Brittle Addison's disease: a new variation on a familiar theme.

Abstract:

:Unstable and unpredictable disease control in diabetes or asthma, with frequent hospitalisations, is frequently referred to as 'brittle'. We describe two cases of Addison's disease with recurrent hospitalisations in hypo-adrenal crises. Both patients had significant psychosocial disruption, and failure to take hydrocortisone replacement therapy was admitted in one and biochemically proven in the other. We propose that 'brittle' Addison's disease in these cases was due to poor treatment compliance related to psychosocial factors. These features have particular similarities with the syndrome of brittle diabetes.

journal_name

Postgrad Med J

authors

Gill GV,Williams G

doi

10.1136/pmj.76.893.166

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

166-7

issue

893

eissn

0032-5473

issn

1469-0756

journal_volume

76

pub_type

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