Abstract：
:An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is an autoimmune disease and presents many immune mechanism aberrancies. An association between autoimmune liver disease and sicca complex has been reported. Labeled mitochondrial antibodies bound to the parotid duct have been noted in patients with autoimmune cholangiostatic jaundice and such antibodies may be similar to the antibody against salivary duct found in Sjögren's syndrome. It is suggested that in these two patients, thiabendazole may have acted as a hapten and by binding to the body protein induced the production of autoantibodies which may have acted against the biliary epithelium, the salivary duct epithelium, and the lacrimal gland ducts.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Fink AI,MacKay CJ,Cutler SSdoi
10.1016/s0161-6420(79)35334-9subject
Has Abstractpub_date
1979-10-01 00:00:00pages
1892-6issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(79)35334-9journal_volume
86pub_type
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