Abstract：
PURPOSE:Adrenergic substances are used widely for lowering intraocular pressure in the treatment of glaucoma. The hypothetic mechanisms for lowering the intraocular pressure by adrenergic drugs are decreased blood flow in the ciliary body and direct receptor-related reduction of aqueous humor production. The aim of this study is to measure noninvasively the blood flow in the anterior uvea in humans after topically administered dipivefrin. METHOD:The blood flow of iris and ciliary body was measured by laser Doppler flowmetry. Laser Doppler flowmetry blood flow and results of the electrocardiogram were simultaneously measured and stored over a period of 3 minutes. In the authors' setup, laser light was projected by a fiber optic transcorneally onto the iris or 2 mm transscerally from the limbus into the ciliary body. For improvement of the signal-to-noise ratio, a statistical averaging procedure was performed by averaging 100 sweeps of 2 seconds of the digitalized laser Doppler flowmetry signals triggered by the R-onset of the electrocardiogram (averaging laser Doppler flowmetry). Using this method, reproducible pulse curves of blood flow of iris and ciliary body were established with systolic maxima and diastolic minima. In a double-blind study design involving 33 young, healthy persons (mean age, 25 +/- 7 years), the effect of topically administered dipivefrin, naphazoline, and NaCl solution (0.9%) on the blood flow of iris and ciliary body was examined. RESULTS:Dipivefrin reduces significantly (average, 49%) the mean blood flow in the ciliary body. Naphazoline and NaCl solution do not change the blood flow in the ciliary body. Dipivefrin, naphazoline, and 0.9% NaCl show no significant effect on the iridal blood flow. CONCLUSION:The observed data suggest that dipivefrin decreases ciliary body blood flow.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Michelson G,Groh MJdoi
10.1016/s0161-6420(94)31281-4subject
Has Abstractpub_date
1994-04-01 00:00:00pages
659-64issue
4eissn
0161-6420issn
1549-4713pii
S0161-6420(94)31281-4journal_volume
101pub_type
临床试验,杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract：:Two cynomolgous monkeys were exposed to the light of an operating microscope. One eye was exposed to the light with the blue end of the spectrum filtered, while the other was exposed to unfiltered light. Neither group of eyes showed ophthalmoscopic evidence of a discrete retinal lesion. The eyes exposed to unfiltered ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)80024-4
更新日期：1983-08-01 00:00:00
abstract：OBJECTIVE:To report long-term follow-up of Intacs microthin prescription inserts for the management of post-LASIK corneal ectasia. DESIGN:Long-term (5 years), retrospective, nonrandomized study. PARTICIPANTS:Eight eyes of 5 patients with post-LASIK corneal ectasia (3 men and 2 women) ages 31 to 54 years (mean age+/-s...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.05.043
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:To develop a universal gene therapy to overcome the genetic heterogeneity in retinitis pigmentosa (RP) resulting from mutations in rhodopsin (RHO). DESIGN:Experimental study for a combination gene therapy that uses both gene ablation and gene replacement. PARTICIPANTS:This study included 2 kinds of human RHO ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2018.04.001
更新日期：2018-09-01 00:00:00
abstract：TOPIC:The incidence and morbidity of herpes zoster (HZ) and HZ ophthalmicus (HZO), and the potential impact of varicella vaccine on their epidemiology. CLINICAL RELEVANCE:Herpes zoster affects 20% to 30% of the population at some point in their lifetime; approximately 10% to 20% of these individuals will have HZO. ME...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ophtha.2007.10.009
更新日期：2008-02-01 00:00:00
abstract：:A retrospective clinicopathologic review of 105 cases of sympathetic ophthalmia showed histologic features of prognostic significance and evaluated the role of therapy. Classic descriptions omit retinal changes, but 58.0% of our cases had retinal detachment and 42.2% showed intraretinal inflammation. The optic nerve a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35270-6
更新日期：1980-02-01 00:00:00
abstract：OBJECTIVE:To describe presenting and corrected visual acuities after cataract surgery in a nationally representative sample of adults. Another objective was to describe refractive errors in operated eyes and to determine the optimal range of intraocular lens (IOL) powers for this population. DESIGN:Cross-sectional, po...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.08.025
更新日期：2011-04-01 00:00:00
abstract：:Three hundred eight patients with strabismus were treated with botulinum A toxin (Oculinum) chemodenervation; 153 were followed by the authors for at least 6 months. In this study group, 97 received botulinum A toxin injections as the primary method of treatment of their ocular deviation. Fifty-six received injections...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(89)32776-x
更新日期：1989-07-01 00:00:00
abstract：PURPOSE:The authors present a retrospective study designed to assess the effectiveness of the Baerveldt glaucoma implant in controlling intraocular pressure (IOP) and maintaining visual function in eyes with neovascular glaucoma. METHODS:The medical records of all 36 patients (36 eyes) who underwent Baerveldt glaucoma...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30904-9
更新日期：1995-07-01 00:00:00
abstract：PURPOSE:To examine the normative profile and determinants of macular ganglion cell-inner plexiform layer (GCIPL) thickness based on spectral-domain OCT (SD-OCT) in a nonglaucoma, multi-ethnic Asian population. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Ethnic Chinese, Malay, and Indian adults aged ≥...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2020.01.055
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:This study was undertaken to evaluate the risk of eye injury in motor vehicle accidents in which airbags deploy. An attempt was made to assess the possible associations between eye injuries and eyewear in these accidents. DESIGN:Retrospective observational case series and literature review with analysis. PART...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00244-6
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:We compared smartphone fundus photography, nonmydriatic fundus photography, and 7-field mydriatic fundus photography for their abilities to detect and grade diabetic retinopathy (DR). DESIGN:This was a prospective, comparative study of 3 photography modalities. PARTICIPANTS:Diabetic patients (n = 300) were re...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.06.011
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:To estimate the psychometric properties of a vision-targeted measure of health-related quality of life, the National Eye Institute-Refractive Error Quality of Life survey (NEI-RQL), which includes 13 scales designed to assess the impact of refractive error and its correction on day-to-day life. DESIGN:Cross-...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2002.07.001
更新日期：2003-12-01 00:00:00
abstract：PURPOSE:To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) contact lens wearers and to identify modifiable risk factors. DESIGN:Case-control investigation. PARTICIPANTS:Patients were RGP contact lens-wearing United States residents with a diagnosis of AK fro...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.03.039
更新日期：2016-07-01 00:00:00
abstract：:The successful management of suppurative microbial keratitis requires five steps: (1) make the clinical diagnosis, (2) perform the proper laboratory procedures, (3) initiate antimicrobial therapy, (4) modify the initial therapy, and (5) terminate therapy. The most helpful guidelines to decision-making in these steps a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)34943-4
更新日期：1981-08-01 00:00:00
abstract：OBJECTIVE:To describe clinical characteristics, management, and complications of primary iris stromal cysts. DESIGN:A retrospective review. RESULTS:Seventeen consecutive patients with primary iris stromal cysts were found. Nine (52%) patients were diagnosed under age 10 years (range, 1 day-7 years), and eight (47%) p...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(98)97041-5
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To describe characteristics of participants in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) at baseline and to investigate associations among visual function, fundus features, and vision-related quality of life. DESIGN:Cross-sectional study. PARTICIPANTS:The 1052 participant...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2003.10.031
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:The purpose of the study is to assess the strengths and weaknesses of selected clinical and radiologic lacrimal tests in patients with epiphora. DESIGN:The study design was a prospective clinical trial. PARTICIPANTS:Fifteen patients with epiphora (N = 27 eyes) were studied. METHODS:All patients underwent J...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(97)30013-x
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To evaluate whether an ophthalmologist-led, non-anesthesia-supported, limited monitoring pathway for phacoemulsification/intraocular lens cataract surgery, can be performed safely with only a medical emergency team providing support. DESIGN:Retrospective, observational, cohort study. PARTICIPANTS:All patien...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.08.030
更新日期：2015-02-01 00:00:00
abstract：:The authors have reviewed the clinical presentation, visual fields, color vision testing, visual-evoked potentials, and computed tomographic (CT) findings of 58 patients (95 eyes) with dysthyroid optic neuropathy. The authors compared these findings to a control group of 60 patients (119 eyes) with thyroid eye disease...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(88)32978-7
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:To develop a simulator for training in phacoemulsification to be used as a learning device for both beginners and experienced surgeons to shorten the learning curve. DESIGN:Experimental study. METHODS:The system consists of a personal computer, a 3-dimensional visual interface, a phacoemulsification handpie...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.06.023
更新日期：2004-04-01 00:00:00
abstract：:After the appropriate workup, the size, location, and consistency of an orbital mass will dictate the surgical approach chosen. Masses in the muscle cone area or in the temporal portion of the orbit are most easily approached by the lateral orbitotomy. For lacrimal gland tumors a superior extension of the lateral orbi...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35440-9
更新日期：1979-05-01 00:00:00
abstract：OBJECTIVE:West Nile virus (WNV) disease is a zoonotic infection with recent outbreaks in the United States. Recent reports have highlighted the intraocular findings associated with WNV disease. We describe the intraocular findings observed in two patients infected by the West Nile virus. DESIGN:Observational case repo...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00720-6
更新日期：2003-09-01 00:00:00
abstract：:The authors studied the characteristics of 376 eyes of 361 patients with primary retinal detachment (RD) and surgical aphakia (103 eyes) or pseudophakia (273 eyes). Of the pseudophakic eyes, 17 had an iris-fixated intraocular lens (IOL), 111 had an anterior chamber (AC) IOL, and 145 had a posterior chamber (PC) IOL. O...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(92)31953-0
更新日期：1992-03-01 00:00:00
abstract：PURPOSE:To determine the prevalence of relative anterior microphthalmos (RAM) and evaluate intraoperative performance and surgical outcome in eyes with RAM undergoing cataract surgery. DESIGN:Nested case-control series. PARTICIPANTS:One thousand four hundred consecutive patients undergoing cataract surgery were evalu...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.02.027
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:To study the anatomic and visual outcomes of a surgical procedure in which tissue plasminogen activator and air are injected subretinally to displace massive submacular hemorrhages secondary to age-related macular degeneration. DESIGN:Prospective, consecutive, interventional case series. PARTICIPANTS:Thirte...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.07.027
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To investigate the impact of age-related change of macular and circumpapillary retinal nerve fiber layer (RNFL) measurements on evaluation of glaucoma progression. DESIGN:Prospective, longitudinal study. PARTICIPANTS:A total of 150 eyes of 90 patients with glaucoma and 72 eyes of 40 normal individuals. MET...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.07.021
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:To describe the morphologic and anatomic relationships at the vitreoretinal interface, from the macula into the periphery, in patients with idiopathic macular hole. Montaged images of posterior and peripheral spectral-domain (SD) optical coherence tomography (OCT) studies were used to describe the anatomic vitr...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.06.027
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:To assess the status of choriocapillaris in eyes with macular atrophy secondary to age-related macular degeneration (AMD) (geographic atrophy [GA]) and Stargardt disease (STGD) using optical coherence tomography angiography (OCTA). DESIGN:Prospective, observational case series. PARTICIPANTS:A total of 14 pati...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.05.041
更新日期：2016-09-01 00:00:00
abstract：:In a comparative study, subjective refractions were carried out on 115 normal subjects and 118 patients with four instruments (Humphrey Vision Analyzer, Möller/CooperVision Visutron, Reichert SR-IV, Rodenstock/Coburn Phoromat). The accuracy of the prescriptions obtained, the visual acuity results and the measurement t...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(86)33586-3
更新日期：1986-09-01 00:00:00
abstract：OBJECTIVE:To compare the ice test with the rest test in subjects with myasthenic and nonmyasthenic ptosis. DESIGN:Randomized, noninterventional trial. PARTICIPANTS:(1) Ten subjects with ptosis from previously undiagnosed myasthenia gravis. (2) Fifteen subjects with nonmyasthenic ptosis. METHODS:Application of ice co...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(00)00458-9
更新日期：2000-11-01 00:00:00
