Abstract:
OBJECTIVE:To investigate vitreous levels of reactive oxygen species (ROS) in patients with proliferative diabetic retinopathy (PDR) and analyze ROS levels among different groups of PDR patients. DESIGN:Retrospective case-control study. PARTICIPANTS:Thirty-nine eyes of 39 patients with PDR and 16 eyes of 16 non-PDR patients (control group) that underwent primary vitrectomy for complications of PDR and other conditions (control group), with a follow-up time > or = 12 months. METHODS:Proliferative diabetic retinopathy patients were classified into 3 groups according to the extent of fibrovascular proliferation: (1) no or focal adhesions at < or =3 sites (n = 17); (2) > or =1 broad adhesions or vitreous-retinal adhesions around disc, macula, and arcade (n = 12); and (3) vitreous-retinal attachment extending to the periphery or no posterior vitreous detachment with or without retinal detachment (RD) (n = 10). The control group (n = 16) contained non-PDR patients. Vitreous samples were obtained during measurement of vitrectomy and vitreous levels of ROS by luminol-enhanced chemiluminescence assay. MAIN OUTCOME MEASURES:Reactive oxygen species levels were recorded as mean (+/- standard deviation) chemiluminescence counts per 10 seconds. Correlations of vitreous levels of ROS among the 3 PDR groups and anatomic prognosis were evaluated. Multiple linear regression analysis of selective potential risk factors was performed to investigate the main determinants of ROS levels. RESULTS:Vitreous ROS levels were significantly higher in patients with PDR (125.76+/-351.72 chemiluminescence counts per 10 seconds) than in control patients (0.37+/-0.72 chemiluminescence counts per 10 seconds; P<0.0001). Reactive oxygen species levels were 1.86+/-1.63 (group 1), 24.47+/-22.68 (group 2), and 457.94+/-597.01 (group 3); the difference among groups was significant (P = 0.001). Regression analysis indicated that only patient grouping (according to the severity of fibrovascular proliferation) had a strong dependent association with ROS levels (P = 0.001). Final anatomic results revealed that recurrent untreatable RD occurred in 3 patients of group 3, who also had the highest ROS levels. CONCLUSIONS:Reactive oxygen species levels were significantly elevated in the vitreous fluid of PDR patients, and patients with a more advanced clinical PDR appearance had higher ROS levels. These findings suggest an association between ROS and the pathogenesis of PDR. Reactive oxygen species might be correlated with PDR severity.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Yeh PT,Yang CM,Huang JS,Chien CT,Yang CH,Chiang YH,Shih YFdoi
10.1016/j.ophtha.2007.05.041subject
Has Abstractpub_date
2008-04-01 00:00:00pages
734-737.e1issue
4eissn
0161-6420issn
1549-4713pii
S0161-6420(07)00598-2journal_volume
115pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:West Nile virus (WNV) disease is a zoonotic infection with recent outbreaks in the United States. Recent reports have highlighted the intraocular findings associated with WNV disease. We describe the intraocular findings observed in two patients infected by the West Nile virus. DESIGN:Observational case repo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00720-6
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Subconjunctival hemorrhage (SCH) is a relatively common disease, but there have been no reports concerning the relationship between SCH and conjunctivochalasis (CCh). We compared the grade of CCh between patients with SCH and control patients. DESIGN:Prospective, nonrandomized study. PARTICIPANTS:A total of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.03.021
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Although allergic fungal sinusitis is a relatively common, noninvasive form of paranasal sinus mycosis, and despite frequent orbital involvement, there have been few reports of this condition in the ophthalmic literature. METHODS:Two cases of allergic fungal sinusitis having orbital symptoms are described. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30054-2
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy and reliability of 2 single-use tonometry devices (Tonosafe and Tonojet) as an alternative to standard Goldmann prisms in patients attending dedicated glaucoma clinics. DESIGN:Prospective experimental study with human subjects. PARTICIPANTS:Two hundred forty glaucoma patients who atte...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2006.05.031
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:To investigate whether single nucleotide polymorphisms (SNPs) in interleukin (IL)-1β, IL-6, and IL-12β are associated with the susceptibility and severity of contact lens-related keratitis. DESIGN:Retrospective, case control study. PARTICIPANTS:One hundred twelve cases of keratitis and 225 controls were recru...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.01.031
更新日期:2012-07-01 00:00:00
abstract::Five hundred forty-seven reports of adverse reactions to timolol maleate received by the National Registry for Drug-induced Ocular Side Effects during an eleven-month period were reviewed. Approximately half the reports concerned systemic reactions affecting the cardiac, pulmonary, central nervous, gastrointestinal, a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35215-9
更新日期:1980-05-01 00:00:00
abstract:PURPOSE:Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN:Case-control study. PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.11.029
更新日期:2017-04-01 00:00:00
abstract::In an attempt to elucidate the mechanism whereby the Fasanella-Servat operation corrects ptosis, the authors examined the histopathologic features of 40 consecutive surgical specimens from 37 patients. Because all specimens contained tarsus, this tissue was graded into two groups according to vertical height: (1) mini...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32876-4
更新日期:1989-04-01 00:00:00
abstract::Patients suffering a central retinal vein occlusion should be evaluated for conditions that promote and/or contribute to the formation of a thrombosis in the central retinal vein. These conditions include alterations of blood flow, altered viscosity of the blood, abnormalities of coagulation, and abnormalities of vess...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)34528-0
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:One of the largest series of patients with incontinentia pigmenti who have undergone detailed ophthalmologic examination is reported here, including previously unrecognized findings with visually disabling consequences. METHODS:Thirteen females with incontinentia pigmenti from eight unrelated families were ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31422-3
更新日期:1993-11-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate 24-hour intraocular pressure (IOP) control in patients with moderate to severe open-angle glaucoma treated by trabeculectomy and mitomycin C versus maximum tolerated medical therapy. DESIGN:Prospective observational study. PARTICIPANTS:Thirty surgical patients and 30 ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2006.01.029
更新日期:2006-05-01 00:00:00
abstract::This article discusses the experience of progressing from a young ophthalmic resident to a full-time professional and, ultimately, to service on the American Board of Ophthalmology. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.06.013
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To describe the ocular reactivity of the rabbit to bacterial endotoxin contained in an aqueous medium and in a cohesive and a dispersive ophthalmic viscosurgical device (OVD). DESIGN:Experimental, randomized animal study. PARTICIPANTS:Seventy-five New Zealand white rabbits. METHODS:This study was performed...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.04.006
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To compare the long-term safety and ocular-hypotensive efficacy of brimonidine tartrate 0.2% with timolol maleate 0.5% administered twice daily in patients with glaucoma or ocular hypertension. DESIGN:A double-masked, parallel-group, active-controlled, multicenter clinical trial of 12 months' duration. PART...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0161-6420(98)91048-x
更新日期:1998-10-01 00:00:00
abstract::Topical carbonic anhydrase inhibitors MK-507 and sezolamide hydrochloride (previously known as MK-417) were compared in a double-masked, randomized, placebo-controlled study in 82 patients with bilateral primary open-angle glaucoma or ocular hypertension. MK-507 was given every 8 or 12 hours, sezolamide every 8 hours,...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0161-6420(91)32295-4
更新日期:1991-03-01 00:00:00
abstract::The authors studied 80 eyes of patients with choroidal neovascular membranes (CNVMs) associated with age-related macular degeneration between 1982 and 1988. In each case, fluorescein angiography was done on two occasions separated by an interval of 2 days to 11 weeks (average, 13 days) without intervening photocoagula...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32741-2
更新日期:1989-09-01 00:00:00
abstract:PURPOSE:Age-related macular degeneration (AMD) is a common threat to vision. While classification of disease stages is critical to understanding disease risk and progression, several systems based on color fundus photographs are known. Most of these require in-depth and time-consuming analysis of fundus images. Herein,...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.02.037
更新日期:2018-09-01 00:00:00
abstract::Three patients with idiopathic central serous chorioretinopathy (ICSC) and bullous retinal detachment (RD) were examined at least 2 years after the onset of the disease in one patient and over 10 years in the other two patients. There were large areas of retinal pigment epithelium (RPE) degeneration in each patient. I...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33243-9
更新日期:1987-12-01 00:00:00
abstract::The recent establishment of a rare book collection as part of the American Academy of Ophthalmology Foundation Museum gives Academy members additional access to an important facet of our ophthalmic heritage. Many 17th and 18th century works, such as those of Cotton Mather and Philip Syng Physick, long remained in manu...
journal_title:Ophthalmology
pub_type: 历史文章,杂志文章
doi:10.1016/s0161-6420(86)33693-5
更新日期:1986-05-01 00:00:00
abstract::A review was undertaken of nine eyes of nine patients who suffered tightly bound dense premacular hemorrhage as a complication of proliferative diabetic retinopathy. Patients who did not receive vitrectomy within four weeks of the onset of the hemorrhage all progressed to late macular traction and visual acuity no bet...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)34014-9
更新日期:1985-04-01 00:00:00
abstract::The use of the specular microscope as a noninvasive in vivo method of identifying cholesterol crystals in two cases of crystalline corneal deposits is described. This illustrates the advantage of using the specular microscope under living conditions with a much higher magnification than is obtained with the slit lamp....
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33149-0
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Superior oblique palsy is the most frequent isolated cranial nerve palsy seen in strabismus practice. It is traditionally diagnosed according to etiology as acquired, congenital, or idiopathic, but surgical treatment is based on deviation not etiology. Observations at surgery led to speculation that the supe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31759-2
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:To prospectively examine the change in upper eyelid position on downgaze in patients with blepharoptosis. METHODS:Upper eyelid margin to corneal light reflex distance (uMRD) was measured in primary gaze and in 30 degrees to 40 degrees downgaze in 50 consecutive patients with acquired ptosis and 10 consecutive ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30837-8
更新日期:1995-10-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare patient-reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI), a 12-item symptom frequency-based questionnaire, and the Symptom Assessment iN Dry Eye (SANDE), a 2-item frequency- and severity-based visual analog scale. DESIGN:Clin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.02.037
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:Indocyanine green (ICG) angiography may improve visualization of choroidal neovascularization (CNV) associated with serous retinal pigment epithelial detachment (RPED) in age-related macular degeneration (AMD). The features of ICG hyperfluorescence associated with serous RPED and therapeutic effect of ICG-direc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30236-x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To determine the long-term motor and sensory results after early surgical correction of patients with congenital esotropia. DESIGN:Noncomparative interventional case series. PARTICIPANTS:Ten infants with congenital esotropia. INTERVENTION:Patients had bimedial rectus recession between 83 and 159 days of ag...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90337-8
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:To evaluate the short-term and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma. DESIGN:Prospective study. PARTICIPANTS:Twenty-two patients previously implanted with a sulcus-based IOP sensor (EyeMate, Implandata GmbH, Germany). METHODS:Twenty-two patients previous...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.07.016
更新日期:2021-02-01 00:00:00
abstract::Experiments were performed to determine the absorption by and transmission through blood of argon blue-green (ABG) and green (AG) and krypton red (KR) laser light. Krypton was transmitted better through intact erythrocytes than argon. The difference between krypton and argon was greater if the erythrocytes contained o...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)34083-6
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To measure the magnitude and direction of visual field (VF) rates of change in glaucoma patients after intraocular pressure (IOP) reduction with trabeculectomy. DESIGN:Retrospective, comparative, longitudinal cohort study. PARTICIPANTS:Patients with open-angle glaucoma. METHODS:Patients who underwent trabecu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.09.027
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to determine the nature and course of ophthalmic abnormalities in long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency, a recently discovered disorder of mitochondrial fatty acid beta-oxidation. STUDY DESIGN:The study design was a cohort (case series). PARTICIPANTS:A re...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)95019-9
更新日期:1998-05-01 00:00:00