Abstract:
PURPOSE:To evaluate the association between cystoid macular edema (CME) observed in very preterm infants and developmental outcomes at 18 to 24 months corrected age. DESIGN:Cohort study. PARTICIPANTS:Infants born at or less than 1500 g or at or less than 30 weeks postmenstrual age who underwent screening for retinopathy of prematurity (ROP) in an intensive care nursery. METHODS:Bedside handheld spectral-domain optical coherence tomography (SD OCT; Envisu, Bioptigen, Inc, Research Triangle Park, NC) imaging was obtained from preterm infants who were being screened for ROP and graded for presence of CME, central foveal thickness (CFT), inner nuclear layer thickness, and foveal-to-parafoveal thickness ratio. At 18 to 24 months corrected age, the children were assessed with the Bayley Scales of Infant and Toddler Development, Third Edition. MAIN OUTCOME MEASURES:Scores on the Bayley cognitive, language, and motor subscales. RESULTS:Among 77 children with SD OCT imaging, 53 were evaluated with the Bayley Scales. Compared with children who did not have CME as infants (n=22), the mean score for children who had CME (n=31) was 7.3 points (95% confidence interval [CI], -15.5 to 0.9; P=0.08) lower on the cognitive subscale, 14.1 points (95% CI, -22.7 to -5.5; P=0.002) lower for the language subscale, and 11.5 points (95% CI, -21.6 to -1.3; P=0.03) lower for the motor subscale. Differences were maintained after adjusting for gestational age and birth weight. Severity of CME, as assessed by foveal-to-parafoveal thickness ratio, within the CME group correlated with poorer cognitive (R2=0.16, P=0.03) and motor (R2=0.15, P=0.03) development. CONCLUSIONS:Cystoid macular edema observed on SD OCT in very preterm infants screened for ROP is associated with poorer language and motor skills at 18 to 24 months corrected age. Evaluation of the retina with SD-OCT may serve as an indicator of neurodevelopmental health for very preterm infants in the intensive care nursery.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Rothman AL,Tran-Viet D,Gustafson KE,Goldstein RF,Maguire MG,Tai V,Sarin N,Tong AY,Huang J,Kupper L,Cotten CM,Freedman SF,Toth CAdoi
10.1016/j.ophtha.2014.09.022subject
Has Abstractpub_date
2015-03-01 00:00:00pages
610-9issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(14)00881-1journal_volume
122pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To assess the risk of advanced age-related macular degeneration (AMD) developing after cataract surgery. DESIGN:Cohort study. PARTICIPANTS:Four thousand five hundred seventy-seven participants (8050 eyes) from a multicenter, controlled, randomized clinical trial, the Age-Related Eye Disease Study (AREDS). ME...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2008.09.019
更新日期:2009-02-01 00:00:00
abstract::Isolated involvement of the optic nerve with metastatic tumor is uncommon. A 19-year-old man had a midline cerebellar medulloblastoma; a gross total removal was performed. He received postoperative radiation therapy to the whole brain, posterior fossa, and craniospinal axis. A progressive optic neuropathy developed 28...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32912-5
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVES:To analyze the temporal correlations of vascular endothelial growth factor (VEGF) suppression, morphologic recurrence of choroidal neovascularization (CNV), and visual acuity loss in eyes with exudative age-related macular degeneration (AMD) treated with ranibizumab. DESIGN:Nonrandomized, prospective, clini...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.07.041
更新日期:2012-10-01 00:00:00
abstract:AIM:To report a rare presentation of colloid milium occurring only on the upper eyelid margins. DESIGN:Interventional case report. METHODS:(1) Slit-lamp examination of eyelids and eyes and clinical examination including the face and a general physical examination; (2) photography of the lesions on the lids; and (3) e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01180-6
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To investigate the hypothesis that the excessive growth of the eye in myopia is associated with general growth and thus influenced by early life biological and social factors, and that these associations underlie recent secular trends of increasing prevalence and severity of myopia. DESIGN:Cohort study. PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.09.025
更新日期:2011-05-01 00:00:00
abstract:TOPIC:The incidence and morbidity of herpes zoster (HZ) and HZ ophthalmicus (HZO), and the potential impact of varicella vaccine on their epidemiology. CLINICAL RELEVANCE:Herpes zoster affects 20% to 30% of the population at some point in their lifetime; approximately 10% to 20% of these individuals will have HZO. ME...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ophtha.2007.10.009
更新日期:2008-02-01 00:00:00
abstract::Vitreous amyloid may be the presenting clinical manifestation of types 1 and 2 familial amyloidotic polyneuropathy or complicate the course of these syndromes. Recent studies have shown that the major subunit protein composing amyloid fibrils in these conditions is a variant or abnormal prealbumin molecule and that af...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33531-6
更新日期:1987-07-01 00:00:00
abstract:PURPOSE:To assess the immediate effect of laser peripheral iridotomy (LPI) and mechanisms of angle closure in a population-based study of primary angle closure (PAC) suspects. DESIGN:Prospective interventional study. PARTICIPANTS:People identified as PAC suspects aged 50 to 79 years from a population-based survey in ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.06.053
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:To compare the impact of first eye versus second eye cataract surgery on visual function and quality of life. DESIGN:Cohort study. PARTICIPANTS:A total of 328 patients undergoing separate first eye and second eye phacoemulsification cataract surgeries at 5 veterans affairs centers in the United States. Patien...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.04.014
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To examine the decrease in the intraocular concentration of intravitreally injected triamcinolone acetonide over an 8-month period in a rabbit model. DESIGN:Experimental study. PARTICIPANTS:The study included 18 white New Zealand rabbits. METHODS:The animals received an intravitreal injection of 6 mg triamci...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.01.019
更新日期:2008-08-01 00:00:00
abstract::Endothelial cell loss, persistent cystoid macular edema and a chronic low-grade uveitis may complicate intracapsular cataract extraction combined with iris supported intraocular lenses. Clinical examination of 19 eyes of 17 patients, at 1.1 to 5 years after cataract surgery, and correlation with wide field specular mi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34228-2
更新日期:1984-07-01 00:00:00
abstract:PURPOSE:We studied the 3-year efficacy and safety results of a 4-year study evaluating fluocinolone acetonide (FA) intravitreal implants in eyes with persistent or recurrent diabetic macular edema (DME). DESIGN:Prospective, evaluator-masked, controlled, multicenter clinical trial. PARTICIPANTS:We included 196 eyes wi...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2011.02.048
更新日期:2011-08-01 00:00:00
abstract::Few cases of recurrent inverted follicular keratosis (IFK) have been reported in the literature, none with histopathologic confirmation. The authors report two cases of IFK that recurred within weeks of primary excision. Histologic confirmation was obtained on all four specimens. By establishing the benign nature of t...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:The authors report the case of an 83-year-old patient with a benign oncocytoma of the inferior eyelid. DESIGN:INTERVENTIONal case report. INTERVENTION:Treatment consisted of a large orbital exenteration followed by reconstruction with a pedicled temporalis muscle flap. MAIN OUTCOME MEASURES:Histologic eval...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)91219-2
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To describe clinical characteristics, management, and complications of primary iris stromal cysts. DESIGN:A retrospective review. RESULTS:Seventeen consecutive patients with primary iris stromal cysts were found. Nine (52%) patients were diagnosed under age 10 years (range, 1 day-7 years), and eight (47%) p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)97041-5
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence and extent of visual recovery in patients with giant cell arteritis (GCA) treated with high doses of systemic corticosteroids. DESIGN:Multicenter prospective case series. PARTICIPANTS:Thirty-four consecutive patients with biopsy-proven GCA and visual loss seen at either Wills Eye H...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2005.01.036
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to establish a practical diagnostic test for choroideremia (CHM) and to show its application in a family with the clinical diagnosis of choroideremia. DESIGN:Case series. PARTICIPANTS:Sixteen males from 13 families with clinically documented CHM and unaffected normal males were enrolled in ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)99031-5
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:Correctable vision impairment caused by refractive error is common in the United States population. We estimated the direct costs of providing eyeglasses to all Americans (age> or =12) who need refractive correction to achieve good distance vision. DESIGN:Cross-sectional study of a nationally representative ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.06.033
更新日期:2006-12-01 00:00:00
abstract::Fourteen patients with well- or intermediately differentiated monoclonal B-lymphocytic tumors of the conjunctiva or orbit had a favorable prognosis with follow-ups of 4 to 9 years (mean and median, 7.5 years). The lesions were, for the most part, diffuse proliferations of small lymphocytes, either with round or minima...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33532-2
更新日期:1986-12-01 00:00:00
abstract::Seventeen patients having a posterior uveal melanoma underwent enucleation following documentation of tumor growth. Duration of follow-up from diagnosis to enucleation ranged from 3 weeks to 30 months. The mean rate of enlargement in cubic tumor volume was 56.3 mm3/mo for eight spindle cell melanomas and 270.3 mm3/mo ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34088-x
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:To determine whether adjusting the intraocular pressure (IOP) change of the trial eye for the IOP change of the fellow eye (i.e., monocular trial) is a better assessment of medication response than testing each eye independently. DESIGN:Analysis of data from a prospective, randomized, clinical trial. PARTIC...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2010.02.020
更新日期:2010-11-01 00:00:00
abstract::The Collaborative Ocular Melanoma Study (COMS) is an international, multicenter-controlled study. The organization includes an Executive Committee, Steering Committee, 6 Central Units, 32 Clinical Centers, and a Data and Safety Monitoring Committee. Scientifically, the COMS consists of (1) a randomized trial of patien...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33086-1
更新日期:1988-07-01 00:00:00
abstract:PURPOSE:To update the findings from the Choroidal Neovascularization Prevention Trial (CNVPT) with respect to resolution of drusen, incidence of choroidal neovascularization, and visual function. DESIGN:A multicenter, randomized, controlled, pilot clinical trial. PARTICIPANTS:The 120 patients enrolled in the CNVPT. P...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/S0161-6420(03)00098-8
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:It has been recently documented that multiple bilateral pigmented lesions at the level of the retinal pigment epithelium may be an indicator of patients with familial adenomatous polyposis who are prone to develop intestinal cancer, particularly if there is a positive family history of these intestinal disor...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31736-1
更新日期:1992-11-01 00:00:00
abstract:PURPOSE:To report the long-term results of corneal collagen cross-linking (CXL) in ectasia after LASIK and photorefractive keratectomy (PRK). DESIGN:Retrospective, interventional cases series. PARTICIPANTS:Twenty-six eyes of 26 patients (18 male, 8 female) with postoperative ectasia after LASIK (23 eyes) and PRK (3 e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.12.027
更新日期:2013-07-01 00:00:00
abstract::The case of a young woman with giant cell polymyositis is described. She had bilateral, severe, midly painful proptosis and ophthalmoplegia. Extensive pharyngeal, laryngeal, and cardiac muscle involvement occurred 18 months later coincident with fatal cardiac arrhythmia. At autopsy, extensive muscle necrosis and giant...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32554-x
更新日期:1990-04-01 00:00:00
abstract::After routine retrobulbar injection of a 4-ml 1:1 mixture of 0.75% bupivacaine, and of 2% lidocaine and one ampule of hyaluronidase for cataract extraction, the patient sustained bilateral opthalmoplegia, blindness, central respiratory arrest, and loss of consciousness. Neurologic examination shortly thereafter sugges...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33543-7
更新日期:1986-11-01 00:00:00
abstract::Ten patients had large recession of four horizontal recti at one procedure for treatment of nystagmus. Six patients had congenital motor nystagmus, two had oculocutaneous albinism, and two had optic nerve hypoplasia. Anomalous head posture with null point was also present in five patients. The rectus muscles were plac...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32139-0
更新日期:1991-08-01 00:00:00
abstract:PURPOSE:A study was performed to determine if diabetic subjects who fail to respond to initial panretinal photocoagulation with regression of retinopathy risk factors do better with supplemental panretinal photocoagulation. METHODS:Thirty-five patients with 3 or more retinopathy risk factors who failed to respond to p...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(92)31739-7
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Leber's hereditary optic neuropathy is associated with four known pathogenetic mutations of mitochondrial DNA (mtDNA) at nucleotide positions (np) 11778, 3460, 15257, and 14484. METHODS:The authors collected clinical data from 12 visually symptomatic patients from seven different pedigrees with the 15257 mu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31527-7
更新日期:1993-07-01 00:00:00