Cognitive impairment among patients with multiple sclerosis: associations with employment and quality of life.

Abstract:

OBJECTIVES:To explore the relationship between cognitive impairment and conventional measures of disability in multiple sclerosis (MS), quality of life (QOL) and employment status using the brief international cognitive assessment for multiple sclerosis (BICAMS) in the routine outpatient clinic. METHODS:62 patients with MS were assessed on the BICAMS test battery for cognitive impairment. Data were obtained on employment status and a number of questionnaires completed including fatigue severity score, multiple sclerosis neuropsychological questionnaire, hospital anxiety and depression scale, the functional assessment of multiple sclerosis (FAMS) as well as on the EuroQOL five dimension questionnaire (EQ-5D). Other assessments include the patient activation measure and unidimensional self-efficacy scale for multiple sclerosis. RESULTS:Cognitive assessment revealed 44 subjects (65%) had evidence of cognitive impairment on formal testing. In comparison with patients without evidence of cognitive impairment, cognitively impaired patients exhibited significantly higher rates of unemployment (p=0.009). The symbol digits modalities test was the most significant predictor of unemployment. Cognitive impairment was associated with lower QOL scores on the FAMS (p=0.001) and EQ-5D (p<0.001). CONCLUSIONS:BICAMS provides a sensitive and easy to administer screening test for cognitive impairment within the outpatient setting. Cognitive impairment is common in our cohort of patients with MS attending outpatients and appears to be associated with increased rates of unemployment and lower measures of QOL.

journal_name

Postgrad Med J

authors

Campbell J,Rashid W,Cercignani M,Langdon D

doi

10.1136/postgradmedj-2016-134071

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

143-147

issue

1097

eissn

0032-5473

issn

1469-0756

pii

postgradmedj-2016-134071

journal_volume

93

pub_type

杂志文章
  • Drug interaction with anti-mycobacterial treatment as a cause of clopidogrel resistance.

    abstract::The case is reported of a patient presenting with recurrent acute myocardial infarction due to stent thrombosis resulting from possible clopidogrel resistance caused by interaction between clopidogrel and anti-tuberculosis drugs. A brief overview of drug interaction as a risk factor for clopidogrel resistance is given...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2007.065193

    authors: Srinivasan M,Smith D

    更新日期:2008-04-01 00:00:00

  • Uterine and ovarian leukaemic relapse during bone marrow remission in acute lymphoblastic leukaemia.

    abstract::A patient with acute lymphoblastic leukaemia who developed ovarian and uterine leukaemic relapse while in bone marrow remission is described. Pelvic relapse is rarely reported during the clinical course of leukaemia in females. Pelvic ultrasonography, a non-invasive procedure, was of value as an aid in detecting pelvi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.58.685.724

    authors: Cantwell B,Cantwell D,Fennelly JJ

    更新日期:1982-11-01 00:00:00

  • Stones in the common bile duct: experience with medical dissolution therapy.

    abstract::Thirty-one patients with radiolucent common bile duct stones received medical treatment. Nineteen had Rowachol, a terpene preparation, eight (42%) achieving complete stone disappearance within 3 to 48 months. Fifteen (including 3 of the above) took Rowachol with bile acid (chenodeoxycholic in 11, ursodeoxycholic in 4)...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.714.313

    authors: Somerville KW,Ellis WR,Whitten BH,Balfour TW,Bell GD

    更新日期:1985-04-01 00:00:00

  • Consultation activities of clinical ethics committees in the United Kingdom: an empirical study and wake-up call.

    abstract:OBJECTIVE:To identify the consultation activities of clinical ethics committees (CECs) in the UK and the views of CEC chairpersons regarding such activities. METHODS:An anonymous, password-protected online questionnaire was sent by e-mail to 70 CEC chairpersons. The questionnaire contained 14 items. RESULTS:Of the 70...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2008.075879

    authors: Whitehead JM,Sokol DK,Bowman D,Sedgwick P

    更新日期:2009-09-01 00:00:00

  • Global health training in US obstetrics and gynaecology residency programmes: perspectives of students, residents and programme directors.

    abstract:BACKGROUND:Benefits of exposure to global health training during medical education are well documented and residents' demand for this training is increasing. Despite this, it is offered by few US obstetrics and gynaecology (OBGYN) residency training programmes. OBJECTIVES:To evaluate interest, perceived importance, pr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-133144

    authors: Nathan LM,Banks EH,Conroy EM,McGinn AP,Ghartey JP,Wagner SA,Merkatz IR

    更新日期:2015-12-01 00:00:00

  • A double-blind crossover trial of domperidone in chronic postprandial dyspepsia.

    abstract::A doubld-blind crossover study of oral domperidone (10 mg t.d.s.) involving 48 patients suffering from chronic postprandial dyspepsia, showed a significant relief of symptoms on active treatment compared to placebo. The trial lasted eight weeks, the crossover in medication taking place at four weeks. Side effects were...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Englert W,Schlich D

    更新日期:1979-01-01 00:00:00

  • Near fatal puerperal fever due to Mycoplasma hominis.

    abstract::We describe a case of severe septicaemia caused by Mycoplasma hominis in a 23 year old patient following childbirth. She developed disseminated intravascular coagulation and acute respiratory distress syndrome which have not hitherto been described in association with septicaemia due to this organism. Investigation an...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.772.147

    authors: Young MJ,Cox RA

    更新日期:1990-02-01 00:00:00

  • Association of adiposity, measured by skinfold thickness, with parental history of diabetes in a South Indian population: data from CURES-114.

    abstract:PURPOSE OF THE STUDY:To look at the association of central and peripheral skinfold thickness with parental history of diabetes in subjects without diabetes. METHODS:Subjects with no parental history of diabetes (n=1132), subjects with one parent with diabetes (n=271) and subjects with both parents with diabetes (n=51)...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2015-133363

    authors: Surendar J,Indulekha K,Deepa M,Mohan V,Pradeepa R

    更新日期:2016-07-01 00:00:00

  • Placebo.

    abstract::Placebo, used here to mean an inert treatment given as if it was a real treatment, means lots of different things to different people. The structure of the article is that it begins by talking about the technical use of placebos in clinical trials, and the extent of the placebo response, then about the mechanism--"How...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2004.024737

    authors: McQuay HJ,Moore RA

    更新日期:2005-03-01 00:00:00

  • Leprosy presenting as unilateral foot drop in an immigrant boy.

    abstract::This is a case report of a boy who presented with unilateral foot drop approximately 1 year after traumatic injury from skateboarding. Exploratory surgical operation was eventually performed, and histological examination of the surgical specimen revealed leprous peripheral neuropathy of the peroneal nerve. The patient...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.70.820.111

    authors: Choe W

    更新日期:1994-02-01 00:00:00

  • Cardiac troponin: more than meets the eye.

    abstract::Exercise is known to have a vast array of health benefits. It may however confer delirious effects on most body systems, with the cardiovascular system taking particular prominence. Athletes in particular are known to be at a higher risk for sudden cardiac death as a result of several cardiac adaptations which take pl...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2017-134984

    authors: Abela M,Sammut L

    更新日期:2017-12-01 00:00:00

  • Sheehan's syndrome presenting with type III hyperlipoproteinaemia.

    abstract::A patient is described in whom the presenting feature of hypopituitarism was the development of palmar xanthomata associated with type III hyperlipoproteinaemia. Treatment of her secondary hypothyroidism with thyroxine caused resolution of the xanthomata and hyperlipidaemia, but the underlying compositional abnormalit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.746.1099

    authors: Carr D,Thornes HM,Rutter AC,Finney RD,Turner PR

    更新日期:1987-12-01 00:00:00

  • Brittle Addison's disease: a new variation on a familiar theme.

    abstract::Unstable and unpredictable disease control in diabetes or asthma, with frequent hospitalisations, is frequently referred to as 'brittle'. We describe two cases of Addison's disease with recurrent hospitalisations in hypo-adrenal crises. Both patients had significant psychosocial disruption, and failure to take hydroco...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.76.893.166

    authors: Gill GV,Williams G

    更新日期:2000-03-01 00:00:00

  • Hepatomegaly with bull's eye calcifications.

    abstract::A woman aged 35 years from the Philippines presented with epigastric discomfort associated with an epigastric mass. On examination the liver was markedly enlarged. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.762.233

    authors: Kreel L

    更新日期:1989-04-01 00:00:00

  • Plasma sex hormone concentrations in men with hypertension treated with methyldopa and/or propranolol.

    abstract::Serum concentrations of LH, FSH, testosterone and prolactin were measured in patients with hypertension treated with propranolol (34 cases), methyldopa (13 cases), and methyldopa + propranolol (11 cases). The results were compared with those obtained in 18 controls (hospital out-patients). There were no differences in...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.57.669.425

    authors: Taylor RG,Crisp AJ,Hoffbrand BI,Maguire A,Jacobs HS

    更新日期:1981-07-01 00:00:00

  • Gastric angiodysplasia--a missed cause of gastrointestinal bleeding.

    abstract::We report a case of severe chronic iron deficiency anaemia secondary to blood loss from gastric angiodysplasia. The clinical features, diagnosis and management of this uncommon condition are discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.744.865

    authors: Tung KT,Millar AB

    更新日期:1987-10-01 00:00:00

  • The management of postherpetic neuralgia.

    abstract::Postherpetic neuralgia is defined as pain persisting, or recurring, at the site of shingles at least three months after the onset of the acute rash. Thus defined, at least half of shingles sufferers over the age of 65 years develop postherpetic neuralgia. In addition to increasing age, less important risk factors for ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.73.864.623

    authors: Bowsher D

    更新日期:1997-10-01 00:00:00

  • Yersinia colitis associated with Crohn's disease.

    abstract::A previously healthy patient developed serologically-proven Yersinia pseudotuberculosis enterocolitis and made a complete recovery. Over a year later, further gastrointestinal symptoms developed and Crohn's disease was diagnosed. The possible relevance to the aetiology of Crohn's disease is discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.712.173

    authors: Treacher DF,Jewell DP

    更新日期:1985-02-01 00:00:00

  • Treatment of severe localized pulmonary interstitial emphysema by selective bronchial intubation.

    abstract::A pre-term infant being ventilated for respiratory distress syndrome developed severe localized pulmonary interstitial emphysema which was successfully treated by selective bronchial intubation. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.60.699.58

    authors: Oliver JE,Smith IJ

    更新日期:1984-01-01 00:00:00

  • Amniotic fluid embolism and disseminated intravascular coagulation complicating hypertonic saline-induced abortion.

    abstract::Amniotic fluid embolism (AFE) associated with disseminated intravascular clotting (DIC) is usually fatal. Such a combination generally occurs at the term of pregnancy or in the immediate postpartum period. A case of AFE with DIC following a hypertonic-saline-induced abortion, is reported. The patient was in the midtri...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.688.127

    authors: Ballas S,Lessing JB,Michowitz M

    更新日期:1983-02-01 00:00:00

  • High-dose intravenous gammaglobulin therapy for acquired von Willebrand disease.

    abstract::Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII/von Willebrand factor concentrates or with the administration of desmopressin. We report a case ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.70.830.916

    authors: Van Genderen PJ,Papatsonis DN,Michiels JJ,Wielenga JJ,Stibbe J,Huikeshoven FJ

    更新日期:1994-12-01 00:00:00

  • Coeliac disease with mild mucosal abnormalities: a report of four patients.

    abstract::In a routine adult gastroenterological practice, seventeen (15%) of 123 patients had small-intestinal biopsies which were neither normal nor were completely flat as found in classical coeliac disease. Some of these had a possible cause for the mild mucosal abnormality, but in six there was no other apparent cause and ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.617.134

    authors: Scott BB,Losowsky MS

    更新日期:1977-03-01 00:00:00

  • Magnetic resonance imaging in fetal medicine: a pictorial review of current and developing indications.

    abstract::Improvements in magnetic resonance (MR) imaging now permit diagnostic images of the fetus to be obtained. Ultrasound remains vital in all aspects of fetal imaging but MR provides a useful second line imaging test. Its value is best researched in fetal central nervous system disorders but it can be applied in other are...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2009.083543

    authors: Weston MJ

    更新日期:2010-01-01 00:00:00

  • Gentamicin-resistant enterococci and endocarditis.

    abstract::We report a case of endocarditis associated with a highly gentamicin-resistant enterococcus that failed to respond to conventional antibiotic combination therapy. Clinical resolution was achieved following cardiac surgery and antimicrobial treatment dictated by in vitro testing of the patient's organism. Laboratories ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.764.390

    authors: Holliman R,Smyth E

    更新日期:1989-06-01 00:00:00

  • Testis cancer.

    abstract::Testis cancer is an increasing problem, especially in northern European male populations. However, survival has improved dramatically over one generation. Environmental factors may have a role in the aetiology with high oestrogen concentrations implicated. Testis cancer is subdivided between seminoma and non-seminoma....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2007.057992

    authors: Khan O,Protheroe A

    更新日期:2007-10-01 00:00:00

  • Republished: developing capable quality improvement leaders.

    abstract:BACKGROUND/OBJECTIVE:Cincinnati Children's Hospital Medical Center created the Intermediate Improvement Science Series (I(2)S(2)) training course to develop organisational leaders to do improvement, lead improvement and get results on specific projects. DESIGN METHODS:Each multidisciplinary class consists of 25-30 par...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2012-000890rep

    authors: Kaminski GM,Britto MT,Schoettker PJ,Farber SL,Muething S,Kotagal UR

    更新日期:2013-02-01 00:00:00

  • Recurrent thrombo-embolic episodes: the association of cholangiocarcinoma with antiphospholipid syndrome.

    abstract::Antiphospholipid syndrome is a disorder of recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies. It was first described in a group of patients with systemic lupus erythematosus but has since been associated with a wide range of c...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.879.45

    authors: Samadian S,Estcourt L

    更新日期:1999-01-01 00:00:00

  • Cytomegalovirus infection in the neonate and its prevention.

    abstract::About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.53.624.588

    authors: Stern H

    更新日期:1977-10-01 00:00:00

  • Calcific constrictive pericarditis due to rheumatoid arthritis.

    abstract::A patient with calcific constrictive pericarditis due to rheumatoid arthritis is presented: the literature reveals only one previous case which was attributed to the long duration of the rheumatoid arthritis. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.771.57

    authors: Manji H,Raven P

    更新日期:1990-01-01 00:00:00

  • Heparin-associated skin necrosis.

    abstract::A case of skin necrosis at the sites of injection of subcutaneous heparin is described. The patient went on to develop heparin-induced thrombocytopenia and pulmonary embolism. Review of the previously described cases of heparin-associated skin necrosis reveals that this sequence of events is not uncommon. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.66.777.573

    authors: Fowlie J,Stanton PD,Anderson JR

    更新日期:1990-07-01 00:00:00