Abstract:
PURPOSE:To evaluate the effect of dopaminergic medication and deep brain stimulation on ocular function in Parkinson's disease (PD) and to measure vision-related quality of life in subjects with PD. DESIGN:Prospective, comparative case series. PARTICIPANTS AND CONTROLS:Twenty-seven PD and 16 control subjects were recruited. METHODS:Visual acuity, ocular motor function, convergence, and vision-related quality of life using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) were measured. Visual sensory and motor measurements were obtained during the on and off states of PD dopaminergic treatment. MAIN OUTCOME MEASURES:Convergence ability and vision-related quality of life. RESULTS:The PD subjects had a mean age of 58.8 years; 30% were female. Their mean duration of PD was 10.9 ± 6.8 years. The control subjects had a mean age of 61.6 years; 56% were female. There was no difference in visual acuity, contrast sensitivity, or color vision of the PD subjects in their on state compared with controls. Convergence amplitudes measured with base-out prism were significantly poorer in PD subjects in their on state compared with controls (24.1 ± 8 Δ vs. 14.8 ± 10.3 Δ; P = 0.003). The mean composite VFQ-25 score was significantly worse in the PD subjects compared with the controls (87.1 ± 8.69 vs. 96.6 ± 3.05; P = 0.0001). Comparing the PD subjects in their on with their off states, there was no difference in distance exodeviation, near exodeviation, or ocular ductions. Mean convergence amplitudes and near point of convergence were better in the on state compared with the off state: 14.8 ± 10.3 Δ versus 10.7 ± 9.0 Δ (P = 0.0006) and 13.1 ± 9.1 cm versus 18.1 ± 12.2 cm (P = 0.002), respectively. CONCLUSIONS:Convergence ability is significantly poorer in PD subjects in both the on and off states compared with controls, but improves significantly with systemic dopaminergic treatment. Ocular motor function in PD subjects fluctuates in response to treatment, which complicates ophthalmic management. Parkinson's disease subjects have a significant reduction in vision-related quality of life, especially with near activities, that is not associated with visual acuity. FINANCIAL DISCLOSURE(S):The author(s) have no proprietary or commercial interest in any materials discussed in this article.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Almer Z,Klein KS,Marsh L,Gerstenhaber M,Repka MXdoi
10.1016/j.ophtha.2011.06.040subject
Has Abstractpub_date
2012-01-01 00:00:00pages
178-82issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(11)00619-1journal_volume
119pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract::The authors have reviewed the clinical presentation, visual fields, color vision testing, visual-evoked potentials, and computed tomographic (CT) findings of 58 patients (95 eyes) with dysthyroid optic neuropathy. The authors compared these findings to a control group of 60 patients (119 eyes) with thyroid eye disease...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)32978-7
更新日期:1988-11-01 00:00:00
abstract::The age distribution, frequency, and correlation among histologic macular changes, including formation of a basal laminar deposit, drusen, and thickening and calcification of Bruch's membrane, were studied by light microscopy. The authors studied 182 unpaired postmortem human maculae from patients between 8 and 100 ye...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31982-7
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma. DESIGN:Cross-sectional study. PARTICIPANTS:Twenty-three eyes with PAS (detected by indentation gonioscopy) fr...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.12.006
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the change in intraocular pressure (IOP) in subjects with Graves' orbitopathy (GO) after orbital decompression, strabismus surgery, and orbital radiation. DESIGN:Retrospective case review. METHODS:The charts of 172 consecutive subjects from the Neuro-ophthalmology Service at Wills Eye Hospital (...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00477-2
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To describe 2 adult patients who presented with papilledema after band atrophy (i.e., twin and triple peaks papilledema). DESIGN:Retrospective small case series. PARTICIPANTS:Two outpatients. METHODS:Observations made on 2 patients whose cases were reviewed in the neuro-ophthalmology clinic. RESULTS:The fir...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.01.047
更新日期:2005-07-01 00:00:00
abstract::An integrated ophthalmic office computer system is now functional at five sites. The system automates clerical functions such as appointment scheduling, billing, and preparation of doctors' schedules and insurance forms. It eliminates the need for filing and storage of records. The medical system records the history a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35060-x
更新日期:1981-02-01 00:00:00
abstract:PURPOSE:To study the associations between long-term and short-term use of topical beta-blockers and mortality. DESIGN:Prospective population-based cohort study. PARTICIPANTS:To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484 incident beta-blocker...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.07.004
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:To determine the incidence of full-thickness macular holes in Olmsted County, Minnesota. DESIGN:Population-based retrospective chart review (cross-sectional study). PARTICIPANTS:Ninety-four eyes of 85 patients who were residents of Olmsted County, Minnesota. METHODS:A population-based retrospective chart rev...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.01.052
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To determine the antibiotic susceptibility patterns of conjunctival bacterial flora isolated preoperatively from patients undergoing anterior segment surgery. DESIGN:Prospective observational study. PARTICIPANTS:One hundred fifty-six eyes from 139 patients scheduled for anterior segment surgery were enrolled ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(03)00735-8
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:To evaluate the clinical features and management of diffuse infiltrating retinoblastoma. DESIGN:Retrospective case series. PARTICIPANTS:Thirty-four eyes in 32 patients. METHODS:The patients' records were reviewed for patient and tumor features, ocular management, histopathologic findings, and patient surviva...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.07.003
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To learn whether dilating the pupil will have an impact on glare testing for cataract evaluation. DESIGN:Evaluation of diagnostic test. PARTICIPANTS:Fifty-four adult patients at the Jones Eye Institute at the University of Arkansas for Medical Sciences. METHODS:One eye of each patient was randomized for stud...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.01.043
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To present the largest cohort of preschool children screened by the MTI PhotoScreener over a 9-year period from a single, statewide vision screening effort. DESIGN:Cross-sectional study. PARTICIPANTS:We included 147,809 children screened between May 1, 2000, and April 30, 2009 by a photoscreening program. ME...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.03.036
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To determine the presence of 4 clinically relevant bacterial endosymbionts in Acanthamoeba isolates obtained from patients with Acanthamoeba keratitis (AK) and the possible contribution of endosymbionts to the pathogenesis of AK. DESIGN:Experimental study. PARTICIPANTS:Acanthamoeba isolates (N = 37) recovered...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.08.033
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:West Nile virus (WNV) disease is a zoonotic infection with recent outbreaks in the United States. Recent reports have highlighted the intraocular findings associated with WNV disease. We describe the intraocular findings observed in two patients infected by the West Nile virus. DESIGN:Observational case repo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00720-6
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To determine the incidence and types of posterior staphylomas in eyes with pathologic myopia by analyzing the entire eye shape by 3-dimensional (3D) magnetic resonance imaging (MRI). DESIGN:Observational, case series. PARTICIPANTS:A total of 105 patients with pathologic myopia (spherical equivalent <-8.0 diop...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.03.035
更新日期:2014-09-01 00:00:00
abstract::Carbonic anhydrase inhibitors used in the treatment of glaucoma are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This report documents two cases of aplastic anemia, at least one of w...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35229-9
更新日期:1980-04-01 00:00:00
abstract::Immunologic differences exist between the peripheral and central cornea. The peripheral cornea is closer to the conjunctiva, which has all of the immunologic machinery necessary to generate an immune response. The peripheral cornea has more Langerhans' cells and IgM than the central cornea. The peripheral cornea also ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(88)33164-7
更新日期:1988-04-01 00:00:00
abstract::This article discusses the experience of progressing from a young ophthalmic resident to a full-time professional and, ultimately, to service on the American Board of Ophthalmology. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.06.013
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To compare the rotational stability of the 2 most commonly used toric intraocular lenses (TIOLs). DESIGN:Retrospective cohort study in a single private practice. SUBJECTS:The study included all patients receiving an Acrysof (n = 626) or Tecnis TIOL (n = 647) over an 18-month period from April 2015 to Septembe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.02.012
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To evaluate the association between use of antiplatelet or anticoagulant drugs and retinal or subretinal hemorrhage in participants with neovascular age-related macular degeneration (AMD) in the Comparison of AMD Treatments Trials (CATT). DESIGN:Cohort study within CATT. PARTICIPANTS:Participants in CATT with...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2015.09.046
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To evaluate the clinical results of epi-LASIK for the treatment of low to moderate myopia and myopic astigmatism. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Two hundred thirty-four eyes of 138 patients underwent epi-LASIK for the correction of low to moderate myopia. Mean p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.08.052
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To ascertain the clinical features, visual outcome, and recurrence rates of ocular toxoplasmosis (OT) in a large series of patients. To determine the efficacy of various treatment strategies and identify the patients at risk of visual loss. DESIGN:Retrospective noncomparative observational case series. PARTIC...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)00990-9
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To report the incidence of macular hole reopening after initial successful surgery. DESIGN:A noncomparative retrospective case series. PARTICIPANTS:From a series of 137 consecutive cases of idiopathic macular holes operated on between August 1993 and May 1996, the authors analyzed the charts of 116 cases of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00182-7
更新日期:2000-04-01 00:00:00
abstract::The accurate clinical diagnosis of benign mixed tumors of the lacrimal gland is imperative for proper therapeutic management. Although benign mixed tumors of the orbital portion of the lacrimal gland have an established identity, those tumors arising in the palpebral lobe are unusual. Four patients with benign mixed t...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32572-1
更新日期:1990-04-01 00:00:00
abstract::The pattern dystrophies are a group of hereditary macular dystrophies characterized by lesions of the retinal pigment epithelium (RPE) arranged in various patterns of dots, lines, and branched figures. This report of two pedigrees expands the clinical spectrum. The onset is usually in the second and third decade, ther...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34632-1
更新日期:1982-12-01 00:00:00
abstract::Twenty-five ambulatory patients with acquired immunodeficiency syndrome (AIDS) were studied over a 6-month period. Fourteen (56%) of the patients were heterosexuals with a history of intravenous drug abuse. Ocular involvement was seen in 40% of patients, cotton-wool spots being the major manifestation. Findings consis...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:To measure the magnitude and direction of visual field (VF) rates of change in glaucoma patients after intraocular pressure (IOP) reduction with trabeculectomy. DESIGN:Retrospective, comparative, longitudinal cohort study. PARTICIPANTS:Patients with open-angle glaucoma. METHODS:Patients who underwent trabecu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.09.027
更新日期:2016-01-01 00:00:00
abstract::Thirteen keratophakia patients were followed for 13 to 35 months. Eighteen cases of hyperopic keratomileusis or hyperopic keratomileusis using preserved corneal tissue were followed for 2 to 30 months. All 13 patients who underwent keratophakia achieved 20/50 or better acuity. All seven patients having hyperopic kerat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34957-4
更新日期:1981-08-01 00:00:00
abstract:PURPOSE:Although the impact of vision-related quality of life (VRQoL) is assessed optimally using binocular visual acuity (VA), uniocular VA remains the preferred measurement method in clinic-based and epidemiologic studies. We compared the impact of distance presenting binocular VA and uniocular VA in the better-seein...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.01.056
更新日期:2020-09-01 00:00:00
abstract::Eyes undergoing routine intracapsular cataract extraction (without alpha-chymotrypsin) often experience marked ocular hypertension in the first six hours after surgery. We conducted a randomized, prospective, double-blind study to determine if timolol maleate would prevent this increase in pressure. Thirty-five eyes u...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(81)35053-2
更新日期:1981-03-01 00:00:00