition: effect of a Himalayan trek on whole body composition, nitrogen and potassium.

    abstract::The body composition of the 17 members of the BMRES was studied using body weight and fat fold calipers, with measurements of whole body potassium and nitrogen. The full assessment was made just before departure from Birmingham and immediately on return. Daily observations of body weight and fat folds were made during...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.55.645.475

    authors: Harvey TC,James HM,Chettle DR

    更新日期:1979-07-01 00:00:00

  • Current problems in the measurement of gastrin release. A reproducible measure of physiological gastrin release.

    abstract::The interpretation of gastrin release is confused because of variation in the technique of the radioimmuoassay of gastrin, the lack of a standard stimulus for the release of gastrin and diversity in the method used to express the results. These problems have been analysed (a) by examining the cross-reactivity of three...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.52.612.645

    authors: Russel RC,Bloom SR,Fielding LP,Bryant MG

    更新日期:1976-10-01 00:00:00

  • Community-acquired bacteraemic Acinetobacter pneumonia with survival.

    abstract::A 65 year old man was admitted with segmental consolidation of the left upper lobe after having stayed in a hotel for 2 days. He deteriorated rapidly on conventional antibiotic therapy and required ventilatory support. Acinetobacter calcoaceticus var. anitratus was grown from the sputum and blood cultures, which was t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.818.934

    authors: Achar KN,Johny M,Achar MN,Menon NK

    更新日期:1993-12-01 00:00:00

  • Elevated serum parathyroid hormone related protein and 1,25-dihydroxycholecalciferol in hypercalcaemia associated with adult T-cell leukaemia-lymphoma.

    abstract::Hypercalcaemia occurs in up to 80% of patients with adult T-cell leukaemia-lymphoma (ATLL) associated with human T-cell leukaemia virus-1 infection. Elevated serum levels of 1,25-dihydroxycholecalciferol, implicated in the pathogenesis of hypercalcaemia in lymphoma, and of parathyroid hormone-related protein (PTHrP), ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.803.753

    authors: Johnston SR,Hammond PJ

    更新日期:1992-09-01 00:00:00

  • Cognitive impairment among patients with multiple sclerosis: associations with employment and quality of life.

    abstract:OBJECTIVES:To explore the relationship between cognitive impairment and conventional measures of disability in multiple sclerosis (MS), quality of life (QOL) and employment status using the brief international cognitive assessment for multiple sclerosis (BICAMS) in the routine outpatient clinic. METHODS:62 patients wi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2016-134071

    authors: Campbell J,Rashid W,Cercignani M,Langdon D

    更新日期:2017-03-01 00:00:00

  • Evolution of hypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review of the literature.

    abstract::We studied two sisters who developed large non-toxic goitres in adolescence. Deiodinase deficiency was diagnosed by a rapid thyroid uptake of radioactive iodine (RAI) at 2 hours associated with a marked fall in thyroidal 131I by 24 hours. Serial RAI scans in the second patient documented evolution of the iodine-defici...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.728.477

    authors: Hirsch HJ,Shilo S,Spitz IM

    更新日期:1986-06-01 00:00:00

  • Abdominal epilepsy misdiagnosed as psychogenic pain.

    abstract::The authors present the case report of a child with abdominal epilepsy who had suffered from abdominal pain for several months under the label of psychogenic pain. The important historical clues were pallor and cold sweating during the paroxysm, followed by lethargy and prolonged sleep. An abnormal electroencephalogra...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.750.281

    authors: Singhi PD,Kaur S

    更新日期:1988-04-01 00:00:00

  • Angiotensin converting enzyme inhibitor induced hyperkalaemic paralysis.

    abstract::Secondary hyperkalaemic paralysis is a rare condition often mimicking the Guillain-Barré syndrome. There have been a few case reports of hyperkalaemia caused by renal failure, trauma, and drugs where the presentation has been with muscle weakness. A case of hyperkalaemic paralysis caused by an angiotensin converting e...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.77.904.114

    authors: Dutta D,Fischler M,McClung A

    更新日期:2001-02-01 00:00:00

  • Is Nd-Yag laser treatment for upper gastrointestinal bleeds of benefit in a district general hospital?

    abstract::104 consecutive patients with upper gastrointestinal bleeding admitted to a district general hospital over a period of 20 months were considered for laser photocoagulation. 58 patients were found to have peptic ulcers, of which 42 had stigmata of recent haemorrhage accessible to laser photocoagulation. 17 were treated...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/pgmj.61.711.19

    authors: Homer AC,Powell S,Vicary FR

    更新日期:1985-01-01 00:00:00

  • Toxic shock syndrome in Britain--epidemiology and microbiology.

    abstract::By 30 June 1984, only 99 confirmed and probable cases of toxic shock syndrome (TSS) had been reported in the British Isles. Sixty-three were related to menstruation in women aged 14 to 54 years who used tampons of various brands and absorbencies; 33 (52%) of these cases were in girls under 20. Five women died (8%) and...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: de Saxe MJ,Hawtin P,Wieneke AA

    更新日期:1985-01-01 00:00:00

  • Republished paper: Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events.

    abstract:OBJECTIVE:To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation. METHODS:Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2010.199026rep

    authors: Mackay DF,Irfan MO,Haw S,Pell JP

    更新日期:2011-04-01 00:00:00

  • Prognostic and predictive factors in colorectal cancer.

    abstract::Prognostication of newly diagnosed colorectal cancer (CRC) predominantly relies on stage as defined by the UICC-TNM and American Joint Committee on Cancer classifications. Tumour extent, lymph node status, tumour grade and the assessment of lymphatic and venous invasion are still the most important morphological progn...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2007.054858

    authors: Zlobec I,Lugli A

    更新日期:2008-08-01 00:00:00

  • Macrocytic anaemia due to copper deficiency in a patient with late onset hypogammaglobulinaemia.

    abstract::Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.737.205

    authors: Oppenheimer SM,Hoffbrand BI,Dormandy TL,Parker N,Wickens DG

    更新日期:1987-03-01 00:00:00

  • Drugs and ionic channels: mechanisms and implications.

    abstract::There is evidence that acetylcholine antagonists at the neuromuscular junction and elsewhere can act by blocking the ionic channels opened by acetylcholine as well as by competing with acetylcholine for receptor sites. This type of uncompetitive antagonism can be distinguished from competitive antagonism in various wa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Rang HP

    更新日期:1981-01-01 00:00:00

  • Antenatal appendicular perforation.

    abstract::Antenatal appendicular perforation leading to localized meconium peritonitis and intestinal obstruction is reported in a premature neonate. The baby was successfully treated by a limited ileocaecal resection. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.745.1001

    authors: Narasimharao KL,Mitra SK,Pathak IC

    更新日期:1987-11-01 00:00:00

  • In vitro efficacy of povidone-iodine solution and cream against methicillin-resistant Staphylococcus aureus.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has emerged worldwide as a significant and difficult-to-treat source of nosocomial infection, emphasizing the ever-present need for reliable and effective antisepsis. Betadine Solution (10% povidone-iodine; PVP-I) and Betadine Cream (5% povidone-iodine) are broad-spec...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Goldenheim PD

    更新日期:1993-01-01 00:00:00

  • The effect of oral digoxin on sodium excretion, renin-angiotensin-aldosterone system and blood pressure in normotensive subjects.

    abstract::The effect of digoxin (0.25 mg t.d.s.) given orally for 5 days, on sodium excretion, plasma renin activity, plasma aldosterone and blood pressure has been studied in 6 normotensive subjects, on a constant sodium intake. Average serum digoxin level measured in 5 subjects on the 5th day of treatment was in the upper ran...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.726.265

    authors: Cappuccio FP,Markandu ND,Sagnella GA,MacGregor GA

    更新日期:1986-04-01 00:00:00

  • Tamoxifen for retroperitoneal fibrosis.

    abstract::Retroperitoneal fibrosis, either idiopathic or associated with aortic inflammatory aneurysm, is a chronic fibrotic disease that causes progressive obstruction of ureters and vessels around the lower abdominal aorta. Treatment is often difficult (surgery) or hazardous (steroids). We report a case of a woman with retrop...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.73.864.653

    authors: Frankart L,Lorge F,Donckier J

    更新日期:1997-10-01 00:00:00

  • Primary central nervous malignant melanoma in the bathing trunk naevus syndrome.

    abstract::The gross and microscopic features of an unusual case of neurocutaneous melanosis are described. This is an example of the rare association between a primary central nervous system malignant melanoma and a giant congenital melanocytic naevus of 'bathing trunk' distribution. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.764.387

    authors: Salisbury JR,Rose PE

    更新日期:1989-06-01 00:00:00

  • Variable use of endoscopic haemostasis in the management of bleeding peptic ulcers.

    abstract:BACKGROUND:Randomised controlled trials (RCTs) have shown that endoscopic haemostasis is beneficial for patients with a bleeding peptic ulcer. The relevance of such data to management outside of RCTs is unclear. Therefore we examined management of patients with a bleeding peptic ulcer in a UK teaching hospital. METHOD...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.78.920.347

    authors: Mahadeva S,Linch M,Hull MA

    更新日期:2002-06-01 00:00:00

  • Comparative trials of cefaclor AF in uncomplicated cystitis and asymptomatic bacteriuria.

    abstract::Two different doses of cefaclor advanced formulation (AF), a new sustained-release formulation of cefaclor, were compared with the regular formulation of cefaclor for efficacy and safety in the treatment of uncomplicated cystitis and asymptomatic bacteriuria. A 7-day course of treatment was used, and the trials were d...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Hamilton-Miller JM,Iravani A,Brumfitt W,Byers KS,Dere WH

    更新日期:1992-01-01 00:00:00

  • Pitfalls in the interpretation of common biochemical tests.

    abstract::This review considers some of the more common problems in the interpretation of the results of biochemical tests and, where possible, highlights ways in which errors can be identified or avoided. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.76.893.129

    authors: Ayling RM

    更新日期:2000-03-01 00:00:00

  • Mammary tuberculosis: report on 52 cases.

    abstract::Fifty two cases of tuberculosis of the breast encountered over a 15 year period and accounting for 3% of all breast lesions are reported. The classic presentation was a breast lump with associated sinus in 39%, isolated breast lump in 23%, sinus without lump in 12%, and tender nodularity in 23% of the patients. Associ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.78.921.422

    authors: Khanna R,Prasanna GV,Gupta P,Kumar M,Khanna S,Khanna AK

    更新日期:2002-07-01 00:00:00

  • Use of diuretics in cardiovascular diseases: (1) heart failure.

    abstract::Diuretics are used extensively in hospitals and in community medical practice for the management of cardiovascular diseases. They are used frequently as the first line treatment for mild to moderate hypertension and are an integral part of the management of symptomatic heart failure. Although diuretics have been used ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2003.010835

    authors: Shah SU,Anjum S,Littler WA

    更新日期:2004-04-01 00:00:00

  • The clinical value of Haemoccult and Fecatwin in the detection of colorectal neoplasia in hospital and general practice patients.

    abstract::Four hundred and fifty asymptomatic general practice patients and 330 hospital inpatients had their stools tested for occult blood with the Haemoccult and Fecatwin methods. In general practice, 9/64 (14%) of patients with a positive result had a colonic neoplasm (three carcinomas, one Dukes' Stage A, two Dukes' Stage ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章

    doi:10.1136/pgmj.61.718.701

    authors: Barrison IG,Parkins RA

    更新日期:1985-08-01 00:00:00

  • Parent preferences for telephone coaching to prevent and manage childhood obesity.

    abstract:OBJECTIVE:To assess parent preferences for utilisation of a parent-focused, telephone-based coaching service, or 'FITLINE,' to prevent or manage childhood obesity. METHODS:A cross-sectional survey of parents of children aged 2-12 years was conducted at a paediatric practice in Greater Boston, Massachusetts, USA, betwe...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-132928

    authors: Blaine RE,Pbert L,Geller AC,Powers EM,Mitchell K

    更新日期:2015-04-01 00:00:00

  • Congenital and acquired conditions of the aortic root: multidetector computed tomography features.

    abstract::The aortic root links the left ventricle and ascending aorta and functions as a support structure for the aortic valve. It can be affected by a variety of congenital and acquired conditions, some of which are potentially life threatening. Echocardiography and cardiac magnetic resonance imaging are established non-inva...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2008.075531

    authors: Vargas HA,Hoey ET,Gopalan D,Agrawal SK,Screaton NJ,Gulati GS

    更新日期:2009-07-01 00:00:00

  • Acute pancreatitis and Cushing's syndrome.

    abstract::A case of acute necrotizing pancreatitis in a 53-year-old man with an ectopic adrenocorticotrophin (ACTH) producing bronchial carcinoma is described. The aetiology of acute pancreatitis in relation to steroid therapy and malignancy is discussed and it is suggested that excess endogenous steroid production may also cau...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.60.707.618

    authors: Clague HW,Warren B,Krasner N

    更新日期:1984-09-01 00:00:00

  • Thoracic disc herniation in acromegaly.

    abstract::Herniation of a thoracic disc in an acromegalic giant is reported. Degenerative changes in the spine in association with dorsal kyphosis, and the additional strain, resulted in the disc prolapse. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.765.491

    authors: Chhang WH,Sharma BS,Dash RJ,Kak VK

    更新日期:1989-07-01 00:00:00