Late diagnosis of choroidal malignant melanomas in eyes with clear media and low visual acuity.

Abstract:

:Five patients seen in a one-year period with advanced malignant melanoma of the choroid in eyes with low visual acuity and clear media are reported. The low visual acuity appeared clinically to be antecedent to the malignant tumor; although in certain cases it may have been related to the occult melanoma, this was not appreciated clinically. Because of the low visual acuity, these patients did not have vision symptoms referable to the melanoma, and the malignancy was diagnosed late in its course. All five cases had extrascleral extension of the tumor at the time of surgical treatment; three are dead of metastatic disease, and two have undergone orbital exenteration with only brief follow-up periods. This experience suggests that eyes with clear media and low vision owing to presumably unrelated causes should undergo periodic examination to rule out the presence of a growing malignant melanoma and to prevent its late diagnosis.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Albert DM,Zakov ZN,Smith TR

doi

10.1016/s0161-6420(79)35423-9

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

1037-47

issue

6

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(79)35423-9

journal_volume

86

pub_type

杂志文章
  • Randomized Trial of Treat and Extend Ranibizumab with and without Navigated Laser for Diabetic Macular Edema: TREX-DME 1 Year Outcomes.

    abstract:PURPOSE:To compare monthly dosing with a treat and extend algorithm using ranibizumab 0.3 mg with and without angiography-guided macular laser photocoagulation for center-involving diabetic macular edema (DME). DESIGN:Multicenter, prospective, randomized clinical trial. PARTICIPANTS:A total of 150 eyes from 116 subje...

    journal_title:Ophthalmology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ophtha.2016.09.021

    authors: Payne JF,Wykoff CC,Clark WL,Bruce BB,Boyer DS,Brown DM,TREX-DME Study Group.

    更新日期:2017-01-01 00:00:00

  • Intraocular lymphoma. Clinical and histopathologic diagnosis.

    abstract:BACKGROUND:Intraocular lymphoma is associated with significant morbidity and mortality, but early diagnosis and treatment may improve prognosis. METHODS:The diagnostic features of 12 cases of intraocular lymphoma diagnosed at the National Eye Institute between 1984 and 1992 were retrospectively reviewed. RESULTS:A pa...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(93)31469-7

    authors: Whitcup SM,de Smet MD,Rubin BI,Palestine AG,Martin DF,Burnier M Jr,Chan CC,Nussenblatt RB

    更新日期:1993-09-01 00:00:00

  • The importance of initial management in the treatment of severe infectious corneal ulcers.

    abstract:PURPOSE:To identify factors that influence the outcome of patients with severe infectious corneal ulcers. METHOD:A retrospective review was performed of the hospital records of all such patients admitted to the Doheny Eye Hospital during a 30 month period. Outcome variables examined were change in visual acuity, durat...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(95)30771-3

    authors: McLeod SD,LaBree LD,Tayyanipour R,Flowers CW,Lee PP,McDonnell PJ

    更新日期:1995-12-01 00:00:00

  • Three-year results of the Prospective Evaluation of Radial Keratotomy (PERK) Study.

    abstract::The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refractive error between -2.00 and -8.00 diopters (D). The authors report results for one eye of each patient. The surg...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(87)80021-0

    authors: Waring GO 3rd,Lynn MJ,Culbertson W,Laibson PR,Lindstrom RD,McDonald MB,Myers WD,Obstbaum SA,Rowsey JJ,Schanzlin DJ

    更新日期:1987-10-01 00:00:00

  • Primary cystadenocarcinoma of the lacrimal gland.

    abstract:PURPOSE:To report a patient with a cystadenocarcinoma of the lacrimal gland, a tumor not previously described in the ophthalmic literature. Salivary gland cystadenocarcinomas constitute a distinct group of epithelial malignancies characterized by an invasive, predominantly cystic pattern of growth that have an indolent...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/S0161-6420(03)00490-1

    authors: Devoto MH,Croxatto JO

    更新日期:2003-10-01 00:00:00

  • Update report on intraocular lenses.

    abstract::Intraocular lenses have been regulated by the Bureau of Devices of the Food and Drug Administration since February 9, 1978. One year ago, data were reported through August 9, 1979, at which time more than 177,000 lenses of four different classes had been implanted. In the meantime, appeals and legal action by the Publ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(81)35014-3

    authors: Worthen DM,Boucher JA,Buxton J,Lowther G,Talbott M

    更新日期:1981-05-01 00:00:00

  • Association between corneal allograft reactions and HLA compatibility.

    abstract::The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. M...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(90)32360-6

    authors: Boisjoly HM,Roy R,Bernard PM,Dubé I,Laughrea PA,Bazin R

    更新日期:1990-12-01 00:00:00

  • Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).

    abstract:PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. DESIGN:Randomized, 20-month, multicenter, subject- and efficacy evaluator-masked, par...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2020.06.018

    authors: Medeiros FA,Walters TR,Kolko M,Coote M,Bejanian M,Goodkin ML,Guo Q,Zhang J,Robinson MR,Weinreb RN,ARTEMIS 1 Study Group.

    更新日期:2020-12-01 00:00:00

  • Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome.

    abstract:OBJECTIVE:To investigate systematically the natural history of visual outcome in nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN:Cohort study. PARTICIPANTS:Three hundred forty consecutive untreated patients (386 eyes) with NAION, first seen in our clinic from 1973 to 2000. METHODS:At first visit, all...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2007.05.027

    authors: Hayreh SS,Zimmerman MB

    更新日期:2008-02-01 00:00:00

  • Surgical anatomy of the lacrimal fossa a prospective computed tomodensitometry scan analysis.

    abstract:PURPOSE:To establish the accurate surgical anatomy of endonasal dacryocystorhinostomy (DCR) based on the radiological analysis of underlying bony structures. DESIGN:Prospective noncomparative observational case series study. PARTICIPANTS:Fifty-nine patients with complete nasolacrimal stenosis underwent a computed tom...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2005.01.012

    authors: Fayet B,Racy E,Assouline M,Zerbib M

    更新日期:2005-06-01 00:00:00

  • Intraocular lens exchange for anterior chamber intraocular lens-induced corneal endothelial damage.

    abstract:BACKGROUND:Anterior chamber and iris-plane intraocular lenses (IOLs) have been implicated in causing corneal endothelial damage and progression to pseudophakic bullous keratopathy. METHODS:The authors performed IOL exchanges on 102 eyes with signs of early corneal decompensation or progressive endothelial cell loss as...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(93)31637-4

    authors: Coli AF,Price FW Jr,Whitson WE

    更新日期:1993-03-01 00:00:00

  • Pre-keratoplasty potential acuity evaluation. Laser interferometer and potential acuity meter.

    abstract::Twenty-three patients who underwent penetrating keratoplasty were evaluated preoperatively for potential retinal acuity utilizing the Randwal Laser Interferometer and the Mentor Potential Acuity Meter. When compared with Snellen visual acuity during the early postoperative period (1-6 months), both instruments were us...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(84)34172-0

    authors: Steinert RF,Minkowski JS,Boruchoff SA

    更新日期:1984-10-01 00:00:00

  • Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: Clinical Characteristics of 36 Eyes.

    abstract:PURPOSE:To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV). DESIGN:Retrospective case series. PARTICIPANTS:Thirty-six eyes of 23 patients. METHODS:The American Society of Cataract and Refractive Surgery (ASCRS) and the American Society of Retina Specia...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2016.11.042

    authors: Witkin AJ,Chang DF,Jumper JM,Charles S,Eliott D,Hoffman RS,Mamalis N,Miller KM,Wykoff CC

    更新日期:2017-05-01 00:00:00

  • The Bionic Eye: A Quarter Century of Retinal Prosthesis Research and Development.

    abstract::This article describes the history of visual prostheses, with emphasis on the development of the Argus II retinal prosthesis system (Second Sight Medical Products, Inc., Sylmar, CA). A brief overview of cortical electrical stimulation in the blind is provided, followed by an account of the design and development of re...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2016.06.044

    authors: Humayun MS,de Juan E Jr,Dagnelie G

    更新日期:2016-10-01 00:00:00

  • Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups.

    abstract:PURPOSE:To determine efficacy and safety of latanoprost, a prostaglandin analog for glaucoma, during 1 year of treatment. METHODS:After baseline measurements, 0.005% latanoprost was topically applied once daily for 12 months in patients from Scandinavia, the United Kingdom, and the United States who had elevated intra...

    journal_title:Ophthalmology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0161-6420(96)30407-7

    authors: Camras CB,Alm A,Watson P,Stjernschantz J

    更新日期:1996-11-01 00:00:00

  • The capsular bag after short- and long-term fixation of intraocular lenses.

    abstract:PURPOSE:To investigate the effect of posterior chamber intraocular lens (PC IOL) size and construction on the capsular bag in human cadaver eyes. METHODS:Studies were done at two timeframes: (1) short term (prospective)--the effect of 12 different IOLs on the capsular bag configuration after experimental implantation;...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(95)30897-4

    authors: Assia EI,Legler UF,Apple DJ

    更新日期:1995-08-01 00:00:00

  • Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the Randomized Phase III OPUS-2 Study.

    abstract:PURPOSE:Lifitegrast is an integrin antagonist that decreases T-cell-mediated inflammation associated with dry eye disease (DED). We report the results of OPUS-2, a phase III study evaluating the efficacy and safety of lifitegrast compared with placebo for the treatment of DED. DESIGN:A 12-week, multicenter, randomized...

    journal_title:Ophthalmology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ophtha.2015.08.001

    authors: Tauber J,Karpecki P,Latkany R,Luchs J,Martel J,Sall K,Raychaudhuri A,Smith V,Semba CP,OPUS-2 Investigators.

    更新日期:2015-12-01 00:00:00

  • Adrenal Suppression in Infants Treated with Topical Ocular Glucocorticoids.

    abstract:PURPOSE:To analyze the incidence of adrenal suppression and the glucocorticoid (GC) dose per kilogram body weight given in infants treated with standard protocol for topical ophthalmic GCs after congenital cataract surgery. DESIGN:Retrospective, consecutive case series. PARTICIPANTS:All children younger than 2 years ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2018.04.035

    authors: Bangsgaard R,Main KM,Boberg-Ans G,la Cour M,Forman JL,Haargaard B,Kiilgaard JF

    更新日期:2018-10-01 00:00:00

  • The onset and evolution of glaucomatous visual field defects.

    abstract::Long-term follow-up was recorded on the visual fields of 251 patients with chronic open-angle glaucoma and 826 patients with ocular hypertension. Observation periods exceeded ten years for 73 patients with manifest glaucoma. Initial glaucomatous defects appeared in 98 eyes of 72 patients while under continuous observa...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(82)34798-3

    authors: Hart WM Jr,Becker B

    更新日期:1982-03-01 00:00:00

  • Five-year experience of the 2-incision push-pull technique for anterior and posterior capsulorrhexis in pediatric cataract surgery.

    abstract:PURPOSE:To describe the authors' 5-year experience of the 2-incision push-pull (TIPP) technique for pediatric anterior and posterior capsulorrhexis formation. DESIGN:Retrospective descriptive study over a 5-year period. PARTICIPANTS:A total of 84 eyes of 63 patients who had undergone cataract surgery in 1 center. ME...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2006.03.057

    authors: Hamada S,Low S,Walters BC,Nischal KK

    更新日期:2006-08-01 00:00:00

  • Visual function in prolactinoma patients treated with bromocriptine.

    abstract::Ten patients with prolactin-secreting pituitary adenomas (prolactinoma) and visual dysfunction were treated primarily with bromocriptine. Nine patients had improvement of visual field or acuity associated with computed tomography (CT) evidence of a decrease in tumor size and reduction of serum prolactin level (SPL). V...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(85)33853-8

    authors: Moster ML,Savino PJ,Schatz NJ,Snyder PJ,Sergott RC,Bosley TM

    更新日期:1985-10-01 00:00:00

  • Intraocular pressure control and complications with two-stage insertion of the Baerveldt implant.

    abstract:PURPOSE:To evaluate intraocular pressure (IOP) control and the prevalence of complications associated with the two-stage insertion of the Baerveldt implant. DESIGN:Retrospective, noncomparative, interventional case series. METHODS:We reviewed the medical records of all patients who underwent the two-stage Baerveldt i...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/S0161-6420(02)01752-9

    authors: Tong L,Frazao K,LaBree L,Varma R

    更新日期:2003-02-01 00:00:00

  • Tear film aberration dynamics and vision-related quality of life in patients with dry eye disease.

    abstract:OBJECTIVE:Corneal and ocular wavefront aberrations were recorded together with clinical examination results and patient-reported vision-related quality-of-life evaluation results to define the relevance of dynamic optical analysis of the eye in dry eye disease (DED). DESIGN:Prospective and comparative clinical study. ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2012.03.004

    authors: Denoyer A,Rabut G,Baudouin C

    更新日期:2012-09-01 00:00:00

  • Nasolacrimal duct probing in infants.

    abstract::Use of a fiberoptic endoscope to visualize the vault of the inferior turbinate during lacrimal duct probing and irrigation revealed a high incidence of false passages. This was confirmed on dacryocystofluoroscopy. The creation of false passages as documented by us can help explain clinical probing failure in apparentl...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(79)35373-8

    authors: Cibis GW,Jazbi BU

    更新日期:1979-08-01 00:00:00

  • Dapsone-induced neutropenia in patients treated for ocular cicatricial pemphigoid.

    abstract:BACKGROUND:Dapsone is used widely in treating ocular cicatricial pemphigoid, leprosy, and dermatologic disorders. Hemolysis is a well-known complication of dapsone therapy. Rarely, neutropenia or agranulocytosis may occur, resulting in up to a 50% mortality rate. To the authors' knowledge, agranulocytosis has not been ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(94)31098-0

    authors: Raizman MB,Fay AM,Weiss JS

    更新日期:1994-11-01 00:00:00

  • Conjunctival autograft transplantation for advanced and recurrent pterygium.

    abstract::The technique and results of conjunctival autograft transplantation for advanced and recurrent pterygium are presented for 57 eyes of 54 patients. The pterygia were primary in 16 eyes and recurrent in 41; among the latter group, 14 patients had diplopia resulting from cicatricial involvement of the medial rectus muscl...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(85)33831-9

    authors: Kenyon KR,Wagoner MD,Hettinger ME

    更新日期:1985-11-01 00:00:00

  • Voluntary suppression of the multifocal electroretinogram.

    abstract:OBJECTIVE:To describe multifocal electroretinogram (mfERG) responses in 2 patients with nonorganic visual loss and in 11 eyes of 6 healthy persons who suppressed their mfERG responses. DESIGN:Observational case series. METHODS:The mfERG results were recorded in all individuals using the Veris Science 4.2 instrument. ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2003.04.011

    authors: Vrabec TR,Affel EL,Gaughan JP,Foroozan R,Tennant MT,Klancnik JM Jr,Jordan CS,Savino PJ

    更新日期:2004-01-01 00:00:00

  • Risk factors for conversion to neovascular age-related macular degeneration based on longitudinal morphologic and visual acuity data.

    abstract:PURPOSE:To use longitudinal quantitative morphologic and visual acuity (VA) data to investigate the risk of choroidal neovascularization (CNV) event occurrence in eyes with dry age-related macular degeneration (AMD). DESIGN:Prospective observational study. PARTICIPANTS:A total of 513 participants (844 eyes) followed ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2012.02.048

    authors: Friberg TR,Bilonick RA,Brennen PM

    更新日期:2012-07-01 00:00:00

  • Pattern dystrophy of the retinal pigment epithelium.

    abstract::The pattern dystrophies are a group of hereditary macular dystrophies characterized by lesions of the retinal pigment epithelium (RPE) arranged in various patterns of dots, lines, and branched figures. This report of two pedigrees expands the clinical spectrum. The onset is usually in the second and third decade, ther...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0161-6420(82)34632-1

    authors: Watzke RC,Folk JC,Lang RM

    更新日期:1982-12-01 00:00:00

  • The Relationship between Medicare Payment and Service Volume for Retina Procedures from 2005 through 2009.

    abstract:PURPOSE:To calculate the relationship between Medicare payment and service volume for the 3 highest-volume retina procedures: intravitreal injection (Current Procedural Terminology [CPT] code 67028), laser treatment for retinal edema (CPT code 67210), and laser treatment for proliferative retinopathy (CPT code 67228). ...

    journal_title:Ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ophtha.2015.04.040

    authors: Gong D,Jun L,Tsai JC

    更新日期:2015-08-01 00:00:00