Inflammatory diseases of the peripheral cornea.


:Immunologic differences exist between the peripheral and central cornea. The peripheral cornea is closer to the conjunctiva, which has all of the immunologic machinery necessary to generate an immune response. The peripheral cornea has more Langerhans' cells and IgM than the central cornea. The peripheral cornea also has more C1, the recognition unit of the classic pathway of complement, than the central cornea so that antigen-antibody complexes, whether formed in the cornea itself or whether derived from the tears, aqueous humor, or limbal vessels, may activate complement more effectively in the peripheral than central cornea. Autoimmune diseases that involve the peripheral cornea include Mooren's ulcer and collagen vascular diseases. The humoral- and cell-mediated autoimmune phenomena that are associated with Mooren's ulcer and its response to immunosuppressive therapy suggest that it is an autoimmune disease directed against the cornea itself. Collagen vascular diseases may be associated with peripheral corneal ulcers with or without scleritis. In these diseases, circulating immune complexes may lodge in the limbal vasculature causing an immune vasculitis or deposit in the peripheral cornea setting off the complement cascade. Peripheral corneal diseases that probably represent a hypersensitivity reaction to exogenous antigens include catarrhal infiltrates and ulcers and phlyctenules. In the United States today, these corneal lesions are generally associated with staphylococcal blepharitis. Experimental models suggest that hypersensitivity to Staphylococcus aureus cell wall antigens may be important to their immunopathogenesis.






Mondino BJ




Has Abstract


1988-04-01 00:00:00














  • Epibulbar subconjunctival fibroma. A tumor possibly arising from Tenon's capsule.

    abstract::A fibroma, a benign neoplasm arising from the periorbita or tendon sheaths, is described in a 74-year-old woman as an indolent, lobular tumor situated in the episcleral and subconjunctival connective tissues with superior limbal fixation. Because most fibromas arise from tendon sheaths or fascial planes, we speculate ...


    pub_type: 杂志文章


    authors: Herschorn BJ,Jakobiec FA,Hornblass A,Iwamoto T,Harrison WG

    更新日期:1983-12-01 00:00:00

  • Previous Intravitreal Therapy Is Associated with Increased Risk of Posterior Capsule Rupture during Cataract Surgery.

    abstract:PURPOSE:To investigate if previous intravitreal therapy is a predictor of posterior capsule rupture (PCR) during cataract surgery. DESIGN:Multicenter, national electronic medical record (EMR) database study with univariate and multivariate regression modeling. PARTICIPANTS:A total of 65 836 eyes of 44 635 patients un...


    pub_type: 杂志文章,多中心研究


    authors: Lee AY,Day AC,Egan C,Bailey C,Johnston RL,Tsaloumas MD,Denniston AK,Tufail A,United Kingdom Age-related Macular Degeneration and Diabetic Retinopathy Electronic Medical Records Users Group.

    更新日期:2016-06-01 00:00:00

  • Colloid milium of the upper eyelid margins: a rare presentation.

    abstract:AIM:To report a rare presentation of colloid milium occurring only on the upper eyelid margins. DESIGN:Interventional case report. METHODS:(1) Slit-lamp examination of eyelids and eyes and clinical examination including the face and a general physical examination; (2) photography of the lesions on the lids; and (3) e...


    pub_type: 杂志文章


    authors: Muzaffar W,Dar NR,Malik AM

    更新日期:2002-10-01 00:00:00

  • Impact of age-related change of retinal nerve fiber layer and macular thicknesses on evaluation of glaucoma progression.

    abstract:OBJECTIVE:To investigate the impact of age-related change of macular and circumpapillary retinal nerve fiber layer (RNFL) measurements on evaluation of glaucoma progression. DESIGN:Prospective, longitudinal study. PARTICIPANTS:A total of 150 eyes of 90 patients with glaucoma and 72 eyes of 40 normal individuals. MET...


    pub_type: 杂志文章


    authors: Leung CKS,Ye C,Weinreb RN,Yu M,Lai G,Lam DS

    更新日期:2013-12-01 00:00:00

  • Comparison of one-day versus one-hour application of topical gatifloxacin in eliminating conjunctival bacterial flora.

    abstract:PURPOSE:To compare efficacies of 1-day, 1-hour, and combined 1-day/1-hour preoperative topical gatifloxacin in eliminating conjunctival bacterial flora. DESIGN:Prospective, comparative case series. PARTICIPANTS:Sixty patients (120 eyes) scheduled to undergo anterior segment intraocular surgery at Stanford University ...


    pub_type: 临床试验,杂志文章


    authors: Moss JM,Nguyen D,Liu YI,Singh K,Montague A,Egbert PR,Kaspar HM,Ta CN

    更新日期:2008-11-01 00:00:00

  • Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases.

    abstract:OBJECTIVE:To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina. DESIGN:Prospective cross-sectional study. PARTICIPANTS:One hundred one eyes of 84 patients with various retinal diseases. METHODS:A prototype SD OCT system was ...


    pub_type: 杂志文章


    authors: Sakamoto A,Hangai M,Yoshimura N

    更新日期:2008-06-01 00:00:00

  • A fluorescein angiographic study of patients with pars planitis and peripheral exudation (snowbanking) before and after cryopexy.

    abstract:BACKGROUND:Transconjunctival cryopexy of the vitreous base is clinically effective in patients with steroid nonresponsive pars planitis who have peripheral neovascularization. Cryoablation of the region previously has been thought to eliminate the areas of permeable neovascular tissue, thus removing the focus of exudat...


    pub_type: 杂志文章


    authors: Josephberg RG,Kanter ED,Jaffee RM

    更新日期:1994-07-01 00:00:00

  • The ora serrata and the spiral of Tillaux. Anatomic relationship and clinical correlation.

    abstract::Conventional teaching states that the spiral of Tillaux marks the location of the ora serrata. On literature review, no source for this was found. This study explores this anatomic relationship. In 20 cadaver eyes, narrow-gauge needles were placed penetrating the center of each rectus muscle insertion, and distance to...


    pub_type: 杂志文章


    authors: White MH,Lambert HM,Kincaid MC,Dieckert JP,Lowd DK

    更新日期:1989-04-01 00:00:00

  • Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.

    abstract:PURPOSE:To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV). DESIGN:Cross-sectional, case-control association study. PARTICIPANTS:Fifty-five patients with PCV, 368 patients with...


    pub_type: 杂志文章,多中心研究


    authors: Lima LH,Schubert C,Ferrara DC,Merriam JE,Imamura Y,Freund KB,Spaide RF,Yannuzzi LA,Allikmets R

    更新日期:2010-08-01 00:00:00

  • Teller acuity cards versus clinical judgment in the diagnosis of amblyopia with strabismus.

    abstract::Teller acuity card testing, which is a form of the preferential-looking procedure, is a popular way of assessing visual acuity in preverbal patients. The authors suspected that the clinical judgment of a pediatric ophthalmologist is superior to the Teller acuity cards in diagnosing amblyopia when strabismus is present...


    pub_type: 杂志文章


    authors: Ellis GS Jr,Hartmann EE,Love A,May JG,Morgan KS

    更新日期:1988-06-01 00:00:00

  • Antimetabolite drug therapy in herpes simplex.

    abstract::Idoxuridine (IDU) and adenine arabinoside (Ara-A) are less than ideal drugs for the treatment of herpes because of toxicity, only partial efficacy with initial dendritic ulcers, and insufficient antiviral activity to prevent occasional epithelial breakthrough. Trifluorothymidine (TFT), soon to be released by the FDA f...


    pub_type: 杂志文章


    authors: Kaufman HE

    更新日期:1980-02-01 00:00:00

  • Shrinkage of the scleral canal during cupping reversal in children.

    abstract:PURPOSE:The mechanism of cupping reversal seen after lowering intraocular pressure (IOP) in pediatric glaucoma is unknown. Theories include forward movement of the lamina cribrosa or shrinkage of a stretched scleral canal. Our study aimed to quantify changes in optic disc size occurring in children who had undergone gl...


    pub_type: 杂志文章


    authors: Mochizuki H,Lesley AG,Brandt JD

    更新日期:2011-10-01 00:00:00

  • Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19.

    abstract:PURPOSE:To describe the association of demographic, behavioral, medical, and nonretinal ocular factors with the incidence of neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA) in the Age-Related Eye Disease Study (AREDS), a randomized trial of antioxidants and zinc supplementation p...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Clemons TE,Milton RC,Klein R,Seddon JM,Ferris FL 3rd,Age-Related Eye Disease Study Research Group.

    更新日期:2005-04-01 00:00:00

  • Graft dislocation and hypotony after Descemet's stripping automated endothelial keratoplasty in patients with previous glaucoma surgery.

    abstract:PURPOSE:To determine if patients with prior glaucoma surgery experience higher rates of postoperative graft dislocation after Descemet's stripping automated endothelial keratoplasty (DSAEK) and to determine if postoperative hypotony may be a risk factor in these patients. DESIGN:Retrospective, comparative analysis of ...


    pub_type: 杂志文章


    authors: Goshe JM,Terry MA,Li JY,Straiko MD,Davis-Boozer D

    更新日期:2012-06-01 00:00:00

  • A pharmacologist looks at medical treatment in glaucoma--in retrospect and in prospect.

    abstract::The histochemical distribution of carbonic anhydrase activity in the ciliary processes is shown. There is a multiplicity of possible points of attack of carbonic anhydrase inhibitors, We do not know which sites are critically inhibited at clinical dosage. One primary mechanism of the therapeutic action of miotics is c...


    pub_type: 杂志文章


    authors: Bárány EH

    更新日期:1979-01-01 00:00:00

  • Intraocular lens exchange for anterior chamber intraocular lens-induced corneal endothelial damage.

    abstract:BACKGROUND:Anterior chamber and iris-plane intraocular lenses (IOLs) have been implicated in causing corneal endothelial damage and progression to pseudophakic bullous keratopathy. METHODS:The authors performed IOL exchanges on 102 eyes with signs of early corneal decompensation or progressive endothelial cell loss as...


    pub_type: 杂志文章


    authors: Coli AF,Price FW Jr,Whitson WE

    更新日期:1993-03-01 00:00:00

  • Ocular adnexal lymphoma: assessment of a tumor-node-metastasis staging system.

    abstract:PURPOSE:To assess distribution, correlations, and prognostic effect of tumor (T), node (N), and metastasis (M) staging on relapse and survival. DESIGN:Retrospective clinical review. PARTICIPANTS:Sixty-three patients diagnosed with primary ocular adnexal lymphoma (OAL) between January 1986 and November 2011. METHODS:...


    pub_type: 杂志文章


    authors: Aronow ME,Portell CA,Rybicki LA,Sweetenham JW,Singh AD

    更新日期:2013-09-01 00:00:00

  • Symposium: Clinical management of physiologic myopia. Introduction.

    abstract::Myopia is not a cause of serious disease, although the two are sometimes associated. In contrast to hyperopia, it is a symptom and is easily understood. Myopia can have social as well as physical effects. Myopic patients often fear that they have increased their refractive error by their own behavior. This belief is e...


    pub_type: 杂志文章


    authors: Safir A

    更新日期:1979-05-01 00:00:00

  • Malakoplakia of the eyelid.

    abstract::A 35-year-old white man, on immunosuppressive medications for 3 1/2 years following a renal transplant, presented with a whitish-yellow mass at the medial end of the left lower eyelid. An initial incisional biopsy was performed that was misinterpreted as granular cell myoblastoma. The mass was subsequently excised and...


    pub_type: 杂志文章


    authors: Addison DJ

    更新日期:1986-08-01 00:00:00

  • Potential impact of seatbelt use on the spectrum of ocular injuries and visual acuity outcomes after motor vehicle accidents with airbag deployment.

    abstract:PURPOSE:To investigate the association between seatbelt use and (1) the spectrum of ocular injuries and (2) visual acuity outcomes after motor vehicle accidents (MVAs) with airbag deployment. DESIGN:Single-center retrospective observational case series. PARTICIPANTS:Forty-seven patients involved in MVAs with airbag d...


    pub_type: 杂志文章


    authors: Rao SK,Greenberg PB,Filippopoulos T,Scott IU,Katsoulakis NP,Enzer YR

    更新日期:2008-03-01 00:00:00

  • The Fyodorov Sputnik intraocular lens.

    abstract::The author has implanted 197 Fyodorov intraocular lenses. With careful selection of patients, good surgical judgment, and meticulous surgery, a degree of success can be obtained with this lens, which will equal that of conventional cataract surgery. The surgical technique of implantation will be described. ...


    pub_type: 杂志文章


    authors: Kwitko ML

    更新日期:1979-04-01 00:00:00

  • Spontaneous reattachment of rhegmatogenous retinal detachment.

    abstract:PURPOSE:To describe the clinical characteristics of spontaneous reattachment of rhegmatogenous retinal detachment (SRRRD). DESIGN:Retrospective observational case series. PARTICIPANTS:Fifteen patients who were diagnosed with SRRRD. METHODS:The medical records of 15 patients were reviewed. Spontaneous reattachment of...


    pub_type: 杂志文章


    authors: Cho HY,Chung SE,Kim JI,Park KH,Kim SK,Kang SW

    更新日期:2007-03-01 00:00:00

  • National outcomes of cataract extraction. Retinal detachment and endophthalmitis after outpatient cataract surgery. Cataract Patient Outcomes Research Team.

    abstract:BACKGROUND:A near-total shift to cataract extraction on an outpatient basis occurred as a result of an administrative ruling by the Health Care Financing Administration. No national study has been conducted to assess the possible effects of that decision on clinical outcomes of surgery. The authors compared the rates o...


    pub_type: 杂志文章


    authors: Javitt JC,Street DA,Tielsch JM,Wang Q,Kolb MM,Schien O,Sommer A,Bergner M,Steinberg EP

    更新日期:1994-01-01 00:00:00

  • Primary Open-Angle Glaucoma Suspect Preferred Practice Pattern(®) Guidelines.

    abstract:UNLABELLED:PRIMARY OPEN-ANGLE GLAUCOMA SUSPECT PREFERRED PRACTICE PATTERN® GUIDELINES:Evidence-based update of the Primary Open-Angle Suspect Glaucoma Preferred Practice Pattern® (PPP) guidelines, describing the diagnosis and management of patients with primary open-angle glaucoma suspect with detailed recommendations...


    pub_type: 杂志文章,实务指引


    authors: Prum BE Jr,Lim MC,Mansberger SL,Stein JD,Moroi SE,Gedde SJ,Herndon LW Jr,Rosenberg LF,Williams RD

    更新日期:2016-01-01 00:00:00

  • Primary intravitreal bevacizumab for diffuse diabetic macular edema: the Pan-American Collaborative Retina Study Group at 24 months.

    abstract:PURPOSE:To report the 24-month anatomic and Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) response after primary intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA; 1.25 or 2.5 mg) in patients with diffuse diabetic macular edema (DDME). In addition, a comparis...


    pub_type: 杂志文章,多中心研究


    authors: Arevalo JF,Sanchez JG,Wu L,Maia M,Alezzandrini AA,Brito M,Bonafonte S,Lujan S,Diaz-Llopis M,Restrepo N,Rodríguez FJ,Udaondo-Mirete P,Pan-American Collaborative Retina Study Group.

    更新日期:2009-08-01 00:00:00

  • Is there a racial difference in physiologic cup size?

    abstract::Although many clinicians believe that there is a racial difference in the size of the physiologic cup, this premise has not been studied. To evaluate this, we prospectively examined 100 black and 100 white volunteers. Stereoscopic optic disc photographs taken of each subject were masked to block out the fundus pigment...


    pub_type: 杂志文章


    authors: Beck RW,Messner DK,Musch DC,Martonyi CL,Lichter PR

    更新日期:1985-07-01 00:00:00

  • Microbial keratitis predisposing factors and morbidity.

    abstract:PURPOSE:To examine predisposing factors, treatment costs, and visual outcome of microbial keratitis in an ophthalmic casualty and inpatient population. DESIGN:Retrospective medical records review. PARTICIPANTS:Fifteen- to 64-year-olds with microbial keratitis treated at the Royal Victorian Eye and Ear Hospital betwee...


    pub_type: 杂志文章


    authors: Keay L,Edwards K,Naduvilath T,Taylor HR,Snibson GR,Forde K,Stapleton F

    更新日期:2006-01-01 00:00:00

  • Prospective study of sub-Tenon's versus retrobulbar anesthesia for inpatient and day-surgery trabeculectomy.

    abstract:PURPOSE:Several retrospective studies have demonstrated the safety and efficacy of sub-Tenon's anesthesia in ocular surgery. This is the first prospective randomized study comparing sub-Tenon's versus retrobulbar anesthesia for glaucoma surgery. METHODS:Thirty-nine patients undergoing both inpatient and day surgery tr...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Buys YM,Trope GE

    更新日期:1993-10-01 00:00:00

  • Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series.

    abstract:OBJECTIVE:To estimate the rate of acute postoperative endophthalmitis after uncomplicated cataract surgery in patients treated before and after surgery with 1 of 2 different fourth-generation fluoroquinolone ophthalmic drops for surgical prophylaxis. DESIGN:Retrospective, multicenter, observational case series. PARTI...


    pub_type: 杂志文章,多中心研究


    authors: Moshirfar M,Feiz V,Vitale AT,Wegelin JA,Basavanthappa S,Wolsey DH

    更新日期:2007-04-01 00:00:00

  • Plaque radiotherapy for juxtapapillary choroidal melanoma: tumor control in 650 consecutive cases.

    abstract:PURPOSE:To evaluate treatment of juxtapapillary choroidal melanoma with plaque radiotherapy and to investigate the role of supplemental transpupillary thermotherapy (TTT). DESIGN:Retrospective, comparative case series. PARTICIPANTS:We included 650 consecutive eyes with juxtapapillary choroidal melanoma within 1 mm of...


    pub_type: 杂志文章


    authors: Sagoo MS,Shields CL,Mashayekhi A,Freire J,Emrich J,Reiff J,Komarnicky L,Shields JA

    更新日期:2011-02-01 00:00:00