Abstract：
:Topical carbonic anhydrase inhibitors MK-507 and sezolamide hydrochloride (previously known as MK-417) were compared in a double-masked, randomized, placebo-controlled study in 82 patients with bilateral primary open-angle glaucoma or ocular hypertension. MK-507 was given every 8 or 12 hours, sezolamide every 8 hours, or placebo every 8 or 12 hours for 4 days. Both drugs lowered intraocular pressure (IOP) substantially. MK-507 was somewhat more active than sezolamide, with a peak mean IOP reduction of 26.2% for MK-507 versus 22.5% for sezolamide, although the difference between the treatments was not statistically significant. These drugs may have potential in the treatment of glaucoma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Lippa EA,Schuman JS,Higginbotham EJ,Kass MA,Weinreb RN,Skuta GL,Epstein DL,Shaw B,Holder DJ,Deasy DAdoi
10.1016/s0161-6420(91)32295-4subject
Has Abstract,Author List Incompletepub_date
1991-03-01 00:00:00pages
308-12; discussion 312-3issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(91)32295-4journal_volume
98pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract：OBJECTIVE:To describe the safety and efficacy of an analgesia protocol that enables the surgeon to maintain control over an alert patient experiencing seemingly painless ambulatory cataract surgery, while eliminating the risks and side effects associated with general, local, topical, and intracameral anesthesia. DESIG...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00008-7
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVE:To identify any mutation of the UbiA prenyltransferase domain-containing protein 1 (UBIAD1) gene in Japanese patients with Schnyder's crystalline corneal dystrophy (SCCD) and to investigate in vivo microstructural phenotype and genotype correlations using laser scanning confocal microscopy (Heidelberg Retina ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.12.042
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:To investigate when retinal pigment epithelium (RPE) tears occur and their associated treatment patterns and long-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD) during anti-vascular endothelial growth factor (VEGF) treatment. DESIGN:Case-control analysis from a prospe...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2017.08.039
更新日期：2018-02-01 00:00:00
abstract：:The clinical features of 290 patients with scleral inflammation were reviewed to determine whether a classification based on the anatomical site and clinical appearance of the disease at presentation reflected its natural history. The authors' results confirm that the majority of patients remain in the same clinical c...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32269-3
更新日期：1991-04-01 00:00:00
abstract：:The blue field entoptic technique was used to study autoregulation of the macular retinal circulation in response to acute alterations of intraocular pressure in 71 diabetic eyes and 30 normals matched for age, systemic blood pressure, and ophthalmic artery diastolic pressure. IOPmax, the maximal intraocular pressure ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(82)34720-x
更新日期：1982-07-01 00:00:00
abstract：PURPOSE:The authors quantified the vascular resistance for venous outflow in central retinal vein occlusion (CRVO). METHODS:The blood velocity in the central retinal vein (CRV) and central retinal artery (CRA) was measured by pulsed Doppler sonography (4-Mhz probe), and the pulse curve of the intraocular pressure (IOP...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30255-3
更新日期：1997-04-01 00:00:00
abstract：:The technique and results of conjunctival autograft transplantation for advanced and recurrent pterygium are presented for 57 eyes of 54 patients. The pterygia were primary in 16 eyes and recurrent in 41; among the latter group, 14 patients had diplopia resulting from cicatricial involvement of the medial rectus muscl...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(85)33831-9
更新日期：1985-11-01 00:00:00
abstract：PURPOSE:To present ophthalmic patient time-tradeoff vision utilities for quantifying vision-related quality-of-life when the fellow eye still has good vision. These utilities are important for performing reliable cost-utility analyses. DESIGN:Consecutive time-tradeoff vision utilities were obtained from ophthalmic pat...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2017.12.033
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic capability of optical coherence tomography (Stratus OCT 3) for early glaucoma in Asian Indian eyes. DESIGN:Cross-sectional observational study. PARTICIPANTS:Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early gla...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.03.005
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:The granular cell tumor (GCT) is a common, usually benign, neoplasm of uncertain histogenesis that may affect any organ in the body. It occurs rarely in ophthalmic sites, where orbital location is most frequent. The purpose of this report is to describe a unique case of an epibulbar, subconjunctival GCT in a...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(97)30117-1
更新日期：1997-09-01 00:00:00
abstract：:The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refractive error between -2.00 and -8.00 diopters (D). The authors report results for one eye of each patient. The surg...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)80021-0
更新日期：1987-10-01 00:00:00
abstract：OBJECTIVE:To determine the safety and efficacy of subconjunctival triamcinolone (Kenalog) in treating nonnecrotizing anterior scleritis. DESIGN:The authors conducted a retrospective review of all patients treated with depot subconjunctival corticosteroid injection for scleritis from January 1988 to May 1993. Response ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30963-3
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:We developed low-concentration homogenized castor oil eye drops for the treatment of patients with noninflamed obstructive meibomian gland dysfunction (MGD), a major cause of lipid-deficiency dry eye, and assessed the safety, stability, and efficacy of the eye drops. DESIGN:Randomized, double-masked, placebo...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(02)01262-9
更新日期：2002-11-01 00:00:00
abstract：:Asymptomatic hyperdeviation (HD) in peripheral gaze may be caused by muscle paresis, restrictive orbital diseases, cranial neuropathy, or skew deviation. The authors suspected that this finding was often physiologic and therefore examined 61 normal subjects with the Maddox rod. Forty-seven of 61 patients (77%) showed ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(88)33108-8
更新日期：1988-06-01 00:00:00
abstract：:Five hundred forty-seven reports of adverse reactions to timolol maleate received by the National Registry for Drug-induced Ocular Side Effects during an eleven-month period were reviewed. Approximately half the reports concerned systemic reactions affecting the cardiac, pulmonary, central nervous, gastrointestinal, a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35215-9
更新日期：1980-05-01 00:00:00
abstract：PURPOSE:To determine if patients with prior glaucoma surgery experience higher rates of postoperative graft dislocation after Descemet's stripping automated endothelial keratoplasty (DSAEK) and to determine if postoperative hypotony may be a risk factor in these patients. DESIGN:Retrospective, comparative analysis of ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.01.012
更新日期：2012-06-01 00:00:00
abstract：:Triamcinolone acetonide (TA) was injected subconjunctivally in nine human eyes one week before trabeculectomy. A biopsy specimen of conjunctiva and subconjunctiva was obtained from the site of drug injection, as well as a site 6 mm from the injection at the time of trabeculectomy. The tissue was evaluated by electron ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：:This article presents data gathered in a prospective clinical trial of constant monitoring of oxygen therapy on the diagnosis, severity (as coded by a severity index [SI]) and natural history of retinopathy of prematurity (ROP) in 214 surviving infants with birthweights less than or equal to 1300 g. ROP developed in 1...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:The practicality of extended-wear contact lenses in the refractive correction of pediatric aphakia was assessed with 240 eyes in 184 patients. Patient ages at the time of contact lens fitting ranged from 18 days to 9.8 years. One hundred forty-one eyes were fit from 1 day to 55 months postoperatively and then followed...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(88)33052-6
更新日期：1988-08-01 00:00:00
abstract：PURPOSE:To determine whether scleral buckle placement at the time of primary repair of open-globe injury of the posterior segment is beneficial. DESIGN:Retrospective, comparative, nonrandomized interventional study. PARTICIPANTS:One hundred twenty-five open-globe injuries treated at the Duke University Medical Center...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00212-8
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To analyze the use of the Cutler-Beard transmarginal rotation entropion clamp (Karl Ilg & Co., St. Charles, IL) in patients undergoing the Cutler-Beard procedure for repair of eyelid defects after tumor excision or trauma. DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Twenty-five patients under...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(02)01995-4
更新日期：2003-04-01 00:00:00
abstract：:An analysis of acute contact lens-related complications, with particular emphasis on severe microbial keratitis, was undertaken at the Department of Ophthalmology, Sahlgren's Hospital in Gothenburg. A total of 224 contact lens wearers presented with acute complications over a 2-year period (1981-1982). The lowest inci...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)33513-4
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:To review the published literature on the visual acuity results and complications of different surgical techniques for intraocular lens (IOL) implantation in the absence of zonular support. METHODS:Peer-reviewed literature searches were conducted last in PubMed and the Cochrane Library in July 2019. The search...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ophtha.2020.03.005
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To document the long-term effect of argon laser peripheral iridoplasty (ALPI) in eyes with plateau iris syndrome. DESIGN:Retrospective, noncomparative, interventional case series. SETTING:New York Eye and Ear Infirmary. METHODS:The charts of all patients with plateau iris syndrome treated with ALPI from 19...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.05.001
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To investigate whether interleukin (IL)-6 or vascular endothelial growth factor (VEGF) influences macular edema in patients with central retinal vein occlusion (CRVO). DESIGN:Retrospective case-control study. PARTICIPANTS:Twenty-seven patients who had macular edema with CRVO and 16 patients with nonischemic...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.09.034
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To objectively measure and compare halo, flicker, and glare disability in pseudophakic eyes with monofocal (MONO) and multifocal (MULTI) intraocular lenses (IOLs) with respect to the influence of corneal surface quality, astigmatism, and age. DESIGN:Prospective case series. PARTICIPANTS:This clinical trial ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/S0161-6420(99)90396-2
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed. METHODS:All admission records and operative reports, as well as available office notes, on patients with blebitis or bleb-associated endophthalmitis admitted to a large referral ey...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30196-1
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:To determine whether topical aqueous suppressant therapy applied after pars plana vitrectomy with gas tamponade prevents postoperative intraocular pressure (IOP) elevation. DESIGN:Prospective, nonrandomized comparative study. PARTICIPANTS:Forty-one patients who met inclusion criteria and underwent pars plan...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(99)00083-4
更新日期：2000-03-01 00:00:00
abstract：:Ocular inflammatory diseases and ocular adnexal lymphoid tumors have become less obscure and intimidating by virtue of our ability to study the infiltrates in these various diseases for their B-lymphocyte and T-lymphocyte composition. Comparisons are also possible between lymphocytic profiles in the peripheral blood a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34256-7
更新日期：1984-06-01 00:00:00
abstract：OBJECTIVE:This study aimed to assess the effect of contact lens wear on the mucosal defenses of the outer eye against infection. DESIGN:A case-controlled study of daily contact lens wearers in their initial 6 months of contact lens wear. PARTICIPANTS:Contact lens wearers (mean age, 23.1 years; 47 subjects) were compa...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(98)98031-9
更新日期：1998-08-01 00:00:00
