Republished: obesity and colorectal cancer.


:Excess body weight, as defined by the body mass index (BMI), has been associated with several diseases and includes subjects who are overweight (BMI≥25-29.9 kg/m(2)) or obese (BMI≥30 kg/m(2)). Overweight and obesity constitute the fifth leading risk for overall mortality, accounting for at least 2.8 million adult deaths each year. In addition around 11% of colorectal cancer (CRC) cases have been attributed to overweight and obesity in Europe. Epidemiological data suggest that obesity is associated with a 30-70% increased risk of colon cancer in men, whereas the association is less consistent in women. Similar trends exist for colorectal adenoma, although the risk appears lower. Visceral fat, or abdominal obesity, seems to be of greater concern than subcutaneous fat obesity, and any 1 kg/m(2) increase in BMI confers additional risk (HR 1.03). Obesity might be associated with worse cancer outcomes, such as recurrence of the primary cancer or mortality. Several factors, including reduced sensitivity to antiangiogenic-therapeutic regimens, might explain these differences. Except for wound infection, obesity has no significant impact on surgical procedures. The underlying mechanisms linking obesity to CRC are still a matter of debate, but metabolic syndrome, insulin resistance and modifications in levels of adipocytokines seem to be of great importance. Other biological factors such as the gut microbita or bile acids are emerging. Many questions still remain unanswered: should preventive strategies specifically target obese patients? Is the risk of cancer great enough to propose prophylactic bariatric surgery in certain patients with obesity?


Postgrad Med J


Bardou M,Barkun AN,Martel M




Has Abstract


2013-09-01 00:00:00














  • Reversible acute renal failure due to Churg-Strauss syndrome.

    abstract::Renal disease in Churg-Strauss syndrome is generally thought to be benign in nature, thereby distinguishing this rare condition from other necrotizing vasculitides. We report a case in which acute renal failure developed during the aggressive vasculitic phase of the illness requiring dialysis therapy. After one week o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Davenport A,McDicken I,Goldsmith HJ

    更新日期:1988-09-01 00:00:00

  • Cardiovascular complications of cirrhosis.

    abstract::Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction and electrophysiological abnormalities...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Møller S,Henriksen JH

    更新日期:2009-01-01 00:00:00

  • What is osteoporosis?

    abstract::Osteoporosis is a very common disorder, which results in an increase in fracture risk. The annual cost attributable to hip, vertebral, and wrist fractures in England and Wales is pound 1.7 billion. Significant mortality and morbidity are associated with osteoporotic fractures. The method that is most widely used for t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Christodoulou C,Cooper C

    更新日期:2003-03-01 00:00:00

  • Current difficulties in the diagnosis and management of spinal tuberculosis.

    abstract:BACKGROUND:The diagnosis of spinal tuberculosis (ST) is difficult and it commonly presents at an advanced stage. The management and follow up is complicated by a lack of guidance on the appropriate use and interpretation of spinal magnetic resonance studies (MR). AIMS:A retrospective study was performed at a UK centre...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Cormican L,Hammal R,Messenger J,Milburn HJ

    更新日期:2006-01-01 00:00:00

  • Massive cardiac invasion by amelanotic melanoma with obstructive clinical features.

    abstract::Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour. We describe, and illustrate, a patient presenting with features related to cardiac tamponade and intracardiac obstruction. Transthoracic echocardiography initially showed a large mass wit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dubrey S,Grocott-Mason R,Mittal T,Burke M

    更新日期:2008-03-01 00:00:00

  • Paradoxical embolism associated with oral contraceptives: an underdiagnosed lesion?

    abstract::A case of cerebral embolism is described in which paradoxical features have been proved clinically, and which may explain some hitherto unaccountable reported cases, and suggests the value of prospective studies. A successful outcome of such a proved case, associated with oral contraceptives, does not appear to have b...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: de Swiet J

    更新日期:1979-06-01 00:00:00

  • Reversibility of alcoholic cardiomyopathy.

    abstract::A patient with alcoholic cardiomyopathy is described in whom cardiovascular function capacity and radiological heart size fluctuated widely with periods of heavy drinking and abstinence. On two occasions, cessation of drinking resulted in clinical recovery from severe degrees of congestive failure and in complete reve...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Kupari M

    更新日期:1984-02-01 00:00:00

  • The presentation, diagnosis and treatment of cervical osteoid osteoma.

    abstract::A case of cervical osteoid osteoma is reported, with a brief account of the diagnosis and treatment of these lesions. Cervical osteoid osteoma is rare but its pattern of presentation varies little and it should therefore be possible to suspect it on clinical grounds alone. Bone scanning is now regarded as more efficie...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Walker AP

    更新日期:1980-10-01 00:00:00

  • Global health training in US obstetrics and gynaecology residency programmes: perspectives of students, residents and programme directors.

    abstract:BACKGROUND:Benefits of exposure to global health training during medical education are well documented and residents' demand for this training is increasing. Despite this, it is offered by few US obstetrics and gynaecology (OBGYN) residency training programmes. OBJECTIVES:To evaluate interest, perceived importance, pr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Nathan LM,Banks EH,Conroy EM,McGinn AP,Ghartey JP,Wagner SA,Merkatz IR

    更新日期:2015-12-01 00:00:00

  • Microvascular investigations in diabetes mellitus.

    abstract::This paper reviews the current literature concerning the different investigative modalities available to assess the microcirculation in diabetic microangiopathy. The advantages and disadvantages of the different invasive and noninvasive methods available are presented objectively. We have concentrated on the tests tha...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Chittenden SJ,Shami SK

    更新日期:1993-06-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection.

    abstract::The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Kennedy PG

    更新日期:1988-03-01 00:00:00

  • Lymphocytic meningitis as the sole manifestation of Q fever.

    abstract::A young man who presented with a 3 week history of fever and severe headache accompanied by mild leukocytosis, was found to have lymphocytic meningitis due to Coxiella burnetti. Thus, Q fever can present as lymphocytic (aseptic) meningitis responsive to tetracycline with no evidence of pulmonary involvement. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Schattner A,Kushnir M,Zhornicky T,Fenakel G

    更新日期:1993-08-01 00:00:00

  • Micronutrients in health and disease.

    abstract::Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Shenkin A

    更新日期:2006-09-01 00:00:00

  • Camel bites: report of severe osteolysis as late bone complications.

    abstract::Four cases of severe osteolysis of bones subsequent to camel bite are described. The first had osteolysis of the ribs with traumatic diaphragmatic hernia. Two cases had similar appearances of gross osteolysis of the shafts of the radius and ulna, whilst one had osteolysis of the humeral shaft. The similarities in the ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: al-Boukai AA,Hawass NE,Patel PJ,Kolawole TM

    更新日期:1989-12-01 00:00:00

  • Propranolol in patients with acute myocardial infarction at the Royal Melbourne Hospital from 1965: a review.

    abstract::This review presents our experience in the use of propranolol in the management of cardiac infarction. The drug has now been shown to have a definite place, not only in the prevention of cardiac infarction, but also in the treatment of some of the complications. The drug has also been advocated because it may minimiz...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Sloman G,Hunt D,Ross D

    更新日期:1976-01-01 00:00:00

  • Patients' views on follow up of colorectal cancer: implications for risk communication and decision making.

    abstract:BACKGROUND:Medical views about the clinical value and potential detrimental effect on quality of life of postoperative follow up are divided. There is no literature on the views of British patients with colorectal cancer towards the follow up process. AIM:To investigate patients' views and experiences of follow up of ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Papagrigoriadis S,Heyman B

    更新日期:2003-07-01 00:00:00

  • Grit and burnout in UK doctors: a cross-sectional study across specialties and stages of training.

    abstract:PURPOSE OF THE STUDY:Grit is characterised by the ability to persevere during difficulties and maintain a sustained effort over an extended period of time. Throughout their careers, doctors will experience many periods of stress and difficulty. This may result in burnout, defined by the presence of exhaustion and disen...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究


    authors: Halliday L,Walker A,Vig S,Hines J,Brecknell J

    更新日期:2017-07-01 00:00:00

  • The classification of anxiety disorders.

    abstract::This paper discusses the relationship between panic and other symptoms of anxiety disorders. The approach to classification of these disorders described in the Diagnostic and Statistical Manual of Mental Disorders (Third Edition) of the American Psychiatric Association is outlined. It is concluded that there are subst...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Brandon S

    更新日期:1988-01-01 00:00:00

  • Prostatic involvement in Wegener's granulomatosis.

    abstract::Prostatic involvement is an unusual complication of Wegener's granulomatosis. We report two cases with this complication and emphasize the importance of recognizing this manifestation in diagnosis and management of the disease condition. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Tung KT,Woolf A,Falzon M

    更新日期:1987-01-01 00:00:00

  • Complex gynaecological and urological problems in adolescents: challenges and transition.

    abstract::The diagnosis and early management of genitourinary disorders in children is challenging for the child, parents and carers. There have been enormous developments in paediatric care medically and surgically and as a result many patients with complex anomalies reach adult life and have a normal desire for a good quality...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Creighton SM,Wood D

    更新日期:2013-01-01 00:00:00

  • Eosinophilic fasciitis with pulmonary and pleural involvement.

    abstract::We report a case of eosinophilic fasciitis, with the unusual features of pulmonary and pleural involvement. Similar cases which involve the lungs have been reported after exposure to L-tryptophan, but there is no relevant drug history in this case. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Killen JW,Swift GL,White RJ

    更新日期:2000-01-01 00:00:00

  • Peyronie's disease in a district general hospital.

    abstract::Peyronie's disease can cause severe physical and psychological distress. Of 31 cases in this retrospective study, 12 underwent spontaneous improvement in their symptoms which makes the assessment of active treatment in other patients difficult. The indications and limitations of operative approach are discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Odiase VO,Whitaker RH

    更新日期:1980-11-01 00:00:00

  • Orthostatic haemodynamic responses in acute stroke.

    abstract::Little is known about orthostatic blood pressure regulation in acute stroke. We determined postural haemodynamic responses in 40 patients with acute stroke (mild or moderate severity) and 40 non-stroke control in-patients, at two days ('Day 1') and one week ('Week 1') post-admission. Following a 10-minute supine rest ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章


    authors: Panayiotou B,Reid J,Fotherby M,Crome P

    更新日期:1999-04-01 00:00:00

  • Treatment of airways obstruction.

    abstract::This review of the treatment of airways obstruction attempts to demonstrate that treatment needs to be guided by an understanding of pathophysiology and pathogenesis as well as a knowledge of the natural history of the diseases underlying airways obstruction and their causes. This enables effective health education an...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Clark TJ

    更新日期:1983-01-01 00:00:00

  • Severe acute respiratory syndrome (SARS): epidemiology and clinical features.

    abstract::Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common lab...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Hui DS,Chan MC,Wu AK,Ng PC

    更新日期:2004-07-01 00:00:00

  • Bartter's syndrome in two generations of an Irish family.

    abstract::We report four cases of Bartter's syndrome in two consecutive generations of an Irish family. Diagnoses were made on the basis of characteristic clinical features, blood and urine biochemistry with additional evidence from renal biopsy in one case. The aetiology, treatment and inheritance of the syndrome are discussed...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Crowe P,Ahmad A,O'Byrne K,Cullen MJ

    更新日期:1993-10-01 00:00:00

  • Typhoid fever with severe pancytopenia.

    abstract::A patient suffering from typhoid fever with severe pancytopenia is presented. Bone marrow examination revealed extensive haemophagocytosis which possibly contributed to the pancytopenia. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Sood R,Roy S,Kaushik P

    更新日期:1997-01-01 00:00:00

  • Assessing clinical competency in medical senior house officers: how and why should we do it?

    abstract::Most consultants are involved in the training and assessment of several grades of doctors in training especially senior house officers (SHOs) and specialist registrars. In the medical and other specialties there is an increasing trend towards assessing junior doctors' competency using the record of in-training assessm...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Carr SJ

    更新日期:2004-02-01 00:00:00

  • Giant lymph node hyperplasia (Castleman's disease): a clinical study of eight patients.

    abstract::We report on 8 patients with giant lymph node hyperplasia (GLNH), diagnosed over a 10-year period. The age of the patients at diagnosis, the clinical presentation and the histological subtype varied, indicating that GNLH is a heterogeneous condition. One case was associated with liver cirrhosis, and in another patient...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Baruch Y,Ben-Arie Y,Kerner H,Lorber M,Best LA,Gershoni-Baruch R

    更新日期:1991-04-01 00:00:00

  • The management of congestive heart failure.

    abstract::Despite the remarkable advances in cardiovascular therapeutics over the past four decades, little impact has been made on either the incidence or mortality rate of congestive heart failure and it remains a major clinical and public health problem. Recent practice audits have suggested that proven efficacious therapies...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: McAlister FA,Teo KK

    更新日期:1997-04-01 00:00:00