Abstract：
CASE REPORT:The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had produced a characteristic telescoping deformity of the digits. Eyelid nodules were excised to relieve pseudoptosis and for cosmesis. MATERIALS:The eyelid nodules were studied by routine light microscopy and a battery of immunohistochemical stains, including S-100 protein and several macrophage markers. RESULTS:Microscopy disclosed an infiltrate of histiocytes and giant cells with glassy eosinophilic cytoplasm and large round or oval vesicular nuclei with prominent nucleoli set in a densely fibrotic stroma consistent with multicentric reticulohistiocytosis. The histiocytes showed positive immunoreactivity for lysozyme, but were negative for alpha-1 antichymotrypsin, S-100 protein, and neuron-specific enolase. CONCLUSION:Multicentric reticulohistiocytosis should be included in the differential diagnosis of multiple eyelid nodules.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Eagle RC Jr,Penne RA,Hneleski IS Jrdoi
10.1016/s0161-6420(95)31005-6subject
Has Abstractpub_date
1995-03-01 00:00:00pages
426-30issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(95)31005-6journal_volume
102pub_type
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