Abstract：
OBJECTIVE:To compare the frequency of posterior segment involvement (PSI), the prevalence of specific posterior segment signs, and visual acuity in ocular sarcoidosis by patient race, sex, and age. DESIGN:Retrospective, cross-sectional observational study. PARTICIPANTS:Seventy-six consecutive patients with biopsy-proven or presumed ocular sarcoidosis seen at the Duke University Eye Center between 1989 and 2001. METHODS:Medical record review. MAIN OUTCOME MEASURES:Patient demographics, presence and laterality of specific posterior segment signs, and visual acuity at initial examination. RESULTS:Of the 76 patients, 68% were black (34 female and 18 male) and 32% were white (18 female and 6 male). A total of 68 patients (89%) had PSI: black patients had 85% and white patients had 100% (P = 0.05). For patients with PSI, white females had the highest mean age at initial examination (58 years compared with 37 years for all others; P = 0.005). The most common findings among the 68 patients with posterior segment disease were vitritis (69%); choroidal "punched-out" lesions (56%); "snowball" lesions (46%); cystoid macular edema (CME; 31%); and periphlebitis, vitreous opacity, and posterior vitreous detachment (29% each). There was a significantly higher prevalence of "punched-out" lesions and CME in whites (79% and 54%, respectively) compared with blacks (43% and 18%, respectively; P = 0.005 each). Additionally, the prevalence of CME was highest in white females (61%) compared with all others (20%; P = 0.002). Patients with vitreous hemorrhage were more likely to be in the youngest age group (P = 0.02). Female patients with posterior segment disease had a significantly lower visual acuity compared with males in both the better (P<0.001) and worse (P = 0.002) eye. CONCLUSIONS:We have identified variations based on patient race, sex, and age in PSI, specific posterior segment signs, and visual acuity in cases of ocular sarcoidosis.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Khalatbari D,Stinnett S,McCallum RM,Jaffe GJdoi
10.1016/S0161-6420(03)00793-0subject
Has Abstractpub_date
2004-02-01 00:00:00pages
357-62issue
2eissn
0161-6420issn
1549-4713pii
S0161-6420(03)00793-0journal_volume
111pub_type
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