Abstract:
OBJECTIVE:To determine whether topical aqueous suppressant therapy applied after pars plana vitrectomy with gas tamponade prevents postoperative intraocular pressure (IOP) elevation. DESIGN:Prospective, nonrandomized comparative study. PARTICIPANTS:Forty-one patients who met inclusion criteria and underwent pars plana vitrectomy with gas tamponade (SF6 18%-20% or C3F8 12%-16%) over a 1-year period. INTERVENTION:Treatment eyes received topical aqueous suppressants at the end of surgery. MAIN OUTCOME MEASURES:Postoperative IOP at 4 to 6 hours, 1 day, and 1 week. RESULTS:Twenty-one control and 20 treatment eyes met the inclusion criteria. The IOP (in mmHg) measured at 4 to 6 hours (23.05 [control, 14.73 [treatment]) and 1 day (23.24 [control], 17.28 [treatment]) postoperatively showed a statistically significant difference between the groups (P = 0.0038) at 4 to 6 hours and a trend toward significance (P = 0.057) at 1 day. Eleven control and three treatment eyes had an IOP spike above 25 mmHg at 4 to 6 hours or 1 day postoperatively (P = 0.02), and six control eyes and one treatment eye had postoperative IOP greater than 30 mmHg. A pressure rise greater than 40 mmHg was seen in two control eyes and no treatment eyes. CONCLUSIONS:Use of topical aqueous suppressants after pars plana vitrectomy with long-acting gas tamponade is effective in preventing significant postoperative IOP elevation in most cases.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Mittra RA,Pollack JS,Dev S,Han DP,Mieler WF,Pulido JS,Connor TBdoi
10.1016/s0161-6420(99)00083-4subject
Has Abstractpub_date
2000-03-01 00:00:00pages
588-92issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(99)00083-4journal_volume
107pub_type
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