Abstract：
PURPOSE:To describe the value and the results of screening of family members of individuals with familial chronic open-angle glaucoma (COAG) for the disease. DESIGN:Cross-sectional study of families with COAG. PARTICIPANTS:Eighty-six individuals from 15 families with COAG. TESTING:Complete ophthalmologic examinations, automated perimetry, and optic nerve photography. MAIN OUTCOME MEASURES:Disease status as glaucoma patient (at least two of three parameters abnormal: intraocular pressure, visual field, or disc appearance), glaucoma suspect (one of three parameters abnormal), or normal. RESULTS:Twenty-six relatives were diagnosed with COAG. The diagnosis was most frequently made on the basis of intraocular pressure readings and automated perimetry. Twenty-three relatives were classified as glaucoma suspects; automated perimetry was the most useful modality for the detection of abnormalities in these individuals. Siblings of COAG patients had the highest risk of COAG developing (64.7%) compared with children (13.2%) or other blood relatives (22.2%). CONCLUSIONS:When COAG is present in more than one family member, immediate and other relatives should be evaluated for glaucoma by means of clinical examination and automated perimetry.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Nguyen RL,Raja SC,Traboulsi EIdoi
10.1016/s0161-6420(00)00156-1subject
Has Abstractpub_date
2000-07-01 00:00:00pages
1294-7issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(00)00156-1journal_volume
107pub_type
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