Blood dyscrasias in patients using methazolamide (neptazane) for glaucoma.

Abstract:

:Carbonic anhydrase inhibitors used in the treatment of glaucoma are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This report documents two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, one case of agranulocytosis, and two cases of neutropenia related to the use of methazolamide. In each case several weeks to months elapsed between initiation of therapy and onset of reaction. This suggests that changes in patients' general medical condition should be continually monitored when using these drugs.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Werblin TP,Pollack IP,Liss RA

doi

10.1016/s0161-6420(80)35229-9

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

350-4

issue

4

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(80)35229-9

journal_volume

87

pub_type

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