Single oral dose pharmacokinetics of clomipramine in depressed patients.

abstract：:Forty-five healthy men aged 21-34 years took part in a double-blind, parallel-group, placebo-controlled study of the effects of 28 days' treatment with lornoxicam 4 mg twice daily or indomethacin 50 mg twice daily on faecal blood loss and the endoscopic appearances of gastric and duodenal mucosa. After an initial endo...

journal_title：Postgraduate medical journal

authors： Warrington SJ,Debbas NM,Farthing M,Horton M,Johnston A,Thillainayagam A,Turner P,Ferber H

更新日期：1990-08-01 00:00:00

abstract：:A 12-year-old boy presented with typical features of short incubation tetanus. Spastic paraparesis with a mid-thoracic sensory level was present from the time of the initial examination. X-rays of the spine and lumbar myelogram were normal. The paraparesis improved rapidly and within a month the patient was free of ne...

journal_title：Postgraduate medical journal

authors： Bahemuka M

更新日期：1981-07-01 00:00:00

abstract：:Clinical and biochemical data obtained from 163 patients who had taken an overdose of paracetamol were examined to determine which factors or measurements were of value in predicting the severity of ensuing liver damage early after ingestion of tablets. Although the overall severity of hepatic necrosis was found to in...

journal_title：Postgraduate medical journal

authors： Gazzard BG,Widdop B,Davis M,Hughes RD,Goulding R,Williams R

更新日期：1977-05-01 00:00:00

abstract：:A patient is described who developed mild hyponatraemia on two occasions when treated with bendrofluazide alone, but severe hyponatraemia when treated with the combination of enalapril and bendrofluazide. ...

journal_title：Postgraduate medical journal

authors： Collier JG,Webb DJ

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVE:Obesity in mid-life may increase the risk of subsequent dementia. Our objective was to study this risk, focusing on differences by age at the time of recording of obesity, in a large defined population. METHODS:A record linkage cohort study was undertaken using national administrative statistical data on hos...

journal_title：Postgraduate medical journal

authors： Wotton CJ,Goldacre MJ

更新日期：2014-10-01 00:00:00

abstract：:This study examines clinical features of late onset anorexia nervosa. This involved the scrutiny of a large database of patients with anorexia nervosa comprising data gathered at standardized initial assessments over the period 1960-1990. Patients with a late onset were compared to other selected patient samples. The ...

journal_title：Postgraduate medical journal

authors： Joughin NA,Crisp AH,Gowers SG,Bhat AV

更新日期：1991-11-01 00:00:00

abstract：:A 21 year old woman presenting with galactorrhoea, hyperprolactinaemia, and a pituitary mass on magnetic resonance imaging (MRI) is described who was referred to us before planned pituitary surgery. Although a thorough history did not suggest hypothyroidism, laboratory studies revealed profound primary hypothyroidism....

journal_title：Postgraduate medical journal

authors： Brändle M,Schmid C

更新日期：2000-04-01 00:00:00

abstract：:This review of the treatment of airways obstruction attempts to demonstrate that treatment needs to be guided by an understanding of pathophysiology and pathogenesis as well as a knowledge of the natural history of the diseases underlying airways obstruction and their causes. This enables effective health education an...

journal_title：Postgraduate medical journal

authors： Clark TJ

更新日期：1983-01-01 00:00:00

abstract：:We studied two sisters who developed large non-toxic goitres in adolescence. Deiodinase deficiency was diagnosed by a rapid thyroid uptake of radioactive iodine (RAI) at 2 hours associated with a marked fall in thyroidal 131I by 24 hours. Serial RAI scans in the second patient documented evolution of the iodine-defici...

journal_title：Postgraduate medical journal

authors： Hirsch HJ,Shilo S,Spitz IM

更新日期：1986-06-01 00:00:00

abstract：INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been caused the greatest pandemic of our century. Many of the deaths related to it are due to a systemic inflammatory response, which has been called 'cytokine storm'. OBJECTIVES:We developed a comprehensive review of the pathophysiology mec...

journal_title：Postgraduate medical journal

authors： Mélo Silva Júnior ML,Souza LMA,Dutra REMC,Valente RGM,Melo TS

更新日期：2020-10-02 00:00:00

abstract：:Serum lysozyme (muramidase) estimation is a simple, convenient and useful laboratory investigation. A review of the literature shows that lysozyme has been implicated as an aetiological factor in various disorders, and credited with being a prognostic indicator in acute myeloid leukaemia, but these promises have not b...

journal_title：Postgraduate medical journal

authors： Mir MA

更新日期：1977-05-01 00:00:00

abstract：:Epilepsy is common and serious (prevalence 750 per 100 000) and has an impact upon employment, education, and driving. The diagnosis requires a detailed history including witness account. Clinicians must distinguish seizures particularly from syncope and psychogenic attacks. Electroencephalography and magnetic resonan...

journal_title：Postgraduate medical journal

authors： Hadjikoutis S,Smith PE

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF STUDY:The aim of the study is to describe the prevalence of illicit drug use in England and Wales using data from the UK Survey of Non-Medical Use of Prescription Drugs (NMURx) programme and to compare against the well-established Crime Survey England and Wales (CSEW). The rationale is that recreational and ...

journal_title：Postgraduate medical journal

authors： Ng FL,Rockhill K,Black J,May KP,Whittington MD,Wood DM,Dargan PI,Green JL

更新日期：2018-11-01 00:00:00

abstract：:Focused assessment with sonography in trauma (FAST) is a limited ultrasound scan performed in the emergency department to assess patients admitted with blunt abdominal trauma (BAT). It is normally undertaken by emergency physicians in order to identify the presence of free fluid, which may represent haemoperitoneum. T...

journal_title：Postgraduate medical journal

authors： Smith J

更新日期：2010-05-01 00:00:00

abstract：:A case is presented of a young competitive body-builder who abused anabolic steroid drugs and developed profound symptomatic hypogonadotrophic hypogonadism. With the help of prescribed testosterone (Sustanon) he stopped taking anabolic drugs, and later stopped Sustanon also. Hypogonadism returned, but was successfully...

journal_title：Postgraduate medical journal

authors： Gill GV

更新日期：1998-01-01 00:00:00

abstract：:A case of primary purulent meningococcal pericarditis presenting with chest pain, hypotension and cardiac tamponade followed by oliguric renal failure is reported. Treatment with antibiotics and surgical drainage was successful. ...

journal_title：Postgraduate medical journal

authors： Ramsdale DR,Kaul TK,Coulshed N

更新日期：1985-12-01 00:00:00

abstract：:Leuco-erythroblastosis has many known associations (Burkett, Cox and Fields, 1965; Weick, Hagedorn and Linman, 1974; Retief, 1964), but the only ones related to drug therapy are the well established response to haematinics (Burkett et al., 1965) and one possible case following anti-epileptic therapy (Retief, 1964). Th...

journal_title：Postgraduate medical journal

authors： Trenchard PM,Wells CE,Jarriwalla AG

更新日期：1977-07-01 00:00:00

abstract：:Attempts were made to reduce defaulting rates for new appointments to see a consultant in a general medical and gastroenterology clinic. Despite optimising the operation of the clinic, the non-attendance rate remained unsatisfactory, and comparable to the average for the NHS. There were short term improvements in defa...

journal_title：Postgraduate medical journal

authors： Bateson MC

更新日期：2004-10-01 00:00:00

abstract：:A 72 year old man developed acute myeloblastic leukaemia two years after he had been treated with local curative therapy and chemotherapy for a solitary plasma cytoma of the ilium. ...

journal_title：Postgraduate medical journal

authors： Maharaj D,Dolan G

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of, and implement a diagnostic strategy for, imported helminth infection in the gastroenterology clinic. DESIGN:A retrospective study of eosinophil count and probable tropical exposure (phase I) followed by a prospective study of parasitological investigation (phase II). SETTING:G...

journal_title：Postgraduate medical journal

authors： Smith PJ,Theis B,McCartney S,Brown M

更新日期：2012-01-01 00:00:00

abstract：:Although an extensive literature exists on factors controlling sodium excretion in animal experimental models of heart failure, the relevance of these to the human condition remains largely unexplored. Increased renal sympathetic stimulation is considered responsible for heightened urinary sodium retention. Stimulatio...

journal_title：Postgraduate medical journal

authors： Good J,Frost G,Oakley CM,Cleland JG

更新日期：1992-01-01 00:00:00

abstract：:A patient suffering from typhoid fever with severe pancytopenia is presented. Bone marrow examination revealed extensive haemophagocytosis which possibly contributed to the pancytopenia. ...

journal_title：Postgraduate medical journal

authors： Sood R,Roy S,Kaushik P

更新日期：1997-01-01 00:00:00

abstract：:Non-invasive assessment of coronary artery patency has been attempted with different imaging modalities over the last few decades. The continuous motion of the heart, the respiratory movement, together with the small and tortuous nature of the coronary arteries, made this a technically challenging task. Over the last ...

journal_title：Postgraduate medical journal

authors： Yerramasu A,Venuraju S,Lahiri A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Patients with irreversible chronic kidney disease who require dialysis immediately are a subset of ultra late referrals for whom the term chronic kidney disease presenting acutely might usefully be applied. Although well known to nephrologists and recognised as a specific group with considerable problems, li...

journal_title：Postgraduate medical journal

authors： Wolfe M,Almond A,Robertson S,Donaldson K,Isles C

更新日期：2010-07-01 00:00:00

abstract：:Thiazide diuretics used alone to treat hypertension can cause hypokalaemia in a substantial proportion of patients. The possibility exists that any benefit of reducing high blood pressure by such treatment may be offset by an increased mortality due to arrhythmias initiated by hypokalaemia. ...

journal_title：Postgraduate medical journal

authors： Poole-Wilson PA

更新日期：1983-01-01 00:00:00

abstract：:Teams within surgery have been through countless cycles of refinement with an ever-increasing list of surgical team members. This results in a more dispersed team, making effective teamwork harder to achieve. Furthermore, the ad hoc nature of surgical teams means that team familiarity is not always given. The impact o...

journal_title：Postgraduate medical journal

authors： Kumar H,Morad R,Sonsati M

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Obesity is an increasing problem in the UK and bariatric surgery is likely to increase in volume in the future. While substantial weight loss is the primary outcome following bariatric surgery, the effect on obesity-related morbidity, mortality and quality of life (QOL) is equally important. This study repor...

journal_title：Postgraduate medical journal

authors： Titi M,Jenkins JT,Modak P,Galloway DJ

更新日期：2007-07-01 00:00:00

abstract：:A 20-year-old woman presented with tendon and tuberous xanthomas. Plasma lipid levels were normal. Xanthomatosis with normal lipid levels is rare. ...

journal_title：Postgraduate medical journal

authors： Handa R,Gupta K,Wali JP

更新日期：1995-09-01 00:00:00

abstract：:The effects of nilvadipine on the peripheral circulation in the lower extremities using a duplex system of two-dimensional colour and pulse Doppler ultrasonography were studied in 32 patients with type 2 diabetes mellitus and mild essential hypertension. The patients (19 men and 13 women) were randomly divided into tr...

journal_title：Postgraduate medical journal

authors： Sone H,Okuda Y,Mizutani M,Kawakami Y,Bannai C,Yamashita K

更新日期：1995-10-01 00:00:00

abstract：:Proper understanding of the pathological process of a ruptured plaque followed by thrombus formation remains the basis for rational therapy of cardiac ischaemia and myocardial infarction. With the advent of better thrombolytic regimens, improved direct reperfusion via angioplasty and streamlined recognition/admission ...

journal_title：Postgraduate medical journal

authors： Hugenholtz PG

更新日期：1994-01-01 00:00:00