Clinical spectrum of diffuse infiltrating retinoblastoma in 34 consecutive eyes.


PURPOSE:To evaluate the clinical features and management of diffuse infiltrating retinoblastoma. DESIGN:Retrospective case series. PARTICIPANTS:Thirty-four eyes in 32 patients. METHODS:The patients' records were reviewed for patient and tumor features, ocular management, histopathologic findings, and patient survival. MAIN OUTCOME MEASURES:Clinical features, tumor management, and patient survival. RESULTS:Of 1507 patients with retinoblastoma, only 32 (2%) were classified with diffuse infiltrating retinoblastoma. The mean age at diagnosis was 4 years (range 1.5-16 years). The referring diagnoses included retinoblastoma (26 eyes, 76%), uveitis (3, 9%), Coats disease (1, 3%), trauma (1, 3%), and unspecified retinal problem (3, 9%). The anterior segment displayed tumor seeds on the corneal endothelium (8, 24%), cornea stromal edema (3, 9%), pseudohypopyon (11, 32%), hyphema (3, 9%), iris neovascularization (17, 50%), and iris tumor nodules (6, 18%). The posterior segment revealed extensive ill-defined retinoblastoma infiltrating the retina for a mean basal diameter of 20 mm and overall flat growth, sometimes with undulating retinal thickening. Overlying extensive vitreous tumor seeds (31, 91%) and vitreous hemorrhage (8, 24%) were noted. Calcification was present on ultrasonography (27/34, 79%) and computed tomography (8/9, 89%). Enucleation was performed for all 34 eyes, and there were no cases of metastases at 47 months follow-up. CONCLUSIONS:Diffuse infiltrating retinoblastoma can masquerade as uveitis or unexplained hyphema or keratic precipitates. Suspicion for retinoblastoma is important. FINANCIAL DISCLOSURE(S):The authors have no proprietary or commercial interest in any materials discussed in this article.






Shields CL,Ghassemi F,Tuncer S,Thangappan A,Shields JA




Has Abstract


2008-12-01 00:00:00














  • Scleral buckling in 2 1/2- to 11-month-old premature infants with retinal detachment associated with acute retrolental fibroplasia.

    abstract::The authors' experience over the past five years in the cryosurgical management of retinal detachment in ten eyes of eight premature infants with retrolental fibroplasia, whose ages at the time of detachment surgery ranged from 2 1/2 months to 11 months with an average of 5 1/2 months, is reported. Postoperative follo...


    pub_type: 杂志文章


    authors: McPherson A,Hittner HM

    更新日期:1979-05-01 00:00:00

  • Topographic analyses of shape of eyes with pathologic myopia by high-resolution three-dimensional magnetic resonance imaging.

    abstract:OBJECTIVE:To analyze the topography of human eyes with pathologic myopia by high-resolution magnetic resonance imaging (MRI) with volume rendering of the acquired images. DESIGN:Observational case series. PARTICIPANTS:Eighty-six eyes of 44 patients with high myopia (refractive error ≥-8.00 diopters [D] or axial lengt...


    pub_type: 杂志文章


    authors: Moriyama M,Ohno-Matsui K,Hayashi K,Shimada N,Yoshida T,Tokoro T,Morita I

    更新日期:2011-08-01 00:00:00

  • Foveal Hypoplasia in Patients with Stickler Syndrome.

    abstract:PURPOSE:To determine the microstructure of the fovea in patients with Stickler syndrome using imaging by spectral-domain optical coherence tomography (SD OCT) and swept-source OCT. DESIGN:Retrospective case series study. PARTICIPANTS:A total of 39 eyes of 25 patients with genetically confirmed Stickler syndrome were ...


    pub_type: 杂志文章,多中心研究


    authors: Matsushita I,Nagata T,Hayashi T,Kimoto K,Kubota T,Ohji M,Kusaka S,Kondo H

    更新日期:2017-06-01 00:00:00

  • Retinal Specialist versus Artificial Intelligence Detection of Retinal Fluid from OCT: Age-Related Eye Disease Study 2: 10-Year Follow-On Study.

    abstract:PURPOSE:To evaluate the performance of retinal specialists in detecting retinal fluid presence in spectral domain OCT (SD-OCT) scans from eyes with age-related macular degeneration (AMD) and compare performance with an artificial intelligence algorithm. DESIGN:Prospective comparison of retinal fluid grades from human ...


    pub_type: 杂志文章


    authors: Keenan TDL,Clemons TE,Domalpally A,Elman MJ,Havilio M,Agrón E,Benyamini G,Chew EY

    更新日期:2021-01-01 00:00:00

  • Specular microscopy of hard contact lens wearers II.

    abstract::Specular microscopy was done on 65 long-term hard contact lens (CL) wearers and controls matched for age, sex, race, and refractive error. There was no difference in mean endothelial cell size between the two groups, although median cell area was slightly smaller in the CL group. Standard deviation and coefficient of ...


    pub_type: 杂志文章


    authors: Yamauchi K,Hirst LW,Enger C,Rosenfeld J,Vogelpohl W

    更新日期:1989-08-01 00:00:00

  • Extraocular extension of unrecognized choroidal melanoma simulating a primary optic nerve tumor: report of two cases.

    abstract:BACKGROUND:Orbital extraocular extension of choroidal melanoma is well known and is usually detected in eyes with medium and large tumors, but it is very rare with small melanomas. It is particularly unusual for choroidal melanomas of any size to invade the optic nerve or its meninges. DESIGN:Two case reports. PARTIC...


    pub_type: 杂志文章


    authors: Shields CL,Santos MC,Shields JA,Singh AD,Eagle RC Jr

    更新日期:1999-07-01 00:00:00

  • Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

    abstract:PURPOSE:To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN:Multicenter, prospective cohort study. PARTICIPANTS:A total of 1061 subjects in CATT. METHODS:Color photographic and fluorescein angi...


    pub_type: 杂志文章,多中心研究


    authors: Daniel E,Pan W,Ying GS,Kim BJ,Grunwald JE,Ferris FL 3rd,Jaffe GJ,Toth CA,Martin DF,Fine SL,Maguire MG,Comparison of Age-related Macular Degeneration Treatments Trials.

    更新日期:2018-07-01 00:00:00

  • Abscessed hydroxyapatite orbital implants. A report of two cases.

    abstract:PURPOSE:The authors describe the rare condition of an abscess within a hydroxyapatite orbital implant in two patients who had undergone seemingly uncomplicated enucleation and orbital implant surgery. METHODS:In the first patient, 14 weeks postoperatively, a chronic discharge developed and the socket became uncomforta...


    pub_type: 杂志文章


    authors: Jordan DR,Brownstein S,Jolly SS

    更新日期:1996-11-01 00:00:00

  • Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal Imaging.

    abstract:PURPOSE:To assess the prevalence of subretinal drusenoid deposits (SDD) in older adults with healthy maculas and early and intermediate age-related macular degeneration (AMD) using multimodal imaging. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 651 subjects aged ≥60 years enrolled in the Alabama Study of Ea...


    pub_type: 杂志文章


    authors: Zarubina AV,Neely DC,Clark ME,Huisingh CE,Samuels BC,Zhang Y,McGwin G Jr,Owsley C,Curcio CA

    更新日期:2016-05-01 00:00:00

  • Holmium laser thermokeratoplasty.

    abstract:PURPOSE:Corneal curvature can be altered by shrinking stromal collagen with a pulsed solid-state holmium: YAG laser in a procedure termed laser thermokeratoplasty. METHODS:The authors performed laser thermokeratoplasty in 40 human cadaver eyes using a ring pattern of 32 spots, each spot having a diameter of 300 micron...


    pub_type: 杂志文章


    authors: Moreira H,Campos M,Sawusch MR,McDonnell JM,Sand B,McDonnell PJ

    更新日期:1993-05-01 00:00:00

  • Foldable Artiflex phakic intraocular lens for the correction of myopia: two-year follow-up results of a prospective European multicenter study.

    abstract:OBJECTIVE:To evaluate the safety, efficacy, predictability, stability, and complications of the foldable Artiflex iris-fixated intraocular lens (Ophtec BV, Groningen, The Netherlands) for the correction of myopia in phakic eyes. DESIGN:Prospective, nonrandomized, open-label, multicenter trial. PARTICIPANTS:Two hundre...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Dick HB,Budo C,Malecaze F,Güell JL,Marinho AA,Nuijts RM,Luyten GP,Menezo JL,Kohnen T

    更新日期:2009-04-01 00:00:00

  • Three-year treatment outcomes in the Ahmed Baerveldt comparison study.

    abstract:PURPOSE:To compare 3-year outcomes and complications of the Ahmed FP7 Glaucoma Valve (AGV) (New World Medical, Cucamonga, CA) and the Baerveldt Glaucoma Implant (BGI) 101-350 (Abbott Medical Optics, Abbott Park, IL) for the treatment of refractory glaucoma. DESIGN:Multicenter, randomized, controlled clinical trial. P...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Barton K,Feuer WJ,Budenz DL,Schiffman J,Costa VP,Godfrey DG,Buys YM,Ahmed Baerveldt Comparison Study Group.

    更新日期:2014-08-01 00:00:00

  • Retinal detachment after cataract surgery. Predisposing factors.

    abstract::The authors studied the characteristics of 376 eyes of 361 patients with primary retinal detachment (RD) and surgical aphakia (103 eyes) or pseudophakia (273 eyes). Of the pseudophakic eyes, 17 had an iris-fixated intraocular lens (IOL), 111 had an anterior chamber (AC) IOL, and 145 had a posterior chamber (PC) IOL. O...


    pub_type: 杂志文章


    authors: Yoshida A,Ogasawara H,Jalkh AE,Sanders RJ,McMeel JW,Schepens CL

    更新日期:1992-03-01 00:00:00

  • A small foveal avascular zone may be an historic mark of prematurity.

    abstract:OBJECTIVE:To compare in children the area and diameter of the foveal avascular zone (FAZ) of former preterm infants, when no significant retinopathy of prematurity (ROP) developed, to the area and diameter of the FAZ of former term infants. DESIGN:Retrospective observational case series and literature review. PARTICI...


    pub_type: 杂志文章


    authors: Mintz-Hittner HA,Knight-Nanan DM,Satriano DR,Kretzer FL

    更新日期:1999-07-01 00:00:00

  • Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract.

    abstract:PURPOSE:To analyze the association of the polymorphisms in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and AP endonuclease-1 (APE1) genes in the base excision repair pathway and xeroderma pigmentosum complementation group D (XPD) in the nucleotide excision repair pathway with the risk...


    pub_type: 杂志文章


    authors: Zhang Y,Zhang L,Song Z,Sun DL,Liu HR,Fu SB,Liu DR,Liu P

    更新日期:2012-05-01 00:00:00

  • Anterior granulomatous uveitis in patients with multiple sclerosis.

    abstract::Granulomatous uveitis has infrequently been described as a manifestation of the autoimmune phenomena of multiple sclerosis (MS). The authors describe six cases of anterior granulomatous uveitis in patients with MS. All six patients had features of iridocyclitis and three patients had features of periphlebitis, which w...


    pub_type: 杂志文章


    authors: Lim JI,Tessler HH,Goodwin JA

    更新日期:1991-02-01 00:00:00

  • Warburg syndrome.

    abstract::Warburg syndrome is a congenital oculocerebral disorder. It is caused by a genetic defect that simultaneously affects ocular and cerebral embryogenesis. The characteristic ophthalmic findings reflect the cerebral malformation (agyria or lissencephaly). Two cases, siblings, have been described. The characteristic bilat...


    pub_type: 杂志文章


    authors: Levine RA,Gray DL,Gould N,Pergament E,Stillerman ML

    更新日期:1983-12-01 00:00:00

  • Longitudinal Changes of Optic Nerve Head and Peripapillary Structure during Childhood Myopia Progression on OCT: Boramae Myopia Cohort Study Report 1.

    abstract:PURPOSE:To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN:Prospective cohort study. PARTICIPANTS:Twenty-three healthy ...


    pub_type: 杂志文章


    authors: Kim M,Choung HK,Lee KM,Oh S,Kim SH

    更新日期:2018-08-01 00:00:00

  • Clinical ability of Heidelberg retinal tomograph examination to detect glaucomatous visual field changes.

    abstract:PURPOSE:To determine the agreement between Heidelberg Retinal Tomograph (HRT; Heidelberg Instruments, Heidelberg, Germany) and visual field examinations in differentiating normal from glaucomatous eyes and to evaluate the sensitivity and specificity of HRT optic disc examination in detecting eyes with glaucomatous dama...


    pub_type: 杂志文章


    authors: Miglior S,Casula M,Guareschi M,Marchetti I,Iester M,Orzalesi N

    更新日期:2001-09-01 00:00:00

  • A new low-concentration preparation for mydriasis and cycloplegia.

    abstract::This study was designed to evaluate a low-concentration, cycloplegic-mydriatic mixture of phenylephrine and tropicamide in a routine office examination. No clinically significant difference in pupillary dilation was found between the usual instillation of the standard, commercially available phenylephrine 10% and trop...


    pub_type: 杂志文章


    authors: Forman AR

    更新日期:1980-03-01 00:00:00

  • Validity of self-report in type 1 diabetic subjects for laser treatment of retinopathy.

    abstract:PURPOSE:This study sought to determine the validity of self-report of prior panretinal photocoagulation (PRP) and focal photocoagulation (FP) compared with fundus photography. DESIGN:Prospective cohort study. PARTICIPANTS:One thousand three hundred sixty-three type 1 diabetic subjects from the Epidemiology of Diabete...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Grassi MA,Sun W,Gangaputra S,Cleary PA,Hubbard L,Lachin JM,Gao X,Kiss S,Barkmeier AJ,Almony A,Davis M,Klein R,Danis RP,DCCT\/EDIC Research Group.

    更新日期:2013-12-01 00:00:00

  • Patients with Sjögren-Larsson syndrome lack macular pigment.

    abstract:PURPOSE:Sjögren-Larsson syndrome (SLS), an autosomal recessive hereditary disorder with congenital ichthyosis, spastic diplegia or tetraplegia, and mental retardation, reveals a characteristic macular dystrophy with intraretinal crystals and foveal pseudocysts. Ophthalmic symptoms in SLS are reduced visual acuity and p...


    pub_type: 杂志文章


    authors: van der Veen RL,Fuijkschot J,Willemsen MA,Cruysberg JR,Berendschot TT,Theelen T

    更新日期:2010-05-01 00:00:00

  • Prevalence of lens opacities in Latinos: the Los Angeles Latino Eye Study.

    abstract:OBJECTIVE:To estimate the age- and gender-specific prevalence of posterior subcapsular (PSC), nuclear, cortical, and mixed lens opacities in a population-based sample of Latinos 40 years and older. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Six thousand three hundred fifty-seven Latinos 40 years and...


    pub_type: 杂志文章


    authors: Varma R,Torres M,Los Angeles Latino Eye Study Group.

    更新日期:2004-08-01 00:00:00

  • Cataract Surgery Outcomes in Uveitis: The Multicenter Uveitis Steroid Treatment Trial.

    abstract:PURPOSE:To assess the visual outcomes of cataract surgery in eyes that received fluocinolone acetonide implant or systemic therapy with oral corticosteroids and immunosuppression during the Multicenter Uveitis Steroid Treatment (MUST) Trial. DESIGN:Nested prospective cohort study of patients enrolled in a randomized c...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sen HN,Abreu FM,Louis TA,Sugar EA,Altaweel MM,Elner SG,Holbrook JT,Jabs DA,Kim RY,Kempen JH,Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study Research Group.

    更新日期:2016-01-01 00:00:00

  • Measurement of intraocular pressure with a flat anterior chamber.

    abstract::When a flat chamber develops in an eye after filtration surgery, management depends on whether the cause is excessive filtration or aqueous misdirection (ciliary block or malignant glaucoma). This diagnosis is often based on the intraocular pressure: low pressure in excessive filtration, high pressure in aqueous misdi...


    pub_type: 杂志文章


    authors: Wright MM,Grajewski AL

    更新日期:1991-12-01 00:00:00

  • Evaluation of artifacts associated with macular spectral-domain optical coherence tomography.

    abstract:PURPOSE:To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements. DESIGN:Retrospective, observational chart review. PARTICIPANT...


    pub_type: 杂志文章


    authors: Han IC,Jaffe GJ

    更新日期:2010-06-01 00:00:00

  • Clinical characteristics of reticular pseudodrusen in the fellow eye of patients with unilateral neovascular age-related macular degeneration.

    abstract:PURPOSE:To describe associations between reticular pseudodrusen, individual characteristics, and retinal function. DESIGN:Cohort study. PARTICIPANTS:We recruited 105 patients (age range, 52-93 years) who had advanced neovascular age-related macular degeneration (AMD) in only 1 eye from 3 clinical centers in Europe. ...


    pub_type: 杂志文章


    authors: Hogg RE,Silva R,Staurenghi G,Murphy G,Santos AR,Rosina C,Chakravarthy U

    更新日期:2014-09-01 00:00:00

  • Comparative evaluation of the Autofield-I, CFA-120, and Fieldmaster Model 101-PR automated perimeters.

    abstract::Clinical evaluations of the Autofield-I, CFA-120, and Fieldmaster Model 101-PR automated perimeters were performed in comparison with manual kinetic testing on the Goldmann perimeter. All the automated perimeters displayed similar high rates of detecting visual field defects, although their false-alarm (false-positive...


    pub_type: 杂志文章


    authors: Johnson CA,Keltner JL

    更新日期:1980-08-01 00:00:00

  • Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.

    abstract:PURPOSE:To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS:Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citat...


    pub_type: 杂志文章,评审


    authors: Shtein RM,Shen JF,Kuo AN,Hammersmith KM,Li JY,Weikert MP

    更新日期:2020-01-01 00:00:00

  • Immunocytochemical diagnosis as inflammation by vitrectomy cell blocks in patients with vitreous opacity.

    abstract:PURPOSE:To describe the clinical and cytopathologic characteristics in patients with vitreous opacity of unknown cause or preceding inflammation, diagnosed cytopathologically as inflammation. DESIGN:Retrospective case series. PARTICIPANTS:Forty-three consecutive patients (61 eyes) who underwent vitrectomy for vitreou...


    pub_type: 杂志文章


    authors: Matsuo T,Ichimura K

    更新日期:2012-04-01 00:00:00