High-dose intravenous gammaglobulin therapy for acquired von Willebrand disease.

Abstract:

:Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII/von Willebrand factor concentrates or with the administration of desmopressin. We report a case of acquired von Willebrand disease with severe postoperative bleeding, responding poorly to classical von Willebrand factor replacement therapy but successfully treated with high-dose intravenous gammaglobulins. This new treatment mode of acquired von Willebrand disease is discussed in the light of a critical analysis of the literature.

journal_name

Postgrad Med J

authors

Van Genderen PJ,Papatsonis DN,Michiels JJ,Wielenga JJ,Stibbe J,Huikeshoven FJ

doi

10.1136/pgmj.70.830.916

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

916-20

issue

830

eissn

0032-5473

issn

1469-0756

journal_volume

70

pub_type

杂志文章,评审
  • National review of urology outpatient practice in the UK.

    abstract:OBJECTIVE:To audit the current UK outpatient workload and compare this to the national standards as set out by the British Association of Urological Surgeons (BAUS) in A Quality Urological Service for Patients in the New Millennium published in October 2000. PARTICIPANTS:520 UK (NHS) and 21 Republic of Ireland (non-NH...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.1136/pgmj.2004.020693

    authors: Gilmore PE,Shackley DC,Clarke NW,Betts CD,O'Flynn KJ

    更新日期:2005-01-01 00:00:00

  • Caverno-saphenous shunt in the treatment of priapism.

    abstract::The painful pathological condition of the penis, priapism, is usually associated with serious destructive changes which lead to impotence if treatment is with-held or delayed. Conservative therapy is slow, uncertain and usually ineffective. Early surgical decompression of the corpora cavernosa, repeated if necessary, ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.57.664.132

    authors: Ihekwaba FN,Lawani J

    更新日期:1981-02-01 00:00:00

  • Diagnosis and management of chronic persistent dry cough.

    abstract::Cough is one of the commonest symptoms of lung disease and is a frequent problem encountered in general practice as well as in hospital practice. A wide range of disease processes may present with cough and definitive treatment depends on making an accurate diagnosis of the cause. A diagnostic work-up for patients wit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.72.852.594

    authors: Chung KF,Lalloo UG

    更新日期:1996-10-01 00:00:00

  • Evaluation and management of hypersensitivity reactions to chemotherapy agents.

    abstract::Hypersensitivity reactions to chemotherapy drugs pose significant difficulties in management, especially when no suitable alternative is available or acceptable and delay in continuation of treatment may be life-threatening. Such reactions may be IgE- or non-IgE-mediated and have varied manifestations. Timely recognit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2014-132686

    authors: Tham EH,Cheng YK,Tay MH,Alcasabas AP,Shek LP

    更新日期:2015-03-01 00:00:00

  • Widespread cutaneous vasculitis associated with diltiazem.

    abstract::Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist. In both cases, spontaneous resolution occurred over several weeks following withdrawal of the drug. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.752.467

    authors: Sheehan-Dare RA,Goodfield MJ

    更新日期:1988-06-01 00:00:00

  • Pseudotumour cerebri in a patient with Castleman's disease.

    abstract::A patient with systemic Castleman's disease (angiofollicular lymph node hyperplasia) including bone changes and peripheral neuropathy, is described. She also had pseudotumour cerebri, and, as this association has been reported previously, it is unlikely to be due to chance. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.749.217

    authors: Black DA,Forgacs I,Davies DR,Thompson RP

    更新日期:1988-03-01 00:00:00

  • Psychosis in Parkinson's disease.

    abstract::Psychosis is common in Parkinson's disease (PD), particularly in its later stages. The symptoms range from comparatively minor illusions, vivid dreams, and occasional, non-disturbing visual hallucinations to frank psychosis. The pathogenesis of psychosis in PD is not fully known. Management of psychosis in PD requires...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2004.032029

    authors: Thanvi BR,Lo TC,Harsh DP

    更新日期:2005-10-01 00:00:00

  • Mortality in adult patients with fluid overload evaluated by BIVA upon admission to the emergency department.

    abstract:PURPOSE OF THE STUDY:The aim of this study was to investigate the association of fluid overload, measured by bioelectrical impedance vector analysis (BIVA) and also by accumulated fluid balance, with 30-day mortality rates in patients admitted to the emergency department (ED). DESIGN:We conducted a prospective observa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135695

    authors: Kammar-García A,Pérez-Morales Z,Castillo-Martinez L,Villanueva-Juárez JL,Bernal-Ceballos F,Rocha-González HI,Remolina-Schlig M,Hernández-Gilsoul T

    更新日期:2018-07-01 00:00:00

  • Postgraduate training in family medicine in Albania.

    abstract::In the Balkan context education in general practice varies greatly and it is in different stages of reorganisation and curriculum development. The postgraduate training in family medicine in Albania started in January 1997 with the goal of providing future family doctors with the proper knowledge, skills, attitudes, a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.78.919.308

    authors: Rrumbullaku L,Theodorakis PN,Pulluqi P,Lionis C,Trell E

    更新日期:2002-05-01 00:00:00

  • Vertebral osteomyelitis due to Pseudomonas aeruginosa.

    abstract::A case of vertebral osteomyelitis due to Pseudomonas aeruginosa is described and the problems of diagnosis and treatment discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.620.347

    authors: Denham MJ,Goodwin CS

    更新日期:1977-06-01 00:00:00

  • Post-typhoid anhidrosis: a clinical curiosity.

    abstract::A 19-year-old girl developed generalised anhidrosis following typhoid fever. Elaborate investigations disclosed nothing abnormal. A skin biopsy revealed the presence of atrophic as well as normal eccrine glands. This appears to be the third case of its kind in the English literature. It is postulated that typhoid feve...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.837.435

    authors: Raveenthiran V

    更新日期:1995-07-01 00:00:00

  • Response to thyrotrophin-releasing hormone in atrial dysrhythmias.

    abstract::Seventy-eight clinically euthyroid patients with atrial dysrhythmias, either established or paroxysmal, and sixty-three patients in sinus rhythm with coronary disease were screened for hyperthyroidism using thyroid function tests including the thyroid-stimulating hormone (TSH) response to thyrotrophin-releasing hormon...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.636.658

    authors: Symons C,Myers A,Kingstone D,Boss M

    更新日期:1978-10-01 00:00:00

  • Micronutrients in health and disease.

    abstract::Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2006.047670

    authors: Shenkin A

    更新日期:2006-09-01 00:00:00

  • The site of protein loss in Schönlein-Henoch purpura.

    abstract::Schönlein-Henoch purpura may be complicated by hypoproteinaemia, which in most patients is due to the development of nephrotic syndrome. However, in some proteinuria is insignificant and enteric protein loss has been suggested as the cause. A case with supportive evidence for this is reported. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.655.361

    authors: Waller DG,Dalziel KL

    更新日期:1980-05-01 00:00:00

  • Coeliac disease and goitre.

    abstract::Two cases of coeliac disease associated with thyroid enlargement are presented. One had a large simple adenomatous goitre which was removed surgically and the other had histological confirmation of lymphadenoma (Hashimoto's disease). ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.616.95

    authors: Robinson TJ

    更新日期:1977-02-01 00:00:00

  • Republished: Daily consultant gastroenterologist ward rounds: reduced length of stay and improved inpatient mortality.

    abstract:BACKGROUND:For gastroenterology, The Royal College of Physicians reiterates the common practice of two to three consultant ward rounds per week. The Royal Bolton Hospital NHS Foundation Trust operated a 26-bed gastroenterology ward, covered by two consultants at any one time. A traditional system of two ward rounds per...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2012-100033rep

    authors: Singh S,Lipscomb G,Padmakumar K,Ramamoorthy R,Ryan S,Bates V,Crompton S,Dermody E,Moriarty K

    更新日期:2012-10-01 00:00:00

  • Adenocarcinoma of the lung in Chinese patients: a revisit and some perspectives from the literature.

    abstract:AIM:To establish an updated clinical profile of adenocarcinoma of the lung. DESIGN:Retrospective review of clinical charts, chest radiography, and computed tomography of consecutive patients who attended Queen Mary Hospital in Hong Kong between June 1995 and December 1997. RESULTS:In the 115 patients studied, 13% wer...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.77.913.708

    authors: Lam B,Lam WK,Lam CL,Ooi GC,Ho JC,Wong MP,Tsang KW

    更新日期:2001-11-01 00:00:00

  • The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.

    abstract::The anti-hypertensive effect of 250 mg tienilic acid was comparable to that of 50 mg hydrochlorothiazide. Unlike hydrochlorothiazide, tienilic acid caused a statistically significant decrease in the serum uric acid values. Clinically non-significant rises in blood urea nitrogen and serum creatinine occurred with both ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: McMahon FG,Ryan JR,Jain AK

    更新日期:1979-01-01 00:00:00

  • Hypercalcaemia and multiple osteolytic lesions in childhood acute lymphoblastic leukaemia.

    abstract::A 12 year old boy presenting with hypercalcaemia (calcium 3.25 mmol/l) and osteopaenia with multiple osteolytic lesions was found to have acute lymphoblastic leukaemia without lymph-adenopathy or organomegaly. Hypercalcaemia is a rare feature of acute leukaemia, but the patients previously described all show very simi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.812.483

    authors: Soni PN

    更新日期:1993-06-01 00:00:00

  • Roth's spots: an unusual presentation of HIV.

    abstract::A 46 year old Nigerian man presented with a four week history of progressive bilateral visual loss. He had been unwell, with weight loss, fever, and night sweats for six months. Dilated fundoscopy revealed macular haemorrhages and diffuse Roth's spots. The patient was found to be severely anaemic and a bone marrow asp...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.79.928.108

    authors: Vose MJ,Charles SJ

    更新日期:2003-02-01 00:00:00

  • Surgical team: improving teamwork, a review.

    abstract::Teams within surgery have been through countless cycles of refinement with an ever-increasing list of surgical team members. This results in a more dispersed team, making effective teamwork harder to achieve. Furthermore, the ad hoc nature of surgical teams means that team familiarity is not always given. The impact o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2018-135943

    authors: Kumar H,Morad R,Sonsati M

    更新日期:2019-06-01 00:00:00

  • Mondor's disease associated with metastatic lung cancer in the breast.

    abstract::We report what we believe is the first recorded case of Mondor's disease associated with metastatic lung cancer presenting in the breast. An association between Mondor's disease and primary breast cancer has been described previously. In patients with Mondor's disease and primary breast cancer has been described previ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.768.779

    authors: Courtney SP,Polacarz S,Raftery AT

    更新日期:1989-10-01 00:00:00

  • The effect of cold on patients with angina pectoris--a review.

    abstract::The effect of cold in the manifestations of coronary heart disease is reviewed. The mechanisms involved which may include increased peripheral resistance and increased coronary vascular resistance are unclear. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Hall RJ,Bullock RE,Albers C

    更新日期:1983-01-01 00:00:00

  • Community-acquired pneumonia: doctors do not follow national guidelines.

    abstract:OBJECTIVES:Appropriate assessment of community-acquired pneumonia (CAP) allows accurate severity scoring and hence optimal management, leading to reduced morbidity and mortality. British Thoracic Society (BTS) guidelines provide an appropriate score. Adherence to BTS guidelines was assessed in our medical assessment un...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.056556

    authors: Collini P,Beadsworth M,Anson J,Neal T,Burnham P,Deegan P,Beeching N,Miller A

    更新日期:2007-08-01 00:00:00

  • Camel bites: report of severe osteolysis as late bone complications.

    abstract::Four cases of severe osteolysis of bones subsequent to camel bite are described. The first had osteolysis of the ribs with traumatic diaphragmatic hernia. Two cases had similar appearances of gross osteolysis of the shafts of the radius and ulna, whilst one had osteolysis of the humeral shaft. The similarities in the ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.770.900

    authors: al-Boukai AA,Hawass NE,Patel PJ,Kolawole TM

    更新日期:1989-12-01 00:00:00

  • To bed or not to bed: the sleep question?

    abstract:BACKGROUND:Sleep deprivation and fatigue from long-shift work impacts doctors' personal safety, inhibits cognitive performance and risks clinical error. The aim of this study was to assess the sleep quality of surgical trainees participating in European Working Time Directive-compliant training rotations within a UK de...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135795

    authors: Brown C,Abdelrahman T,Lewis W,Pollitt J,Egan R,members of the Welsh Surgical Research Initiative.

    更新日期:2020-09-01 00:00:00

  • Propranolol, renin and hypertension: a review.

    abstract::When plasma renin activity is related to sodium balance as evaluated from urinary sodium excretion, a physiological index of normality is obtained along with the ability to detect subtle variations in renin secretion. This has made it possible to correlate more closely the antihypertensive action of propranolol with t...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Laragh JH,Bühler FR

    更新日期:1976-01-01 00:00:00

  • Timing of intervention in acute pancreatitis.

    abstract::This review examines the appropriate timing of intervention in acute pancreatitis. In gallstone pancreatitis, it is now clear that cholecystectomy during the primary admission carries no greater risk of complications than delayed cholecystectomy and enables earlier recovery to normal activity. This course of action pr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.69.813.509

    authors: Johnson CD

    更新日期:1993-07-01 00:00:00

  • Horizontal transmission of hepatitis B virus amongst British 2nd World War soldiers in South-East Asia.

    abstract::Infection with hepatitis B virus (HBV) is much more common in tropical than in temperate countries. Visitors to the tropics are thus at risk from HBV, though the degree of risk, and the routes of infection involved are uncertain. We report serological markers of HBV in two groups of 2nd World War soldiers, who served ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.783.39

    authors: Gill GV,Bell DR,Vandervelde EM

    更新日期:1991-01-01 00:00:00

  • Incidence of dual antiplatelet therapy interruption within 1 year after primary percutaneous coronary intervention in patients with acute ST elevation myocardial infarction.

    abstract:BACKGROUND:After primary percutaneous coronary intervention (PPCI) in patients with acute ST elevation myocardial infarction (STEMI), dual antiplatelet therapy (DAPT) is recommended to continue for 1 year. Occasionally, DAPT interruption may be required due to bleeding issues or unplanned surgical procedures. OBJECTIV...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2019-136760

    authors: Tam CC,Lee J,Chan KW,Lam CC,Wong YT,Chan E,Sze M,Lam YM,Chan C,Tse HF,Siu CW

    更新日期:2020-01-01 00:00:00