当前位置： SCI文献检索 > POSTGRADUATE MEDICAL JOURNAL期刊下所有文献 > Republished research: Helminths: an unrecognised disease burden prevalent among migrants in the gastroenterology clinic.

Republished research: Helminths: an unrecognised disease burden prevalent among migrants in the gastroenterology clinic.

Abstract：

OBJECTIVE:To estimate the prevalence of, and implement a diagnostic strategy for, imported helminth infection in the gastroenterology clinic. DESIGN:A retrospective study of eosinophil count and probable tropical exposure (phase I) followed by a prospective study of parasitological investigation (phase II). SETTING:Gastroenterology service of an inner London hospital. PATIENTS:Adult patients newly attending general gastroenterology and inflammatory bowel disease clinics. INTERVENTIONS:In phase I, evidence of undiagnosed helminth infection was sought by analysing patient records for associations between eosinophil count and ethnicity. In phase II, a UK guideline for investigation of eosinophilia in migrants was implemented and diagnostic yield determined. MAIN OUTCOME MEASURES:In phase I, prevalence of eosinophilia was determined; in phase II, helminth prevalence and degree of eosinophilia before and after treatment were reported. Information on symptomatic response to treatment was recorded. Ethnicity was used as a proxy measure for tropical exposure. RESULTS:426 new patients attended in a 12 month period. Eosinophilia was present in 27 (6.3%). 10/27 (37.0%) patients with eosinophilia were of African or Asian ethnicity whereas only 20% (85/426) of patients overall were from these ethnic groups (χ(2)=5.27, p=0.02). Following implementation of the protocol, 25/36 migrants with eosinophilia attended for parasitological investigations. Helminth infection was diagnosed in 10/25 (40%). Strongyloidiasis (six patients) and schistosomiasis (three patients) were the most common diagnoses. Median eosinophil count was 1.06×10(9)/l in those with helminths and 0.58×10(9)/l in those without (p=0.004). Eosinophil counts normalised in, and symptomatic improvement was reported by, most patients after treatment. CONCLUSIONS:Eosinophilia is associated with African or Asian ethnicity in an inner city gastroenterology service. This association is probably explained by imported helminths, which are prevalent in this setting, may be a cause of gastrointestinal symptoms and is easily diagnosed and treated by standard protocols.

journal_name

Postgrad Med J

journal_title

Postgraduate medical journal

authors

Smith PJ,Theis B,McCartney S,Brown M

doi

10.1136/pgmj.2010.003392rep

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

28-33

issue

1035

eissn

0032-5473

issn

1469-0756

pii

pgmj.2010.003392rep

journal_volume

pub_type

杂志文章

在线工具

Republished research: Helminths: an unrecognised disease burden prevalent among migrants in the gastroenterology clinic.