Abstract：
PURPOSE:To identify factors that influence the outcome of patients with severe infectious corneal ulcers. METHOD:A retrospective review was performed of the hospital records of all such patients admitted to the Doheny Eye Hospital during a 30 month period. Outcome variables examined were change in visual acuity, duration of hospitalization, hospital charges, and percentage of patients who required penetrating keratoplasty. RESULTS:Sixty-two ulcers were included. An organism was identified and antibiotic sensitivities established in 52 patients (84%). Inpatient therapy involved a combination of fortified aminoglycoside and cephalosporin antibiotics in 39 patients (63%) and was found to be appropriate on the basis of sensitivity studies in 49 (94%) of 52 patients. Inappropriate initial treatment was related to increased hospital charge (P = 0.024) as well as increased risk of penetrating keratoplasty (P = 0.001). CONCLUSIONS:Appropriate initial therapy is most critical in the course of serious corneal ulcers, and aggressive, broad-spectrum antibiotic coverage is advocated.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
McLeod SD,LaBree LD,Tayyanipour R,Flowers CW,Lee PP,McDonnell PJdoi
10.1016/s0161-6420(95)30771-3subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1943-8issue
12eissn
0161-6420issn
1549-4713pii
S0161-6420(95)30771-3journal_volume
102pub_type
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